Considerations for routine coagulation monitoring with rivaroxaban: A case report and review of the literature.


BACKGROUND:Rivaroxaban is a non-vitamin K antagonist oral anticoagulant that does not require coagulation monitoring based on current recommendations. Our goal is to explore whether routine coagulation monitoring should not be required for all patients receiving oral rivaroxaban, what relationship between routine coagulation abnormalities and bleeding, and how to deal with the above clinical situations through our case and review of the literature. CASE SUMMARY:We report a 67-year-old woman with a history of atrial fibrillation who presented to the hospital with worsening dyspnea and cough. Based on electrocardiogram, venous compression ultrasonography, and computed tomography pulmonary angiography, the diagnosis of atrial fibrillation, deep venous thrombosis, and acute pulmonary embolism was confirmed. Her coagulation assays and renal function were normal on admission; she was not underweight, did not have a history of hemorrhagic disease, and her CHA2DS2-VAS, HAS-BLED, and simplified Pulmonary Embolism Severity Index scores were 3, 0, and 0, respectively. Oral rivaroxaban (15 mg twice daily) was administered. The following day, she presented gastrointestinal and gum bleeding, combined with coagulation abnormalities. Following cessation of rivaroxaban, her bleeding stopped and tests improved over the next 2 d. Rivaroxaban was begun again 3 d after recovery. However, she again presented with gastrointestinal and gum bleeding and the abnormal tests, and the therapy was discontinued. At 30-d follow-up after discharge, she presented normal coagulation tests without bleeding. CONCLUSION:Although current guidelines recommend that using non-vitamin K antagonist oral anticoagulants including rivaroxaban do not require coagulation monitoring, a small number of patients may develop routine coagulation test changes and bleeding during rivaroxaban therapy, especially in the elderly. Clinicians should pay attention to these patients and further obtain evidence in practice.


World J Clin Cases


Wu HD,Cao HY,Song ZK,Yang S,Tang ML,Liu Y,Qin L




Has Abstract


2019-02-06 00:00:00










  • Crohn's disease confined to the duodenum: A case report.

    abstract::Crohn's disease (CD) can involve any part of the gastrointestinal tract from the mouth to anus. However, gastroduodenal CD is rare with a frequency reported to range between 0.5% and 4.0%. Most patients with gastroduodenal CD have concomitant lesions in the terminal ileum or colon, but isolated gastroduodenal Crohn's ...

    journal_title:World journal of clinical cases



    authors: Song DJ,Whang IS,Choi HW,Jeong CY,Jung SH

    更新日期:2016-06-16 00:00:00

  • Small-cell neuroendocrine carcinoma of the rectum - a rare tumor type with poor prognosis: A case report and review of literature.

    abstract:BACKGROUND:Small-cell neuroendocrine carcinoma (SNEC) of the rectum is a rare tumor associated with poor prognosis. CASE SUMMARY:We report a case of a 77-year-old male who came into our hospital because of blood with his stool. An endoscopy revealed a cauliflower-like neoplasm in his rectum. Imaging examination showed...

    journal_title:World journal of clinical cases



    authors: Chen ZZ,Huang W,Wei ZQ

    更新日期:2020-12-06 00:00:00

  • Correlation analysis of collagen proportionate area in Budd-Chiari syndrome: A preliminary clinicopathological study.

    abstract:BACKGROUND:Collagen proportionate area (CPA) is an important index for assessing the severity of liver fibrosis. Budd-Chiari syndrome can frequently progress to liver fibrosis and cirrhosis. CPA might play an important role in the pathological progress of Budd-Chiari syndrome. AIM:To explore the role of CPA in predict...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: He FL,Li C,Liu FQ,Qi XS

    更新日期:2019-01-26 00:00:00

  • Large carotid body tumor successfully resected in hybrid operating theatre: A case report.

    abstract:BACKGROUND:Surgical treatment for large carotid body tumor (CBT), particularly the Shamblin III type, is challenging and rarely reported. CASE SUMMARY:In July 2014, a 63-year-old woman presented to our hospital with a large CBT (130 mm × 60 mm × 70 mm). The lesion was hypervascular, spanned from the first to the seven...

    journal_title:World journal of clinical cases



    authors: Li MQ,Zhao Y,Sun HY,Yang XY

    更新日期:2019-08-26 00:00:00

  • Catastrophic vertebral artery and subclavian artery pseudoaneurysms caused by a fishbone: A case report.

    abstract:BACKGROUND:Fishbone is the most common esophageal foreign body and tends to migrate after piercing the esophagus to nearby structures. Vascular injury around the esophagus is a serious complication and has a high mortality rate, especially in the case of multiple vascular injuries. CASE SUMMARY:We report an extremely ...

    journal_title:World journal of clinical cases



    authors: Huang W,Zhang GQ,Wu JJ,Li B,Han SG,Chao M,Jin K

    更新日期:2020-10-26 00:00:00

  • Hodgkin's lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B.

    abstract::Acute on chronic liver failure (ACLF) is rarely the initial manifestation of a malignant process or precipitated by the initiation of anti-viral treatment with a nucleoside or nucleotide agent. We report an unusual case of ACLF temporally associated with initiation of Entecavir for treatment of chronic hepatitis B. Ea...

    journal_title:World journal of clinical cases



    authors: Palta R,McClune A,Esrason K

    更新日期:2013-04-16 00:00:00

  • Adrenal metastasis from endometrial cancer: A case report.

    abstract:BACKGROUND:Metastases to adrenal glands originate principally from lung, breast, or gastrointestinal cancers, followed by malignant melanoma and thyroid neoplasms. We present an unusual case of uterine cancer metastasizing to the adrenal glands with a review of the English literature on the management of this rare dise...

    journal_title:World journal of clinical cases



    authors: Da Dalt G,Friziero A,Grego A,Serafini S,Fassina A,Blandamura S,Sperti C

    更新日期:2019-07-26 00:00:00

  • Pancreaticoduodenectomy with combined superior mesenteric vein resection without reconstruction is possible: A case report and review of the literature.

    abstract::We report the case of a 56-year-old woman with pancreatic adenocarcinoma (PA) discovered during an episode of febrile jaundice. A computed tomography (CT) scan showed a mass in the head of the pancreas with circumferential infiltration of the superior mesenteric vein (SMV) and dilatation of the biliary and pancreatic ...

    journal_title:World journal of clinical cases



    authors: Jouffret L,Guilbaud T,Turrini O,Delpero JR

    更新日期:2018-08-16 00:00:00

  • Influencing factors of postoperative early delayed gastric emptying after minimally invasive Ivor-Lewis esophagectomy.

    abstract:BACKGROUND:The main clinical treatment for esophageal cancer is surgery. Since traditional open esophageal cancer resection has the disadvantages of large trauma, long recovery period, and high postoperative complication rate, its clinical application is gradually reduced. The current report of minimally invasive Ivor-...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Huang L,Wu JQ,Han B,Wen Z,Chen PR,Sun XK,Guo XD,Zhao CM

    更新日期:2019-02-06 00:00:00

  • COVID-19: A review of what radiologists need to know.

    abstract::Coronavirus disease-2019 (COVID-19) is spreading throughout the world. Chest radiography and computed tomography play an important role in disease diagnosis, differential diagnosis, severity evaluation, prognosis prediction, therapeutic effects assessment and follow-up of patients with COVID-19. In this review, we sum...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Tang L,Wang Y,Zhang Y,Zhang XY,Zeng XC,Song B

    更新日期:2020-11-26 00:00:00

  • Synchronous multiple primary gastrointestinal cancers with CDH1 mutations: A case report.

    abstract:BACKGROUND:Synchronous multiple primary cancers (SMPC) mean two or more malignant tumors occurring simultaneously and with different origins no matter what types they are or where they are located. The carcinogenesis of SMPC often involves variations of some specific genes. However, the correlation between CDH1 mutatio...

    journal_title:World journal of clinical cases



    authors: Hu MN,Lv W,Hu RY,Si YF,Lu XW,Deng YJ,Deng H

    更新日期:2019-07-06 00:00:00

  • CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review.

    abstract:BACKGROUND:Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also ...

    journal_title:World journal of clinical cases



    authors: Yang L,Liang H,Liu L,Guo L,Ying JM,Shi SS,Hu XS

    更新日期:2020-04-06 00:00:00

  • Colovesical fistula caused by glucocorticoid therapy for IgG4-related intrapelvic mass.

    abstract::IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid co...

    journal_title:World journal of clinical cases



    authors: Yabuuchi Y,Matsubayashi H,Matsuzaki M,Shiomi A,Moriguchi M,Kawamura I,Ito I,Ono H

    更新日期:2015-12-16 00:00:00

  • Jejunal cavernous lymphangioma manifested as gastrointestinal bleeding with hypogammaglobulinemia in adult: A case report and literature review.

    abstract:BACKGROUND:Lymphangioma is a benign lesion that rarely involves the gastrointestinal tract, especially in adults. Small bowel lymphangioma is a rare cause of gastrointestinal bleeding. Here, we report a case of an adult diagnosed with jejunal lymphangioma presenting with melena, anemia and hypogammaglobulinemia. We als...

    journal_title:World journal of clinical cases



    authors: Tan B,Zhang SY,Wang YN,Li Y,Shi XH,Qian JM

    更新日期:2020-01-06 00:00:00

  • Association between resting energy expenditure, psychopathology and HPA-axis in eating disorders.

    abstract:AIM:To investigate the complex relationships between resting energy expenditure (REE), eating psychopathology, and Hypothalamus Pituitary Adrenal axis functioning in patients with eating disorders. METHODS:The study was designed as a cross-sectional survey, and it was planned by the Clinic for Eating Disorders of the ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Castellini G,Castellani W,Lelli L,Sauro CL,Dini C,Lazzeretti L,Bencini L,Mannucci E,Ricca V

    更新日期:2014-07-16 00:00:00

  • Impact of perioperative transfusion in patients undergoing resection of colorectal cancer liver metastases: A population-based study.

    abstract:BACKGROUND:Perioperative allogeneic blood transfusion is associated with poorer outcomes. AIM:To identify the factors that were associated with perioperative transfusion and to examine the impact of perioperative transfusion in patients undergoing resection of colorectal cancer (CRC) liver metastases. METHODS:The Uni...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Long B,Xiao ZN,Shang LH,Pan BY,Chai J

    更新日期:2019-05-26 00:00:00

  • Successful treatment of plasma exchange-refractory thrombotic thrombocytopenic purpura with rituximab: A case report.

    abstract:BACKGROUND:Thrombotic thrombocytopenic purpura (TTP), a subtype of thrombotic microangiopathy, has a very high fatality rate if there is no timely diagnosis or treatment. Here, we report a case of TTP refractory to high displacement plasma exchange, which was later successfully treated with rituximab. CASE SUMMARY:Her...

    journal_title:World journal of clinical cases



    authors: Chen J,Jin JX,Xu XF,Zhang XX,Ye XN,Huang J

    更新日期:2020-06-26 00:00:00

  • Medical research during the COVID-19 pandemic.

    abstract::The current pandemic of coronavirus disease 2019 (COVID-19) which was first detected in Wuhan, China in December 2019 is caused by the novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The virus has quickly spread to a large number of countries leading to a great number of deaths. U...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: AlNaamani K,AlSinani S,Barkun AN

    更新日期:2020-08-06 00:00:00

  • Non-invasive home lung impedance monitoring in early post-acute heart failure discharge: Three case reports.

    abstract:BACKGROUND:Patients discharged after hospitalization for acute heart failure (AHF) are frequently readmitted due to an incomplete decongestion, which is difficult to assess clinically. Recently, it has been shown that the use of a highly sensitive, non-invasive device measuring lung impedance (LI) reduces hospitalizati...

    journal_title:World journal of clinical cases



    authors: Lycholip E,Palevičiūtė E,Aamodt IT,Hellesø R,Lie I,Strömberg A,Jaarsma T,Čelutkienė J

    更新日期:2019-04-26 00:00:00

  • Challenging rescue of a 4 years old boy with H1N1 infection by extracorporeal membrane oxygenator: A case report.

    abstract:INTRODUCTION:World Health Organization announced on April 2009 a public health emergency of international concern caused by swine-origin influenza A (H1N1) virus. Acute respiratory distress syndrome (ARDS) has been reported to be the most devastating complications of this pathogen. Extracorporeal membrane oxygenator (E...

    journal_title:World journal of clinical cases



    authors: Papadopoulos N,Martens S,Keller H,El-Sayed Ahmad A,Moritz A,Zierer A

    更新日期:2014-10-16 00:00:00

  • Health care associated infections, antibiotic resistance and clinical outcome: A surveillance study from Sanandaj, Iran.

    abstract:AIM:To study the antibiotic susceptibility patterns of gram-negative healthcare associated bacterial infections at two tertiary hospitals in the Sanandaj city, Kurdistan Province, Iran. METHODS:From January 2012 to December 2012, all positive cultures from potentially sterile body fluids were gathered. They sent to pr...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Soltani J,Poorabbas B,Miri N,Mardaneh J

    更新日期:2016-03-16 00:00:00

  • Neurofibroma discharged from the anus with stool: A case report and review of literature.

    abstract::Isolated neurofibromas that affect the gastrointestinal tract are rare and almost always manifest as neurofibromatosis type 1 or multiple endocrine neoplasia type 2b. In this paper, we present a case of a 24-year-old female with abdominal pain who discharged a neurofibroma in her stool without any blood on it. A colon...

    journal_title:World journal of clinical cases



    authors: Miao Y,Wang JJ,Chen ZM,Zhu JL,Wang MB,Cai SQ

    更新日期:2018-10-06 00:00:00

  • Robot-assisted retroperitoneal laparoscopic excision of perirenal vascular tumor: A case report.

    abstract:BACKGROUND:A vascular tumor is a benign tumor with unique clinical and pathological features. Perirenal vascular tumor is extremely rare and has not yet been reported. Clinically, it manifests as soreness and swelling. Color ultrasound and renal angiography illustrated the perirenal mass, which was closely connected wi...

    journal_title:World journal of clinical cases



    authors: Zhang C,Fu B,Xu S,Zhou XC,Cheng XF,Fu WQ,Wang GX

    更新日期:2020-05-26 00:00:00

  • Melanotic Xp11-associated tumor of the sigmoid colon: A case report.

    abstract:BACKGROUND:Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far, most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are rare. CASE SUMMARY:Here we describe the case of a 25-year-old woman who presented with a m...

    journal_title:World journal of clinical cases



    authors: Wang G,Li GG,Zhu SM,Cai BJ,Yu PJ,Zhang CW

    更新日期:2019-03-06 00:00:00

  • Characteristics of clear cell renal cell carcinoma metastases to the thyroid gland: A systematic review.

    abstract:BACKGROUND:Thyroid gland is an uncommon site for metastases from clear cell renal cell carcinoma (CCRCC) and literature is scarce. Due to the variable and often long lag time before development of metastases in patients with CCRCC, thyroid nodules may be misdiagnosed initially as benign. This systematic review aims at ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Khaddour K,Marernych N,Ward WL,Liu J,Pappa T

    更新日期:2019-11-06 00:00:00

  • Celiomesenteric trunk: New classification based on multidetector computed tomography angiographic findings and probable embryological mechanisms.

    abstract:BACKGROUND:In previous studies, celiomesenteric trunk (CMT) was narrowly defined as a hepato-gastro-spleno-mesenteric (HGSM) trunk, but other possible types were ignored. With the widespread use of multidetector computed tomography (MDCT) angiography, it is easy to collect a large sampling of data on arterial anatomy o...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Tang W,Shi J,Kuang LQ,Tang SY,Wang Y

    更新日期:2019-12-06 00:00:00

  • Gene diagnosis of infantile neurofibromatosis type I: A case report.

    abstract:BACKGROUND:Neurofibromatosis is an autosomal dominant genetic disorder with various manifestations. Systemic multiple neurofibromatosis is rare in infancy. The disease is difficult to identify in the early stage, and it is prone to misdiagnosis and missed diagnosis. In the presence of lower limb swelling with subcutane...

    journal_title:World journal of clinical cases



    authors: Li MZ,Yuan L,Zhuo ZQ

    更新日期:2020-11-26 00:00:00

  • Predictive value of serum cystatin C for risk of mortality in severe and critically ill patients with COVID-19.

    abstract:BACKGROUND:The outbreak of coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. COVID-19 is clinically categorized into mild, moderate, severe, and critical illness. Acute kidney injury is an independent risk factor for poor prognosis in patients with. Serum cystatin C (sCys C) is considered ...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章


    authors: Li Y,Yang S,Peng D,Zhu HM,Li BY,Yang X,Sun XL,Zhang M

    更新日期:2020-10-26 00:00:00

  • Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer.

    abstract::Inflammation is a central process in several disorders and contributes to cancer progression. Inflammation involves a complex cascade of pro-inflammatory and anti-inflammatory signaling events with protein and lipid mediators. Recent advances in lipid detection have revealed the importance of lipid mediators in inflam...

    journal_title:World journal of clinical cases

    pub_type: 杂志文章,评审


    authors: Moro K,Nagahashi M,Ramanathan R,Takabe K,Wakai T

    更新日期:2016-07-16 00:00:00

  • Elusive left ventricular thrombus: Diagnostic role of cardiac magnetic resonance imaging-A case report and review of the literature.

    abstract::Identification of left ventricular mural thrombus (LVT) may be challenging depending on the imaging modality used. We present a case of LVT which was incidentally identified on cine cardiac magnetic resonance imaging (CMR). A sixty-four years old female presented with worsening dyspnea on exertion with troponin elevat...

    journal_title:World journal of clinical cases



    authors: Siddiqui I,Nguyen T,Movahed A,Kabirdas D

    更新日期:2018-06-16 00:00:00