CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review.

Abstract:

BACKGROUND:Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also performed a literature review to summarize the epidemiological, clinical, and prognostic features of this disease. CASE SUMMARY:A 51-year-old man was admitted to Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College due to cough and chest pain lasting > 2 mo and 1 wk, respectively. Positron emission tomography-computed tomography and magnetic resonance imaging examinations revealed the presence of a mass in the right upper lobe with enlargement of lymph nodes and multiple bone metastases. According to the results of bronchoscopy and cervical lymph node biopsy, a diagnosis of lung LELC with CD56-positive staining (CD56+ lung LELC) was made. In the literature, 458 cases of lung LELC have been reported. However, only one other case of CD56+ lung LELC has been reported thus far. CONCLUSION:The mechanism and potential role of CD56 expression in CD56+ lung LELC require further investigation.

journal_name

World J Clin Cases

authors

Yang L,Liang H,Liu L,Guo L,Ying JM,Shi SS,Hu XS

doi

10.12998/wjcc.v8.i7.1257

subject

Has Abstract

pub_date

2020-04-06 00:00:00

pages

1257-1264

issue

7

issn

2307-8960

journal_volume

8

pub_type

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