Abstract:
:Object: Diabetes is associated with cerebral vascular dysfunction and increased vascular cognitive impairment. The objective of this study was to use arterial spin labeling (ASL) perfusion-weighted magnetic resonance imaging to investigate whether cerebral perfusion was changed in newly-diagnosed children with type 1 diabetes mellitus (T1DM) and the possible relationship between aberrant cerebral blood flow (CBF) with cognitive as well as clinical variables. Methods: Between January 2017 and February 2018, 34 children with newly-diagnosed T1DM and 34 age, gender, and education-matched healthy controls were included. Three dimensional pseudo-continuous ASL perfusion MRI was used to evaluate CBF. A conventional T2WI sequence was added to exclude intracranial disease. Regions with CBF differences between T1DM children and the controls were detected via voxel-wise comparisons in REST software. Associations among the result of neuropsychological test, clinical variables, and CBF values of different brains were investigated by using partial correlation analysis. Results: Compared with the controls, T1DM children show decreased CBF in the left calcarine and postcentral gyrus, and right precentral gyrus. The perfusion in the postcentral gyrus was positively correlated with IQ performance. No significant correlations were found between CBF and HbA1c, blood glucose level before imaging and IQ in other brain regions in T1DM children. Conclusion: There is an abnormal cerebral perfusion in children with newly diagnosed T1DM. The visual and sensorimotor areas are brain areas where perfusion is prone to change at the beginning of T1DM. Our study provided clues for cerebral pathophysiological changes in the initial stage of T1DM.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Song J,Cui S,Chen Y,Ye X,Huang X,Su H,Zhou Y,Liu X,Chen W,Shan X,Yan Z,Liu Kdoi
10.3389/fneur.2020.00572subject
Has Abstractpub_date
2020-06-19 00:00:00pages
572issn
1664-2295journal_volume
11pub_type
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pub_type: 杂志文章
doi:10.3389/fneur.2013.00067
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pub_type: 杂志文章,评审
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pub_type:
doi:10.3389/fneur.2019.00089
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pub_type: 杂志文章,评审
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journal_title:Frontiers in neurology
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更新日期:2018-03-02 00:00:00
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2018.00124
更新日期:2018-03-06 00:00:00
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