Extreme Short Stature and Severe Neurological Impairment in a 17-Year-Old Male With Untreated Combined Pituitary Hormone Deficiency Due to POU1F1 Mutation.

abstract：:Background: Obesity and maternal age are the two most important factors independently affecting the risk of gestational diabetes mellitus (GDM). However, the age differences in the association between obesity and GDM remain unclear. The objectives of this cohort study included: (1) to determine the current incidence o...

journal_title：Frontiers in endocrinology

authors： Li G,Wei T,Ni W,Zhang A,Zhang J,Xing Y,Xing Q

更新日期：2020-09-11 00:00:00

abstract：Background:The risk of spontaneous abortion in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive treatment (ART) is higher than that in patients without PCOS, however, no definitive risk factors have been confirmed to associate with the high spontaneous abortion rate in PCOS patients under...

journal_title：Frontiers in endocrinology

authors： Sun YF,Zhang J,Xu YM,Cao ZY,Wang YZ,Hao GM,Gao BL

更新日期：2020-12-03 00:00:00

abstract：Objective:Both vitamin D and K2 are involved in a number of metabolic processes, including bone metabolism; however, associations between the vitamins are not fully understood. The aim of the study was to evaluate serum concentrations of 25-hydroxyvitamin D [25(OH)D] in adult patients receiving long-term acenocoumarol ...

journal_title：Frontiers in endocrinology

authors： Sawicka-Powierza J,Konstantynowicz J,Jablonska E,Zelazowska-Rutkowska B,Jelski W,Abramowicz P,Sasinowski C,Chlabicz S

更新日期：2018-05-04 00:00:00

abstract：:Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected...

journal_title：Frontiers in endocrinology

authors： Baldini E,Odorisio T,Sorrenti S,Catania A,Tartaglia F,Carbotta G,Pironi D,Rendina R,D'Armiento E,Persechino S,Ulisse S

更新日期：2017-10-27 00:00:00

abstract：:Regenerative medicine is a multidisciplinary field that aims to determine different factors and develop various methods to regenerate impaired tissues, organs, and cells in the disease and impairment conditions. When treatment procedures are specified according to the individual's information, the leading role of pers...

journal_title：Frontiers in endocrinology

authors： Arjmand B,Tayanloo-Beik A,Foroughi Heravani N,Alaei S,Payab M,Alavi-Moghadam S,Goodarzi P,Gholami M,Larijani B

更新日期：2020-07-17 00:00:00

abstract：:SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such as ribosome biogenesis, gene expression, cellular metabolism and c...

journal_title：Frontiers in endocrinology

authors： Wu D,Li Y,Zhu KS,Wang H,Zhu WG

更新日期：2018-11-19 00:00:00

abstract：:Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data from the radioimmunoassay indicated that dopamine inhibited insu...

journal_title：Frontiers in endocrinology

authors： Liu M,Ren L,Zhong X,Ding Y,Liu T,Liu Z,Yang X,Cui L,Yang L,Fan Y,Liu Y,Zhang Y

更新日期：2020-04-07 00:00:00

abstract：:The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed...

journal_title：Frontiers in endocrinology

authors： Betz MJ,Enerbäck S

更新日期：2011-11-29 00:00:00

abstract：:RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons...

journal_title：Frontiers in endocrinology

authors： Poling MC,Kauffman AS

更新日期：2015-09-24 00:00:00

abstract：:Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by peripheral organs or by production within the CNS itself using pe...

journal_title：Frontiers in endocrinology

authors： Remage-Healey L,Saldanha CJ,Schlinger BA

更新日期：2011-09-29 00:00:00

abstract：Background:Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, ...

journal_title：Frontiers in endocrinology

authors： Benvenga S,Capodicasa G,Perelli S,Ferrari SM,Fallahi P,Antonelli A

更新日期：2018-04-18 00:00:00

abstract：:In some organisms and cells, oxygen availability influences oxygen consumption. In this review, we examine this phenomenon of hypoxic hypometabolism (HH), discussing its features, mechanisms, and implications. Small mammals and other vertebrate species exhibit "oxyconformism," a downregulation of metabolic rate and bo...

journal_title：Frontiers in endocrinology

authors： Gu C,Jun JC

更新日期：2018-11-13 00:00:00

abstract：:The p53-related gene p63 is required for epithelial cell establishment and its expression is often altered in tumor cells. Great strides have been made in understanding the pathways and mechanisms that regulate p63 levels, such as the Wnt, Hedgehog, Notch, and EGFR pathways. We discuss here the multiple signaling path...

journal_title：Frontiers in endocrinology

authors： Yoh K,Prywes R

更新日期：2015-04-28 00:00:00

abstract：:The incidence of type 2 diabetes significantly increases with age. The relevance of this association is dramatically magnified by the concomitant global aging of the population, but the underlying mechanisms remain to be fully elucidated. Here, some recent advances in this field are reviewed at the level of both the p...

journal_title：Frontiers in endocrinology

authors： De Tata V

更新日期：2014-09-03 00:00:00

abstract：:Older women with type 2 diabetes mellitus (DM) have higher bone mineral density (BMD) but also have higher rates of fracture compared to those without DM. Limited evidence suggests that DM may also be associated with more rapid bone loss. To determine if bone loss rates differ by DM status in older women, we analyzed ...

journal_title：Frontiers in endocrinology

authors： Schwartz AV,Ewing SK,Porzig AM,McCulloch CE,Resnick HE,Hillier TA,Ensrud KE,Black DM,Nevitt MC,Cummings SR,Sellmeyer DE

更新日期：2013-05-30 00:00:00

abstract：:Oxidative stress induced by free fatty acid overload in pancreatic β-cells is a potential contributory factor to dysfunction of insulin secretion and apoptotic cell death. Perilipin 5 (Plin5) has been reported to ameliorate oxidative stress-mediated damage in non-insulin-secreting tissues. We tested the hypothesis tha...

journal_title：Frontiers in endocrinology

authors： Zhu Y,Ren C,Zhang M,Zhong Y

更新日期：2020-03-31 00:00:00

abstract：:Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity, in part, by targeting the hypothalamus. Palmitate, the most abun...

journal_title：Frontiers in endocrinology

authors： Tran A,He W,Jiang N,Chen JTC,Belsham DD

更新日期：2020-06-12 00:00:00

abstract：:Insulin-like growth factor-binding proteins (IGFBPs) are multifunctional proteins that possess IGF-dependent and -independent actions. Recent studies suggest that its IGF-independent action appeared early and that the IGF-binding function may have been acquired later in evolution. The timing of the emergence of IGF-de...

journal_title：Frontiers in endocrinology

authors： Zhong Y,Duan C

更新日期：2017-01-18 00:00:00

abstract：Objective:Two missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent somatic growth of patie...

journal_title：Frontiers in endocrinology

authors： Huttunen H,Hero M,Lääperi M,Känsäkoski J,Swan H,Hirsch JA,Miettinen PJ,Raivio T

更新日期：2018-04-24 00:00:00

abstract：:Several studies have shown that a woman's vaginal or axillary odors convey information on her attractivity. Yet, whether such scents induce psychoneuroendocrinological changes in perceivers is still controversial. We studied if smelling axillary and vulvar odors collected in the periovulatory and late luteal phases of...

journal_title：Frontiers in endocrinology

authors： Cerda-Molina AL,Hernández-López L,de la O CE,Chavira-Ramírez R,Mondragón-Ceballos R

更新日期：2013-10-28 00:00:00

abstract：:Physiological concentrations of the green tea extract epigallocatechin-3-gallate (EGCG) caused growth inhibition in estrogen receptor α (ERα)-positive MCF7 cells that was associated with down-regulation of the ERα and reduced insulin-like growth factor binding protein-2 abundance and increased protein abundance of the...

journal_title：Frontiers in endocrinology

authors： Zeng L,Holly JM,Perks CM

更新日期：2014-05-07 00:00:00

abstract：:The prolactin receptor (PRLR) is emerging as a therapeutic target in oncology. Knowledge-based drug design led to the development of a pure PRLR antagonist (Del1-9-G129R-hPRL) that was recently shown to prevent PRL-induced mouse prostate tumorogenesis. In humans, the first gain-of-function mutation of the PRLR (PRLR(I...

journal_title：Frontiers in endocrinology

authors： Tallet E,Fernandez I,Zhang C,Salsac M,Gregor N,Ayoub MA,Pin JP,Trinquet E,Goffin V

更新日期：2011-09-16 00:00:00

abstract：:Although G protein-coupled receptor (GPCR) internalization has long been considered as a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Intern...

journal_title：Frontiers in endocrinology

authors： Levoye A,Zwier JM,Jaracz-Ros A,Klipfel L,Cottet M,Maurel D,Bdioui S,Balabanian K,Prézeau L,Trinquet E,Durroux T,Bachelerie F

更新日期：2015-11-09 00:00:00

abstract：:Limb length inequality results from many types of musculoskeletal disorders. Asymmetric weight bearing from a limb length discrepancy of less than 2% can have debilitating consequences such as back problems and early-onset osteoarthritis. Existing treatments include invasive surgeries and/or drug regimens that are oft...

journal_title：Frontiers in endocrinology

authors： Racine HL,Meadows CA,Ion G,Serrat MA

更新日期：2018-06-04 00:00:00

abstract：:Objective: Quantitative investigations of facial changes in acromegaly are rare. A new imaging technique, three-dimensional (3D) stereophotography, can accurately quantify whole facial changes. We aimed to measure facial characteristics in acromegaly patients using 3D stereophotography, analyze gender-specific feature...

journal_title：Frontiers in endocrinology

authors： Guo X,Meng T,Huang J,Wang X,Lian W,Deng K,Gao L,Wang Z,Xing B,Long X

更新日期：2018-11-29 00:00:00

abstract：Background:Levothyroxine sodium (LT4) is the therapy of choice for hypothyroidism. In the last decade, new LT4 formulations, such as liquid and softgel capsules, became available. Even if some evidence has been reached in the efficacy of liquid LT4 in patients with suboptimal TSH on tablet LT4, the usefulness of softge...

journal_title：Frontiers in endocrinology

authors： Trimboli P,Virili C,Centanni M,Giovanella L

更新日期：2018-03-21 00:00:00

abstract：Objectives:Based on data from the China National Health Survey, we aimed to examine the association between body height and cardiometabolic disease (CMD) in a large adult population from Shaanxi province, and further to test whether this association was hinged upon other population characteristics. Methods:This popula...

journal_title：Frontiers in endocrinology

authors： Yuan Y,Zhou B,Wang S,Ma J,Dong F,Yang M,Zhang Z,Niu W

更新日期：2020-12-21 00:00:00

abstract：:Background: This study investigated the relationship strength between hypothyroidism and cardiovascular and renal outcomes in diabetic patients. Methods: The electronic databases PubMed, EmBase, and Cochrane library were screened for relevant studies published before November 2018. The outcomes included major cardiova...

journal_title：Frontiers in endocrinology

authors： Zhang S,Feng G,Kang F,Guo Y,Ti H,Hao L,Gao P,Gao J

更新日期：2020-01-10 00:00:00

abstract：:Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands able to induce their activation. Indeed, PARs are physiologically activated after proteolytic cleavage of their N-terminal...

journal_title：Frontiers in endocrinology

authors： Sébert M,Sola-Tapias N,Mas E,Barreau F,Ferrand A

更新日期：2019-10-24 00:00:00

abstract：:Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT) physiology in rodents housed below their thermoneutral zone (i.e., 28-32°C). In these conditions, BAT is chronically hyperactive and, unlike human residence, closer to thermoneutrality. Therefore, we set out to determine the e...

journal_title：Frontiers in endocrinology

authors： Aldiss P,Lewis JE,Lupini I,Bloor I,Chavoshinejad R,Boocock DJ,Miles AK,Ebling FJP,Budge H,Symonds ME

更新日期：2020-03-20 00:00:00