Diagnostic and Prognostic Performance of Neurofilaments in ALS.

Abstract:

:There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal fluid and blood, as biomarker for ALS. The most widely studied neurofilament subunits are neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH). Neurofilament levels are reflecting neuronal injury and therefore potentially of value in ALS and other neurological disorders. In this mini-review, we summarize and discuss the available evidence about neurofilaments as diagnostic and prognostic biomarker for human ALS.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Poesen K,Van Damme P

doi

10.3389/fneur.2018.01167

subject

Has Abstract

pub_date

2019-01-18 00:00:00

pages

1167

issn

1664-2295

journal_volume

9

pub_type

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