Diagnostic and Prognostic Performance of Neurofilaments in ALS.


:There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal fluid and blood, as biomarker for ALS. The most widely studied neurofilament subunits are neurofilament light chain (NfL) and phosphorylated neurofilament heavy chain (pNfH). Neurofilament levels are reflecting neuronal injury and therefore potentially of value in ALS and other neurological disorders. In this mini-review, we summarize and discuss the available evidence about neurofilaments as diagnostic and prognostic biomarker for human ALS.


Front Neurol


Frontiers in neurology


Poesen K,Van Damme P




Has Abstract


2019-01-18 00:00:00








  • HLA Polymorphism Affects Risk of de novo Mutation of dystrophin Gene and Clinical Severity of Duchenne Muscular Dystrophy in a Southern Chinese Population.

    abstract::Immune-mediated pathology has been thought to be an important factor contributing to Duchenne muscular dystrophy (DMD). Allele frequencies of certain HLA types are known to differ between patients with dystrophinopathies and healthy controls with low-resolution HLA gene typing data in limit reports. Using Polymerase c...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Li H,Xiao L,Wang L,Lin J,Luo M,Chen M,He R,Zhu Y,Zhang C

    更新日期:2018-11-15 00:00:00

  • Risk Factors of External Ventricular Drain Infection: Proposing a Model for Future Studies.

    abstract::Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this rev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Sorinola A,Buki A,Sandor J,Czeiter E

    更新日期:2019-03-15 00:00:00

  • High Compliance with Scheduled Nimodipine Is Associated with Better Outcome in Aneurysmal Subarachnoid Hemorrhage Patients Cotreated with Heparin Infusion.

    abstract:INTRODUCTION:We sought to determine whether compliance with scheduled nimodipine in subarachnoid hemorrhage patients impacted patient outcomes, with the intent of guiding future nimodipine management in patients who experience nimodipine-induced hypotension. METHODS:We performed a retrospective analysis of 118 consecu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wessell A,Kole MJ,Badjatia N,Parikh G,Albrecht JS,Schreibman DL,Simard JM

    更新日期:2017-06-09 00:00:00

  • Current Conceptual Understanding of the Epileptogenic Network From Stereoelectroencephalography-Based Connectivity Inferences.

    abstract::Localization of the epileptogenic zone (EZ) is crucial in the surgical treatment of focal epilepsy. Recently, EEG studies have revealed that the EZ exhibits abnormal connectivity, which has led investigators to now consider connectivity as a biomarker to localize the EZ. Further, abnormal connectivity of the EZ may pr...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Gupta K,Grover P,Abel TJ

    更新日期:2020-11-25 00:00:00

  • Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease.

    abstract::Lifestyle factors such as intellectual stimulation, cognitive and social engagement, nutrition, and various types of exercise appear to reduce the risk for common age-associated disorders such as Alzheimer's disease (AD) and vascular dementia. In fact, many studies have suggested that promoting physical activity can h...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Foster PP,Rosenblatt KP,Kuljiš RO

    更新日期:2011-05-06 00:00:00

  • Aging Increases Compensatory Saccade Amplitude in the Video Head Impulse Test.

    abstract:OBJECTIVE:Rotational vestibular function declines with age resulting in saccades as a compensatory mechanism to improve impaired gaze stability. Small reductions in rotational vestibulo-ocular reflex (VOR) gain that would be considered clinically normal have been associated with compensatory saccades. We evaluated whet...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Anson ER,Bigelow RT,Carey JP,Xue QL,Studenski S,Schubert MC,Weber KP,Agrawal Y

    更新日期:2016-07-18 00:00:00

  • Phase 1 Trial of Amnion Cell Therapy for Ischemic Stroke.

    abstract:Background:There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive endovascular clot retrieval or thrombolysis therapies, or for whom standard treatment has failed. We have recently shown that human amniotic epithelial cells (hAECs) ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Phan TG,Ma H,Lim R,Sobey CG,Wallace EM

    更新日期:2018-06-07 00:00:00

  • Cognitive Processing Impacts High Frequency Intracranial EEG Activity of Human Hippocampus in Patients With Pharmacoresistant Focal Epilepsy.

    abstract::The electrophysiological EEG features such as high frequency oscillations, spikes and functional connectivity are often used for delineation of epileptogenic tissue and study of the normal function of the brain. The epileptogenic activity is also known to be suppressed by cognitive processing. However, differences bet...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cimbalnik J,Pail M,Klimes P,Travnicek V,Roman R,Vajcner A,Brazdil M

    更新日期:2020-10-27 00:00:00

  • Self-Motion Versus Environmental-Motion Perception Following Rotational Vestibular Stimulation and Factors Modifying Them.

    abstract::Motion perception following rotational vestibular stimulation is described either as a self-motion or as an environmental-motion. The purpose of the present study was to establish frequency of occurrence of both sensations in healthy humans; what other sensations they experience and how factors insinuation and visual ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Kolev OI

    更新日期:2019-02-27 00:00:00

  • Clinical Features of Embolic Stroke of Undetermined Source.

    abstract::Background and Objective: One-third of ischemic strokes have no identifiable cause following standard evaluation. In 2014, researchers have proposed the concept of Embolic Stroke of Undetermined Source (ESUS). The purpose of this study was to report the clinical characteristics of ESUS and its difference from cardioge...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wang W,Tang X,Liu W,Jia K,Zhao X,Yu F

    更新日期:2020-02-05 00:00:00

  • A Case of Acoustic Shock with Post-trauma Trigeminal-Autonomic Activation.

    abstract::This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

    journal_title:Frontiers in neurology



    authors: Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

    更新日期:2017-08-16 00:00:00

  • What Comes First: Return to School or Return to Activity for Youth After Concussion? Maybe We Don't Have to Choose.

    abstract::Objectives: Return to School (RTS) and Return to Activity/Play (RTA) protocols are important in concussion management. Minimal evidence exists as to sequence and whether progression can occur simultaneously. Experts recommend that children/youth fully return to school before beginning RTA protocols. This study investi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: DeMatteo CA,Randall S,Lin CA,Claridge EA

    更新日期:2019-07-23 00:00:00

  • Accuracy and Feasibility of an Android-Based Digital Assessment Tool for Post Stroke Visual Disorders-The StrokeVision App.

    abstract:Background:Visual impairment affects up to 70% of stroke survivors. We designed an app (StrokeVision) to facilitate screening for common post stroke visual issues (acuity, visual fields, and visual inattention). We sought to describe the test time, feasibility, acceptability, and accuracy of our app-based digital visua...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Quinn TJ,Livingstone I,Weir A,Shaw R,Breckenridge A,McAlpine C,Tarbert CM

    更新日期:2018-03-28 00:00:00

  • Decoding Circadian Rhythm and Epileptic Activities: Clues From Animal Studies.

    abstract::The relationship between circadian rhythm and epilepsy has been recognized for decades. Yet many questions underlying the complex mechanisms of their interaction remain elusive. A better understanding on this topic allows the development of accurate seizure-detection algorithm and alternative precise therapeutic strat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Xu C,Yu J,Ruan Y,Wang Y,Chen Z

    更新日期:2020-07-24 00:00:00

  • Multiparametric Analysis of Sniff Nasal Inspiratory Pressure Test in Middle Stage Amyotrophic Lateral Sclerosis.

    abstract::The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these para...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sarmento A,Aliverti A,Marques L,Pennati F,Dourado-Júnior ME,Fregonezi G,Resqueti V

    更新日期:2018-05-02 00:00:00

  • In a Heartbeat: Light and Cardiovascular Physiology.

    abstract::Light impinging on the retina fulfils a dual function: it serves for vision and it is required for proper entrainment of the endogenous circadian timing system to the 24-h day, thus influencing behaviors that promote health and optimal quality of life but are independent of image formation. The circadian pacemaker loc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Chellappa SL,Lasauskaite R,Cajochen C

    更新日期:2017-10-20 00:00:00

  • Monitoring the Neuroinflammatory Response Following Acute Brain Injury.

    abstract::Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are major contributors to morbidity and mortality. Following the initial insult, patients may deteriorate due to secondary brain damage. The underlying molecular and cellular cascades incorporate components of the innate immune system. There are different ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Thelin EP,Tajsic T,Zeiler FA,Menon DK,Hutchinson PJA,Carpenter KLH,Morganti-Kossmann MC,Helmy A

    更新日期:2017-07-20 00:00:00

  • Optical Coherence Tomography in Patients with Chronic Migraine: Literature Review and Update.

    abstract::Migraine is a chronic disease characterized by unilateral, pulsating, and often moderate-to-severe recurrent episodes of headache with nausea and vomiting. It affects approximately 15% of the general population, yet the underlying pathophysiological mechanisms are not fully understood. Optical coherence tomography (OC...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Ascaso FJ,Marco S,Mateo J,Martínez M,Esteban O,Grzybowski A

    更新日期:2017-12-13 00:00:00

  • Historical Review of the Fluid-Percussion TBI Model.

    abstract::Traumatic brain injury (TBI) is a major health concern worldwide. Laboratory studies utilizing animal models of TBI are essential for addressing pathological mechanisms of brain injury and development of innovative treatments. Over the past 75 years, pioneering head injury researchers have devised and tested a number ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Lyeth BG

    更新日期:2016-12-02 00:00:00

  • TuberOus SClerosis Registry to Increase Disease Awareness: A Review on Alignment of Its Planning, Execution, and Publications With European Medicines Agency Guidelines.

    abstract::Patient registries offer a powerful and practical means of real-world data collection system for rare diseases. Many guidelines have been released to standardize patient registries, although most of them do not address issues specific to rare disease patient registries. In November 2018, the European Medicines Agency ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Marques R,Thole H,Ruiz de Morales JG

    更新日期:2020-05-15 00:00:00

  • Blood Flow and Glucose Metabolism Dissociation in the Putamen Is Predictive of Levodopa Induced Dyskinesia in Parkinson's Disease Patients.

    abstract::Background: The forefront treatment of Parkinson's disease (PD) is Levodopa. When patients are treated with Levodopa cerebral blood flow is increased while cerebral metabolic rate is decreased in key subcortical regions including the putamen. This phenomenon is especially pronounced in patients with Levodopa-induced d...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Aljuaid M,Booth S,Hobson DE,Borys A,Williams K,Katako A,Ryner L,Goertzen AL,Ko JH

    更新日期:2019-11-21 00:00:00

  • Screening Gene Mutations in Chinese Patients With Benign Essential Blepharospasm.

    abstract::Objective: This study aimed to screen gene mutations in Chinese patients with benign essential blepharospasm (BEB) to understand its etiology. Methods: Twenty BEB patients diagnosed by clinical manifestations between April 2015 and October 2015 were enrolled. All the cases were investigated by questionnaires about gen...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Dong H,Luo Y,Fan S,Yin B,Weng C,Peng B

    更新日期:2020-01-23 00:00:00

  • Coding of Velocity Storage in the Vestibular Nuclei.

    abstract::Semicircular canal afferents sense angular acceleration and output angular velocity with a short time constant of ≈4.5 s. This output is prolonged by a central integrative network, velocity storage that lengthens the time constants of eye velocity. This mechanism utilizes canal, otolith, and visual (optokinetic) infor...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Yakushin SB,Raphan T,Cohen B

    更新日期:2017-08-16 00:00:00

  • Takotsubo Cardiomyopathy-Acute Cardiac Dysfunction Associated With Neurological and Psychiatric Disorders.

    abstract::Takotsubo cardiomyopathy (TTC) is an acute and reversible cardiac wall motion abnormality of the left myocardium. Although many studies focused on etiology, diagnostic and treatment of TTC, precise clinical guidelines on TTC are not available. Research revealed emotional and physical triggering factors of TTC and emph...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Buchmann SJ,Lehmann D,Stevens CE

    更新日期:2019-08-22 00:00:00

  • Expression of Human Endogenous Retrovirus-K in Spinal and Bulbar Muscular Atrophy.

    abstract::Background: Spinal and Bulbar Muscular Atrophy (SBMA) is caused by the extension of the polyglutamine tract within the androgen receptor (AR) gene, and results in a multisystem presentation, including the degeneration of lower motor neurons. The androgen receptor (AR) is known to modulate the expression of endogenous ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rex C,Nadeau MJ,Douville R,Schellenberg K

    更新日期:2019-09-04 00:00:00

  • Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke.

    abstract:Background:Previous studies demonstrated that cardioembolism (CE) was prone to develop hemorrhagic transformation (HT), whereas hyper-permeability of blood-brain barrier (BBB) might be one reason for the development of HT. We, thus, aimed to investigate whether the BBB permeability (BBBP) was higher in CE stroke than o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Liu C,Shi F,Chen Z,Yan S,Ding X,Lou M

    更新日期:2018-02-08 00:00:00

  • Nurse-Led Intervention to Improve Knowledge of Medications in Survivors of Stroke or Transient Ischemic Attack: A Cluster Randomized Controlled Trial.

    abstract:INTRODUCTION:Limited evidence exists on effective interventions to improve knowledge of preventive medications in patients with chronic diseases, such as stroke. We investigated the effectiveness of a nurse-led intervention, where a component was to improve knowledge of prevention medications, in patients with stroke o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Olaiya MT,Cadilhac DA,Kim J,Ung D,Nelson MR,Srikanth VK,Bladin CF,Gerraty RP,Fitzgerald SM,Phan TG,Frayne J,Thrift AG

    更新日期:2016-11-18 00:00:00

  • Prevalence of Extrapyramidal Symptoms in In-Patients With Severe Mental Illnesses: Focus on Parkinsonism.

    abstract::Patients with severe mental illnesses may present extrapyramidal symptoms as part of a concomitant neurological disorder or secondary to medications. Extrapyramidal symptoms are frequently unrecognized, have negative consequences for adherence to treatment, negatively affect quality of life and can induce stigma. We e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Roiter B,Pigato G,Antonini A

    更新日期:2020-11-10 00:00:00

  • MRI Characteristics of the Evolution of Supratentorial Recent Small Subcortical Infarcts.

    abstract:OBJECTIVE:Morphological changes of recent small subcortical infarcts are not well defined. The purpose of the present study was to describe the MRI characteristics of the evolution for this stroke subtype. METHODS:We conducted a retrospective review of patients diagnosed with definite supratentorial recent small subco...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Okazaki S,Hornberger E,Griebe M,Gass A,Hennerici MG,Szabo K

    更新日期:2015-05-26 00:00:00

  • Interdisciplinary Decision Making in Hemorrhagic Stroke Based on CT Imaging-Differences Between Neurologists and Neurosurgeons Regarding Estimation of Patients' Symptoms, Glasgow Coma Scale, and National Institutes of Health Stroke Scale.

    abstract::Background and Purpose: Acute intracerebral hemorrhage (ICH) requires rapid decision making toward neurosurgery or conservative neurological stroke unit treatment. In a previous study, we found overestimation of clinical symptoms when clinicians rely mainly on cerebral computed tomography (cCT) analysis. The current s...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wagner A,Schebesch KM,Isenmann S,Steinbrecher A,Kapapa T,Zeman F,Baldaranov D,Grauer O,Backhaus R,Linker RA,Schlachetzki F

    更新日期:2019-09-26 00:00:00