Abstract:
BACKGROUND:Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor. Apatinib has demonstrated encouraging antitumor activities. This study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain micrometastases. CASE SUMMARY:We report two patients with multiple brain micrometastases after failure of second-line treatment. Both patients had extracerebral metastases. When the patients took 250 mg/d apatinib orally, the intracerebral lesions disappeared. The extracerebral lesions were partially alleviated. Both patients had a progression-free survival of more than 12 mo and were still stable. The safety was good. The main adverse events (AEs) were mild hypertension and proteinuria, which could be controlled. CONCLUSION:Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.
journal_name
World J Clin Casesjournal_title
World journal of clinical casesauthors
Guo JH,Wang YY,Zhang JW,Liu PM,Hao YJ,Duan HRdoi
10.12998/wjcc.v8.i7.1326subject
Has Abstractpub_date
2020-04-06 00:00:00pages
1326-1336issue
7issn
2307-8960journal_volume
8pub_type
abstract:BACKGROUND:Squamous cell carcinoma of head and neck (SCCHN) is the fifth most common cancer worldwide. Inhibition of epidermal growth factor receptor signaling has been shown to be a critical component of therapeutic option. Herein, we report a case of durable complete response to erlotinib. CASE SUMMARY:An 81-year-ol...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i5.616
更新日期:2019-03-06 00:00:00
abstract::In commenting on a case report of a 55-year-old man who suffered Takotsubo syndrome (TTS), in the setting of receiving chemotherapy with cytarabine and daunorubicin for acute myeloid leukemia, the author expresses his views that TTS in the setting of chemotherapy for malignancies may not be chemotherapeutic drug-speci...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v3.i2.204
更新日期:2015-02-16 00:00:00
abstract::Colovesical fistulas (CVFs) are rare complications of very advanced cancers of the abdominal or pelvic cavity and often cause diagnostic troubles. CVFs are found more often in males, whereas females usually suffer from rectovaginal or vesicovaginal fistulas. This article presents a case of a female patient who was adm...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v6.i12.538
更新日期:2018-10-26 00:00:00
abstract:BACKGROUND:In previous studies, celiomesenteric trunk (CMT) was narrowly defined as a hepato-gastro-spleno-mesenteric (HGSM) trunk, but other possible types were ignored. With the widespread use of multidetector computed tomography (MDCT) angiography, it is easy to collect a large sampling of data on arterial anatomy o...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i23.3980
更新日期:2019-12-06 00:00:00
abstract::Coronavirus disease-2019 (COVID-19) has so far caused hundreds of mortalities worldwide. Although respiratory symptoms are the main complication in COVID-19 patients, the disease is also associated with gastrointestinal problems, with diarrhea, nausea, and vomiting being primary COVID-19 symptoms. Thus, cancer and inf...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i18.3934
更新日期:2020-09-26 00:00:00
abstract::A 50-year-old male who underwent a HeartMate II left ventricular assist device placement for ischemic cardiomyopathy presented with discolored urine and hemolysis 3 mo after the operation. His hemolysis was thought to be due to thrombosis within the pump. Imaging studies were not able to visualize a left ventricular t...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i8.373
更新日期:2014-08-16 00:00:00
abstract::IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid co...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v3.i12.1000
更新日期:2015-12-16 00:00:00
abstract:BACKGROUND:Lymphangioma is a benign lesion that rarely involves the gastrointestinal tract, especially in adults. Small bowel lymphangioma is a rare cause of gastrointestinal bleeding. Here, we report a case of an adult diagnosed with jejunal lymphangioma presenting with melena, anemia and hypogammaglobulinemia. We als...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i1.140
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Ganglioneuroma (GN) is a rare and benign tumor that originates from autonomic nervous system ganglion cells. The most frequently involved sites are the posterior mediastinum, the abdominal cavity, and the retroperitoneal space. It rarely occurs in the cervical area, compressing the spinal cord. Neurofibromat...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i1.109
更新日期:2019-01-06 00:00:00
abstract:BACKGROUND:Femoral shaft fractures are a common type of fracture among adults and have high union rates. However, clinical decisions are difficult to make because of the different types of nonunions. Atrophic nonunion usually requires revision surgery combined with bone grafting. Furthermore, no study of teriparatide a...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i18.2838
更新日期:2019-09-26 00:00:00
abstract:AIM:To analyze the bacterial community structure and distribution of intestinal microflora in people with and without metabolic syndrome and combined these data with clinical indicators to determine relationships between selected bacteria and metabolic diseases. METHODS:Faecal samples were collected from 20 patients w...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v6.i4.54
更新日期:2018-04-16 00:00:00
abstract:BACKGROUND:The prognosis of paediatric primary refractory/relapsed acute myeloid leukaemia (R/R AML) remains poor. Intensive therapy is typically used as salvage treatment for those with R/R AML. No data are currently available about the use of the CLAG-M protocol as salvage therapy in paediatric patients with R/R AML....
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i22.5603
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Emergency department (ED) overcrowding is a severe health care concern, while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population. We hypothesized that anxiety due to over crowdedness may lead to adverse events in EDs. AIM:To invest...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i13.2802
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Myocardial bridge (MB) will compress the mural coronary artery (MCA) during the systole and cause myocardial ischemia. In the diagnosis of coronary heart disease (CHD), because the structure of MB is difficult to be observed by coronary angiography (CAG), the clinical study of the influence of MB on CHD is l...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i15.1986
更新日期:2019-08-06 00:00:00
abstract::We report a case of a 54-year-old patient who was denied surgical replacement for severe aortic stenosis because of complicated acquired immunodeficiency syndrome and who successfully underwent transcatheter aortic valve implantation at our institution. ...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i4.97
更新日期:2014-04-16 00:00:00
abstract::Identification of left ventricular mural thrombus (LVT) may be challenging depending on the imaging modality used. We present a case of LVT which was incidentally identified on cine cardiac magnetic resonance imaging (CMR). A sixty-four years old female presented with worsening dyspnea on exertion with troponin elevat...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v6.i6.127
更新日期:2018-06-16 00:00:00
abstract:BACKGROUND:Since the beginning of the pandemic, coronavirus disease-2019 (COVID-19) in children has shown milder cases and a better prognosis than adults. Although the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), cardiovascular involvement is emerging as one ...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i21.5250
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:We analyzed the main features of an infant diagnosed with temporary neonatal cyanosis in order to strengthen our understanding of the disease. CASE SUMMARY:We report a patient diagnosed with temporary neonatal cyanosis. The main clinical characteristics, gene mutation and treatment are discussed and a revie...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i1.217
更新日期:2020-01-06 00:00:00
abstract::Probiotics are known as "live microorganisms" and have been proven to have a health effect on hosts at the proper dose. Recently, a kind of probiotic mixture including eight live bacterial strains, VSL#3, has attracted considerable attention for its combined effect. VSL#3 is the only probiotic considered as a kind of ...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i8.1361
更新日期:2020-04-26 00:00:00
abstract:BACKGROUND:Acute ischemic stroke (AIS) is mainly caused by cerebral blood flow disorders, which further leads to ischemic brain necrosis or encephalomalacia. The role of homocysteine (Hcy), an independent risk factor for cardiovascular disease, in the development of atherosclerosis is gradually revealed. However, studi...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i22.3751
更新日期:2019-11-26 00:00:00
abstract:AIM:To investigated the association between the tumor cells' expression of E-cadherin and the numbers of several types of inflammatory cells infiltrating into the invasive portion of gallbladder cancer (GBC). METHODS:We analyzed 50 GBC cases for which a sufficient amount of tumor tissues for tissue microarray (TMA) ha...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v5.i1.1
更新日期:2017-01-16 00:00:00
abstract:BACKGROUND:Sebaceous lymphadenoma is a benign tumor that occurs rarely in the salivary glands, most commonly in the parotid glands or periparotid lymph nodes, and even more rarely undergoes malignant transformation into a sebaceous lymphadenocarcinoma. CASE SUMMARY:We report an 82-year-old woman who presented with a p...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i22.5751
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far, most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are rare. CASE SUMMARY:Here we describe the case of a 25-year-old woman who presented with a m...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i5.684
更新日期:2019-03-06 00:00:00
abstract:BACKGROUND:Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice. Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn (HDN). Unfortunately, regional status of Rh-HDN is unavailable. We hypothesize tha...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i20.3202
更新日期:2019-10-26 00:00:00
abstract:BACKGROUND:This study aimed to identify factors associated with antibiotic-associated diarrhea (AAD) in patients in the department of intensive care medicine who received antibiotic monotherapy in order to reduce the incidence of AAD and improve rational use of antibiotics in these patients. AIM:To report the incidenc...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i10.1908
更新日期:2020-05-26 00:00:00
abstract::Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a very rare variant of non-Hodgkin's lymphoma. Currently, there is no standard imaging method for staging of SPTCL nor for assessment of treatment response. Here, we describe our use of fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed ...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v4.i9.258
更新日期:2016-09-16 00:00:00
abstract:BACKGROUND:Penetrating brain injury (PBI) is an uncommon emergency in neurosurgery, and transorbital PBI is a rare type of PBI. Reasonable surgical planning and careful postoperative management can improve the prognosis of patients. CASE SUMMARY:The first case is a 68-year-old male patient who was admitted to the hosp...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i2.471
更新日期:2020-01-26 00:00:00
abstract:BACKGROUND:Concomitant allergic fungal rhinosinusitis (AFRS) and allergic bronchopulmonary aspergillosis (ABPA) are extremely rare, with no more than 20 cases reported in the English literature. CASE SUMMARY:A 52-year-old female patient complained of right-sided nasal obstruction, rhinorrhea, sneezing, epistaxis, and ...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i22.3821
更新日期:2019-11-26 00:00:00
abstract::Pneumomediastinum, pneumorachis and subcutaneous emphysema are frequently benign and most commonly result from air escaping from the upper respiratory tract, intrathoracic airways, or gastrointestinal tract. Gas can also be generated by certain infections or reach the mediastinal space from outside air after trauma or...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v2.i5.170
更新日期:2014-05-16 00:00:00
abstract::Posterior reversible encephalopathy syndrome (PRES) is a clinico-ragiological syndrome presenting with neurological symptoms and characteristic radiologic findings. PRES occurs in the setting of various clinical conditions and requires prompt management of the causative factor for a full recovery. This is a case repor...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v4.i4.103
更新日期:2016-04-16 00:00:00