Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro.

Abstract:

:Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. Genotoxicity tests represent an important part of cancer research to assess the risk of potential carcinogens. In the current study, the potential DNA damage associated with exposure to fluoride was assessed by the single cell gel (comet) assay in vitro. Chinese hamster ovary cells were exposed to sodium fluoride (NaF) at final concentration ranging from 7 to 100 micro/ml for 3 h, at 37 dgrees C. The results pointed out that NaF in all concentrations tested did not contribute to DNA damage as depicted by the mean tail moment and tail intensity. These findings are clinically important since they represent an important contribution to a correct evaluation of the potential health risk associated with the exposure to dental agents.

journal_name

Braz Oral Res

journal_title

Brazilian oral research

authors

Ribeiro DA,Scolastici C,Marques ME,Salvadori DM

doi

10.1590/s1806-83242004000300003

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

192-6

issue

3

eissn

1806-8324

issn

1807-3107

journal_volume

18

pub_type

杂志文章
  • Is there justification for prophylactic extraction of third molars? A systematic review.

    abstract::The present systematic review was performed to investigate if there is evidence justifying the prophylactic extraction of third molars, one of the most frequent procedures in oral surgery. A series of searches was carried out for randomized, clinical trials and systematic reviews in seven databases (MEDLINE, BBO, LILA...

    journal_title:Brazilian oral research

    pub_type: 杂志文章,评审

    doi:

    authors: Costa MG,Pazzini CA,Pantuzo MC,Jorge ML,Marques LS

    更新日期:2013-03-01 00:00:00

  • Adhesion strategy and early bond strengths of glass-fiber posts luted into root canals.

    abstract::This study investigated the effect of coinitiator solutions and self-adhesive resin cement on the early retention of glass-fiber posts. Cylindrical glass-fiber posts were luted into 40 incisor roots with different adhesion strategies (n = 10): SB2, Single Bond 2 + conventional resin cement (RelyX ARC); AP, Scotchbond ...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242012005000017

    authors: Faria-e-Silva AL,Mendonça AA,Garcez RM,Oliveira Ada S,Moreira AG,Moraes RR

    更新日期:2012-09-01 00:00:00

  • Evaluation of the risk of a stripping perforation with Gates-Glidden drills: serial versus crown-down sequences.

    abstract::The aim of this study was to evaluate the remaining dentine/cementum thickness using Gates-Glidden burs in serial and crown-down sequences and to observe which of the two sequences is the safest for preparing mesial roots of molars. Thirty-six left and right human mandibular first molars were selected. Standard access...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242008000100004

    authors: Coutinho-Filho T,De-Deus G,Gurgel-Filho ED,Rocha-Lima AC,Dias KR,Barbosa CA

    更新日期:2008-01-01 00:00:00

  • Erratum: Health-related quality of life of patients with squamous cell carcinoma: a comparison according to tumor location. Braz Oral Res. 2017;31:e105.

    abstract::[This corrects the article doi: 10.1590/1807-3107BOR-2017.vol31.0105]. ...

    journal_title:Brazilian oral research

    pub_type: 杂志文章,已发布勘误

    doi:10.1590/1807-3107BOR-2017.vol31.0105erratum

    authors:

    更新日期:2018-02-01 00:00:00

  • Masticatory performance and bite force in children with primary dentition.

    abstract::The aim of this study was to evaluate the relationship between masticatory performance and maximum bite force in the primary dentition. The sample comprised 15 children of both genders, aged 3 to 5.5 years, with good systemic and oral health, presence of all primary teeth without large caries, no structural anomalies,...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242007000200009

    authors: Gavião MB,Raymundo VG,Rentes AM

    更新日期:2007-04-01 00:00:00

  • Assessment of the flexural strength of two heat-curing acrylic resins for artificial eyes.

    abstract::Prosthetic eyes are artificial substitutes for the eyeball, made of heat-curing acrylic resin, serving to improve the esthetic appearance of the mutilated patient and his/her inclusion in society. The aim of this study was to assess the flexural strength of two heat-curing acrylic resins used for manufacturing prosthe...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242009000300007

    authors: Fernandes AU,Portugal A,Veloso LR,Goiato MC,Santos DM

    更新日期:2009-07-01 00:00:00

  • Analysis of mesiodistal angulations of preadjusted brackets.

    abstract::Manufacturers offer various prescriptions of preadjusted brackets for use in the "straight-wire" orthodontic technique. However, the need to incorporate bends in the rectangular wires during orthodontic finishing has led to concerns regarding the type of prescription chosen and the credibility of information provided ...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107bor-2014.vol28.0038

    authors: Mendonça MR,Verri AC,Fabre AF,Cuoghi OA

    更新日期:2014-01-01 00:00:00

  • Anti-dentine Salivary SIgA in young adults with a history of dental trauma in deciduous teeth.

    abstract::Anti-dentin autoantibodies are associated with inflammatory root resorption in permanent teeth and are modulated by dental trauma and orthodontic force. However, it is not known whether deciduous tooth trauma can stimulate the development of a humoral immune response against dentin. The aim of this study was to evalua...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107BOR-2015.vol29.0102

    authors: Seixas GF,Garbelini CC,Aida KL,Cheirubim AP,Venâncio EJ,Ramos Sde P

    更新日期:2015-01-01 00:00:00

  • HPV in oral squamous cell carcinomas of a Brazilian population: amplification by PCR.

    abstract::Human Papilomaviruses (HPV) are a group of viruses associated with benign and malignant lesions of cutaneous and mucosal epithelia. Some "high risk" HPV types, especially HPV 16 and 18, are strongly correlated with cervical and anogenital cancers and are also related to the genesis of oral squamous cell carcinomas (OS...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242006000100005

    authors: Rivero ER,Nunes FD

    更新日期:2006-01-01 00:00:00

  • Periodontal conditions of teeth presenting pathologic migration.

    abstract::The aim of the present study was to evaluate the periodontal conditions of anterior teeth that presented pathologic migration in patients with chronic periodontitis and to compare periodontal destruction in migrated versus non-migrated teeth. The sample included 32 patients of both sexes (mean age: 46.0 +/- 11.6 years...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242004000400005

    authors: Costa MR,Silvério KG,Rossa CJ,Cirelli JA

    更新日期:2004-10-01 00:00:00

  • Differences in responses to the Oral Health Impact Profile (OHIP14) used as a questionnaire or in an interview.

    abstract::The objective of this study was to compare the completion rates and performance of the Brazilian version of the Oral Health Impact Profile (OHIP14) when applied as an interview or in its original self-reported form. A convenience sample of 74 adult patients was selected in a Dental Clinic (University of Araras, Brazil...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242009000400002

    authors: Sousa PC,Mendes FM,Imparato JC,Ardenghi TM

    更新日期:2009-10-01 00:00:00

  • Prevalence of periodontopathogens and Candida spp. in smokers after nonsurgical periodontal therapy - a pilot study.

    abstract::This pilot study aimed to evaluate the influence of smoking on clinical and microbiological parameters after nonsurgical periodontal therapy. Forty-eight subjects were grouped into smokers (SM, n = 24) and nonsmokers (NS, n = 24) and paired according to gender, age, ethnicity, and periodontal status. Both groups recei...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107BOR-2016.vol30.0092

    authors: Camargo GA,Abreu MG,Cordeiro Rdos S,Wenderoscky Lde F,Duque C

    更新日期:2016-08-22 00:00:00

  • Salivary stress biomarkers and anxiety symptoms in children with and without temporomandibular disorders.

    abstract::The etiology of temporomandibular disorders (TMD), which are considered as a heterogeneous group of psychophysiological disturbances, remains a controversial issue in clinical dentistry. This study aimed to evaluate whether the salivary alpha-amylase (sAA), cortisol levels, and anxiety symptoms differ between children...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107BOR-2017.vol31.0078

    authors: Kobayashi FY,Gavião MBD,Marquezin MCS,Fonseca FLA,Montes ABM,Barbosa TS,Castelo PM

    更新日期:2017-09-28 00:00:00

  • Skeletal maturation of the cervical vertebrae: association with various types of malocclusion.

    abstract::The identification of the skeletal maturation stage of the cervical vertebrae has proven an important reference for orthodontic diagnosis. The aim of the present study was to determine the association between the skeletal maturation stage of the cervical vertebrae and types of malocclusion according to the age and gen...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242012005000003

    authors: Armond MC,Generoso R,Falci SG,Ramos-Jorge ML,Marques LS

    更新日期:2012-03-01 00:00:00

  • Impact of malocclusion on oral health-related quality of life among schoolchildren.

    abstract::The aim of the present study was to evaluate the prevalence and impact of malocclusion on oral health-related quality of life (OHRQoL) among schoolchildren aged 8 to 10 years and their parents in Diamantina, a town in the southeast of Brazil. A cross-sectional study was conducted with a sample of 390 randomly selected...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107bor-2018.vol32.0095

    authors: Guimarães SPA,Jorge KO,Fontes MJF,Ramos-Jorge ML,Araújo CTP,Ferreira EF,Melgaço CA,Zarzar PM

    更新日期:2018-01-01 00:00:00

  • Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin.

    abstract::Gingival overgrowth (GO) is a frequent finding in patients treated with cyclosporine (CsA). This study investigated the prevalence and severity of GO in patients who received kidney transplant and CsA therapy, as well as associations with pharmacological and clinical factors. This cross-sectional study included 63 kid...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242011005000016

    authors: Wentz LA,Oliveira SC,Moreira CH,Rösing CK

    更新日期:2012-01-01 00:00:00

  • Signs and symptoms of temporomandibular disorders in adolescents.

    abstract::The aim of this study was to verify the prevalence of signs and symptoms of temporomandibular disorders (TMD) in adolescents and its relationship to gender. The sample comprised 217 subjects, aged 12 to 18. The subjective symptoms and clinical signs of TMD were evaluated, using, respectively, a self-report questionnai...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242005000200004

    authors: Bonjardim LR,Gavião MB,Pereira LJ,Castelo PM,Garcia RC

    更新日期:2005-04-01 00:00:00

  • Effect of the sense of coherence and associated factors in the quality of life of head and neck cancer patients.

    abstract::The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharyn...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107bor-2020.vol34.0009

    authors: Bonzanini LIL,Soldera EB,Ortigara GB,Schulz RE,Knorst JK,Ardenghi TM,Ferrazzo KL

    更新日期:2020-02-07 00:00:00

  • Evaluation of alternative methods for the disinfection of toothbrushes.

    abstract::The aim of this study was to evaluate alternative methods for the disinfection of toothbrushes considering that most of the previously proposed methods are expensive and cannot be easily implemented. Two-hundred toothbrushes with standardized dimensions and bristles were included in the study. The toothbrushes were di...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242010000100005

    authors: Komiyama EY,Back-Brito GN,Balducci I,Koga-Ito CY

    更新日期:2010-01-01 00:00:00

  • Comparative therapeutic use of Risedronate and Calcarea phosphorica--allopathy versus homeopathy--in bone repair in castrated rats.

    abstract::Osteoporosis, a disease characterized by progressive bone loss, has been the target of several studies in the past few years. It results in a much higher risk for fractures and might cause slower bone lesion healing. The aim of this work was to study the effects of Risedronate (allopathic medicine) and Calcarea phosph...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242006000300003

    authors: Werkman C,Senra GS,da Rocha RF,Brandão AA

    更新日期:2006-07-01 00:00:00

  • Effect of filling technique on the bond strength of methacrylate and silorane-based composite restorations.

    abstract::The bond strength of methacrylate (Z350, 3M ESPE) and silorane (P90, 3M ESPE) restorations, using different cavity filling techniques, was investigated. Cavities (6 × 3 × 3) in bovine teeth were filled using bulk, oblique, or horizontal increments. A push-out test was carried out after 24 h. Data were statistically an...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107BOR-2016.vol30.0044

    authors: Machado FW,Borges FB,Cenci MS,Moraes RR,Boscato N

    更新日期:2016-01-01 00:00:00

  • Mouthwashes for the control of supragingival biofilm and gingivitis in orthodontic patients: evidence-based recommendations for clinicians.

    abstract::Properly performed daily mechanical biofilm control is the most important prevention strategy for periodontal diseases. However, proper mechanical biofilm control is not performed effectively by the majority of the population, mainly due to lack of motivation and of manual dexterity. Local biofilm retention factors ma...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107bor-2014.vol28.0021

    authors: Haas AN,Pannuti CM,Andrade AK,Escobar EC,Almeida ER,Costa FO,Cortelli JR,Cortelli SC,Rode SD,Pedrazzi V,Oppermann RV

    更新日期:2014-07-11 00:00:00

  • Low-intensity pulsed ultrasound promotes tissue regeneration in rat dental follicle cells in a porous ceramic scaffold.

    abstract::The aim of this study was to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on the osteogenic differentiation of dental follicle cells (DFCs) in vitro and on the regenerative effects of DFC-OsteoBoneTM complexes in vivo. DFCs were isolated and characterized. In the in vitro study, DFCs were culture...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107bor-2019.vol33.0045

    authors: Kuang Y,Hu B,Xia Y,Jiang D,Huang H,Song J

    更新日期:2019-09-09 00:00:00

  • Effect of occlusal splint thickness on electrical masticatory muscle activity during rest and clenching.

    abstract::The extent of separation between the maxillary and mandibular teeth in the fabrication of interocclusal splints designed to achieve efficiency and muscle relaxation is controversial and undefined in the literature. Based on this premise, the aim of this study was to evaluate the effect of interocclusal splint thicknes...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242011000600006

    authors: Pita MS,Ribeiro AB,Garcia AR,Pedrazzi V,Zuim PR

    更新日期:2011-11-01 00:00:00

  • A multicenter study of biopsied oral and maxillofacial lesions in a Brazilian pediatric population.

    abstract::The aim of this study was to investigate the prevalence of oral and maxillofacial lesions among children from representative regions of Brazil. A retrospective descriptive study was conducted. Biopsy records comprising the period from 2000 to 2015 were obtained from the archives of three Brazilian oral pathology refer...

    journal_title:Brazilian oral research

    pub_type: 杂志文章,多中心研究

    doi:10.1590/1807-3107bor-2018.vol32.0020

    authors: Silva LVO,Arruda JAA,Martelli SJ,Kato CNAO,Nunes LFM,Vasconcelos ACU,Tarquinio SBC,Gomes APN,Gomez RS,Mesquita RA,Silveira MMFD,Sobral APV

    更新日期:2018-03-15 00:00:00

  • Changes in irradiance and energy density in relation to different curing distances.

    abstract::The present study aimed to assess the influence of curing distance on the loss of irradiance and power density of four curing light devices. The behavior in terms of power density of four different dental curing devices was analyzed (Valo, Elipar 2, Radii-Cal, and Optilux-401) using three different distances of photop...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107BOR-2015.vol29.0060

    authors: Beolchi RS,Moura-Netto C,Palo RM,Rocha Gomes Torres C,Pelissier B

    更新日期:2015-01-01 00:00:00

  • Psychological factors and the incidence of temporomandibular disorders in early adolescence.

    abstract::The purpose of the present study was to evaluate the relationship between psychological variables and the clinical diagnosis of temporomandbular disorders (TMD) in 12-year-old adolescents. TMD pain was assessed by RDC/TMD examination (Research Diagnostic Criteria for Temporomandibular Disorders) (Axis I and II). Five-...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242009000200011

    authors: Pereira LJ,Pereira-Cenci T,Pereira SM,Cury AA,Ambrosano GM,Pereira AC,Gavião MB

    更新日期:2009-04-01 00:00:00

  • Torsional fatigue strength of reciprocating and rotary pathfinding instruments manufactured from different NiTi alloys.

    abstract::To evaluate the torsional properties of engine-driven pathfinding instruments manufactured from different NiTi alloys - R-Pilot (tip size 12.5;.04 taper; M-Wire) and One G (tip size 14;.03 taper; Conventional NiTi). A total of 40 NiTi instruments from engine-driven pathfinding instruments (n = 20) were used. The torsi...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/1807-3107bor-2019.vol33.0097

    authors: Vivan RR,Alcalde MP,Candeiro G,Gavini G,Caldeira CL,Duarte MAH

    更新日期:2019-10-28 00:00:00

  • Over-the-counter whitening agents: a concise review.

    abstract::Tooth discoloration is commonly found in the dental clinic and tooth bleaching has been considered the preferred esthetic alternative, being more conservative, safe and with predictable results. Supervised home-use of 10% Carbamide Peroxide (CP) bleaching with custom-trays is the most common bleaching procedure dispen...

    journal_title:Brazilian oral research

    pub_type: 杂志文章,评审

    doi:10.1590/s1806-83242009000500010

    authors: Demarco FF,Meireles SS,Masotti AS

    更新日期:2009-01-01 00:00:00

  • Clinical and biochemical evaluation of the saliva of patients with xerostomia induced by radiotherapy.

    abstract::Clinical aspects and biochemical properties in the saliva of 21 patients prior to and following radiotherapy for head and neck cancer were evaluated (experimental group) and compared with the same properties in a control group of 21 subjects free of cancer. Salivary flow was evaluated by measuring the time necessary, ...

    journal_title:Brazilian oral research

    pub_type: 杂志文章

    doi:10.1590/s1806-83242004000100013

    authors: de Barros Pontes C,Polizello AC,Spadaro AC

    更新日期:2004-01-01 00:00:00