Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.

abstract：:Signal transduction and gene regulation determine a major reorganization of metabolic activities in order to support cell proliferation. Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis and cellular biosynthesis, two activities shown by both...

journal_title：Frontiers in physiology

authors： Mosca E,Alfieri R,Maj C,Bevilacqua A,Canti G,Milanesi L

更新日期：2012-11-21 00:00:00

abstract：:Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which...

journal_title：Frontiers in physiology

authors： Yang CH,Zhuang WL,Shen YJ,Lai CJ,Kou YR

更新日期：2016-05-09 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:Physiological calibration (Physiocal) improves the quality of continuous blood pressure (BP) signal from finger. However, the effects of Physiocal on spectral characteristics of systolic BP (SBP) variability are not well-known. We tested the hypothesis that the use of Physiocal may alter the results on SBP variability...

journal_title：Frontiers in physiology

authors： Kiviniemi AM,Hintsala H,Hautala AJ,Ikäheimo TM,Jaakkola JJ,Tiinanen S,Seppänen T,Tulppo MP

更新日期：2014-12-03 00:00:00

abstract：:Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertroph...

journal_title：Frontiers in physiology

authors： Pazó-Sayós L,González MC,Quintana-Villamandos B

更新日期：2020-08-26 00:00:00

abstract：:Highly aerobically trained individuals are unable to achieve maximal oxygen uptake ([Formula: see text]) during exhaustive running lasting ~2 min, instead [Formula: see text] plateaus below [Formula: see text] after ~1 min. Hypoxia offers the opportunity to study the ([Formula: see text]) response to an exhaustive run...

journal_title：Frontiers in physiology

authors： Black MI,Potter CR,Corbett J,Clark CC,Draper SB

更新日期：2017-02-21 00:00:00

abstract：:Left ventricular (LV) myocardial dysfunction occurs after myocardial infarction (MI) is associated with the location, infarct size, and transmurality degrees of MI. The myocardial strain is a sensitive index used for the quantification of myocardium dysfunction. This study used Tissue-Tracking to evaluate whether the ...

journal_title：Frontiers in physiology

authors： Li S,Zhao L,Lu A,Tian J,Gong L,Ma X

更新日期：2020-12-10 00:00:00

abstract：:Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteri...

journal_title：Frontiers in physiology

authors： Kumar RK,Foster PS

更新日期：2012-07-31 00:00:00

abstract：:Mature spermatozoa have highly condensed DNA that is essentially silent both transcriptionally and translationally. Therefore, post translational modifications are very important for regulating sperm motility, morphology, and for male fertility in general. Protein sumoylation was recently demonstrated in human and rod...

journal_title：Frontiers in physiology

authors： Brohi RD,Wang L,Hassine NB,Cao J,Talpur HS,Wu D,Huang CJ,Rehman ZU,Bhattarai D,Huo LJ

更新日期：2017-06-13 00:00:00

abstract：:We recorded via telemetry the arterial blood pressure (BP) and heart rate (HR) response to classical conditioning following the spontaneous onset of autoimmune diabetes in BBDP/Wor rats vs. age-matched, diabetes-resistant control (BBDR/Wor) rats. Our purpose was to evaluate the autonomic regulatory responses to an acu...

journal_title：Frontiers in physiology

authors： Randall DC,Speakman RO,Silcox DL,Brown LV,Brown DR,Gong MC,Patwardhan A,Reynolds LR,Karounos DG,Burgess DE,Anigbogu CN

更新日期：2011-08-27 00:00:00

abstract：:Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce...

journal_title：Frontiers in physiology

authors： Zhang C,Hua Q

更新日期：2016-01-07 00:00:00

abstract：:Stable gait requires active control of the mediolateral (ML) kinematics of the body center of mass (CoM) and the base of support (BoS) in relation to each other. Stance leg hip abductor (HA) muscle spindle afference may be used to guide contralateral swing foot placement and adequately position the BoS in relation to ...

journal_title：Frontiers in physiology

authors： Arvin M,Hoozemans MJM,Pijnappels M,Duysens J,Verschueren SM,van Dieën JH

更新日期：2018-08-21 00:00:00

abstract：:Excitatory and inhibitory junction potentials of circular smooth muscle cells in guinea pig ileum and colon are suppressed 30-90 min after setting up in vitro preparations. We have previously shown this "unresponsive" period is associated with a transient loss of dye coupling between smooth muscle cells, which subsequ...

journal_title：Frontiers in physiology

authors： Carbone SE,Wattchow DA,Spencer NJ,Hibberd TJ,Brookes SJ

更新日期：2014-08-22 00:00:00

abstract：:Muscle tone represents one of the important concepts for characterizing changes in the state of the developing nervous system. It can be manifested in the level of activity of flexors and extensors and in muscle reactions to its passive stretching (StR) or shortening (ShR). Here we investigated such reactions in a coh...

journal_title：Frontiers in physiology

authors： Solopova IA,Zhvansky DS,Dolinskaya IY,Keshishian ES,Selionov VA,Sylos-Labini F,Lacquaniti F,Ivanenko Y

更新日期：2019-09-13 00:00:00

abstract：:This study investigates the complex interplay between the cardiac and respiratory systems in 268 healthy neonates born between 35 and 40 weeks of gestation. The aim is to provide a comprehensive description of the developing cardiorespiratory information transfer mechanisms as a function of gestational age (GA). This ...

journal_title：Frontiers in physiology

authors： Lucchini M,Pini N,Burtchen N,Signorini MG,Fifer WP

更新日期：2020-08-27 00:00:00

abstract：:Fractal phenomena can be found in numerous scientific areas including neuroscience. Fractals are structures, in which the whole has the same shape as its parts. A specific structure known as pink noise (also called fractal or 1/f noise) is one key fractal manifestation, exhibits both stability and adaptability, and ca...

journal_title：Frontiers in physiology

authors： Akhrif A,Romanos M,Domschke K,Schmitt-Boehrer A,Neufang S

更新日期：2018-10-04 00:00:00

abstract：:Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both...

journal_title：Frontiers in physiology

authors： Nomikos NN,Nikolaidis PT,Sousa CV,Papalois AE,Rosemann T,Knechtle B

更新日期：2018-12-18 00:00:00

abstract：:Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an obligatory requirement of G-protein βγ subunits for its voltage dependent ...

journal_title：Frontiers in physiology

authors： Greenwood IA,Stott JB

更新日期：2020-01-14 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being markedly different from heart failure with reduced EF in terms of etiology and natural history (Graziani et al., 2018). Recently, a growi...

journal_title：Frontiers in physiology

authors： D'Amario D,Migliaro S,Borovac JA,Restivo A,Vergallo R,Galli M,Leone AM,Montone RA,Niccoli G,Aspromonte N,Crea F

更新日期：2019-11-05 00:00:00

abstract：:Human physiological signals are inherently rhythmic and have a hallmark feature in that even distant intrasignal measurements are related to each other. This relationship is termed long-range correlation and has been recognized as an indicator of the optimal state of the observed physiological systems, among which the...

journal_title：Frontiers in physiology

authors： Ravi DK,Marmelat V,Taylor WR,Newell KM,Stergiou N,Singh NB

更新日期：2020-06-23 00:00:00

abstract：:Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irr...

journal_title：Frontiers in physiology

authors： Félix Garza ZC,Liebmann J,Born M,Hilbers PA,van Riel NA

更新日期：2017-01-26 00:00:00

abstract：:Chronic pressure overload can result in ventricular hypertrophy and eventually diastolic dysfunction. In normal myocardium, the time from peak tension to 50% relaxation of isolated cardiac myocardium is not directly determined by the time for calcium decline. This study aims to determine whether the time for calcium d...

journal_title：Frontiers in physiology

authors： Monasky MM,Torres CAA,Janssen PML

更新日期：2017-12-04 00:00:00

abstract：:Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the d...

journal_title：Frontiers in physiology

authors： Kondratskyi A,Yassine M,Kondratska K,Skryma R,Slomianny C,Prevarskaya N

更新日期：2013-10-02 00:00:00

abstract：:Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multiscale by nature, project work, and software tools usually focus on isolated aspects o...

journal_title：Frontiers in physiology

authors： Eissing T,Kuepfer L,Becker C,Block M,Coboeken K,Gaub T,Goerlitz L,Jaeger J,Loosen R,Ludewig B,Meyer M,Niederalt C,Sevestre M,Siegmund HU,Solodenko J,Thelen K,Telle U,Weiss W,Wendl T,Willmann S,Lippert J

更新日期：2011-02-24 00:00:00

abstract：:Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence ratio. Traditional therapeutic approaches such as surgery in combination with chemo- or radiotherapy have had limited efficacy in improving the outcome of this disease. Up until just under a decade ago, the prominent desmoplast...

journal_title：Frontiers in physiology

authors： Wilson JS,Pirola RC,Apte MV

更新日期：2014-02-14 00:00:00

abstract：:While many effectors have been identified in enamel matrix and cells via genetic studies, physiological networks underlying their expression levels and thus the natural spectrum of enamel thickness and degree of mineralization are now just emerging. Several transcription factors are candidates for enamel gene expressi...

journal_title：Frontiers in physiology

authors： Babajko S,de La Dure-Molla M,Jedeon K,Berdal A

更新日期：2015-01-05 00:00:00

abstract：:The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX). B...

journal_title：Frontiers in physiology

authors： Smith A,McCulloh RJ

更新日期：2015-06-30 00:00:00

abstract：:Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum and ZAG mRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated ...

journal_title：Frontiers in physiology

authors： Liu M,Zhu H,Dai Y,Pan H,Li N,Wang L,Yang H,Yan K,Gong F

更新日期：2018-02-07 00:00:00

abstract：:Aquaculture is a growing industry that is increasingly providing a sizable proportion of fishery products for human consumption. Dietary energy and temperature fluctuations affect fish health and may even trigger mortality, causing great losses in fish production during winter. To better understand this unproductive w...

journal_title：Frontiers in physiology

authors： Sánchez-Nuño S,Sanahuja I,Fernández-Alacid L,Ordóñez-Grande B,Fontanillas R,Fernández-Borràs J,Blasco J,Carbonell T,Ibarz A

更新日期：2018-07-17 00:00:00

abstract：INTRODUCTION:Gases, such as nitric oxide (NO), carbon monoxide (CO), or hydrogen sulfide (H2S), termed gasotransmitters, play an increasingly important role in understanding of how electrical signaling of cells is modulated. H2S is well-known to act on various ion channels and receptors. In a previous study we reported...

journal_title：Frontiers in physiology

authors： Sitdikova GF,Fuchs R,Kainz V,Weiger TM,Hermann A

更新日期：2014-11-12 00:00:00