A Role for Electrotonic Coupling Between Cortical Pyramidal Cells.

Abstract:

:Many brain regions communicate information through synchronized network activity. Electrical coupling among the dendrites of interneurons in the cortex has been implicated in forming and sustaining such activity in the cortex. Evidence for the existence of electrical coupling among cortical pyramidal cells, however, has been largely absent. A recent experimental study measured properties of electrical connections between pyramidal cells in the cortex deemed "electrotonic couplings." These junctions were seen to occur pair-wise, sparsely, and often coexist with electrically-coupled interneurons. Here, we construct a network model to investigate possible roles for these rare, electrotonically-coupled pyramidal-cell pairs. Through simulations, we show that electrical coupling among pyramidal-cell pairs significantly enhances coincidence-detection capabilities and increases network spike-timing precision. Further, a network containing multiple pairs exhibits large variability in its firing pattern, possessing a rich coding structure.

journal_name

Front Comput Neurosci

authors

Crodelle J,Zhou D,Kovačič G,Cai D

doi

10.3389/fncom.2019.00033

subject

Has Abstract

pub_date

2019-05-28 00:00:00

pages

33

issn

1662-5188

journal_volume

13

pub_type

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