Abstract:
BACKGROUND:Type A insulin resistance syndrome is a rare disorder caused by mutations in the gene encoding the insulin receptor. Its coexistence with ovarian serous papillary cystadenofibroma is even rarer. CASE SUMMARY:A 14-year-old girl developed type A insulin resistance syndrome and showed high fasting insulin, glucose, and hemoglobin A1c (HbA1c) levels. The girl suffered from ovarian serous papillary cystadenofibroma. The laboratory results were as follows: fasting insulin was 2624.90 pmol/L and HbA1c was 8.5%. A heterozygous missense mutation on exon 20 of the insulin receptor gene (c.3601C>T, Arg1201Trp) was observed. The histopathological diagnosis was a cystic lesion that extended to the upper right uterus, indicating a right ovarian serous papillary cystadefibroma accompanied by focal interstitial hyperplasia. The patient was treated with metformin for over 6 mo. Additionally, laparoscopic resection (bilateral) of the ovarian lesion and laparoscopic intestinal adhesiolysis were performed under general anesthesia. Diet therapy combined with exercise was then initiated. The patient had an uneventful recovery. The patient also showed improved blood glucose control, with reduced levels of fasting insulin (857.84 pmol/L) and HbA1c (7.0%). CONCLUSION:Insulin resistance may play a significant role in the induction of tumors. It is important to investigate further the association between insulin resistance and tumors and the underlying mechanism.
journal_name
World J Clin Casesjournal_title
World journal of clinical casesauthors
Yan FF,Huang BK,Chen YL,Zhuang YZ,You XY,Liu CQ,Li XJdoi
10.12998/wjcc.v8.i15.3334subject
Has Abstractpub_date
2020-08-06 00:00:00pages
3334-3340issue
15issn
2307-8960journal_volume
8pub_type
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journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v5.i10.384
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journal_title:World journal of clinical cases
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journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v7.i17.2611
更新日期:2019-09-06 00:00:00
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journal_title:World journal of clinical cases
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journal_title:World journal of clinical cases
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更新日期:2020-10-26 00:00:00
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journal_title:World journal of clinical cases
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pub_type: 杂志文章,评审
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i4.848
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v7.i10.1177
更新日期:2019-05-26 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i23.3980
更新日期:2019-12-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v5.i7.258
更新日期:2017-07-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v6.i6.110
更新日期:2018-06-16 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus that has generated a worldwide outbreak of infections. Many people with coronavirus disease-2019 (COVID-19) have developed severe illness, and a significant number have died. However, little is known regarding infe...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i23.6016
更新日期:2020-12-06 00:00:00
abstract::In colorectal cancer (CRC), liver metastasis remains a major contributor to the cause of cancer-related death. Putative biomarkers, therapeutic efficacy, and drug insensitivity still pose clinical challenges for metastatic CRC patients. Interestingly, previous studies indicated that tumor cells in CRC did not metastas...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i11.2111
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i21.5250
更新日期:2020-11-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i18.3934
更新日期:2020-09-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v5.i2.61
更新日期:2017-02-16 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i16.3601
更新日期:2020-08-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2020-11-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2018-12-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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journal_title:World journal of clinical cases
pub_type:
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journal_title:World journal of clinical cases
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pub_type: 杂志文章
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2020-11-26 00:00:00