Cardiovascular Functional Changes in Chronic Kidney Disease: Integrative Physiology, Pathophysiology and Applications of Cardiopulmonary Exercise Testing.

abstract：BACKGROUND:Human labor is a complex series of cellular and molecular events that occur at the materno-fetal and uterine levels. Many hypotheses have been proposed for the initiation of human labor, one hypothesis suggests that maturation of the fetus releases a signal in the amniotic fluid that will be transmitted to m...

journal_title：Frontiers in physiology

authors： Alzamil HA,Pawade J,Fortier MA,Bernal AL

更新日期：2014-07-30 00:00:00

abstract：:Kir7.1 encoded by the Kcnj13 gene in the mouse is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. Further investigations of the localisation and function of Kir7.1 would benefit from the availability of a knockout mouse, but perinatal mortality attribu...

journal_title：Frontiers in physiology

authors： Cornejo I,Villanueva S,Burgos J,López-Cayuqueo KI,Chambrey R,Julio-Kalajzić F,Buelvas N,Niemeyer MI,Figueiras-Fierro D,Brown PD,Sepúlveda FV,Cid LP

更新日期：2018-04-23 00:00:00

abstract：:Children with Developmental Coordination Disorder (DCD) and children at risk for DCD (r-DCD) present motor impairments interfering in their school, leisure and daily activities. In addition, these children may have abnormalities in their cardiac autonomic control, which together with their motor impairments, restrict ...

journal_title：Frontiers in physiology

authors： Cavalcante Neto JL,Zamunér AR,Moreno BC,Silva E,Tudella E

更新日期：2018-03-22 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative ...

journal_title：Frontiers in physiology

authors： Smith JF,Starr EG,Goodman MA,Hanson RB,Palmer TA,Woolstenhulme JB,Weyand JA,Marchant AD,Bueckers SL,Nelson TK,Sterling MT,Rose BJ,Porter JP,Eggett DL,Kooyman DL

更新日期：2020-02-18 00:00:00

abstract：:Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by ...

journal_title：Frontiers in physiology

authors： Tao J,Lan Z,Wang Y,Hei H,Tian L,Pan W,Zhang X,Peng W

更新日期：2016-06-21 00:00:00

abstract：:Aim: Acute ingestion of alcohol is often accompanied by cardiovascular dysregulation, malaise and even syncope. The full hemodynamic and cutaneous responses to the combination of alcohol and sugar (i.e., alcopops), a common combination in young people, and the mechanisms for the propensity to orthostatic intolerance a...

journal_title：Frontiers in physiology

authors： Maufrais C,Charriere N,Montani JP

更新日期：2017-11-10 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) not only play essential roles in bone development but also are involved in embryonic growth, organogenesis cell proliferation and differentiation. However, the previous studies on the functions of shellfish BMPs genes are still very limited. To better understand its molecular structu...

journal_title：Frontiers in physiology

authors： Zhao J,Cui B,Yao H,Lin Z,Dong Y

更新日期：2020-08-28 00:00:00

abstract：:Maternal over- and restricted-feeding during gestation have similar negative consequences for the offspring, including decreased muscularity, increased adiposity, and altered metabolism. Our objective was to determine the effects of poor maternal nutrition during gestation (over- and restricted-feeding) on the offspri...

journal_title：Frontiers in physiology

authors： Martin DE,Jones AK,Pillai SM,Hoffman ML,McFadden KK,Zinn SA,Govoni KE,Reed SA

更新日期：2019-05-01 00:00:00

abstract：:Supplementation of omega-3 fatty acids (Ω-3) has been associated with a decreased cardiovascular risk, thereby concentrating attention on a potentially preventive effect regarding tachyarrhythmias and sudden cardiac death. However, recent randomized controlled trials challenge the efficacy of the additional applicatio...

journal_title：Frontiers in physiology

authors： Rauch B,Senges J

更新日期：2012-04-02 00:00:00

abstract：:We investigate analytically the production of entropy during a breathing cycle in healthy and diseased lungs. First, we calculate entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary pressure-volume (P-V) curves of the lung under the assumption that lung tissue be...

journal_title：Frontiers in physiology

authors： Oliveira CL,Araújo AD,Bates JH,Andrade JS Jr,Suki B

更新日期：2016-03-01 00:00:00

abstract：:Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein components involved in the mitochondrial translational machinery is critical....

journal_title：Frontiers in physiology

authors： Koc EC,Cimen H,Kumcuoglu B,Abu N,Akpinar G,Haque ME,Spremulli LL,Koc H

更新日期：2013-07-30 00:00:00

abstract：:Corpus luteum (CL) is a transient endocrine tissue that produces progesterone for maintaining pregnancy in mammals. In addition, the regression of CL is necessary for the initiation of the estrous cycle. Extensive research has shown that the prostaglandin F2α (PGF2α) induces the regression of CL in ruminants. However,...

journal_title：Frontiers in physiology

authors： Wen X,Liu L,Li S,Lin P,Chen H,Zhou D,Tang K,Wang A,Jin Y

更新日期：2020-09-11 00:00:00

abstract：:Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NL...

journal_title：Frontiers in physiology

authors： Zhao W,Zhang L,Chen R,Lu H,Sui M,Zhu Y,Zeng L

更新日期：2018-11-14 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a "disease of the sarcomere." Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms responsible for the deve...

journal_title：Frontiers in physiology

authors： Chowdhury SAK,Warren CM,Simon JN,Ryba DM,Batra A,Varga P,Kranias EG,Tardiff JC,Solaro RJ,Wolska BM

更新日期：2020-03-10 00:00:00

abstract：:The discus fish (Symphysodon aequifasciatus) is an ornamental fish that is well-known around the world. In artificial reproduction, they must be matched by one male and one female, whereas phenotype investigation indicated that there are no significant differences in appearance between males and females, which causes ...

journal_title：Frontiers in physiology

authors： Fu Y,Xu Z,Wen B,Gao J,Chen Z

更新日期：2020-08-11 00:00:00

abstract：:Purpose: Blood biomarkers are a useful tool to study concussion. However, their interpretation is complicated by a number of potential biological confounds, including exercise. This is particularly relevant in military and athletic settings where injury commonly occurs during physical exertion. The impact of high-inte...

journal_title：Frontiers in physiology

authors： Di Battista AP,Moes KA,Shiu MY,Hutchison MG,Churchill N,Thomas SG,Rhind SG

更新日期：2018-09-28 00:00:00

abstract：:Neuromuscular training in young athletes improves performance and decreases the risk of injuries during sports activities. These effects are primarily ascribed to the enhancement of muscle strength and power but also balance, speed and agility. However, most studies have failed to demonstrate significant improvement i...

journal_title：Frontiers in physiology

authors： Zemková E,Hamar D

更新日期：2018-04-11 00:00:00

abstract：:Delivery of exogenous high mobility group box 1 (HMGB1) may exert a beneficial effect on myocardial ischemia-reperfusion (I/R) injury. Since the expression of vascular endothelial growth factor (VEGF) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) in the myocardium mediates the cardioprotective function...

journal_title：Frontiers in physiology

authors： Zhou YH,Han QF,Gao L,Sun Y,Tang ZW,Wang M,Wang W,Yao HC

更新日期：2020-01-29 00:00:00

abstract：:Data-driven computational neural network models have been used to study mechanisms for generating the motor patterns for breathing and breathing related behaviors such as coughing. These models have commonly been evaluated in open loop conditions or with feedback of lung volume simply represented as a filtered version...

journal_title：Frontiers in physiology

authors： O'Connor R,Segers LS,Morris KF,Nuding SC,Pitts T,Bolser DC,Davenport PW,Lindsey BG

更新日期：2012-07-23 00:00:00

abstract：:Background:Plutella xylostella has become a notorious pest of cruciferous crops all over the world. Delta-endotoxins of Bacillus thuringiensis are widely used insecticidal proteins for controlling P. xylostella. However, the interaction mechanism of B. thuringiensis with the immune system of P. xylostella, at the geno...

journal_title：Frontiers in physiology

authors： Li S,Xu X,Shakeel M,Xu J,Zheng Z,Zheng J,Yu X,Zhao Q,Jin F

更新日期：2018-11-15 00:00:00

abstract：:The year 2002 marked the tercentenary of Antonie van Leeuwenhoek's discovery of desiccation tolerance in animals. This remarkable phenomenon to sustain 'life' in the absence of water can be revived upon return of hydrating conditions. Today, coping with climate change-related factors, especially temperature-humidity i...

journal_title：Frontiers in physiology

authors： Thorat L,Nath BB

更新日期：2018-12-21 00:00:00

abstract：:Temperature is an important abiotic factor that drives the evolution of ectotherms owing to its pervasive effects at all levels of organization. Although a species' thermal tolerance is environmentally driven within a spatial cline, it may be constrained over time due to differential phylogenetic inheritance. At the l...

journal_title：Frontiers in physiology

authors： Faria SC,Bianchini A,Lauer MM,Zimbardi ALRL,Tapella F,Romero MC,McNamara JC

更新日期：2020-04-24 00:00:00

abstract：:Highly aerobically trained individuals are unable to achieve maximal oxygen uptake ([Formula: see text]) during exhaustive running lasting ~2 min, instead [Formula: see text] plateaus below [Formula: see text] after ~1 min. Hypoxia offers the opportunity to study the ([Formula: see text]) response to an exhaustive run...

journal_title：Frontiers in physiology

authors： Black MI,Potter CR,Corbett J,Clark CC,Draper SB

更新日期：2017-02-21 00:00:00

abstract：:The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (...

journal_title：Frontiers in physiology

authors： Villa CR,Morales DLS

更新日期：2017-05-09 00:00:00

abstract：:Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a...

journal_title：Frontiers in physiology

authors： Whitehead N,Gill JF,Brink M,Handschin C

更新日期：2018-03-21 00:00:00

abstract：:Patients undergoing the complex treatment for hematological malignancies are exposed to a high physiological and psychological distress inducing fatigue and physical inactivity. In line with cancer-related metabolic changes patients are predisposed for skeletal muscle mass loss that leads to a functional decline, affe...

journal_title：Frontiers in physiology

authors： Schink K,Reljic D,Herrmann HJ,Meyer J,Mackensen A,Neurath MF,Zopf Y

更新日期：2018-12-18 00:00:00

abstract：:Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical outcome following myocardial infarction but is inevitably associated with ischemia-reperfusion injury (IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion pri...

journal_title：Frontiers in physiology

authors： Martin-Puig S,Tello D,Aragonés J

更新日期：2015-05-20 00:00:00

abstract：INTRODUCTION:Severe dengue hemorrhagic fever (DHF) is a viral infection that acts to increase permeability of capillaries, resulting in internal hemorrhage. Linear frequency domain Fourier spectral analysis represents the most published noninvasive tool for diagnosing and assessing health status via calculated heart ra...

journal_title：Frontiers in physiology

authors： Carter R 3rd,Hinojosa-Laborde C,Convertino VA

更新日期：2014-02-25 00:00:00

abstract：:Lung ischemia reperfusion (IR) injury inevitably occurs during lung transplantation. The pulmonary endothelium is the primary target of IR injury that potentially results in severe pulmonary dysfunction. Over the last decades, various molecules, receptors, and signaling pathways were identified in order to develop tre...

journal_title：Frontiers in physiology

authors： Jungraithmayr W

更新日期：2020-12-18 00:00:00

abstract：:Cardiac autonomic function can be quantified through mean heart rate (HR) or heart rate variability (HRV). Numerous studies have supported the utility of different HRV parameters as indicators of cardiorespiratory fitness (CRF). However, HR has recently shown to be a stronger predictor of CRF than HRV in healthy young...

journal_title：Frontiers in physiology

authors： Plaza-Florido A,Migueles JH,Mora-Gonzalez J,Molina-Garcia P,Rodriguez-Ayllon M,Cadenas-Sanchez C,Esteban-Cornejo I,Solis-Urra P,de Teresa C,Gutiérrez Á,Michels N,Sacha J,Ortega FB

更新日期：2019-05-07 00:00:00