Evaluation of a methylation classifier for predicting pre-cancer lesion among women with abnormal results between HPV16/18 and cytology.

abstract：BACKGROUND:A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer biomarker has been identified to date. Here, we explore the potential of ...

journal_title：Clinical epigenetics

authors： Roos L,van Dongen J,Bell CG,Burri A,Deloukas P,Boomsma DI,Spector TD,Bell JT

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3 breadth has an import...

journal_title：Clinical epigenetics

authors： Zhang Z,Shi L,Dawany N,Kelsen J,Petri MA,Sullivan KE

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipit...

journal_title：Clinical epigenetics

authors： Melka MG,Laufer BI,McDonald P,Castellani CA,Rajakumar N,O'Reilly R,Singh SM

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical...

journal_title：Clinical epigenetics

authors： Yáñez Y,Grau E,Rodríguez-Cortez VC,Hervás D,Vidal E,Noguera R,Hernández M,Segura V,Cañete A,Conesa A,Font de Mora J,Castel V

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation. We hypothesized that the disruption of chromatin regulation might result in specific DNA methyl...

journal_title：Clinical epigenetics

authors： Bend EG,Aref-Eshghi E,Everman DB,Rogers RC,Cathey SS,Prijoles EJ,Lyons MJ,Davis H,Clarkson K,Gripp KW,Li D,Bhoj E,Zackai E,Mark P,Hakonarson H,Demmer LA,Levy MA,Kerkhof J,Stuart A,Rodenhiser D,Friez MJ,Stevenson

更新日期：2019-04-27 00:00:00

abstract：BACKGROUND:Aging is a complex phenomenon and characterized by a progressive decline in physiology and function of adult tissues. However, it hasn't been well established of the correlation between aging and global DNA methylation and hydroxymethylation that regulate the growth and development of higher organisms. RESU...

journal_title：Clinical epigenetics

authors： Xiong J,Jiang HP,Peng CY,Deng QY,Lan MD,Zeng H,Zheng F,Feng YQ,Yuan BF

更新日期：2015-07-23 00:00:00

abstract：:Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smok...

journal_title：Clinical epigenetics

authors： Ma K,Cao B,Guo M

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

journal_title：Clinical epigenetics

authors： Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that epigenetic dysregulation in mitochondrial DNA (mtDNA) could contribute to the neurodegenerative pro...

journal_title：Clinical epigenetics

authors： Stoccoro A,Smith AR,Mosca L,Marocchi A,Gerardi F,Lunetta C,Cereda C,Gagliardi S,Lunnon K,Migliore L,Coppedè F

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperglycemia and detrimental birth outcomes. By investigating paired subcutaneous (SAT) and visceral adip...

journal_title：Clinical epigenetics

authors： Ott R,Stupin JH,Melchior K,Schellong K,Ziska T,Dudenhausen JW,Henrich W,Rancourt RC,Plagemann A

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

journal_title：Clinical epigenetics

authors： Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findings that FET provides better obstetric and perinatal outcomes. However, the birth weight of infants ...

journal_title：Clinical epigenetics

authors： Hiura H,Hattori H,Kobayashi N,Okae H,Chiba H,Miyauchi N,Kitamura A,Kikuchi H,Yoshida H,Arima T

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Identifying subjects with a high risk of ischemic stroke is fundamental for prevention of the disease. Both genetic and environmental risk factors contribute to ischemic stroke, but the underlying epigenetic mechanisms which mediate genetic and environmental risk effects are not fully understood. The aim of ...

journal_title：Clinical epigenetics

authors： Qin X,Li J,Wu T,Wu Y,Tang X,Gao P,Li L,Wang M,Wu Y,Wang X,Chen D,Hu Y

更新日期：2019-12-10 00:00:00

abstract：Background:Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic "mortality risk score" (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine...

journal_title：Clinical epigenetics

authors： Gao X,Zhang Y,Schöttker B,Brenner H

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric diseases is DNA methylation at the oxytocin receptor gene (OXTR). Such studies focus on DNA methylat...

journal_title：Clinical epigenetics

authors： Danoff JS,Wroblewski KL,Graves AJ,Quinn GC,Perkeybile AM,Kenkel WM,Lillard TS,Parikh HI,Golino HF,Gregory SG,Carter CS,Bales KL,Connelly JJ

更新日期：2021-01-30 00:00:00

abstract：BACKGROUND:Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous work, we demonstrated that altered DNA methylation at the aryl hydrocarbon receptor repressor (AHRR) is correlated with self-reported smoking in 19-year-old African Americans with relatively low levels of sm...

journal_title：Clinical epigenetics

authors： Philibert RA,Beach SR,Lei MK,Brody GH

更新日期：2013-10-11 00:00:00

abstract：INTRODUCTION:DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation...

journal_title：Clinical epigenetics

authors： Kullmann K,Deryal M,Ong MF,Schmidt W,Mahlknecht U

更新日期：2013-05-02 00:00:00

abstract：BACKGROUND:Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level o...

journal_title：Clinical epigenetics

authors： Westerman K,Sebastiani P,Jacques P,Liu S,DeMeo D,Ordovás JM

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-...

journal_title：Clinical epigenetics

authors： Berni Canani R,Paparo L,Nocerino R,Cosenza L,Pezzella V,Di Costanzo M,Capasso M,Del Monaco V,D'Argenio V,Greco L,Salvatore F

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi) that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (MACE) in patients with cardiovascular disease (CVD) by 44% and in diabetic CVD patients by 57% on top of statins. A phase III trial, BETonM...

journal_title：Clinical epigenetics

authors： Tsujikawa LM,Fu L,Das S,Halliday C,Rakai BD,Stotz SC,Sarsons CD,Gilham D,Daze E,Wasiak S,Studer D,Rinker KD,Sweeney M,Johansson JO,Wong NCW,Kulikowski E

更新日期：2019-07-12 00:00:00

abstract：Background:The dynamic methylation of human papillomavirus (HPV) 16 DNA is thought to be associated with the progression of cervical lesions. Previous studies that did not consider the physical status of HPV 16 may have incorrectly mapped HPV 16 methylomes. In order to identify reliable biomarkers for squamous cervical...

journal_title：Clinical epigenetics

authors： Liu L,Ying C,Zhao Z,Sui L,Zhang X,Qian C,Wang Q,Chen L,Guo Q,Wu J

更新日期：2018-01-23 00:00:00

abstract：Background:Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. Methods:In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were meas...

journal_title：Clinical epigenetics

authors： Coker ES,Gunier R,Huen K,Holland N,Eskenazi B

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory factor X1 (RFX1) is a critical transcription factor regulating epigenetic modifications. In this stud...

journal_title：Clinical epigenetics

authors： Du P,Gao K,Cao Y,Yang S,Wang Y,Guo R,Zhao M,Jia S

更新日期：2019-03-11 00:00:00

abstract：:Lymphocytes from the peripheral blood of patients with prostate cancer-the most frequent (noncutaneous) tumor in men-display epigenetic aberrations (altered modes of allelic replication) characteristic of the malignant phenotype. The present study aims to determine whether replication aberrations add certainty to the ...

journal_title：Clinical epigenetics

authors： Cytron S,Stepnov E,Bounkin I,Mashevich M,Dotan A,Avivi L

更新日期：2011-08-01 00:00:00

abstract：:In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methyla...

journal_title：Clinical epigenetics

authors： Simpkin AJ,Suderman M,Howe LD

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We ...

journal_title：Clinical epigenetics

authors： Sundar IK,Yin Q,Baier BS,Yan L,Mazur W,Li D,Susiarjo M,Rahman I

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:Alcohol consumption during pregnancy is a significant public health problem and can result in a continuum of adverse outcomes to the fetus known as fetal alcohol spectrum disorders (FASD). Subjects with FASD show significant neurological deficits, ranging from microencephaly, neurobehavioral, and mental heal...

journal_title：Clinical epigenetics

authors： Rachdaoui N,Li L,Willard B,Kasumov T,Previs S,Sarkar D

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

journal_title：Clinical epigenetics

authors： Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain largely unknown, DNA methylation has been proposed to reflect systemic inflammation. In this analysis, w...

journal_title：Clinical epigenetics

authors： Moody L,Crowder SL,Fruge AD,Locher JL,Demark-Wahnefried W,Rogers LQ,Delk-Licata A,Carroll WR,Spencer SA,Black M,Erdman JW Jr,Chen H,Pan YX,Arthur AE

更新日期：2020-09-11 00:00:00

abstract：:The study of DNA methylation in development and disease has 'exploded' as a field in recent years, with three major classes of measurement now routine. These encompass (i) locus-specific, (ii) genome-scale/wide and (iii) 'global' methylation approaches. Measures of global methylation refer to the level of 5-methylcyto...

journal_title：Clinical epigenetics

authors： Vryer R,Saffery R

更新日期：2017-01-13 00:00:00