Steering the Volume of Tissue Activated With a Directional Deep Brain Stimulation Lead in the Globus Pallidus Pars Interna: A Modeling Study With Heterogeneous Tissue Properties.

abstract：:Recent research in neuroscience indicates the importance of tripartite synapses and gliotransmission mediated by astrocytes in neuronal system modulation. Although the astrocyte and neuronal network functions are interrelated, they are fundamentally different in their signaling patterns and, possibly, the time scales ...

journal_title：Frontiers in computational neuroscience

authors： Lenk K,Satuvuori E,Lallouette J,Ladrón-de-Guevara A,Berry H,Hyttinen JAK

更新日期：2020-01-22 00:00:00

abstract：:A vast amount of information about the external world continuously flows into the brain, whereas its capacity to process such information is limited. Attention enables the brain to allocate its resources of information processing to selected sensory inputs for reducing its computational load, and effects of attention ...

journal_title：Frontiers in computational neuroscience

authors： Wagatsuma N,Potjans TC,Diesmann M,Fukai T

更新日期：2011-07-08 00:00:00

abstract：:The study of sensory signaling in the visual cortex has been greatly advanced by the recording of neural activity simultaneously with the performance of a specific psychophysical task. Individual nerve cells may also increase their firing leading up to the particular choice or decision made on a single psychophysical ...

journal_title：Frontiers in computational neuroscience

authors： Parker AJ

更新日期：2013-08-13 00:00:00

abstract：:We often encounter pairs of variables in the world whose mutual relationship can be described by a function. After training, human responses closely correspond to these functional relationships. Here we study how humans predict unobserved segments of a function that they have been trained on and we compare how human p...

journal_title：Frontiers in computational neuroscience

authors： Narain D,Smeets JB,Mamassian P,Brenner E,van Beers RJ

更新日期：2014-09-30 00:00:00

abstract：:Dopaminergic neurons in the mammalian substantia nigra display characteristic phasic responses to stimuli which reliably predict the receipt of primary rewards. These responses have been suggested to encode reward prediction-errors similar to those used in reinforcement learning. Here, we propose a model of dopaminerg...

journal_title：Frontiers in computational neuroscience

authors： Chorley P,Seth AK

更新日期：2011-05-18 00:00:00

abstract：:The output of primary visual cortex (V1) is a piecemeal representation of the visual scene and the response of any one cell cannot unambiguously guide sensorimotor behavior. It remains unsolved how subsequent stages of cortical processing combine ("pool") these early visual signals into a coherent representation. We (...

journal_title：Frontiers in computational neuroscience

authors： Rocchi F,Ledgeway T,Webb BS

更新日期：2013-11-18 00:00:00

abstract：:Probabilistic models of decision making under various forms of uncertainty have been applied in recent years to numerous behavioral and model-based fMRI studies. These studies were highly successful in enabling a better understanding of behavior and delineating the functional properties of brain areas involved in deci...

journal_title：Frontiers in computational neuroscience

authors： Marković D,Kiebel SJ

更新日期：2016-04-20 00:00:00

abstract：:Short-term synaptic plasticity is highly diverse across brain area, cortical layer, cell type, and developmental stage. Since short-term plasticity (STP) strongly shapes neural dynamics, this diversity suggests a specific and essential role in neural information processing. Therefore, a correct characterization of sho...

journal_title：Frontiers in computational neuroscience

authors： Costa RP,Sjöström PJ,van Rossum MC

更新日期：2013-06-06 00:00:00

abstract：:Pitch is a perceptual correlate of periodicity. Sounds with distinct spectra can elicit the same pitch. Despite the importance of pitch perception, understanding the cellular mechanism of pitch perception is still a major challenge and a mechanistic model of pitch is lacking. A multi-stage neuronal network model is de...

journal_title：Frontiers in computational neuroscience

authors： Huang C,Rinzel J

更新日期：2016-06-16 00:00:00

abstract：:Previous studies have shown that the auditory cortex can enhance the perception of behaviorally important sounds in the presence of background noise, but the mechanisms by which it does this are not yet elucidated. Rapid plasticity of spectrotemporal receptive fields (STRFs) in the primary (A1) cortical neurons is obs...

journal_title：Frontiers in computational neuroscience

authors： Chambers JD,Elgueda D,Fritz JB,Shamma SA,Burkitt AN,Grayden DB

更新日期：2019-05-24 00:00:00

abstract：:Calcium concentrations as well as time courses have been used to model the signaling cascades leading to changes in the strength of synaptic connections. Previous models consider the dendritic spines as uniform compartments regarding calcium signaling. However, calcium concentrations can vary drastically on distances ...

journal_title：Frontiers in computational neuroscience

authors： Mihalas S

更新日期：2011-01-13 00:00:00

abstract：:Glucose is the brain's principal source of ATP, but the extent to which cerebral glucose consumption (CMRglc) is coupled with its oxygen consumption (CMRO2) remains unclear. Measurements of the brain's oxygen-glucose index OGI = CMRO2/CMRglc suggest that its oxygen uptake largely suffices for oxidative phosphorylation...

journal_title：Frontiers in computational neuroscience

authors： Angleys H,Jespersen SN,Østergaard L

更新日期：2016-10-13 00:00:00

abstract：:In synapses, calcium is required for modulating synaptic transmission, plasticity, synaptogenesis, and synaptic pruning. The regulation of calcium dynamics within neurons involves cellular mechanisms such as synaptically activated channels and pumps, calcium buffers, and calcium sequestrating organelles. Many experime...

journal_title：Frontiers in computational neuroscience

authors： Hu E,Mergenthal A,Bingham CS,Song D,Bouteiller JM,Berger TW

更新日期：2018-07-27 00:00:00

abstract：:Synchrony and asynchrony are essential aspects of the functioning of interconnected neuronal cells and networks. New information on neuronal synchronization can be expected to aid in understanding these systems. Synchronization provides insight in the functional connectivity and the spatial distribution of the informa...

journal_title：Frontiers in computational neuroscience

authors： Kapucu FE,Välkki I,Mikkonen JE,Leone C,Lenk K,Tanskanen JM,Hyttinen JA

更新日期：2016-10-18 00:00:00

abstract：:Molecular switches, such as the protein kinase CaMKII, play a fundamental role in cell signaling by decoding inputs into either high or low states of activity; because the high activation state can be turned on and persist after the input ceases, these switches have earned a reputation as "digital." Although this on/o...

journal_title：Frontiers in computational neuroscience

authors： Clarke SE

更新日期：2018-11-22 00:00:00

abstract：:Statistical models for describing the probability distribution over the states of biological systems are commonly used for dimensional reduction. Among these models, pairwise models are very attractive in part because they can be fit using a reasonable amount of data: knowledge of the mean values and correlations betw...

journal_title：Frontiers in computational neuroscience

authors： Roudi Y,Aurell E,Hertz JA

更新日期：2009-11-17 00:00:00

abstract：:Sensitivity analysis can provide useful information when one is interested in identifying the parameter θ of a system since it measures the variations of the output u when θ changes. In the literature two different sensitivity functions are frequently used: the traditional sensitivity functions (TSF) and the generaliz...

journal_title：Frontiers in computational neuroscience

authors： Troparevsky MI,Rubio D,Saintier N

更新日期：2010-09-30 00:00:00

abstract：:The motor system generates time-varying commands to move our limbs and body. Conventional descriptions of motor control and learning rely on dynamical representations of our body's state (forward and inverse models), and control policies that must be integrated forward to generate feedforward time-varying commands; th...

journal_title：Frontiers in computational neuroscience

authors： Berniker M,Kording KP

更新日期：2015-03-19 00:00:00

abstract：:Animals try to make sense of sensory information from multiple modalities by categorizing them into perceptions of individual or multiple external objects or internal concepts. For example, the brain constructs sensory, spatial representations of the locations of visual and auditory stimuli in the visual and auditory ...

journal_title：Frontiers in computational neuroscience

authors： Daemi M,Harris LR,Crawford JD

更新日期：2016-06-23 00:00:00

abstract：:Often we need to perform tasks in an environment that changes stochastically. In these situations it is important to learn the statistics of sequences of events in order to predict the future and the outcome of our actions. The statistical description of many of these sequences can be reduced to the set of probabiliti...

journal_title：Frontiers in computational neuroscience

authors： Ostojic S,Fusi S

更新日期：2013-04-12 00:00:00

abstract：:The striatum is an important subcortical structure with extensive connections to other regions of the brain. These connections are believed to play important roles in behaviors such as reward-related processes and impulse control, which show significant sex differences. However, little is known about sex differences i...

journal_title：Frontiers in computational neuroscience

authors： Lei X,Han Z,Chen C,Bai L,Xue G,Dong Q

更新日期：2016-09-23 00:00:00

abstract：:Affective human-robot interaction requires lightweight software and cheap wearable devices that could further this field. However, the estimation of emotions in real-time poses a problem that has not yet been optimized. An optimization is proposed for the emotion estimation methodology including artifact removal, feat...

journal_title：Frontiers in computational neuroscience

authors： Val-Calvo M,Álvarez-Sánchez JR,Ferrández-Vicente JM,Fernández E

更新日期：2019-11-26 00:00:00

abstract：:With the emergence of online publishing, opportunities to maximize transparency of scientific research have grown considerably. However, these possibilities are still only marginally used. We argue for the implementation of (1) peer-reviewed peer review, (2) transparent editorial hierarchies, and (3) online data publi...

journal_title：Frontiers in computational neuroscience

authors： Wicherts JM,Kievit RA,Bakker M,Borsboom D

更新日期：2012-04-03 00:00:00

abstract：:Neuroimaging in combination with graph theory has been successful in analyzing the functional connectome. However almost all analysis are performed based on static graph theory. The derived quantitative graph measures can only describe a snap shot of the disease over time. Neurodegenerative disease evolution is poorly...

journal_title：Frontiers in computational neuroscience

authors： Meyer-Bäse A,Roberts RG,Illan IA,Meyer-Bäse U,Lobbes M,Stadlbauer A,Pinker-Domenig K

更新日期：2017-10-05 00:00:00

abstract：:Head direction cells fire to signal the direction in which an animal's head is pointing. They are able to track head direction using only internally-derived information (path integration)In this simulation study we investigate the factors that affect path integration accuracy. Specifically, two major limiting factors ...

journal_title：Frontiers in computational neuroscience

authors： Page HJ,Walters D,Stringer SM

更新日期：2015-02-06 00:00:00

abstract：:Although the representation of space is as fundamental to visual processing as the representation of shape, it has received relatively little attention from neurophysiological investigations. In this study we characterize representations of space within visual cortex, and examine how they differ in a first direct comp...

journal_title：Frontiers in computational neuroscience

authors： Sereno AB,Lehky SR

更新日期：2011-02-01 00:00:00

abstract：:The morphology of presynaptic specializations can vary greatly ranging from classical single-release-site boutons in the central nervous system to boutons of various sizes harboring multiple vesicle release sites. Multi-release-site boutons can be found in several neural contexts, for example at the neuromuscular junc...

journal_title：Frontiers in computational neuroscience

authors： Knodel MM,Geiger R,Ge L,Bucher D,Grillo A,Wittum G,Schuster CM,Queisser G

更新日期：2014-09-09 00:00:00

abstract：:Neuromodulatory inputs from brainstem systems modulate the normal function of spinal motoneurons by altering the activation properties of persistent inward currents (PICs) in their dendrites. However, the effect of the PIC on firing outputs also depends on its location in the dendritic tree. To investigate the interac...

journal_title：Frontiers in computational neuroscience

authors： Kim H,Heckman CJ

更新日期：2014-09-09 00:00:00

abstract：:The problem of cancer risk analysis is of great importance to health-service providers and medical researchers. In this study, we propose a novel Artificial Neural Network (ANN) algorithm based on the probabilistic framework, which aims to investigate patient patterns associated with their disease development. Compare...

journal_title：Frontiers in computational neuroscience

authors： Yang C,Yang J,Liu Y,Geng X

更新日期：2020-07-21 00:00:00

abstract：:What are the functional neuroimaging measurements required for more fully characterizing the events and locations of neocortical activity? A prime assumption has been that modulation of cortical activity will inevitably be reflected in changes in energy utilization (for the most part) changes of glucose and oxygen con...

journal_title：Frontiers in computational neuroscience

authors： Robinson SE,Mandell AJ,Coppola R

更新日期：2013-01-24 00:00:00