Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches.

Abstract:

:In the present review, we provide evidence indicating that although post traumatic stress disorder (PTSD) and substance use disorder (SUD) are two distinct pathologies with very different impacts on people affected by these chronic illnesses, they share numerous common characteristics, present high rates of co-morbidity, and may result from common physiological dysfunctions. We propose that these pathologies result from hyper reactivity to reminders, and thus should be considered as two disorders of memory, treated as such. We review the different possibilities to intervene on pathological memories such as extinction therapy and reconsolidation blockade. We also introduce new therapeutic avenues directly indicate by our recent proposal to replace the consolidation/reconsolidation hypothesis by the integration concept. State dependency and emotional remodeling are two innovative treatments that have already provided encouraging results. In summary, this review shows that the discovery of reactivation-dependent memory malleability has open new therapeutic avenues based on the reprocessing of pathological memories, which constitute promising approaches to treat PTSD and SUD.

journal_name

Front Behav Neurosci

authors

Gisquet-Verrier P,Le Dorze C

doi

10.3389/fnbeh.2019.00026

subject

Has Abstract

pub_date

2019-02-13 00:00:00

pages

26

issn

1662-5153

journal_volume

13

pub_type

杂志文章
  • Slips of Action and Sequential Decisions: A Cross-Validation Study of Tasks Assessing Habitual and Goal-Directed Action Control.

    abstract::Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2016.00234

    authors: Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

    更新日期:2016-12-20 00:00:00

  • Behavioral Plasticity of Audiovisual Perception: Rapid Recalibration of Temporal Sensitivity but Not Perceptual Binding Following Adult-Onset Hearing Loss.

    abstract::The ability to accurately integrate or bind stimuli from more than one sensory modality is highly dependent on the features of the stimuli, such as their intensity and relative timing. Previous studies have demonstrated that the ability to perceptually bind stimuli is impaired in various clinical conditions such as au...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00256

    authors: Schormans AL,Allman BL

    更新日期:2018-10-31 00:00:00

  • Both the COMT Val158Met single-nucleotide polymorphism and sex-dependent differences influence response inhibition.

    abstract::Reactive and proactive controls of actions are cognitive abilities that allow one to deal with a continuously changing environment by adjusting already programmed actions. They also set forthcoming actions by evaluating the outcome of the previous ones. Earlier studies highlighted sex-related differences in the strate...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00127

    authors: Mione V,Canterini S,Brunamonti E,Pani P,Donno F,Fiorenza MT,Ferraina S

    更新日期:2015-05-19 00:00:00

  • Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat.

    abstract::Methamphetamine (METH) is a psychomotor stimulant that is reported to enhance sexual desire and behavior in both men and women, leading to increases in unplanned pregnancies, sexually-transmitted infections, and even comorbid psychiatric conditions. Here, we discuss our rodent model of increased sexually-motivated beh...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00203

    authors: Rudzinskas SA,Williams KM,Mong JA,Holder MK

    更新日期:2019-09-10 00:00:00

  • Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis.

    abstract::Stress disturbs the balance of the gut microbiota and stimulates inflammation-to-brain mechanisms. Moreover, stress leads to anxiety and depressive disorders. Bifidobacterium adolescentis displays distinct anti-inflammatory effects. However, no report has focused on the anxiolytic and antidepressant effects of B. adol...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00126

    authors: Guo Y,Xie JP,Deng K,Li X,Yuan Y,Xuan Q,Xie J,He XM,Wang Q,Li JJ,Luo HR

    更新日期:2019-06-18 00:00:00

  • The Association Between Early Drinking and Dependence Varies by Drinking Context.

    abstract::Evidence regarding the association between early drinking (ED) and later dependence is controversial. It has been alternately hypothesized that ED either plays a causal role in the development of dependence or that it is an early marker of increased psychosocial vulnerabilities. Despite a clear rationale for delaying ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2020.00017

    authors: Conde K,Peltzer RI,Gimenez PV,Cremonte M

    更新日期:2020-03-05 00:00:00

  • Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety.

    abstract::Although gene-environment interactions are known to significantly influence psychopathology-related disease states, only few animal models cover both the genetic background and environmental manipulations. Therefore, we have taken advantage of the bidirectionally inbred high (HAB) and low (LAB) anxiety-related behavio...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00087

    authors: Chekmareva NY,Sotnikov SV,Diepold RP,Naik RR,Landgraf R,Czibere L

    更新日期:2014-03-18 00:00:00

  • Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats.

    abstract::Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotecti...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00142

    authors: Rapley SA,Prickett TCR,Dalrymple-Alford JC,Espiner EA

    更新日期:2018-07-19 00:00:00

  • Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment.

    abstract::Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environmental enrichment has n...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00297

    authors: Zhang Y,Crofton EJ,Li D,Lobo MK,Fan X,Nestler EJ,Green TA

    更新日期:2014-08-29 00:00:00

  • Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice.

    abstract::L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA). An elevated level of KYNA may have multiple effects on the synaptic transm...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00157

    authors: Varga D,Herédi J,Kánvási Z,Ruszka M,Kis Z,Ono E,Iwamori N,Iwamori T,Takakuwa H,Vécsei L,Toldi J,Gellért L

    更新日期:2015-06-16 00:00:00

  • Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.

    abstract::The increased understanding that neuropathology begins decades before symptom onset, has led to the conceptualization and widespread utilization of Mild Cognitive Impairment (MCI) as an important transitional state between healthy aging and dementia. Further subcategorization to MCI subtype has led to more distinct pr...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00259

    authors: Broadhouse KM,Mowszowski L,Duffy S,Leung I,Cross N,Valenzuela MJ,Naismith SL

    更新日期:2019-11-21 00:00:00

  • Genetic and Psychosocial Predictors of Aggression: Variable Selection and Model Building With Component-Wise Gradient Boosting.

    abstract::Rationale: Given datasets with a large or diverse set of predictors of aggression, machine learning (ML) provides efficient tools for identifying the most salient variables and building a parsimonious statistical model. ML techniques permit efficient exploration of data, have not been widely used in aggression researc...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00089

    authors: Suchting R,Gowin JL,Green CE,Walss-Bass C,Lane SD

    更新日期:2018-05-07 00:00:00

  • Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.

    abstract::Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a f...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00361

    authors: Curtin PC,Farrar AM,Oakeshott S,Sutphen J,Berger J,Mazzella M,Cox K,He D,Alosio W,Park LC,Howland D,Brunner D

    更新日期:2016-01-11 00:00:00

  • Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors.

    abstract::β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior;...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00054

    authors: Robins MT,Chiang T,Berry JN,Ko MJ,Ha JE,van Rijn RM

    更新日期:2018-03-20 00:00:00

  • Source-based neurofeedback methods using EEG recordings: training altered brain activity in a functional brain source derived from blind source separation.

    abstract::A developing literature explores the use of neurofeedback in the treatment of a range of clinical conditions, particularly ADHD and epilepsy, whilst neurofeedback also provides an experimental tool for studying the functional significance of endogenous brain activity. A critical component of any neurofeedback method i...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00373

    authors: White DJ,Congedo M,Ciorciari J

    更新日期:2014-10-22 00:00:00

  • Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability.

    abstract::The endocannabinoid (eCB) system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate. A functional interaction between eCBs and the serotonergic system has already been suggested. Previously, we showed that cannabinoid type-1 (...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2015.00235

    authors: Häring M,Enk V,Aparisi Rey A,Loch S,Ruiz de Azua I,Weber T,Bartsch D,Monory K,Lutz B

    更新日期:2015-09-03 00:00:00

  • The Interplay of Achievement Motive-Goal Incongruence and State and Trait Self-Control: A Pilot Study Considering Cortical Correlates of Self-Control.

    abstract::Objective: This study utilized different theoretical perspectives to better understand motor performance. We refered to concepts of achievement motive-goal incongruence and assessed cortical correlates of self-control. We assumed that more self-control is required when people act in conformance with an incongruent goa...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00235

    authors: Schüler J,Hofstetter J,Wolff W

    更新日期:2019-10-04 00:00:00

  • The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia.

    abstract::PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson's disease and haloperidol-induced extrapyramidal movement disorders. PAOPA's unique allosteric mechanism and dopamine D2 ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00302

    authors: Daya RP,Bhandari J,Kooner SK,Ho J,Rowley CD,Bock NA,Farncombe T,Mishra RK

    更新日期:2018-12-12 00:00:00

  • The Impact of Early Postnatal and Juvenile Social Environments on the Effects of Chronic Intranasal Oxytocin in the Prairie Vole.

    abstract::Interactions between social experiences at different stages of development (e.g., with parents as juveniles and peers as subadults) can profoundly shape the expression of social behavior. Rarely are the influences of more than one stage of developmental sensitivity to social environment investigated simultaneously. Fu...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2019.00206

    authors: Prounis GS,Ophir AG

    更新日期:2019-09-13 00:00:00

  • Acetaldehyde as a drug of abuse: insight into AM281 administration on operant-conflict paradigm in rats.

    abstract::Increasing evidence focuses on acetaldehyde (ACD) as the mediator of the rewarding and motivational properties of ethanol. Indeed, ACD stimulates dopamine release in the nucleus accumbens and it is self-administered under different conditions. Besides the dopaminergic transmission, the endocannabinoid system has been ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00064

    authors: Plescia F,Brancato A,Marino RA,Cannizzaro C

    更新日期:2013-06-11 00:00:00

  • Electrophysiological and neuropsychological predictors of conversion to schizophrenia in at-risk subjects.

    abstract::Patients with schizophrenia show neurophysiological and psychological disturbances before the onset of the illness. Mismatch negativity (MMN), an event-related potential, has been shown to be associated with cognitive function. Specifically, duration MMN (dMMN) amplitudes have been indicated to predict progression to ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnbeh.2013.00148

    authors: Sumiyoshi T,Miyanishi T,Seo T,Higuchi Y

    更新日期:2013-10-21 00:00:00

  • Corrigendum: Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with β-adrenergic activity.

    abstract::[This corrects the article on p. 51 in vol. 9, PMID: 25784866.]. ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnbeh.2015.00123

    authors: Careaga MB,Tiba PA,Ota SM,Suchecki D

    更新日期:2015-05-13 00:00:00

  • Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice.

    abstract::Many epidemiological studies have described an adolescent-related psychiatric illness and sensorimotor deficits after Glyphosate based herbicide (GBH) exposure. GBH exposure in animal models of various ages suggests that it may be neurotoxic and could impact brain development and subsequently, behavior in adulthood. H...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2017.00146

    authors: Ait Bali Y,Ba-Mhamed S,Bennis M

    更新日期:2017-08-08 00:00:00

  • Vitamin B12 Levels in Methamphetamine Addicts.

    abstract::Objective: It has been established that reduced vitamin B12 serum levels are associated with cognitive decline and mental illness. The chronic use of methamphetamine (MA), which is a highly addictive drug, can induce cognitive impairment and psychopathological symptoms. There are few studies addressing the association...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00320

    authors: Zhai C,Cui M,Cheng X,Ao X,Zhao T,Wu W,Shao Q,Ge D,Song H,Qi F,Ling Q,Ma M,Xu M,Jiao D

    更新日期:2018-12-18 00:00:00

  • Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.

    abstract::Behaviorally controllable stressors confer protection from the neurochemical and behavioral consequences of future uncontrollable stressors, a phenomenon termed "behavioral immunization". Recent data implicate protein synthesis within the ventromedial prefrontal cortex (mPFC) as critical to behavioral immunization. Ad...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00348

    authors: Christianson JP,Flyer-Adams JG,Drugan RC,Amat J,Daut RA,Foilb AR,Watkins LR,Maier SF

    更新日期:2014-10-02 00:00:00

  • Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

    abstract::The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) and the lateral nuclei (lHb). The mHb is characterized by the expression of specific nicotinic acetylcholine receptor isoforms and the release of acetylcholine to the interpeduncular nucleus (IPN), the sole output regio...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2013.00017

    authors: Kobayashi Y,Sano Y,Vannoni E,Goto H,Suzuki H,Oba A,Kawasaki H,Kanba S,Lipp HP,Murphy NP,Wolfer DP,Itohara S

    更新日期:2013-03-12 00:00:00

  • Alcohol, Self-Regulation and Partner Physical Aggression: Actor-Partner Effects Over a Three-Year Time Frame.

    abstract::The question of how individual differences related to self-regulation interact with alcohol use patterns to predict intimate partner aggression (IPA) is examined. We hypothesized that excessive drinking will be related to partner aggression among those who have low self-regulation. In addition, we explored the extent ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2018.00130

    authors: Quigley BM,Levitt A,Derrick JL,Testa M,Houston RJ,Leonard KE

    更新日期:2018-07-05 00:00:00

  • Dynamical predictions of insular hubs for social cognition and their application to stroke.

    abstract::The insular cortex (IC) is considered a rich hub for context-sensitive emotions/social cognition. Patients with focal IC stroke provide unique opportunities to study socio-emotional processes. Nevertheless, Couto et al. (2013b) have recently reported controversial results regarding IC involvement in emotion and social...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00380

    authors: Limongi R,Tomio A,Ibanez A

    更新日期:2014-11-04 00:00:00

  • ITI-Signals and Prelimbic Cortex Facilitate Avoidance Acquisition and Reduce Avoidance Latencies, Respectively, in Male WKY Rats.

    abstract::As a model of anxiety disorder vulnerability, male Wistar-Kyoto (WKY) rats acquire lever-press avoidance behavior more readily than outbred Sprague-Dawley rats, and their acquisition is enhanced by the presence of a discrete signal presented during the inter-trial intervals (ITIs), suggesting that it is perceived as a...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2014.00403

    authors: Beck KD,Jiao X,Smith IM,Myers CE,Pang KC,Servatius RJ

    更新日期:2014-11-21 00:00:00

  • Neuro-endocrine control of reproduction in hermaphroditic freshwater snails: mechanisms and evolution.

    abstract::Invertebrates are used extensively as model species to investigate neuro-endocrine processes regulating behaviors, and many of these processes may be extrapolated to vertebrates. However, when it comes to reproductive processes, many of these model species differ notably in their mode of reproduction. A point in case ...

    journal_title:Frontiers in behavioral neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnbeh.2010.00167

    authors: Koene JM

    更新日期:2010-10-21 00:00:00