What's in a name? Context-dependent significance of 'global' methylation measures in human health and disease.

abstract：BACKGROUND:Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However, its role in breast carcinogenesis remains elusive. Here, we studied its expression, functions, ...

journal_title：Clinical epigenetics

authors： Tao C,Luo J,Tang J,Zhou D,Feng S,Qiu Z,Putti TC,Xiang T,Tao Q,Li L,Ren G

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we collected cervical samples during screening in clinics. A total of 588 women with HPV16/18+ and/or cyt...

journal_title：Clinical epigenetics

authors： Gu YY,Zhou GN,Wang Q,Ding JX,Hua KQ

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that epigenetic dysregulation in mitochondrial DNA (mtDNA) could contribute to the neurodegenerative pro...

journal_title：Clinical epigenetics

authors： Stoccoro A,Smith AR,Mosca L,Marocchi A,Gerardi F,Lunetta C,Cereda C,Gagliardi S,Lunnon K,Migliore L,Coppedè F

更新日期：2020-09-11 00:00:00

abstract：Background:The dynamic methylation of human papillomavirus (HPV) 16 DNA is thought to be associated with the progression of cervical lesions. Previous studies that did not consider the physical status of HPV 16 may have incorrectly mapped HPV 16 methylomes. In order to identify reliable biomarkers for squamous cervical...

journal_title：Clinical epigenetics

authors： Liu L,Ying C,Zhao Z,Sui L,Zhang X,Qian C,Wang Q,Chen L,Guo Q,Wu J

更新日期：2018-01-23 00:00:00

abstract：BACKGROUND:Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease, but it has been difficult to understand their roles due to the lack of distinct molecular markers. ...

journal_title：Clinical epigenetics

authors： Clifford RL,Yang CX,Fishbane N,Patel J,MacIsaac JL,McEwen LM,May ST,Castellanos-Uribe M,Nair P,Obeidat M,Kobor MS,Knox AJ,Hackett TL

更新日期：2020-10-02 00:00:00

abstract：:Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representation bisulfite sequencing (RR...

journal_title：Clinical epigenetics

authors： Ingerslev LR,Donkin I,Fabre O,Versteyhe S,Mechta M,Pattamaprapanont P,Mortensen B,Krarup NT,Barrès R

更新日期：2018-01-25 00:00:00

abstract：Background:Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic "mortality risk score" (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine...

journal_title：Clinical epigenetics

authors： Gao X,Zhang Y,Schöttker B,Brenner H

更新日期：2018-06-20 00:00:00

abstract：:Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction p...

journal_title：Clinical epigenetics

authors： Guo ZY,Hao XH,Tan FF,Pei X,Shang LM,Jiang XL,Yang F

更新日期：2011-08-01 00:00:00

abstract：:After publication of the original article [1], authors have requested to add a 'J' as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson. ...

journal_title：Clinical epigenetics

authors： Pienkowska M,Choufani S,Turinsky AL,Guha T,Merino DM,Novokmet A,Brudno M,Weksberg R,Shlien A,Hawkins C,Bouffet E,Tabori U,Gilbertson RJ,Finlay JL,Jabado N,Thomas C,Sill M,Capper D,Hasselblatt M,Malkin D

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has been little to no research into the molecular changes that can occur as a result of an incident MI....

journal_title：Clinical epigenetics

authors： Ward-Caviness CK,Agha G,Chen BH,Pfeiffer L,Wilson R,Wolf P,Gieger C,Schwartz J,Vokonas PS,Hou L,Just AC,Bandinelli S,Hernandez DG,Singleton AB,Prokisch H,Meitinger T,Kastenmüller G,Ferrucci L,Baccarelli AA,Waldenber

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

journal_title：Clinical epigenetics

authors： Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later on in life, including cardiovascular diseases. We hypothesized that genome-wide epigenetic alteratio...

journal_title：Clinical epigenetics

authors： Ching T,Ha J,Song MA,Tiirikainen M,Molnar J,Berry MJ,Towner D,Garmire LX

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations in the MutL homolog ...

journal_title：Clinical epigenetics

authors： Sloane MA,Hesson LB,Nunez AC,Thompson BA,Ward RL

更新日期：2014-12-13 00:00:00

abstract：BACKGROUND:ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation. We hypothesized that the disruption of chromatin regulation might result in specific DNA methyl...

journal_title：Clinical epigenetics

authors： Bend EG,Aref-Eshghi E,Everman DB,Rogers RC,Cathey SS,Prijoles EJ,Lyons MJ,Davis H,Clarkson K,Gripp KW,Li D,Bhoj E,Zackai E,Mark P,Hakonarson H,Demmer LA,Levy MA,Kerkhof J,Stuart A,Rodenhiser D,Friez MJ,Stevenson

更新日期：2019-04-27 00:00:00

abstract：BACKGROUND:The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through ...

journal_title：Clinical epigenetics

authors： Luo S,Liu Y,Liang G,Zhao M,Wu H,Liang Y,Qiu X,Tan Y,Dai Y,Yung S,Chan TM,Lu Q

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

journal_title：Clinical epigenetics

authors： Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

更新日期：2019-08-05 00:00:00

abstract：:Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb deletion at chromosome 17q12. An increase in neurodevelopmental disorders has been observed in indi...

journal_title：Clinical epigenetics

authors： Clissold RL,Ashfield B,Burrage J,Hannon E,Bingham C,Mill J,Hattersley A,Dempster EL

更新日期：2018-07-18 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression profile. In skeletal muscle, dystrophin loss is associated with the disintegration of myofibers and their i...

journal_title：Clinical epigenetics

authors： Rugowska A,Starosta A,Konieczny P

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and responding tissues, but whether methylation in accessible tissues such as ...

journal_title：Clinical epigenetics

authors： Toperoff G,Kark JD,Aran D,Nassar H,Ahmad WA,Sinnreich R,Azaiza D,Glaser B,Hellman A

更新日期：2015-03-28 00:00:00

abstract：BACKGROUND:Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during...

journal_title：Clinical epigenetics

authors： Keyhan S,Burke E,Schrott R,Huang Z,Grenier C,Price T,Raburn D,Corcoran DL,Soubry A,Hoyo C,Murphy SK

更新日期：2021-01-25 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical...

journal_title：Clinical epigenetics

authors： Yáñez Y,Grau E,Rodríguez-Cortez VC,Hervás D,Vidal E,Noguera R,Hernández M,Segura V,Cañete A,Conesa A,Font de Mora J,Castel V

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:B vitamins in the one-carbon metabolism pathway (folate, vitamin B6, and vitamin B12) have been implicated in DNA methylation, and their deficiency may contribute to cognitive decline through increased homocysteine (Hcy) levels and subsequent oxidative damage. The aim of this study was to investigate whether...

journal_title：Clinical epigenetics

authors： An Y,Feng L,Zhang X,Wang Y,Wang Y,Tao L,Qin Z,Xiao R

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We ...

journal_title：Clinical epigenetics

authors： Sundar IK,Yin Q,Baier BS,Yan L,Mazur W,Li D,Susiarjo M,Rahman I

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a prevalent pediatric disease worldwide and can cause coronary artery aneurysm as a severe complication. Typically, DNA methylation is thought to repress the expression of nearby genes. However, the cases in which DNA methylation promotes gene expression have been reported. In additi...

journal_title：Clinical epigenetics

authors： Huang LH,Kuo HC,Pan CT,Lin YS,Huang YH,Li SC

更新日期：2018-11-01 00:00:00

abstract：Background:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potential to mediate the interaction...

journal_title：Clinical epigenetics

authors： Clifford RL,Fishbane N,Patel J,MacIsaac JL,McEwen LM,Fisher AJ,Brandsma CA,Nair P,Kobor MS,Hackett TL,Knox AJ

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

journal_title：Clinical epigenetics

authors： Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may provide an unreliable picture of the chronicity of inflammation. Recently, a large-scale epigenome-...

journal_title：Clinical epigenetics

authors： Stevenson AJ,McCartney DL,Hillary RF,Campbell A,Morris SW,Bermingham ML,Walker RM,Evans KL,Boutin TS,Hayward C,McRae AF,McColl BW,Spires-Jones TL,McIntosh AM,Deary IJ,Marioni RE

更新日期：2020-07-27 00:00:00

abstract：:Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smok...

journal_title：Clinical epigenetics

authors： Ma K,Cao B,Guo M

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 methylation levels in Muc1-/- mice compared with controls. However, little is known of the molecul...

journal_title：Clinical epigenetics

authors： Ge Y,Ma G,Liu H,Lin Y,Zhang G,Du M,Wang M,Chu H,Zhang H,Zhang Z

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00