Abstract:
:Physical inactivity has emerged as an important and risk factor for cardiovascular and metabolic diseases, independent of levels of exercise engagement. Moreover, inactivity is associated with poor brain functioning. However, little data on the effects of physical inactivity on the brain is available and few methods are suitable to investigate this matter. We tested whether preventing lid climbing and reducing cage size could be used to model physical inactivity in mice. Sixty young adult C57Bl6 mice (10 weeks old) were divided over six groups with different housing conditions: in cages of three different sizes with lids that either allowed or prevented lid climbing. Housing under these conditions was maintained for a period of 19 weeks before the mice were killed for body composition analysis. Physical fitness tests performed around 5 and 10 weeks into the intervention revealed that motor coordination in the balance beam test was reduced by 30.65%, grip strength by 8.91% and muscle stamina in the inverted screen test by 70.37% in non-climbing mice as compared to climbing controls. Preventing climbing increased visceral fat mass by 17.31%, but did not reduce muscle mass. Neither preventing climbing nor reducing cage size affected anxiety assessed in the Open Field test and the Elevated Plus Maze. We did not find any negative effect of inactivity on spatial learning and memory in the novel object location test or working memory measured with the Y-maze Alternation test. The reduced physical fitness and increase in visceral fat mass show that our inactivity method models most effects of physical inactivity that are observed in experimental and observational studies in humans. Whereas established methods such as hindlimb unloading mimic many of the effects of bed rest, our novel method can be applied to study the effects of less extreme forms of physical inactivity (i.e., sedentary behavior) in various disease models including rodent models for brain diseases (i.e., stroke, Alzheimer's disease).
journal_name
Front Behav Neuroscijournal_title
Frontiers in behavioral neuroscienceauthors
Roemers P,Hulst Y,van Heijningen S,van Dijk G,van Heuvelen MJG,De Deyn PP,van der Zee EAdoi
10.3389/fnbeh.2019.00221subject
Has Abstractpub_date
2019-10-04 00:00:00pages
221issn
1662-5153journal_volume
13pub_type
杂志文章abstract::Magnetoreception can play a substantial role in long distance navigation by animals. I hypothesize that locomotion guided by a magnetic compass sense could also play a role in short distance navigation. Animals identify mates, prey, or other short distance navigational goals using different sensory modalities (olfacti...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2010.00042
更新日期:2010-07-30 00:00:00
abstract::Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a f...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00361
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abstract::Peritraumatic dissociation, a state characterized by alteration in perception and reduced awareness of surroundings, is considered to be a risk factor for the development of post-traumatic stress disorder (PTSD). However, the predictive ability of peritraumatic dissociation is questioned for the inconsistent results i...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00014
更新日期:2014-01-28 00:00:00
abstract::To study visual learning in honey bees, we developed a virtual reality (VR) system in which the movements of a tethered bee walking stationary on a spherical treadmill update the visual panorama presented in front of it (closed-loop conditions), thus creating an experience of immersion within a virtual environment. In...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00139
更新日期:2018-07-13 00:00:00
abstract::This study investigated the effects of early institutional care on memory and executive functioning. Subjects were participants in the Bucharest Early Intervention Project (BEIP) and included institutionalized children, children with a history of institutionalization who were assigned to a foster care intervention, an...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.08.016.2009
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abstract::Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environmental enrichment has n...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00297
更新日期:2014-08-29 00:00:00
abstract::Trauma- and stress-related disorders are among the most common types of mental illness affecting the U.S. population. For many of these disorders, there is a striking sex difference in lifetime prevalence; for instance, women are twice as likely as men to be affected by posttraumatic stress disorder (PTSD). Gonadal st...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00205
更新日期:2015-08-04 00:00:00
abstract::Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID) models were developed for studying rodent binge-like consumption. Traditionally, IA2BC was used with rats and DID with mice. Recently, IA2BC was adapted to study mouse ethanol consumption. However, it is unknown whether DID is s...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2017.00029
更新日期:2017-02-22 00:00:00
abstract::Prior studies have shown that intermittent noxious stimulation has divergent effects on spinal cord plasticity depending upon whether it occurs in a regular (fixed time, FT) or irregular (variable time, VT) manner: In spinally transected animals, VT stimulation to the tail or hind leg impaired spinal learning whereas ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00274
更新日期:2015-10-21 00:00:00
abstract::An imbalance in the neural motivational system may underlie Social Anxiety Disorder (SAD). This study examines social reward and punishment anticipation in SAD, predicting a valence-specific effect: increased striatal activity for punishment avoidance compared to obtaining a reward. Individuals with SAD (n = 20) and a...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00439
更新日期:2015-01-05 00:00:00
abstract::Emotion regulation therapy (ERT) is an efficacious treatment for distress disorders (i.e., depression and anxiety), predicated on a conceptual model wherein difficult to treat distress arises from intense emotionality (e.g., neuroticism, dispositional negativity) and is prolonged by negative self-referentiality (e.g.,...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00010
更新日期:2019-02-04 00:00:00
abstract::People perceive the consequences of their own actions differently to how they perceive other sensory events. A large body of psychology research has shown that people also consistently overrate their own performance relative to others, yet little is known about how these "illusions of superiority" are normally maintai...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00232
更新日期:2014-06-27 00:00:00
abstract::Ecstatic epileptic seizures are a rare but compelling epileptic entity. During the first seconds of these seizures, ecstatic auras provoke feelings of well-being, intense serenity, bliss, and "enhanced self-awareness." They are associated with the impression of time dilation, and can be described as a mystic experienc...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2016.00021
更新日期:2016-02-17 00:00:00
abstract::The article is a perspective on utilization of microorganisms and chemosignals in studying human economic behavior. Research in biological roots of economic development has already confirmed that parasitic pressure influenced the creation and development of cultural norms and institutions. However, other effects of mi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00077
更新日期:2018-05-01 00:00:00
abstract::Molecular processes in GABAergic local circuit neurons critically contribute to information processing in the hippocampus and to stress-induced activation of the amygdala. In the current study, we determined expression changes in GABA-related factors induced in subregions of the dorsal hippocampus as well as in the BL...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00003
更新日期:2014-01-21 00:00:00
abstract::The Supplementary Eye Field (SEF) and the Frontal Eye Field (FEF) have been described as participating in gaze shift control. Recent evidence suggests, however, that other areas of the dorsomedial prefrontal cortex also influence gaze shift. Herein, we have investigated electrically evoked ear- and eye movements from ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00454
更新日期:2015-01-30 00:00:00
abstract::Social interactions are critically important for survival and impact overall-health, but also impose costs on animals, such as exposure to contagious agents. The immune system can play a critical role in modulating social behavior when animals are sick, as has been demonstrated within the context of "sickness behavior...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.00010
更新日期:2020-02-05 00:00:00
abstract::One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety, and post-traumatic stress disorder. We investigated t...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2012.00068
更新日期:2012-10-11 00:00:00
abstract::β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior;...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00054
更新日期:2018-03-20 00:00:00
abstract::We examined the ability of observers to detect the 3D curvature of motion paths when binocular disparity and motion information were present. On each trial, two displays were observed through shutter-glasses. In one display, a sphere moved along a linear path in the horizontal and depth dimensions. In the other displa...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2013.00012
更新日期:2013-02-20 00:00:00
abstract::Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system has been traditionally associated with decision-making. The endocannabinoid system through its actions on inhibitory and excitatory synapses modulates dopamin...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2015.00336
更新日期:2015-12-17 00:00:00
abstract::Mapping animal performance in a behavioral task to underlying cognitive mechanisms and strategies is rarely straightforward, since a task may be solvable in more than one manner. Here, we show that bumblebees perform well on a concept-based visual discrimination task but spontaneously switch from a concept-based solut...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2020.00137
更新日期:2020-08-12 00:00:00
abstract::This paper examines whether foetal testosterone exposure predicts the extent of confidence and over-confidence in own absolute ability in adulthood. To study this question, we elicited incentive-compatible measures of confidence and over-confidence in the lab and correlate them with measures of right hand 2D:4D, used ...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00005
更新日期:2018-01-30 00:00:00
abstract:PURPOSE:The present study assessed the influence of L-DOPA administration on neostriatal dopamine (DA) transporter (DAT) binding in relation to motor and exploratory behaviors in the rat. METHODS:Rats received injections of 5 mg/kg L-DOPA, 10 mg/kg L-DOPA or vehicle. Motor and exploratory behaviors were assessed for 3...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00431
更新日期:2014-12-17 00:00:00
abstract::Interactions between social experiences at different stages of development (e.g., with parents as juveniles and peers as subadults) can profoundly shape the expression of social behavior. Rarely are the influences of more than one stage of developmental sensitivity to social environment investigated simultaneously. Fu...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00206
更新日期:2019-09-13 00:00:00
abstract::In the present review, we provide evidence indicating that although post traumatic stress disorder (PTSD) and substance use disorder (SUD) are two distinct pathologies with very different impacts on people affected by these chronic illnesses, they share numerous common characteristics, present high rates of co-morbidi...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2019.00026
更新日期:2019-02-13 00:00:00
abstract:INTRODUCTION:Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of obesity. The aim of this study was to determine the influence of diet co...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2015.00358
更新日期:2015-12-24 00:00:00
abstract::Social cognition and social behaviors are complex phenomena that involve numerous brain areas and underlying neurobiological mechanisms. Embryonic alcohol exposure may lead to the development of Fetal Alcohol Spectrum Disorder (FASD), a disorder that manifests with varying symptoms including abnormal social behavior a...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnbeh.2020.572175
更新日期:2020-09-25 00:00:00
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journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2018.00220
更新日期:2018-09-25 00:00:00
abstract::Much research has recognized the general importance of maternal behavior in the early development and programing of the mammalian offspring's brain. Exclusive breastfeeding (EBF) duration, the amount of time in which breastfed meals are the only source of sustenance, plays a prominent role in promoting healthy brain a...
journal_title:Frontiers in behavioral neuroscience
pub_type: 杂志文章
doi:10.3389/fnbeh.2014.00459
更新日期:2015-01-22 00:00:00