Clinical effects of apatinib mesylate for treatment of multiple brain micrometastases: Two case reports.

Abstract:

BACKGROUND:Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor. Apatinib has demonstrated encouraging antitumor activities. This study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain micrometastases. CASE SUMMARY:We report two patients with multiple brain micrometastases after failure of second-line treatment. Both patients had extracerebral metastases. When the patients took 250 mg/d apatinib orally, the intracerebral lesions disappeared. The extracerebral lesions were partially alleviated. Both patients had a progression-free survival of more than 12 mo and were still stable. The safety was good. The main adverse events (AEs) were mild hypertension and proteinuria, which could be controlled. CONCLUSION:Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.

journal_name

World J Clin Cases

authors

Guo JH,Wang YY,Zhang JW,Liu PM,Hao YJ,Duan HR

doi

10.12998/wjcc.v8.i7.1326

subject

Has Abstract

pub_date

2020-04-06 00:00:00

pages

1326-1336

issue

7

issn

2307-8960

journal_volume

8

pub_type

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