Idiopathic adulthood ductopenia with elevated transaminase only: A case report.

Abstract:

BACKGROUND:Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease of unknown etiology that usually presents as unexplained jaundice. It is characterized by adult onset, lack of autoantibodies, inflammatory bowel disease and loss of interlobular bile ducts. CASE SUMMARY:This case presents a 27-year-old woman with elevation of transaminases and alkaline phosphatase without clinical symptoms. Five years ago, the patient had abnormal transaminases but no cholestasis. Three months before admission, physical examination revealed an increase in transaminases. Oral hepatoprotective drugs did not show any significant improvement, and she was admitted to hospital for further diagnosis and treatment. Liver biopsy confirmed IAD. After about 2 wk of ursodeoxycholic acid treatment, serological and histological examination showed a significant response. CONCLUSION:IAD is a manifestation of cholestasis, but also may be an abnormal increase in transaminase in the early stage.

journal_name

World J Clin Cases

authors

Zhang XC,Wang D,Li X,Hu YL,Wang C

doi

10.12998/wjcc.v8.i24.6524

subject

Has Abstract

pub_date

2020-12-26 00:00:00

pages

6524-6528

issue

24

issn

2307-8960

journal_volume

8

pub_type

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