Abstract：
:Patients with severe mental illnesses may present extrapyramidal symptoms as part of a concomitant neurological disorder or secondary to medications. Extrapyramidal symptoms are frequently unrecognized, have negative consequences for adherence to treatment, negatively affect quality of life and can induce stigma. We estimated and correlated with demographic and clinical variables prevalence of extrapyramidal symptoms in in-patients with severe mental illnesses. Additionally we evaluated 123I-FP-CIT SPECT binding to striatal dopamine transporter in subjects with clinical manifestations suggestive of Parkinson's Disease and recorded therapeutic management and clinical evolution for 6-months. Extrapyramidal symptoms were present in 144 out of 285 patients (50.5%), mainly tremor (94 patients, 33%). There were 38 patients (13.3%) with parkinsonism and they had older age, more medical comorbidities and medical treatments. In 15/38 patients striatal dopamine transporter binding was abnormal resulting in dose reduction or change of psychotropic drugs as well as combination with antiparkinson therapy. Our study confirmed the clinical and epidemiological relevance of extrapyramidal symptoms among inpatients with severe mental illnesses. A small percentage of patients with extrapyramidal symptoms had features compatible with possible diagnosis of Parkinson's Disease. 123I-FP-CIT SPECT was useful to identify dopaminergic dysfunction and initiate dopamine replacement therapy.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Roiter B,Pigato G,Antonini Adoi
10.3389/fneur.2020.593143subject
Has Abstractpub_date
2020-11-10 00:00:00pages
593143issn
1664-2295journal_volume
11pub_type
杂志文章abstract：:Objectives: Elevated neurofilament light chain (NFL) levels within the cerebrospinal fluid (CSF) are a biomarker representing axonal neurodegeneration in rapid progressive neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). It is unclear to what extent the levels of NFL increase in the CSF (CSF-NFL...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.01037
更新日期：2018-12-14 00:00:00
abstract：:Background: Increasing evidence implicates involvement of the innate immune system in the initiation and progression of Parkinson's disease (PD). Monocytes and monocyte-derived cells perform a number of functions, such as phagocytosis, chemotaxis, and cytokine secretion, which may be particularly relevant to PD pathol...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00870
更新日期：2018-10-16 00:00:00
abstract：:Introduction: With the shift of research focus to personalized medicine in Alzheimer's Dementia (AD), there is an urgent need for tools that are capable of quantifying a patient's risk using diagnostic biomarkers. The Medical Informatics Platform (MIP) is a distributed e-infrastructure federating large amounts of data...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.01021
更新日期：2020-09-23 00:00:00
abstract：:Motion perception following rotational vestibular stimulation is described either as a self-motion or as an environmental-motion. The purpose of the present study was to establish frequency of occurrence of both sensations in healthy humans; what other sensations they experience and how factors insinuation and visual ...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00162
更新日期：2019-02-27 00:00:00
abstract：:Subcortical circuits mediating sleep-wake functions have been well characterized in animal models, and corroborated by more recent human studies. Disruptions in these circuits have been identified in hypersomnia disorders (HDs) such as narcolepsy and Kleine-Levin Syndrome, as well as in neurodegenerative disorders exp...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2014.00165
更新日期：2014-09-11 00:00:00
abstract：:For epileptic patients requiring resective surgery, a modality called stereo-electroencephalography (SEEG) may be used to monitor the patient's brain signals to help identify epileptogenic regions that generate and propagate seizures. SEEG involves the insertion of multiple depth electrodes into the patient's brain, e...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.605696
更新日期：2021-01-06 00:00:00
abstract：:Myasthenia gravis (MG) is the most common autoimmune disorder affecting the neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is caused by autoantibodies targeting proteins of the neuromuscular junction; ~85% of MG patients have autoantibodies against the muscle acetylcholine recep...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2020.596981
更新日期：2020-11-30 00:00:00
abstract：:Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2013.00061
更新日期：2013-05-31 00:00:00
abstract：:Therapeutic hypothermia (HT) is a currently accepted treatment for neonatal asphyxia and is a promising strategy in adult stroke therapy. We previously reported that acute administration of docosahexaenoic acid (DHA) triglyceride emulsion (tri-DHA) protects against hypoxic-ischemic (HI) injury in neonatal mice. We que...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.618419
更新日期：2021-01-15 00:00:00
abstract：:Aim: The aim of the study was to investigate the effect of the onset of Parkinson's disease (PD) on life satisfaction. Method: Data from 2008, 2011, and 2014 were used from a population-based prospective cohort (German Ageing Survey; 8,982 observations in FE regression analysis) of community-residing individuals in th...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00589
更新日期：2018-07-25 00:00:00
abstract：:The purpose of the study was to test the utility of unique panel of blood biomarkers as a means to reflect one's recovery process after sport-related neurotrauma. We established a panel of biomarkers that reacted positive with CD81 (extracellular vesicle marker) and various neuron- and glia-specific antigens [e.g., ne...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00239
更新日期：2018-04-12 00:00:00
abstract：:Background: Spontaneous use of the more-affected arm is a meaningful indicator of stroke recovery. The Bilateral Arm Reaching Test (BART) was previously developed to quantify arm use by measuring arm choice to targets projected over a horizontal hemi-workspace. In order to improve clinical validity, we constrained the...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00883
更新日期：2018-10-22 00:00:00
abstract：:To investigate the usefulness of pain-related evoked potentials (PREP) elicited by electrical stimulation for the identification of small fiber involvement in patients with mixed fiber neuropathy (MFN). Eleven MFN patients with clinical signs of large fiber impairment and neuropathic pain and ten healthy controls unde...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2015.00244
更新日期：2015-12-07 00:00:00
abstract：:Noradrenaline, one of the main brain monoamines, has powerful central influences on forebrain neurobiological processes which support the mental activities occurring during the sleep-waking cycle. Noradrenergic neurons are activated during waking, decrease their firing rate during slow wave sleep, and become silent du...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2011.00081
更新日期：2011-12-12 00:00:00
abstract：:Study Objectives: Coronary artery disease is considered to be the major cause of death amongst patients with ischemic stroke. The coronary artery calcium (CAC) score is related not only to sleep-disordered breathing, but also with future risk of cardiovascular mortality. We investigated the association between the sev...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00819
更新日期：2019-07-31 00:00:00
abstract：:Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as a predictive factor in cardiovascular diseases, but its significance in patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) is still unknown. Methods: Co...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.01192
更新日期：2019-11-13 00:00:00
abstract：:The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's disease (PD) for over 40 years. However, the response to this treatment changes with disease progression, and most patients develop dyskinesias (abnormal involuntary movements) and motor fluctuations within a few years of l-DOPA t...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2014.00242
更新日期：2014-12-15 00:00:00
abstract：:A hand exoskeleton driven by myoelectric pattern recognition was designed for stroke rehabilitation. It detects and recognizes the user's motion intent based on electromyography (EMG) signals, and then helps the user to accomplish hand motions in real time. The hand exoskeleton can perform six kinds of motions, includ...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2017.00107
更新日期：2017-03-20 00:00:00
abstract：:Background and Objective: One-third of ischemic strokes have no identifiable cause following standard evaluation. In 2014, researchers have proposed the concept of Embolic Stroke of Undetermined Source (ESUS). The purpose of this study was to report the clinical characteristics of ESUS and its difference from cardioge...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.00058
更新日期：2020-02-05 00:00:00
abstract：:Aims: To investigate the relationship between clinical and imaging features of stroke patients with patent foramen ovale (PFO) and those with spontaneous intracranial artery dissection (SIAD). Materials and methods: We retrospectively examined both clinical and imaging results of 40 stroke patients with PFO and 29 wit...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00418
更新日期：2019-04-24 00:00:00
abstract：:Wireless transmission of cortical signals is an essential step to improve the safety of epilepsy procedures requiring seizure focus localization and to provide chronic recording of brain activity for Brain Computer Interface (BCI) applications. Our group developed a fully implantable and externally rechargeable device...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2014.00156
更新日期：2014-08-25 00:00:00
abstract：Background:There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive endovascular clot retrieval or thrombolysis therapies, or for whom standard treatment has failed. We have recently shown that human amniotic epithelial cells (hAECs) ...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00198
更新日期：2018-06-07 00:00:00
abstract：:Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2020.00849
更新日期：2020-08-25 00:00:00
abstract：:Objective: We conducted this study to analyze the clinical characteristics of the psychiatric symptoms of patients with anti-NMDAR encephalitis. Methods: A retrospective study of anti-NMDAR encephalitis in China was performed. The clinical characteristics of the psychiatric symptoms, the relationship between the antib...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.01330
更新日期：2020-01-24 00:00:00
abstract：:Mutations in the Potassium channel subfamily T member 1 (KCNT1) gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from the age of 10. The patient had four types of epileptic seizures,...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2019.00064
更新日期：2019-02-05 00:00:00
abstract：:Glaucoma damages retinal ganglion cells, including intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells modulate various non-visual physiological and psychological functions which are modulated by light. In patients with glaucoma, we assessed the effect of daily bright light exposure (LE) on sever...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.584479
更新日期：2021-01-15 00:00:00
abstract：:Several studies have demonstrated the advantages of the bilateral vs. unilateral cochlear implantation in listeners with bilateral severe to profound hearing loss. However, it remains unclear to what extent bilaterally implanted listeners have access to binaural cues, e.g., accurate processing of interaural timing dif...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.00915
更新日期：2020-09-30 00:00:00
abstract：:Cocaine use is associated with the transmission of human immunodeficiency (HIV) virus through risky sexual behavior. In HIV+ individuals, cocaine use is linked with poor health outcomes, including HIV-medication non-adherence and faster disease progression. Both HIV and cocaine dependence are associated with reduced i...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2017.00562
更新日期：2017-10-31 00:00:00
abstract：:We describe the case of one patient with pure sporadic hemiplegic migraine (SHM) with a novel ATP1A2 gene variant and a large patent foramen ovale (PFO) with atrial septal aneurysm. In hemiplegic migraine (HM), the relationship between incomplete penetrance, environmental triggers, and phenotypic expression is underde...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2018.00332
更新日期：2018-05-17 00:00:00
abstract：BACKGROUND:Accurate recognition of stroke symptoms by Emergency Medical Services (EMS) is necessary for timely care of acute stroke patients. We assessed the accuracy of stroke diagnosis by EMS in clinical practice in a major US city. METHODS AND RESULTS:Philadelphia Fire Department data were merged with data from a s...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2017.00466
更新日期：2017-09-14 00:00:00
