Abstract:
:Resting-state functional connectivity (RSFC) has been generally assessed with functional magnetic resonance imaging (fMRI) thanks to its high spatial resolution. However, fMRI has several disadvantages such as high cost and low portability. In addition, fMRI may not be appropriate for people with metal or electronic implants in their bodies, with claustrophobia and who are pregnant. Diffuse optical tomography (DOT), a method of neuroimaging using functional near-infrared spectroscopy (fNIRS) to reconstruct three-dimensional brain activity images, offers a non-invasive alternative, because fNIRS as well as fMRI measures changes in deoxygenated hemoglobin concentrations and, in addition, fNIRS is free of above disadvantages. We recently proposed a hierarchical Bayesian (HB) DOT algorithm and verified its performance in terms of task-related brain responses. In this study, we attempted to evaluate the HB DOT in terms of estimating RSFC. In 20 healthy males (21-38 years old), 10 min of resting-state data was acquired with 3T MRI scanner or high-density NIRS on different days. The NIRS channels consisted of 96 long (29-mm) source-detector (SD) channels and 56 short (13-mm) SD channels, which covered bilateral frontal and parietal areas. There were one and two resting-state runs in the fMRI and fNIRS experiments, respectively. The reconstruction performances of our algorithm and the two currently prevailing algorithms for DOT were evaluated using fMRI signals as a reference. Compared with the currently prevailing algorithms, our HB algorithm showed better performances in both the similarity to fMRI data and inter-run reproducibility, in terms of estimating the RSFC.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Aihara T,Shimokawa T,Ogawa T,Okada Y,Ishikawa A,Inoue Y,Yamashita Odoi
10.3389/fnins.2020.00032subject
Has Abstractpub_date
2020-01-31 00:00:00pages
32eissn
1662-4548issn
1662-453Xjournal_volume
14pub_type
杂志文章abstract::We hypothesized that assessment of brain connectivity may shed light on the underpinnings of ocular hypertension (OHT), characterized by raised intraocular pressure (IOP) and no typical glaucomatous findings. OHT carries a risk for future glaucoma development, thus representing a model of presymptomatic condition. In ...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2020.00146
更新日期:2020-03-05 00:00:00
abstract::Musicians have considerable experience naming pitch-classes with verbal (e.g., Doh, Ré, and Mi) and semiotic tags (e.g., musical notation). On the one end of the spectrum, musicians can identify the pitch of a piano tone or quality of a chord without a reference tone [i.e., absolute pitch (AP) or relative pitch], whic...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.00932
更新日期:2019-09-06 00:00:00
abstract:Background:A number of mental illness is often re-diagnosed to be bipolar disorder (BD). Furthermore, the prefronto-limbic-striatal regions seem to be associated with the main dysconnectivity of BD. Functional connectivity is potentially an appropriate objective neurobiological marker that can assist with BD diagnosis....
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2020.563368
更新日期:2020-10-20 00:00:00
abstract::The efficacy of neuronal function requires a well-balanced extracellular ion homeostasis and a steady supply with nutrients and metabolites. Therefore, all organisms equipped with a complex nervous system developed a so-called blood-brain barrier, protecting it from an uncontrolled entry of solutes, metabolites or pat...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnins.2014.00365
更新日期:2014-11-14 00:00:00
abstract::The autonomic nervous system (ANS) has a significant influence on the structural integrity and electrical conductivity of the atria. Aberrant activation of the sympathetic nervous system can induce heterogeneous changes with arrhythmogenic potential which can result in atrial tachycardia, atrial tachyarrhythmias and a...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnins.2018.01058
更新日期:2019-01-23 00:00:00
abstract::Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually t...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2012.00179
更新日期:2012-12-13 00:00:00
abstract::We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions). In trying to understand the mechanisms responsible for this stability, saccades have been particularly well-studied, and a number of peri-sac...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2020.00217
更新日期:2020-03-17 00:00:00
abstract::The oxytocin receptor (OXTR) has been observed in the periphery of neonatal C57BL/6J mice (Mus musculus), including facial regions and the anogenital area. In those studies, ligand specificity was confirmed with a congenital OXTR knockout mouse as well as competitive binding techniques. The aim of this study was to de...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.00474
更新日期:2019-05-24 00:00:00
abstract::The blood-brain barrier (BBB) mediates the communication between the periphery and the central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play a role in neurodegenerative disease. This has stimulated a wealth of information on the molecular impact of insulin in the brain, particularl...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnins.2019.00521
更新日期:2019-06-04 00:00:00
abstract:Background:Since subjective cognitive decline (SCD) was standardized in 2014, many studies have investigated its features. However, the risk of SCD (plus) progressing to AD is much higher, and yet there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus). Ob...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.00846
更新日期:2019-08-14 00:00:00
abstract:BACKGROUND AND AIMS:Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS:Activity of human submucous ...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2015.00465
更新日期:2015-12-16 00:00:00
abstract:UNLABELLED:α2-adrenoceptors (α2AR) lower central sympathetic output and peripheral catecholamine release, and may therefore prevent sympathetic hyperactivity and hypertension. The α2AR are dysfunctional in male spontaneously hypertensive rats (SHR). Premenopausal females are less hypertensive than males. The purpose of...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2016.00130
更新日期:2016-03-30 00:00:00
abstract::Evaluating the effectiveness and performance of neuromorphic hardware is difficult. It is even more difficult when the task of interest is a closed-loop task; that is, a task where the output from the neuromorphic hardware affects some environment, which then in turn affects the hardware's future input. However, close...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2015.00464
更新日期:2015-12-15 00:00:00
abstract::Basic and neutral neurohypophyseal (NH) nonapeptides have evolved from vasotocin (VT) by a gene duplication at the base of the gnathostome lineage. In teleosts, VT and IT are the basic and neutral peptides, respectively. In the present study, VT and IT precursor genes of Heteropneustes fossilis and Clarias batrachus (...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2015.00166
更新日期:2015-05-15 00:00:00
abstract::This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear effere...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2018.00198
更新日期:2018-04-10 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. Exosomal transfer of mutant copper-zinc superoxide dismutase 1 (mSOD1...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2017.00273
更新日期:2017-05-17 00:00:00
abstract::Growing evidence indicates that neuropathic pain is frequently accompanied by cognitive impairments, which aggravate the quality of life of chronic pain patients. Here, we investigated whether acupuncture treatments can improve cognitive dysfunction as well as allodynia induced by neuropathic pain in mice. One week af...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.00995
更新日期:2019-09-20 00:00:00
abstract::This work presents the design, implementation, and evaluation of a P300-based brain-machine interface (BMI) developed to control a robotic hand-orthosis. The purpose of this system is to assist patients with amyotrophic lateral sclerosis (ALS) who cannot open and close their hands by themselves. The user of this inter...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2020.589659
更新日期:2020-11-27 00:00:00
abstract::The global prevalence of obesity has been steadily increasing. Although pharmacotherapy and bariatric surgeries can be useful adjuvants in the treatment of morbid obesity, they may lose long-term effectiveness. Obesity result largely from unbalanced energy homeostasis. Palatable and densely caloric foods may affect th...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnins.2019.00323
更新日期:2019-04-18 00:00:00
abstract::We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using the changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] in the prefrontal cortex (PFC). Using this system, we investigated the influences of continual mild and equivocal stimuli consistin...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2017.00321
更新日期:2017-06-09 00:00:00
abstract::While neuromorphic systems may be the ultimate platform for deploying spiking neural networks (SNNs), their distributed nature and optimization for specific types of models makes them unwieldy tools for developing them. Instead, SNN models tend to be developed and simulated on computers or clusters of computers with s...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2018.00941
更新日期:2018-12-12 00:00:00
abstract::Environmental stressors including protein malnutrition (PMN) during pre-, neo- and post-natal age have been documented to affect cognitive development and cause increased susceptibility to neuropsychiatric disorders. Most studies have addressed either of the three windows and that does not emulate the clinical conditi...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2015.00446
更新日期:2015-12-08 00:00:00
abstract::Postural control during free stance has been frequently interpreted in terms of balancing an inverted pendulum. This even holds, if subjects do not balance their own, but an external body weight. We introduce here a virtual balancing apparatus, which produces torque in the ankle joint as a function of ankle angle rese...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2017.00531
更新日期:2017-09-26 00:00:00
abstract::Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2016.00108
更新日期:2016-04-12 00:00:00
abstract::Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme genetic heterogene...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnins.2015.00477
更新日期:2015-12-17 00:00:00
abstract::Several neural decoding algorithms have successfully converted brain signals into commands to control a computer cursor and prosthetic devices. A majority of decoding methods, such as population vector algorithms (PVA), optimal linear estimators (OLE), and neural networks (NN), are effective in predicting movement kin...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2016.00556
更新日期:2016-12-09 00:00:00
abstract::Throughout development, neural stem cells (NSCs) give rise to differentiated neurons, astrocytes, and oligodendrocytes which together modulate perception, memory, and behavior in the adult nervous system. To understand how NSCs contribute to postnatal/adult brain remodeling and repair after injury, the lateral ventric...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2016.00111
更新日期:2016-03-24 00:00:00
abstract::Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR). They are multitasking peptides involved in many physiological functions, including regulation of feeding behavior, wakefulness and autonomic/neuroen...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnins.2020.00691
更新日期:2020-07-10 00:00:00
abstract::Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain func...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.01333
更新日期:2019-12-17 00:00:00
abstract::Neural oscillations in the alpha band (7-13 Hz) are commonly associated with disengagement of visual attention. However, recent studies have also associated alpha with processes of attentional control and stability. We addressed this issue in previous experiments by delivering transcranial alternating current stimulat...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2018.00067
更新日期:2018-02-13 00:00:00