Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability.

abstract：:DARPP-32 (PPP1R1B) was discovered as a substrate of cAMP-dependent protein kinase (PKA) enriched in dopamine-innervated brain areas. It is one of three related, PKA-regulated inhibitors of protein phosphatase-1 (PP1). These inhibitors seem to have appeared in early vertebrate ancestors, possibly Gnathostomes. DARPP-32...

journal_title：Frontiers in behavioral neuroscience

authors： Yger M,Girault JA

更新日期：2011-09-08 00:00:00

abstract：:The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of inc...

journal_title：Frontiers in behavioral neuroscience

authors： Calpe-López C,García-Pardo MP,Martínez-Caballero MA,Santos-Ortíz A,Aguilar MA

更新日期：2020-01-09 00:00:00

abstract：:In animals, emotional memory is classically assessed through pavlovian fear conditioning in which a neutral novel stimulus (conditioned stimulus) is paired with an aversive unconditioned stimulus. After conditioning, the conditioned stimulus elicits a fear response characterized by a wide range of behavioral and physi...

journal_title：Frontiers in behavioral neuroscience

authors： Hegoburu C,Shionoya K,Garcia S,Messaoudi B,Thévenet M,Mouly AM

更新日期：2011-05-19 00:00:00

abstract：:Although habituation is possibly the simplest form of learning, we still do not fully understand the neurobiological basis of habituation in any organism. To advance the goal of a comprehensive understanding of habituation, we have studied long-term habituation (LTH) of the gill-withdrawal reflex (GWR) in the marine s...

journal_title：Frontiers in behavioral neuroscience

authors： Esdin J,Pearce K,Glanzman DL

更新日期：2010-11-29 00:00:00

abstract：:Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified specific neural circuits for these functions. Flies with mutations in t...

journal_title：Frontiers in behavioral neuroscience

authors： Ueno T,Kume K

更新日期：2014-09-03 00:00:00

abstract：:The extant literature supports the role of stress in enhancing the susceptibility of drug abuse progressing to a substance use disorder diagnosis. However, the molecular mediators by which stress enhances the progression from cocaine abuse to cocaine use disorder via the mesolimbic pathway remain elusive. In this mini...

journal_title：Frontiers in behavioral neuroscience

authors： Mukhara D,Banks ML,Neigh GN

更新日期：2018-12-21 00:00:00

abstract：:Instrumental learning and decision-making rely on two parallel systems: a goal-directed and a habitual system. In the past decade, several paradigms have been developed to study these systems in animals and humans by means of e.g., overtraining, devaluation procedures and sequential decision-making. These different pa...

journal_title：Frontiers in behavioral neuroscience

authors： Sjoerds Z,Dietrich A,Deserno L,de Wit S,Villringer A,Heinze HJ,Schlagenhauf F,Horstmann A

更新日期：2016-12-20 00:00:00

abstract：:Invertebrates are used extensively as model species to investigate neuro-endocrine processes regulating behaviors, and many of these processes may be extrapolated to vertebrates. However, when it comes to reproductive processes, many of these model species differ notably in their mode of reproduction. A point in case ...

journal_title：Frontiers in behavioral neuroscience

authors： Koene JM

更新日期：2010-10-21 00:00:00

abstract：:The ability to maintain appropriate gaps to objects in one's environment is important when navigating through a three-dimensional world. Previous research has shown that the visual angle subtended by a lead/approaching object and its rate of change are important variables for timing interceptions, collision avoidance,...

journal_title：Frontiers in behavioral neuroscience

authors： Hosking SG,Davey CE,Kaiser MK

更新日期：2013-05-21 00:00:00

abstract：:People perceive the consequences of their own actions differently to how they perceive other sensory events. A large body of psychology research has shown that people also consistently overrate their own performance relative to others, yet little is known about how these "illusions of superiority" are normally maintai...

journal_title：Frontiers in behavioral neuroscience

authors： Wolpe N,Wolpert DM,Rowe JB

更新日期：2014-06-27 00:00:00

abstract：:Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In th...

journal_title：Frontiers in behavioral neuroscience

authors： Zhang K,Lian N,Ding R,Guo C,Dong X,Li Y,Wei S,Jiao Q,Yu Y,Shen H

更新日期：2020-11-23 00:00:00

abstract：:Nicotine use in adolescence is pervasive in the United States and, according to the Gateway Hypothesis, may lead to progression towards other addictive substances. Given the prevalence of nicotine and ethanol comorbidity, it is difficult to ascertain if nicotine is a gateway drug for ethanol. Our study investigated th...

journal_title：Frontiers in behavioral neuroscience

authors： Madayag AC,Czarnecki KS,Wangler LM,Robinson DL

更新日期：2017-08-17 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is a trophic factor regulating cell survival and synaptic plasticity. Recent findings indicate that BDNF could be a potential regulatory factor for cognitive functioning in normal and/or neuropathological conditions. With regard to neurological disorders, recent data suggest th...

journal_title：Frontiers in behavioral neuroscience

authors： Costa A,Peppe A,Carlesimo GA,Zabberoni S,Scalici F,Caltagirone C,Angelucci F

更新日期：2015-09-15 00:00:00

abstract：:Peritraumatic dissociation, a state characterized by alteration in perception and reduced awareness of surroundings, is considered to be a risk factor for the development of post-traumatic stress disorder (PTSD). However, the predictive ability of peritraumatic dissociation is questioned for the inconsistent results i...

journal_title：Frontiers in behavioral neuroscience

authors： Dong X,Li Y

更新日期：2014-01-28 00:00:00

abstract：:Background: Women are twice as likely as men to develop major depression. The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-glutamine cycle involving...

journal_title：Frontiers in behavioral neuroscience

authors： Rappeneau V,Blaker A,Petro JR,Yamamoto BK,Shimamoto A

更新日期：2016-12-06 00:00:00

abstract：:Emerging data suggest that alcohol's effects on central inflammatory factors are not uniform across the lifespan. In particular, prenatal alcohol exposure (PAE) significantly alters steady-state levels of neuroimmune factors, as well as subsequent reactivity to later immune challenge. Thus, the current experiment inve...

journal_title：Frontiers in behavioral neuroscience

authors： Doremus-Fitzwater TL,Youngentob SL,Youngentob L,Gano A,Vore AS,Deak T

更新日期：2020-06-29 00:00:00

abstract：:Corticosteroid hormones, released after stress, are known to influence neuronal activity and produce a wide range of effects upon the brain. They affect cognitive tasks including decision-making. Recently it was shown that systemic injections of corticosterone (CORT) disrupt reward-based decision-making in rats when t...

journal_title：Frontiers in behavioral neuroscience

authors： Koot S,Koukou M,Baars A,Hesseling P,van 't Klooster J,Joëls M,van den Bos R

更新日期：2014-04-21 00:00:00

abstract：:We come to understand other people's physical and mental states by re-mapping their bodily states onto our sensorimotor system. This process, also called somatosensory resonance, is an essential ability for social cognition and is stronger when observing ingroup than outgroup members. Here we investigated, first, whet...

journal_title：Frontiers in behavioral neuroscience

authors： Fini C,Cardini F,Tajadura-Jiménez A,Serino A,Tsakiris M

更新日期：2013-11-18 00:00:00

abstract：:β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior;...

journal_title：Frontiers in behavioral neuroscience

authors： Robins MT,Chiang T,Berry JN,Ko MJ,Ha JE,van Rijn RM

更新日期：2018-03-20 00:00:00

abstract：:First-line treatment of major depression includes administration of a selective serotonin reuptake inhibitor (SSRI), yet studies suggest that remission rates following two trials of an SSRI are <50%. The authors examine the putative biological substrates underlying "treatment resistant depression (TRD)" with the goal ...

journal_title：Frontiers in behavioral neuroscience

authors： Coplan JD,Gopinath S,Abdallah CG,Berry BR

更新日期：2014-05-20 00:00:00

abstract：:One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety, and post-traumatic stress disorder. We investigated t...

journal_title：Frontiers in behavioral neuroscience

authors： Griffiths BB,Schoonheim PJ,Ziv L,Voelker L,Baier H,Gahtan E

更新日期：2012-10-11 00:00:00

abstract：:The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat i...

journal_title：Frontiers in behavioral neuroscience

authors： Yu WC,Liu CY,Lai WS

更新日期：2016-06-10 00:00:00

abstract：:Negative social experiences during adolescence increase the risk of psychiatric disorders in adulthood. Using "resident-intruder" stress, the present study aimed to investigate the effects of adolescent social defeat on emotional and cognitive symptoms associated with psychiatric disorders during adulthood and the eff...

journal_title：Frontiers in behavioral neuroscience

authors： Zhang F,Yuan S,Shao F,Wang W

更新日期：2016-07-20 00:00:00

abstract：:According to recent WHO reports, alcohol remains the number one substance used and abused by adolescents, despite public health efforts to curb its use. Adolescence is a critical period of biological maturation where brain development, particularly the mesocorticolimbic dopamine system, undergoes substantial remodelin...

journal_title：Frontiers in behavioral neuroscience

authors： Kruse LC,Schindler AG,Williams RG,Weber SJ,Clark JJ

更新日期：2017-07-25 00:00:00

abstract：:Emotional events gain special priority in how they are remembered, with emotionally arousing events typically recalled more vividly and with greater confidence than non-emotional events. In dementia, memory and emotion processing are affected to varying degrees, however, whether emotional enhancement of memory for com...

journal_title：Frontiers in behavioral neuroscience

authors： Kumfor F,Irish M,Hodges JR,Piguet O

更新日期：2014-06-24 00:00:00

abstract：:5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the mo...

journal_title：Frontiers in behavioral neuroscience

authors： Liu P,Zhang J,Li M,Sui N

更新日期：2016-03-15 00:00:00

abstract：:Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotecti...

journal_title：Frontiers in behavioral neuroscience

authors： Rapley SA,Prickett TCR,Dalrymple-Alford JC,Espiner EA

更新日期：2018-07-19 00:00:00

abstract：:Humans value rewards less when these are delivered in the future as opposed to immediately, a phenomenon referred to as delay discounting. While delay discounting has been studied during the anticipation of rewards and in the context of intertemporal decision-making, little is known about its neural correlates in the ...

journal_title：Frontiers in behavioral neuroscience

authors： Ludwig VU,Nüsser C,Goschke T,Wittfoth-Schardt D,Wiers CE,Erk S,Schott BH,Walter H

更新日期：2015-10-29 00:00:00

abstract：Background:Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigate...

journal_title：Frontiers in behavioral neuroscience

authors： von Düring F,Ristow I,Li M,Denzel D,Colic L,Demenescu LR,Li S,Borchardt V,Liebe T,Vogel M,Walter M

更新日期：2019-10-02 00:00:00

abstract：:Although an effective treatment for pediatric brain tumors, cranial radiation therapy (CRT) damages surrounding healthy tissue, thereby disrupting brain development. Animal models of pediatric CRT have primarily relied on visual tasks to assess cognitive impairment. Moreover, there has been a lack of sex comparisons a...

journal_title：Frontiers in behavioral neuroscience

authors： Perez EC,Rodgers SP,Inoue T,Pedersen SE,Leasure JL,Gaber MW

更新日期：2018-08-02 00:00:00