Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review.

Abstract:

:Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible association between periodontitis and mild cognitive impairment or dementia. The purpose of this study was to evaluate the clinical/epidemiological evidence regarding the association between periodontitis and cognitive decline in adult patients. A search conducted between September and October 2018 was performed in the electronic databases PubMed, Scopus, Web of Science, The Cochrane Library, LILACS, OpenGrey, and Google Scholar, with no publication date or language restrictions. Analytical observational studies in adults (P-Participants), with (E-Exposure) and without periodontitis (C-Comparison) were included in order to determine the association between periodontitis and cognitive decline (O-Outcome). The search identified 509 references, of which eight observational studies were accorded with the eligibility criteria and evaluated. The results should, however, be interpreted cautiously due to the limited number of studies. This systematic review points to the need for further well-designed studies, such as longitudinal observational studies with control of modifiable variables, as diagnostic criteria and time since diagnosis of periodontitis and cognitive impairment, to confirm the proposed association.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Nascimento PC,Castro MML,Magno MB,Almeida APCPSC,Fagundes NCF,Maia LC,Lima RR

doi

10.3389/fneur.2019.00323

subject

Has Abstract

pub_date

2019-04-24 00:00:00

pages

323

issn

1664-2295

journal_volume

10

pub_type

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