Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes.

Abstract:

:This research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.

journal_name

Braz Oral Res

journal_title

Brazilian oral research

authors

Vieira EM,Ueno CS,Valva VN,Goulart Md,Nogueira Tde O,Gomes MF

doi

10.1590/s1806-83242008000200015

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

184-91

issue

2

eissn

1806-8324

issn

1807-3107

pii

S1806-83242008000200015

journal_volume

22

pub_type

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