Pathway Regulation of p63, a Director of Epithelial Cell Fate.

abstract：:Recent studies discussed the benefit of bariatric surgery on obese patients diagnosed with type 2 diabetes mellitus (T2DM). Several factors play an essential role in predicting the impact of bariatric surgery on T2DM, such as ABCD score (age, BMI, C-peptide, and duration of the disease), HbA1c, and fasting blood gluco...

journal_title：Frontiers in endocrinology

authors： Kassem MA,Durda MA,Stoicea N,Cavus O,Sahin L,Rogers B

更新日期：2017-03-01 00:00:00

abstract：:Objectives: To assess the diagnostic potential of bidirectional axial transmission (BDAT) ultrasound, and high-resolution peripheral quantitative computed tomography (HR-pQCT) in X-linked hypophosphatemia (XLH, OMIM #307800), a rare genetic disorder of phosphate metabolism caused by mutations in the PHEX gene. Methods...

journal_title：Frontiers in endocrinology

authors： Raimann A,Mehany SN,Feil P,Weber M,Pietschmann P,Boni-Mikats A,Klepochova R,Krššák M,Häusler G,Schneider J,Patsch JM,Raum K

更新日期：2020-06-09 00:00:00

abstract：:Background: Myostatin (Mstn), a member of the TGF-β superfamily, is a negative regulator of skeletal muscle mass in mammals. Precise regulation of Mstn expression is important for somite growth in fish. MicroRNA (miRNA), a type of small non-coding RNA, regulates gene expression at the post-transcriptional level and pa...

journal_title：Frontiers in endocrinology

authors： Zhao Z,Yu X,Jia J,Yang G,Sun C,Li W

更新日期：2019-12-03 00:00:00

abstract：:The world-wide obesity epidemic constitutes a severe threat to human health and wellbeing and poses a major challenge to health-care systems. Current therapeutic approaches, relying mainly on reduced energy intake and/or increased exercise energy expenditure, are generally of limited effectiveness. Previously believed...

journal_title：Frontiers in endocrinology

authors： Betz MJ,Enerbäck S

更新日期：2011-11-29 00:00:00

abstract：:Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose depot, it is situated in bone marrow space and resided with bone tissue side-by-side. MAT is considered not only as a regulator of bone metabol...

journal_title：Frontiers in endocrinology

authors： Li Y,Meng Y,Yu X

更新日期：2019-02-08 00:00:00

abstract：:Gonadotropin-releasing hormone 1 (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selecti...

journal_title：Frontiers in endocrinology

authors： Desaulniers AT,Cederberg RA,Lents CA,White BR

更新日期：2017-12-11 00:00:00

abstract：:Background: Slow-wave activity (SWA) in non-rapid eye movement (NREM) sleep, obtained by spectral analysis of the electroencephalogram, is a marker of the depth or intensity of NREM sleep. Higher levels of SWA are associated with lower arousability during NREM sleep and protect against sleep fragmentation. Multiple st...

journal_title：Frontiers in endocrinology

authors： Morselli LL,Temple KA,Leproult R,Ehrmann DA,Van Cauter E,Mokhlesi B

更新日期：2018-07-12 00:00:00

abstract：:Remodeling of the cellular distribution of gap junctions formed mainly by connexin-43 (Cx43) can be related to the increased incidence of cardiac arrhythmias. It has been shown that adaptation to chronic intermittent hypobaric hypoxia (IHH) attenuates the incidence and severity of ischemic and reperfusion ventricular ...

journal_title：Frontiers in endocrinology

authors： Kohutova J,Elsnicova B,Holzerova K,Neckar J,Sebesta O,Jezkova J,Vecka M,Vebr P,Hornikova D,Szeiffova Bacova B,Egan Benova T,Hlavackova M,Tribulova N,Kolar F,Novakova O,Zurmanova JM

更新日期：2019-01-25 00:00:00

abstract：:The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. They belong to the super-family of bHLH proteins and exhibit bi-functional roles as both activators and repressors of gene transcription. The Twist proteins ar...

journal_title：Frontiers in endocrinology

authors： Dobrian AD

更新日期：2012-08-30 00:00:00

abstract：:Measuring salivary cortisol is both convenient and non-invasive for patients; however, its usefulness as a marker for monitoring medical therapy has not yet been established. The aim of this study was to assess the utility of multiple salivary cortisol measurements in patients with Cushing's syndrome (CS) during medic...

journal_title：Frontiers in endocrinology

authors： Yoshida K,Fukuoka H,Odake Y,Nakajima S,Tachibana M,Ito J,Hosokawa Y,Yamada T,Miura H,Suematsu N,Matsumoto R,Bando H,Suda K,Nishizawa H,Iguchi G,Ogawa W,Takahashi Y

更新日期：2018-01-11 00:00:00

abstract：:The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, ha...

journal_title：Frontiers in endocrinology

authors： Avilés-Santa ML,Colón-Ramos U,Lindberg NM,Mattei J,Pasquel FJ,Pérez CM

更新日期：2017-11-10 00:00:00

abstract：:Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility. In addition to being located in the hypothalamus in the anteroventral periventricular and arcuate nuclei, kisspeptin neurons are al...

journal_title：Frontiers in endocrinology

authors： Stephens SBZ,Kauffman AS

更新日期：2017-08-07 00:00:00

abstract：:Background: About 85-90% of children born small for gestational age (SGA) experience a catch-up growth that occurs mostly during the first year of life and results in a full stature recovery by the age of 2. Objective: To investigate the relation between bone maturation (BM) and catch-up growth during the first year o...

journal_title：Frontiers in endocrinology

authors： Pepe G,Calafiore M,Valenzise M,Corica D,Morabito L,Pajno GB,Aversa T,Wasniewska M

更新日期：2020-03-24 00:00:00

abstract：:Introduction: We have previously shown that fetuses of mothers with gestational diabetes mellitus (GDM) and insulin resistance exhibit a prolongation of fetal auditory event-related brain responses (fAER) compared to fetuses of normal glucose tolerant women during an oral glucose tolerance test (oGTT). This implies th...

journal_title：Frontiers in endocrinology

authors： Schleger F,Linder K,Walter L,Heni M,Brändle J,Brucker S,Pauluschke-Fröhlich J,Weiss M,Häring HU,Preissl H,Fritsche A

更新日期：2018-11-20 00:00:00

abstract：:Background: The management of children and adolescents with chronic kidney disease (CKD) and growth failure candidate for recombinant human growth hormone therapy (rhGH) is based on an appraisal of the literature established on a 2006 consensus statement and 2019 Clinical practice recommendations. The performance of t...

journal_title：Frontiers in endocrinology

authors： Cappa M,Maghnie M,Carbone V,Chioma L,Errichiello C,Giavoli C,Giordano M,Guazzarotti L,Klain A,Montini G,Murer L,Parpagnoli M,Pecoraro C,Pesce S,Verrina E

更新日期：2020-09-02 00:00:00

abstract：:Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1-11), expressed in different tissues and cells, including heart and brain. The isoforms PDE4, PDE7, and PDE8 are specific for the second messenger cAMP, which is responsible for me...

journal_title：Frontiers in endocrinology

authors： Bizzi MF,Bolger GB,Korbonits M,Ribeiro-Oliveira A Jr

更新日期：2019-03-19 00:00:00

abstract：:O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification consisting in the addition of a sugar moiety to serine/threonine residues of cytosolic or nuclear proteins. Catalyzed by O-GlcNAc-transferase (OGT) and removed by O-GlcNAcase, this dynamic modification is dependent on ...

journal_title：Frontiers in endocrinology

authors： Fardini Y,Dehennaut V,Lefebvre T,Issad T

更新日期：2013-08-12 00:00:00

abstract：:Exercise training triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic modifications, including DNA methylation, participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induc...

journal_title：Frontiers in endocrinology

authors： Pattamaprapanont P,Garde C,Fabre O,Barrès R

更新日期：2016-12-23 00:00:00

abstract：:Regenerative medicine is a multidisciplinary field that aims to determine different factors and develop various methods to regenerate impaired tissues, organs, and cells in the disease and impairment conditions. When treatment procedures are specified according to the individual's information, the leading role of pers...

journal_title：Frontiers in endocrinology

authors： Arjmand B,Tayanloo-Beik A,Foroughi Heravani N,Alaei S,Payab M,Alavi-Moghadam S,Goodarzi P,Gholami M,Larijani B

更新日期：2020-07-17 00:00:00

abstract：:Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotrop...

journal_title：Frontiers in endocrinology

authors： True C,Grove KL,Smith MS

更新日期：2011-10-17 00:00:00

abstract：:Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Libr...

journal_title：Frontiers in endocrinology

authors： Yuan J,Sun C,Jiang S,Lu Y,Zhang Y,Gao XH,Wu Y,Chen HD

更新日期：2019-01-15 00:00:00

abstract：:Gonadotropin-inhibitory hormone (GnIH) was first identified in the Japanese quail as a hypothalamic neuropeptide inhibitor of gonadotropin secretion. Subsequent studies have shown that GnIH is present in the brains of birds including songbirds, and mammals including humans. The identified avian and mammalian GnIH pept...

journal_title：Frontiers in endocrinology

authors： Ubuka T,Son YL,Tobari Y,Tsutsui K

更新日期：2012-11-28 00:00:00

abstract：:Linagliptin, one of the five dipeptidyl peptidase-4 inhibitors available, has recently entered the market both in the US and in most European countries for treatment of type 2 diabetes mellitus. It presents a xanthine-based structure, and is characterized by unique pharmacokinetics, with non-linear profile, long termi...

journal_title：Frontiers in endocrinology

authors： Sortino MA,Sinagra T,Canonico PL

更新日期：2013-02-26 00:00:00

abstract：Introduction:Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professi...

journal_title：Frontiers in endocrinology

authors： Rusińska A,Płudowski P,Walczak M,Borszewska-Kornacka MK,Bossowski A,Chlebna-Sokół D,Czech-Kowalska J,Dobrzańska A,Franek E,Helwich E,Jackowska T,Kalina MA,Konstantynowicz J,Książyk J,Lewiński A,Łukaszkiewicz J,Marcinowska

更新日期：2018-05-31 00:00:00

abstract：Background:Vandetanib is the most largely used tyrosine kinase inhibitor (TKI) in patients with locally advanced and/or metastatic medullary thyroid cancer (MTC). Here, we conducted a systematic review on its efficacy and attempted to perform a meta-analysis adopting standardized RECIST criteria as end-points. Methods...

journal_title：Frontiers in endocrinology

authors： Trimboli P,Castellana M,Virili C,Giorgino F,Giovanella L

更新日期：2018-05-03 00:00:00

abstract：:In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network and must undergo a maturation process to become responsive to secretagogues. The production of mature SGs requires concentrating newly synthesized soluble content p...

journal_title：Frontiers in endocrinology

authors： Bonnemaison ML,Eipper BA,Mains RE

更新日期：2013-08-14 00:00:00

abstract：:Objective: Quantitative investigations of facial changes in acromegaly are rare. A new imaging technique, three-dimensional (3D) stereophotography, can accurately quantify whole facial changes. We aimed to measure facial characteristics in acromegaly patients using 3D stereophotography, analyze gender-specific feature...

journal_title：Frontiers in endocrinology

authors： Guo X,Meng T,Huang J,Wang X,Lian W,Deng K,Gao L,Wang Z,Xing B,Long X

更新日期：2018-11-29 00:00:00

abstract：:Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription fact...

journal_title：Frontiers in endocrinology

authors： Kozak LP

更新日期：2011-10-31 00:00:00

abstract：:In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of chi...

journal_title：Frontiers in endocrinology

authors： Lischinsky JE,Skocic J,Clairman H,Rovet J

更新日期：2016-02-25 00:00:00

abstract：:Sex pheromone production in most moths is initiated following pheromone biosynthesis activating neuropeptide receptor (PBANR) activation. PBANR was initially cloned from pheromone glands (PGs) of Helicoverpa zea and Bombyx mori. The B. mori PBANR is characterized by a relatively long C-terminus that is essential for l...

journal_title：Frontiers in endocrinology

authors： Lee JM,Hull JJ,Kawai T,Goto C,Kurihara M,Tanokura M,Nagata K,Nagasawa H,Matsumoto S

更新日期：2012-01-24 00:00:00