Small cell lung cancer with panhypopituitarism due to ectopic adrenocorticotropic hormone syndrome: A case report.

Abstract:

BACKGROUND:Small cell lung cancer (SCLC) accounts for 15% of lung cancers, and it commonly expresses peptide and protein factors that are active as hormones. These secreting factors manifest as paraneoplastic disorders, such as ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS). The clinical features are abnormalities in carbohydrate metabolism, hypokalemia, peripheral edema, proximal myopathy, hypertension, hyperpigmentation, and severe systemic infection. However, it is uncommon that EAS has an influence on hypothalamus-pituitary function. CASE SUMMARY:A 62-year-old man presented with complaints of haemoptysis, polyuria, polydipsia, increased appetite, weight loss, and pigmentation. Following a series of laboratory and imaging examinations, he was diagnosed with SCLC, EAS, hypogonadism, hypothyroidism, and central diabetes insipidus. After three rounds of chemotherapy, levels of ACTH, cortisol, thyroid hormone, gonadal hormone, and urine volume had returned to normal levels. In addition, the pulmonary tumor was reduced in size. CONCLUSION:We report a rare case of SCLC complicated with panhypopituitarism due to EAS. We hypothesize that EAS induced high levels of serum glucocorticoid and negative feedback for the synthesis and secretion of antidiuretic hormone from the paraventricular nucleus, and trophic hormones from the anterior pituitary. Therefore, patients who present with symptoms of hypopituitarism, or even panhypopituitarism, with SCLC should be evaluated for EAS.

journal_name

World J Clin Cases

authors

Jin T,Wu F,Sun SY,Zheng FP,Zhou JQ,Zhu YP,Wang Z

doi

10.12998/wjcc.v7.i10.1177

subject

Has Abstract

pub_date

2019-05-26 00:00:00

pages

1177-1183

issue

10

issn

2307-8960

journal_volume

7

pub_type

杂志文章,评审
  • CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review.

    abstract:BACKGROUND:Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also ...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i7.1257

    authors: Yang L,Liang H,Liu L,Guo L,Ying JM,Shi SS,Hu XS

    更新日期:2020-04-06 00:00:00

  • Tattooing: A potential novel risk factor for iliopsoas abscess.

    abstract::Iliopsoas abscess (IPA) is an uncommon infection. The clinical presentation is usually insidious. Most patients present with nonspecific symptoms, leading to difficulty in prompt and accurate diagnosis. Delay in diagnosis can lead to complications, such as sepsis and death. Tattooing has become more popular over the r...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v2.i9.459

    authors: Gulati S,Jain A,Sattari M

    更新日期:2014-09-16 00:00:00

  • Correlations between microbial communities in stool and clinical indicators in patients with metabolic syndrome.

    abstract:AIM:To analyze the bacterial community structure and distribution of intestinal microflora in people with and without metabolic syndrome and combined these data with clinical indicators to determine relationships between selected bacteria and metabolic diseases. METHODS:Faecal samples were collected from 20 patients w...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v6.i4.54

    authors: Lin L,Wen ZB,Lin DJ,Dong JT,Jin J,Meng F

    更新日期:2018-04-16 00:00:00

  • Elevated levels of interleukin-1β, interleukin-6, tumor necrosis factor-α and vascular endothelial growth factor in patients with knee articular cartilage injury.

    abstract:BACKGROUND:Inflammatory cytokines play a vital role in the occurrence of osteoarticular injury and inflammation. Whether inflammation-associated factors interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) are involved in the pathogenesis of keen articular cartilag...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v7.i11.1262

    authors: Wang ZW,Chen L,Hao XR,Qu ZA,Huang SB,Ma XJ,Wang JC,Wang WM

    更新日期:2019-06-06 00:00:00

  • Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date.

    abstract::Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Despite significant advances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combina...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审

    doi:10.12998/wjcc.v3.i8.694

    authors: Crassini K,Mulligan SP,Best OG

    更新日期:2015-08-16 00:00:00

  • Congenital bronchobiliary fistula: A case report and review of the literature.

    abstract:BACKGROUND:Congenital bronchobiliary fistula is a rare developmental abnormality with an abnormal fistula between the respiratory system and biliary tract. The aim of this report is to analyze and summarize the clinical features and experience of diagnosing and treating congenital bronchobiliary fistula (CBBF) occurrin...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v7.i7.881

    authors: Li TY,Zhang ZB

    更新日期:2019-04-06 00:00:00

  • Treating aplasia cutis congenita in a newborn with the combination of ionic silver dressing and moist exposed burn ointment: A case report.

    abstract:BACKGROUND:Aplasia cutis congenita (ACC) in newborns is a condition in which congenital defects or hypoplasia is present in part of the epidermis, dermis and even subcutaneous tissue (including muscle and bones). First reported by Cordon in 1767, ACC is a rare disease with a low incidence of 1/100000 to 3/10000. Curren...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v7.i17.2611

    authors: Lei GF,Zhang JP,Wang XB,You XL,Gao JY,Li XM,Chen ML,Ning XQ,Sun JL

    更新日期:2019-09-06 00:00:00

  • Differential diagnosis of a vanishing brain space occupying lesion in a child.

    abstract::We describe clinical, diagnostic features and follow up of a patient with a vanishing brain lesion. A 14-year-old child admitted to the department of Neurology at September 2009 with a history of subacute onset of fever, anorexia, vomiting, blurring of vision and right hemiparesis since one month. Magnetic resonance i...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v3.i11.956

    authors: Hamed SA,Mekkawy MA,Abozaid H

    更新日期:2015-11-16 00:00:00

  • Guillain-Barré syndrome in a patient with multiple myeloma after bortezomib therapy: A case report.

    abstract:BACKGROUND:Bortezomib is a first-line drug approved for patients with multiple myeloma (MM) and has significantly increased their overall survival. However, bortezomib-induced peripheral neuropathy (PN) remains a significant side effect that has led to its discontinuation in some patients. Guillain-Barré syndrome (GBS)...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v7.i18.2905

    authors: Xu YL,Zhao WH,Tang ZY,Li ZQ,Long Y,Cheng P,Luo J

    更新日期:2019-09-26 00:00:00

  • Colovesical fistula as the initial manifestation of advanced colon cancer: A case report and review of literature.

    abstract::Colovesical fistulas (CVFs) are rare complications of very advanced cancers of the abdominal or pelvic cavity and often cause diagnostic troubles. CVFs are found more often in males, whereas females usually suffer from rectovaginal or vesicovaginal fistulas. This article presents a case of a female patient who was adm...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v6.i12.538

    authors: Skierucha M,Barud W,Baraniak J,Krupski W

    更新日期:2018-10-26 00:00:00

  • Implant biomaterials: A comprehensive review.

    abstract::Appropriate selection of the implant biomaterial is a key factor for long term success of implants. The biologic environment does not accept completely any material so to optimize biologic performance, implants should be selected to reduce the negative biologic response while maintaining adequate function. Every clini...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审

    doi:10.12998/wjcc.v3.i1.52

    authors: Saini M,Singh Y,Arora P,Arora V,Jain K

    更新日期:2015-01-16 00:00:00

  • Mediastinal small cell carcinoma with liver and bone marrow metastasis, mimicking lymphoma.

    abstract::Primary mediastinal neuroendocrine tumors are a rare malignancy that accounts for < 10% of all mediastinal tumors. The case presented here involves a 52-year-old man who had been suffering for 3 mo from chronic cough, anorexia and substantial weight loss, as well as 2 wk of jaundice prior to his admission. A computed ...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v3.i10.915

    authors: Nawarawong N,Pongpruttipan T,Aswakul P,Prachayakul V

    更新日期:2015-10-16 00:00:00

  • Colovesical fistula caused by glucocorticoid therapy for IgG4-related intrapelvic mass.

    abstract::IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid co...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v3.i12.1000

    authors: Yabuuchi Y,Matsubayashi H,Matsuzaki M,Shiomi A,Moriguchi M,Kawamura I,Ito I,Ono H

    更新日期:2015-12-16 00:00:00

  • Radioactive 125I seed implantation for locally advanced pancreatic cancer: A retrospective analysis of 50 cases.

    abstract:BACKGROUND:Pancreatic cancer is one of the common malignant tumors of the digestive system, and radical resection is the first choice of treatment for pancreatic cancer. If patients with locally advanced pancreatic cancer cannot be treated in time and effectively, their disease often develops rapidly and their survival...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v8.i17.3743

    authors: Li CG,Zhou ZP,Jia YZ,Tan XL,Song YY

    更新日期:2020-09-06 00:00:00

  • Sebaceous lymphadenocarcinoma of the parotid gland: A case report.

    abstract:BACKGROUND:Sebaceous lymphadenoma is a benign tumor that occurs rarely in the salivary glands, most commonly in the parotid glands or periparotid lymph nodes, and even more rarely undergoes malignant transformation into a sebaceous lymphadenocarcinoma. CASE SUMMARY:We report an 82-year-old woman who presented with a p...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i22.5751

    authors: Hao FY,Wang YL,Li SM,Xue LF

    更新日期:2020-11-26 00:00:00

  • Serum matrix metalloproteinase 3 in detecting remitting seronegative symmetrical synovitis with pitting edema syndrome: A case report.

    abstract::We report a case of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in a 71-year-old woman. She referred to our hospital with finger stiffness, edema of both hands and feet, pain of bilateral shoulder, wrist, metacarpophalangeal, proximal interphalangeal, and ankle joints. Rheumatoid f...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v6.i5.84

    authors: Kenzaka T,Goda K

    更新日期:2018-05-16 00:00:00

  • Mechanisms of resveratrol in the prevention and treatment of gastrointestinal cancer.

    abstract::Gastrointestinal (GI) cancer is one of the leading causes of cancer-related deaths worldwide. According to the Global Cancer Statistics, colorectal cancer is the second leading cause of cancer-related mortality, closely followed by gastric cancer (GC). Environmental, dietary, and lifestyle factors including cigarette ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审

    doi:10.12998/wjcc.v8.i12.2425

    authors: Wang LY,Zhao S,Lv GJ,Ma XJ,Zhang JB

    更新日期:2020-06-26 00:00:00

  • Correlation between crowdedness in emergency departments and anxiety in Chinese patients.

    abstract:BACKGROUND:Emergency department (ED) overcrowding is a severe health care concern, while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population. We hypothesized that anxiety due to over crowdedness may lead to adverse events in EDs. AIM:To invest...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v8.i13.2802

    authors: Wang S,Gao JY,Li X,Wu Y,Huo XX,Han CX,Kang MJ,Sun H,Ge BL,Liu Y,Liu YQ,Zhou JP,Wang Z

    更新日期:2020-07-06 00:00:00

  • Ascaris-mimicking common bile duct stone: A case report.

    abstract:BACKGROUND:In most cases, it is not difficult to differentiate common bile duct (CBD) stone from Ascaris infection because they are different disease entities and have different imaging findings. The two diseases usually demonstrate unique characteristic findings on computed tomography or magnetic resonance cholangiopa...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i19.4499

    authors: Choi SY,Jo HE,Lee YN,Lee JE,Lee MH,Lim S,Yi BH

    更新日期:2020-10-06 00:00:00

  • Surgical resection of a large hypopharyngeal hemangioma in an adult using neodymium-doped yttrium aluminum garnet laser: A case report.

    abstract:BACKGROUND:Generally, hemangiomas do not require surgical intervention; however, cases of large hemangiomas, potentially involving the throat and trachea, necessitate surgical therapy. Here, we present a case of hypopharyngeal hemangioma in an adult that was successfully treated with neodymium-doped yttrium aluminum ga...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i5.932

    authors: Jin M,Wang CY,Da YX,Zhu W,Jiang H

    更新日期:2020-03-06 00:00:00

  • Transanal minimally invasive surgery vs endoscopic mucosal resection for rectal benign tumors and rectal carcinoids: A retrospective analysis.

    abstract:BACKGROUND:Transanal minimally invasive surgery (TAMIS) is a good choice for resection of rectal neoplasms. Endoscopic mucosal resection (EMR) is also widely used in the treatment of benign rectal tumors such as rectal polyps and rectal adenomas. However, no studies have compared the outcome of TAMIS and EMR. AIM:To c...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v8.i19.4311

    authors: Shen JM,Zhao JY,Ye T,Gong LF,Wang HP,Chen WJ,Cai YK

    更新日期:2020-10-06 00:00:00

  • Sweet syndrome as a paraneoplastic manifestation of cholangiocarcinoma: A case report.

    abstract:BACKGROUND:Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare skin disorder that may be associated with cancer. CASE SUMMARY:A 58-year-old female presented with a cholestatic syndrome and significant weight loss three months before admission. Five months earlier, she had abruptly develope...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i18.4122

    authors: Lemaire CC,Portilho ALC,Pinheiro LV,Vivas RA,Britto M,Montenegro M,Rodrigues LFF,Arruda S,Lyra AC,Cavalcante LN

    更新日期:2020-09-26 00:00:00

  • Healthy neonate born to a SARS-CoV-2 infected woman: A case report and review of literature.

    abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus that has generated a worldwide outbreak of infections. Many people with coronavirus disease-2019 (COVID-19) have developed severe illness, and a significant number have died. However, little is known regarding infe...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i23.6016

    authors: Wang RY,Zheng KQ,Xu BZ,Zhang W,Si JG,Xu CY,Chen H,Xu ZY,Wu XM

    更新日期:2020-12-06 00:00:00

  • Challenging rescue of a 4 years old boy with H1N1 infection by extracorporeal membrane oxygenator: A case report.

    abstract:INTRODUCTION:World Health Organization announced on April 2009 a public health emergency of international concern caused by swine-origin influenza A (H1N1) virus. Acute respiratory distress syndrome (ARDS) has been reported to be the most devastating complications of this pathogen. Extracorporeal membrane oxygenator (E...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v2.i10.578

    authors: Papadopoulos N,Martens S,Keller H,El-Sayed Ahmad A,Moritz A,Zierer A

    更新日期:2014-10-16 00:00:00

  • Accuracy of endoscopic ultrasound-guided needle aspiration specimens for molecular diagnosis of non-small-cell lung carcinoma.

    abstract:BACKGROUND:Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are highly sensitive for diagnosing and staging lung cancer. In recent years, targeted therapy has shown great significance in the treatment of non-small cell lu...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v8.i21.5139

    authors: Su W,Tian XD,Liu P,Zhou DJ,Cao FL

    更新日期:2020-11-06 00:00:00

  • Predictive value of serum cystatin C for risk of mortality in severe and critically ill patients with COVID-19.

    abstract:BACKGROUND:The outbreak of coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. COVID-19 is clinically categorized into mild, moderate, severe, and critical illness. Acute kidney injury is an independent risk factor for poor prognosis in patients with. Serum cystatin C (sCys C) is considered ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章

    doi:10.12998/wjcc.v8.i20.4726

    authors: Li Y,Yang S,Peng D,Zhu HM,Li BY,Yang X,Sun XL,Zhang M

    更新日期:2020-10-26 00:00:00

  • Hodgkin's lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B.

    abstract::Acute on chronic liver failure (ACLF) is rarely the initial manifestation of a malignant process or precipitated by the initiation of anti-viral treatment with a nucleoside or nucleotide agent. We report an unusual case of ACLF temporally associated with initiation of Entecavir for treatment of chronic hepatitis B. Ea...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v1.i1.37

    authors: Palta R,McClune A,Esrason K

    更新日期:2013-04-16 00:00:00

  • Association between liver targeted antiviral therapy in colorectal cancer and survival benefits: An appraisal.

    abstract::In colorectal cancer (CRC), liver metastasis remains a major contributor to the cause of cancer-related death. Putative biomarkers, therapeutic efficacy, and drug insensitivity still pose clinical challenges for metastatic CRC patients. Interestingly, previous studies indicated that tumor cells in CRC did not metastas...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审

    doi:10.12998/wjcc.v8.i11.2111

    authors: Wang Q,Yu CR

    更新日期:2020-06-06 00:00:00

  • Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin's tumor of the parotid gland - immunophenotypic and genetic features: A case report.

    abstract:BACKGROUND:Warthin's tumor (WT) is composed of several cysts that are lined with tall, bilayered oncocytic columnar cells and lymphoid stroma. Within WT, the two components rarely transform into carcinoma or lymphoma, and when it does, carcinoma is the most common type. Approximately 28 cases of lymphoma with WT have b...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v7.i22.3895

    authors: Wang CS,Chu X,Yang D,Ren L,Meng NL,Lv XX,Yun T,Cao YS

    更新日期:2019-11-26 00:00:00

  • Transorbital nonmissile penetrating brain injury: Report of two cases.

    abstract:BACKGROUND:Penetrating brain injury (PBI) is an uncommon emergency in neurosurgery, and transorbital PBI is a rare type of PBI. Reasonable surgical planning and careful postoperative management can improve the prognosis of patients. CASE SUMMARY:The first case is a 68-year-old male patient who was admitted to the hosp...

    journal_title:World journal of clinical cases

    pub_type:

    doi:10.12998/wjcc.v8.i2.471

    authors: Xue H,Zhang WT,Wang GM,Shi L,Zhang YM,Yang HF

    更新日期:2020-01-26 00:00:00