Cardiovascular and Cutaneous Responses to the Combination of Alcohol and Soft Drinks: The Way to Orthostatic Intolerance?

abstract：:Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated the acute (1-2 days) and 2-week effects of blocking ACVR2 ligand...

journal_title：Frontiers in physiology

authors： Hentilä J,Nissinen TA,Korkmaz A,Lensu S,Silvennoinen M,Pasternack A,Ritvos O,Atalay M,Hulmi JJ

更新日期：2019-01-18 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：:Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate l...

journal_title：Frontiers in physiology

authors： Gambara G,Salanova M,Ciciliot S,Furlan S,Gutsmann M,Schiffl G,Ungethuem U,Volpe P,Gunga HC,Blottner D

更新日期：2017-05-05 00:00:00

abstract：:Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium an...

journal_title：Frontiers in physiology

authors： Knöpfel EB,Vilches C,Camargo SMR,Errasti-Murugarren E,Stäubli A,Mayayo C,Munier FL,Miroshnikova N,Poncet N,Junza A,Bhattacharya SS,Prat E,Berry V,Berger W,Heon E,Moore AT,Yanes Ó,Nunes V,Palacín M,Verrey F,Kloecke

更新日期：2019-06-04 00:00:00

abstract：:Many cell division processes have been conserved throughout evolution and are being revealed by studies on model organisms such as bacteria, yeasts, and protozoa. Cellular membrane constriction is one of these processes, observed almost universally during cell division. It happens similarly in all organisms through a ...

journal_title：Frontiers in physiology

authors： Beltrán-Heredia E,Almendro-Vedia VG,Monroy F,Cao FJ

更新日期：2017-05-19 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：:Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which are ectopic nodules of nerve cells that failed to migrate appropria...

journal_title：Frontiers in physiology

authors： Vontell R,Supramaniam VG,Davidson A,Thornton C,Marnerides A,Holder-Espinasse M,Lillis S,Yau S,Jansson M,Hagberg HE,Rutherford MA

更新日期：2019-05-24 00:00:00

abstract：:Objective: Fatigue is a core feature of functional somatic syndromes (FSS). Fatigue is also prominent in patients with thyroid diseases, which is unsurprising given the role of the hypothalamic-pituitary-thyroid (HPT) axis in regulating physiological energy demands. Research in healthy women has shown that early life ...

journal_title：Frontiers in physiology

authors： Fischer S,Markert C,Strahler J,Doerr JM,Skoluda N,Kappert M,Nater UM

更新日期：2018-05-23 00:00:00

abstract：:Hypoxia has important effects on biological activity in crustaceans, and modulation of energy metabolism is a crucial aspect of crustaceans' ability to respond to hypoxia. The adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) enzyme is very important in cellular energy homeostasis; however, little infor...

journal_title：Frontiers in physiology

authors： Sun S,Gu Z,Fu H,Zhu J,Ge X,Wu X

更新日期：2018-06-14 00:00:00

abstract：:Background: Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating NRG4 mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose...

journal_title：Frontiers in physiology

authors： Comas F,Martínez C,Sabater M,Ortega F,Latorre J,Díaz-Sáez F,Aragonés J,Camps M,Gumà A,Ricart W,Fernández-Real JM,Moreno-Navarrete JM

更新日期：2019-01-31 00:00:00

abstract：:The ketogenic diet (KD) has been utilized as a dietary therapeutic for nearly a century. One experimental model particularly responsive to the KD is the BTBRT+tf/j (BTBR) mouse, which displays phenotypic characteristics of autism spectrum disorder (ASD) and insulin resistance. Recently, the study of impaired mitochond...

journal_title：Frontiers in physiology

authors： Newell C,Shutt TE,Ahn Y,Hittel DS,Khan A,Rho JM,Shearer J

更新日期：2016-12-27 00:00:00

abstract：:Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and strength of contractions, and (iii) modulation of autonomic nervous system input to both the primary pa...

journal_title：Frontiers in physiology

authors： Trenor B,Cardona K,Saiz J,Rajamani S,Belardinelli L,Giles WR

更新日期：2013-10-17 00:00:00

abstract：:Muscle quality and the physiological condition of fish are affected greatly by the culture environment. In aquaculture ponds, a bio-floating bed planted with vegetation is often used to improve water quality. This study investigated the growth and muscle quality of grass carp (Ctenopharyngodon idellus) cultured in pon...

journal_title：Frontiers in physiology

authors： Zhang X,Wang J,Tang R,He X,Li L,Takagi Y,Li D

更新日期：2019-05-31 00:00:00

abstract：:FXYD proteins are important regulators of Na+/K+-ATPase (NKA) activity in mammals. As an inhabitant of estuaries, the pufferfish (Tetraodon nigroviridis) responds to ambient salinity changes with efficient osmoregulation, including alterations in branchial, and renal NKA activities. Previous studies on teleostean FXYD...

journal_title：Frontiers in physiology

authors： Wang PJ,Yang WK,Lin CH,Hwang HH,Lee TH

更新日期：2017-08-08 00:00:00

abstract：:Aim: Combined use of herbal medicines in patients underwent dual antiplatelet therapy (DAPT) might cause bleeding or thrombosis because herbal medicines with anti-platelet activities may exhibit interactions with DAPT. In this study, we tried to use a feedback system control (FSC) optimization technique to optimize do...

journal_title：Frontiers in physiology

authors： Liu W,Li YL,Feng MT,Zhao YW,Ding X,He B,Liu X

更新日期：2018-05-04 00:00:00

abstract：:High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM). Adult male Munic...

journal_title：Frontiers in physiology

authors： Foresto-Neto O,Albino AH,Arias SCA,Faustino VD,Zambom FFF,Cenedeze MA,Elias RM,Malheiros DMAC,Camara NOS,Fujihara CK,Zatz R

更新日期：2020-02-11 00:00:00

abstract：:Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota displayed specific features with a prevalence of Lactobacillus, ...

journal_title：Frontiers in physiology

authors： Gillard L,Mayeur C,Robert V,Pingenot I,Le Beyec J,Bado A,Lepage P,Thomas M,Joly F

更新日期：2017-04-19 00:00:00

abstract：:While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging. Several transcription factors are candidates for enamel gene expressi...

journal_title：Frontiers in physiology

authors： Babajko S,de La Dure-Molla M,Jedeon K,Berdal A

更新日期：2015-01-05 00:00:00

abstract：:Progressive aging induces several structural and functional alterations in the cardiovascular system, among whom particularly important are a reduced number of myocardial cells and increased interstitial collagen fibers, which result in impaired left ventricular diastolic function. Even in the absence of cardiovascula...

journal_title：Frontiers in physiology

authors： Vigorito C,Giallauria F

更新日期：2014-02-20 00:00:00

abstract：:Accurate evaluation of the appearance of QTc sex differences during childhood and adolescence is intricate. Inter-subject differences of individual QT/RR patterns make generic heart rate corrections inaccurate because of fast resting heart rates in children. The study investigated 527 healthy children and adolescents ...

journal_title：Frontiers in physiology

authors： Andršová I,Hnatkova K,Helánová K,Šišáková M,Novotný T,Kala P,Malik M

更新日期：2019-08-02 00:00:00

abstract：:Astronauts exposed to microgravity face sensorimotor challenges affecting balance control when readapting to Earth's gravity upon return from spaceflight. Small amounts of electrical noise applied to the vestibular system have been shown to improve balance control during standing and walking under discordant sensory c...

journal_title：Frontiers in physiology

authors： Temple DR,De Dios YE,Layne CS,Bloomberg JJ,Mulavara AP

更新日期：2018-03-29 00:00:00

abstract：:AF is a heterogeneous rhythm disorder that is related to a wide spectrum of etiologies and has broad clinical presentations. Mechanisms underlying AF are complex and remain incompletely understood despite extensive research. They associate interactions between triggers, substrate and modulators including ionic and ana...

journal_title：Frontiers in physiology

authors： Cheniti G,Vlachos K,Pambrun T,Hooks D,Frontera A,Takigawa M,Bourier F,Kitamura T,Lam A,Martin C,Dumas-Pommier C,Puyo S,Pillois X,Duchateau J,Klotz N,Denis A,Derval N,Jais P,Cochet H,Hocini M,Haissaguerre M,Sache

更新日期：2018-10-17 00:00:00

abstract：Background:Spontaneously Hypertensive Rats (SHR) have chronically elevated blood pressures at 30 weeks of age (systolic: 191.0 ± 1.0, diastolic: 128.8 ± 0.9). However, despite this chronic malignant hypertension, SHR kidneys remain relatively free of pathology due to having an augmented myogenic constriction (MC). We h...

journal_title：Frontiers in physiology

authors： Nademi S,Lu C,Dickhout JG

更新日期：2020-07-22 00:00:00

abstract：:Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellu...

journal_title：Frontiers in physiology

authors： Moullé VS,Cansell C,Luquet S,Cruciani-Guglielmacci C

更新日期：2012-09-28 00:00:00

abstract：:Percutaneous edge-to-edge mitral valve (MV) repair using MitraClip has been recently established as a treatment option for patients with heart failure and functional mitral regurgitation (MR), which significantly expands the number of patients that can be treated with this device. This study aimed to quantify the morp...

journal_title：Frontiers in physiology

authors： Caballero A,Mao W,McKay R,Hahn RT,Sun W

更新日期：2020-05-07 00:00:00

abstract：:In an emerging bioelectronics era, there is a clinical need for physiological devices incorporating biofeedback that permits natural and demand-dependent control in real time. Here, we describe a novel device termed a central pattern generator (CPG) that uses cutting edge analog circuitry producing temporally controll...

journal_title：Frontiers in physiology

authors： O'Callaghan EL,Chauhan AS,Zhao L,Lataro RM,Salgado HC,Nogaret A,Paton JF

更新日期：2016-02-04 00:00:00

abstract：:Infants born premature are at increased risk for development of bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), and ultimately right ventricular (RV) dysfunction, which together carry a high risk of neonatal mortality. However, the role alveolar simplification and abnormal pulmonary microvascular develo...

journal_title：Frontiers in physiology

authors： Patel JR,Barton GP,Braun RK,Goss KN,Haraldsdottir K,Hopp A,Diffee G,Hacker TA,Moss RL,Eldridge MW

更新日期：2017-10-25 00:00:00

abstract：:One of the key defining features of an endogenous circadian clock is that it can be entrained or set to local time. Though a number of cues can perform this role, light is the predominant environmental signal that acts to entrain circadian pacemakers in most species. For the past 20 years, a great deal of work has bee...

journal_title：Frontiers in physiology

authors： Steindal IAF,Whitmore D

更新日期：2020-08-14 00:00:00

abstract：:Na(+)/Ca(2+) exchanger (NCX) proteins extrude Ca(2+) from the cell to maintain cellular homeostasis. Since NCX proteins contribute to numerous physiological and pathophysiological events, their pharmacological targeting has been desired for a long time. This intervention remains challenging owing to our poor understan...

journal_title：Frontiers in physiology

authors： Giladi M,Tal I,Khananshvili D

更新日期：2016-02-09 00:00:00

abstract：:Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these findings to adult cardi...

journal_title：Frontiers in physiology

authors： Lei CL,Wang K,Clerx M,Johnstone RH,Hortigon-Vinagre MP,Zamora V,Allan A,Smith GL,Gavaghan DJ,Mirams GR,Polonchuk L

更新日期：2017-12-12 00:00:00