Drug-targeting methodologies with applications: A review.

abstract：:IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid co...

journal_title：World journal of clinical cases

authors： Yabuuchi Y,Matsubayashi H,Matsuzaki M,Shiomi A,Moriguchi M,Kawamura I,Ito I,Ono H

更新日期：2015-12-16 00:00:00

abstract：:We report the case of a 56-year-old woman with pancreatic adenocarcinoma (PA) discovered during an episode of febrile jaundice. A computed tomography (CT) scan showed a mass in the head of the pancreas with circumferential infiltration of the superior mesenteric vein (SMV) and dilatation of the biliary and pancreatic ...

journal_title：World journal of clinical cases

authors： Jouffret L,Guilbaud T,Turrini O,Delpero JR

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Pancreatic cancer is one of the common malignant tumors of the digestive system, and radical resection is the first choice of treatment for pancreatic cancer. If patients with locally advanced pancreatic cancer cannot be treated in time and effectively, their disease often develops rapidly and their survival...

journal_title：World journal of clinical cases

authors： Li CG,Zhou ZP,Jia YZ,Tan XL,Song YY

更新日期：2020-09-06 00:00:00

abstract：BACKGROUND:Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor that exhibits an epithelioid and spindle cell morphology. The tumor is characterized by immunoreactivity for melanocytic and myogenic markers but can be misdiagnosed as more common tumors with similar characteristics, including gastroin...

journal_title：World journal of clinical cases

authors： Kim NI,Lee JS,Choi YD,Ju UC,Nam JH

更新日期：2020-09-26 00:00:00

abstract：BACKGROUND:Synovial sarcoma, a rare mesenchymal tumor type with unclear histological origin and direction of differentiation, accounts for 6%-10% of soft tissue tumors. It is mainly located near the joints and tendons of the limbs, and occurs primarily in children or young adults. Primary renal synovial sarcoma (PRSS) ...

journal_title：World journal of clinical cases

authors： Cai HJ,Cao N,Wang W,Kong FL,Sun XX,Huang B

更新日期：2019-10-06 00:00:00

abstract：:We report a case of a 54-year-old patient who was denied surgical replacement for severe aortic stenosis because of complicated acquired immunodeficiency syndrome and who successfully underwent transcatheter aortic valve implantation at our institution. ...

journal_title：World journal of clinical cases

authors： Salizzoni S,D'Ascenzo F,Moretti C,Bonora S,Calcagno A,Omedè P,Montrucchio C,Cerrato E,Colaci C,Sheiban I,Marra S,Rinaldi M,Gaita F

更新日期：2014-04-16 00:00:00

abstract：:Coronavirus disease-2019 (COVID-19) has so far caused hundreds of mortalities worldwide. Although respiratory symptoms are the main complication in COVID-19 patients, the disease is also associated with gastrointestinal problems, with diarrhea, nausea, and vomiting being primary COVID-19 symptoms. Thus, cancer and inf...

journal_title：World journal of clinical cases

authors： Nie K,Yang YY,Deng MZ,Wang XY

更新日期：2020-09-26 00:00:00

abstract：:Hematopoietic stem cell transplantation has become a curative choice of many hematopoietic malignancy, but graft-vs-host disease (GVHD) has limited the survival quality and overall survival of hematopoietic stem cell transplantation. Understanding of the immune cells' reaction in pathophysiology of GVHD has improved, ...

journal_title：World journal of clinical cases

authors： Hong YQ,Wan B,Li XF

更新日期：2020-05-26 00:00:00

abstract：:We describe clinical, diagnostic features and follow up of a patient with a vanishing brain lesion. A 14-year-old child admitted to the department of Neurology at September 2009 with a history of subacute onset of fever, anorexia, vomiting, blurring of vision and right hemiparesis since one month. Magnetic resonance i...

journal_title：World journal of clinical cases

authors： Hamed SA,Mekkawy MA,Abozaid H

更新日期：2015-11-16 00:00:00

abstract：BACKGROUND:Congenital bronchobiliary fistula is a rare developmental abnormality with an abnormal fistula between the respiratory system and biliary tract. The aim of this report is to analyze and summarize the clinical features and experience of diagnosing and treating congenital bronchobiliary fistula (CBBF) occurrin...

journal_title：World journal of clinical cases

authors： Li TY,Zhang ZB

更新日期：2019-04-06 00:00:00

abstract：BACKGROUND:Basal cell adenoma (BCA) is a rare benign tumour that has unique histological characteristics and primarily arises in the parotid glands. According to published reports, nearby tissue destruction by BCA seems impossible. CASE SUMMARY:We presented a case of a 54-year-old woman with a mass in the deep lobe of...

journal_title：World journal of clinical cases

authors： Du LY,Weng XH,Shen ZY,Cheng B

更新日期：2019-06-06 00:00:00

abstract：BACKGROUND:Despite high risk of bacterial contamination, yet there are no studies that have evaluated the optimal hang time of blenderized and reconstituted powdered formulas at standard room temperature and high temperature. AIM:To investigate the optimal hang time of both types of formulas at standard room temperatu...

journal_title：World journal of clinical cases

authors： Lakananurak N,Nalinthassanai N,Suansawang W,Panarat P

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:The global pandemic of coronavirus disease 2019 pneumonia poses a particular challenge to the emergency surgical treatment of elderly patients with high-risk acute abdominal diseases. Elderly patients are a high-risk group for surgical treatment. If the incarceration of gallstones cannot be relieved, emergen...

journal_title：World journal of clinical cases

authors： Zhang ZM,Zhang C,Liu Z,Liu LM,Zhu MW,Zhao Y,Wan BJ,Deng H,Yang HY,Liao JH,Zhu HY,Wen X,Liu LL,Wang M,Ma XT,Zhang MM,Liu JJ,Liu TT,Huang NN,Yuan PY,Gao YJ,Zhao J,Guo XA,Liao F,Li FY,Wang XT,Yuan RJ,Wu

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Aplasia cutis congenita (ACC) in newborns is a condition in which congenital defects or hypoplasia is present in part of the epidermis, dermis and even subcutaneous tissue (including muscle and bones). First reported by Cordon in 1767, ACC is a rare disease with a low incidence of 1/100000 to 3/10000. Curren...

journal_title：World journal of clinical cases

authors： Lei GF,Zhang JP,Wang XB,You XL,Gao JY,Li XM,Chen ML,Ning XQ,Sun JL

更新日期：2019-09-06 00:00:00

abstract：BACKGROUND:Waldenström macroglobulinemia (WM) is a type of small lymphocytic lymphoma that mainly affects the bone marrow, spleen, and lymph nodes. A subset of patients with WM demonstrates extramedullary involvement (4.4%), and the most frequent extramedullary disease site involved is the lungs (30%). CASE SUMMARY:A ...

journal_title：World journal of clinical cases

authors： Zhao DF,Ning HY,Cen J,Liu Y,Qian LR,Han ZH,Shen JL

更新日期：2020-06-06 00:00:00

abstract：BACKGROUND:The prognosis of paediatric primary refractory/relapsed acute myeloid leukaemia (R/R AML) remains poor. Intensive therapy is typically used as salvage treatment for those with R/R AML. No data are currently available about the use of the CLAG-M protocol as salvage therapy in paediatric patients with R/R AML....

journal_title：World journal of clinical cases

authors： Huang J,Yang XY,Rong LC,Xue Y,Zhu J,Fang YJ

更新日期：2020-11-26 00:00:00

abstract：:Isolated neurofibromas that affect the gastrointestinal tract are rare and almost always manifest as neurofibromatosis type 1 or multiple endocrine neoplasia type 2b. In this paper, we present a case of a 24-year-old female with abdominal pain who discharged a neurofibroma in her stool without any blood on it. A colon...

journal_title：World journal of clinical cases

authors： Miao Y,Wang JJ,Chen ZM,Zhu JL,Wang MB,Cai SQ

更新日期：2018-10-06 00:00:00

abstract：:Acute on chronic liver failure (ACLF) is rarely the initial manifestation of a malignant process or precipitated by the initiation of anti-viral treatment with a nucleoside or nucleotide agent. We report an unusual case of ACLF temporally associated with initiation of Entecavir for treatment of chronic hepatitis B. Ea...

journal_title：World journal of clinical cases

authors： Palta R,McClune A,Esrason K

更新日期：2013-04-16 00:00:00

abstract：:Relapsing polychondritis (RP) is a rare autoimmune disease with chronic inflammatory/destructive lesions of the cartilaginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostly with anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). We report three cases o...

journal_title：World journal of clinical cases

authors： File I,Trinn C,Mátyus Z,Ujhelyi L,Balla J,Mátyus J

更新日期：2014-12-16 00:00:00

abstract：BACKGROUND:Giant paraesophageal hiatal hernias (HH) are very infrequent, and their spectrum of clinical manifestations is large. Giant HH mainly occurs in elderly patients, and its relationship with anemia has been reported. For the surgical treatment of large HH, Nissen fundoplication is the most common antireflux pro...

journal_title：World journal of clinical cases

authors： Yasheng D,Wulamu W,Li YL,Tuhongjiang A,Abudureyimu K

更新日期：2020-03-26 00:00:00

abstract：AIM:To retrospectively evaluate the safety and feasibility of a new modified laparoscopic Sugarbaker repair in patients with parastomal hernias. METHODS:A retrospective study was performed to analyze eight patients who underwent parastomal hernia repair between June 2016 and January 2018. All of these patients receive...

journal_title：World journal of clinical cases

authors： Huang DY,Pan L,Chen QL,Cai XY,Fang J

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are highly sensitive for diagnosing and staging lung cancer. In recent years, targeted therapy has shown great significance in the treatment of non-small cell lu...

journal_title：World journal of clinical cases

authors： Su W,Tian XD,Liu P,Zhou DJ,Cao FL

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:Thrombotic thrombocytopenic purpura (TTP), a subtype of thrombotic microangiopathy, has a very high fatality rate if there is no timely diagnosis or treatment. Here, we report a case of TTP refractory to high displacement plasma exchange, which was later successfully treated with rituximab. CASE SUMMARY:Her...

journal_title：World journal of clinical cases

authors： Chen J,Jin JX,Xu XF,Zhang XX,Ye XN,Huang J

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Knee osteoarthritis is the most prevalent form of osteoarthritis and is becoming the main reason for progressive pain in knee joints. Arthroscopy combined with unicondylar knee arthroplasty (UKA) is one of the effective methods for the treatment of severe unicompartmental knee arthritis. This surgical approa...

journal_title：World journal of clinical cases

authors： Wang HR,Li ZL,Li J,Wang YX,Zhao ZD,Li W

更新日期：2019-12-26 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus that has generated a worldwide outbreak of infections. Many people with coronavirus disease-2019 (COVID-19) have developed severe illness, and a significant number have died. However, little is known regarding infe...

journal_title：World journal of clinical cases

authors： Wang RY,Zheng KQ,Xu BZ,Zhang W,Si JG,Xu CY,Chen H,Xu ZY,Wu XM

更新日期：2020-12-06 00:00:00

abstract：BACKGROUND:Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also ...

journal_title：World journal of clinical cases

authors： Yang L,Liang H,Liu L,Guo L,Ying JM,Shi SS,Hu XS

更新日期：2020-04-06 00:00:00

abstract：:Surgical resection of mandible owing to benign, malignant neoplasm, osteoradionecrosis is common. The resection can be total or segmental depending on the lesion. Loss of mandibular continuity causes deviation of remaining mandibular segment towards the resected side and rotation inferiorly due to muscle pull and scar...

journal_title：World journal of clinical cases

authors： Lingeshwar D,Appadurai R,Sswedheni U,Padmaja C

更新日期：2017-10-16 00:00:00

abstract：AIM:To investigate whether the change in pre-/post-operation serum alpha-fetoprotein (AFP) levels is a predictive factor for hepatocellular carcinoma (HCC) outcomes. METHODS:We retrospectively analyzed 334 HCC patients who underwent hepatic resection at our hospital between January 2006 and December 2016. The patients...

journal_title：World journal of clinical cases

authors： Rungsakulkij N,Suragul W,Mingphruedhi S,Tangtawee P,Muangkaew P,Aeesoa S

更新日期：2018-06-16 00:00:00

abstract：BACKGROUND:Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare. Polycythemia is significantly associated with risk of venous thromboembolism (VTE), which is further increased in case of a large pelvic mass and obesity. Here we report ...

journal_title：World journal of clinical cases

authors： Macciò A,Chiappe G,Lavra F,Sanna E,Nieddu R,Madeddu C

更新日期：2019-10-06 00:00:00

abstract：BACKGROUND:Primary malignant melanoma of the lung (PMML) is a rare and highly malignant tumor with a poor prognosis. Here, we report a PMML case diagnosed by computed tomography (CT)-guided percutaneous biopsy, describe its pathological features and review relevant literature to improve our understanding of this tumor....

journal_title：World journal of clinical cases

authors： Xi JM,Wen H,Yan XB,Huang J

更新日期：2020-12-26 00:00:00