DNA methylation detection methods used in colorectal cancer.

Abstract:

:Colorectal cancer (CRC) remains a major contributor to the number of cancer-related deaths that occur annually worldwide. With the development of molecular biology methods, an increasing number of molecular biomarkers have been identified and investigated. CRC is believed to result from an accumulation of epigenetic changes, and detecting aberrant DNA methylation patterns is useful for both the early diagnosis and prognosis of CRC. Numerous studies are focusing on the development of DNA methylation detection methods or DNA methylation panels. Thus, this review will discuss the commonly used techniques and technologies to evaluate DNA methylation, their merits and deficiencies as well as the prospects for new methods.

journal_name

World J Clin Cases

authors

Zhan YX,Luo GH

doi

10.12998/wjcc.v7.i19.2916

subject

Has Abstract

pub_date

2019-10-06 00:00:00

pages

2916-2929

issue

19

issn

2307-8960

journal_volume

7

pub_type

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