Phage Lysins for Fighting Bacterial Respiratory Infections: A New Generation of Antimicrobials.

abstract：:The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggeri...

journal_title：Frontiers in immunology

authors： Dushek O

更新日期：2012-01-10 00:00:00

abstract：:The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D, STX11, or STXBP2 leads to a potentially fatal immune dysregulation,...

journal_title：Frontiers in immunology

authors： Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

更新日期：2018-03-15 00:00:00

abstract：:The 5-year survival rate of primary anorectal malignant melanoma is less than 20%. Optimal treatment of this condition remains controversial regarding locally disease, and whether any preferential survival benefit arises from either abdominoperineal resection or wide local excision remains unknown. The majority of pat...

journal_title：Frontiers in immunology

authors： Faure M,Rochigneux P,Olive D,Taix S,Brenot-Rossi I,Gilabert M

更新日期：2018-04-19 00:00:00

abstract：:[This corrects the article on p. 299 in vol. 6, PMID: 26150816.]. ...

journal_title：Frontiers in immunology

authors： Frontiers Production Office.

更新日期：2016-04-28 00:00:00

abstract：:Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages. Additionally, HIV-specific cytolytic CD4+ T cell responses in acute HIV infection are predictive of disease progression. CD57 expr...

journal_title：Frontiers in immunology

authors： Phetsouphanh C,Aldridge D,Marchi E,Munier CML,Meyerowitz J,Murray L,Van Vuuren C,Goedhals D,Fidler S,Kelleher A,Klenerman P,Frater J

更新日期：2019-08-08 00:00:00

abstract：:During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is one of the most im...

journal_title：Frontiers in immunology

authors： Rider P,Kaplanov I,Romzova M,Bernardis L,Braiman A,Voronov E,Apte RN

更新日期：2012-09-14 00:00:00

abstract：:Infiltration of immune cells into the tumor microenvironment (TME) can regulate growth and survival of neoplastic cells, impacting tumorigenesis and tumor progression. Correlations between the number of effector immune cells present in a tumor and clinical outcomes in many human tumors, including breast, have been wid...

journal_title：Frontiers in immunology

authors： Pachynski RK,Wang P,Salazar N,Zheng Y,Nease L,Rosalez J,Leong WI,Virdi G,Rennier K,Shin WJ,Nguyen V,Butcher EC,Zabel BA

更新日期：2019-05-08 00:00:00

abstract：:While developing adaptive immune responses, young infants are especially vulnerable to serious infections, including sepsis, meningitis, and pneumonia. Antimicrobial proteins and peptides (APPs) are key effectors that function as broad-spectrum anti-infectives. This review seeks to summarize the clinically relevant fu...

journal_title：Frontiers in immunology

authors： Battersby AJ,Khara J,Wright VJ,Levy O,Kampmann B

更新日期：2016-08-18 00:00:00

abstract：:Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities. In the present study, we examined the effects of dietary indoles, 3,3'-diindolylmethane (DIM) and indole...

journal_title：Frontiers in immunology

authors： Kim WH,Lillehoj HS,Min W

更新日期：2019-03-26 00:00:00

abstract：:In humans, loss-of-function mutation in the Signal Transducer and Activator of Transcription 3 (STAT3) gene is frequently associated with susceptibility to bacterial as well as fungal infections including aspergillosis, although its pathogenesis remains largely unknown. In the present study, we investigated the immune...

journal_title：Frontiers in immunology

authors： Danion F,Aimanianda V,Bayry J,Duréault A,Wong SSW,Bougnoux ME,Tcherakian C,Alyanakian MA,Guegan H,Puel A,Picard C,Lortholary O,Lanternier F,Latgé JP

更新日期：2020-01-28 00:00:00

abstract：:The dramatic female sex bias observed in human lupus is thought to be due, at least in part, to estrogens. Using mouse models, we have shown that estrogens, acting through estrogen receptor alpha (ERα) promote lupus development and contribute significantly to the female sex bias observed in this disease. C57Bl/6 (B6) ...

journal_title：Frontiers in immunology

authors： Graham JH,Yoachim SD,Gould KA

更新日期：2020-11-10 00:00:00

abstract：:Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity. This positive selection process, moreover, is critically contingent on the ligand-independent ...

journal_title：Frontiers in immunology

authors： Greaves SA,Peterson JN,Torres RM,Pelanda R

更新日期：2018-04-09 00:00:00

abstract：Introduction:High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activ...

journal_title：Frontiers in immunology

authors： Marín-Palma D,Castro GA,Cardona-Arias JA,Urcuqui-Inchima S,Hernandez JC

更新日期：2018-06-14 00:00:00

abstract：:Long lasting antibody responses and immunological memory are the desired outcomes of vaccination. In general, multiple vaccine doses result in enhanced immune responses, a notable exception being booster-induced hyporesponsiveness, which has been observed with polysaccharide and glycoconjugate vaccines. In this study,...

journal_title：Frontiers in immunology

authors： Mantile F,Capasso A,De Berardinis P,Prisco A

更新日期：2019-03-19 00:00:00

abstract：:Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks. RBC-specific alloantibodies may form in response to antigenic differences between RBC donors and recipients; these alloantib...

journal_title：Frontiers in immunology

authors： Richards AL,Sheldon K,Wu X,Gruber DR,Hudson KE

更新日期：2018-10-05 00:00:00

abstract：:A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airway surface liquid, a...

journal_title：Frontiers in immunology

authors： Cabrini G,Rimessi A,Borgatti M,Lampronti I,Finotti A,Pinton P,Gambari R

更新日期：2020-08-04 00:00:00

abstract：:High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T-cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks, and accumulated errors that inevitably occur in the course of li...

journal_title：Frontiers in immunology

authors： Mamedov IZ,Britanova OV,Zvyagin IV,Turchaninova MA,Bolotin DA,Putintseva EV,Lebedev YB,Chudakov DM

更新日期：2013-12-23 00:00:00

abstract：:Techniques with high sensitivity and specificity are required for an accurate diagnosis in low-transmission settings, where the conventional parasitological methods are insensitive. We determined the accuracy of an up-converting phosphor-lateral flow circulating anodic antigen (UCP-LF CAA) assay in urine and serum for...

journal_title：Frontiers in immunology

authors： Sousa MS,van Dam GJ,Pinheiro MCC,de Dood CJ,Peralta JM,Peralta RHS,Daher EF,Corstjens PLAM,Bezerra FSM

更新日期：2019-04-04 00:00:00

abstract：:Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the majority of the humora...

journal_title：Frontiers in immunology

authors： Yermanos AD,Dounas AK,Stadler T,Oxenius A,Reddy ST

更新日期：2018-10-02 00:00:00

abstract：:HIV-2 infection is characterized by low viremia and slow disease progression as compared to HIV-1 infection. Circulating CD14++CD16+ monocytes were found to accumulate and CD11c+ conventional dendritic cells (cDC) to be depleted in a Portuguese cohort of people living with HIV-2 (PLWHIV-2), compared to blood bank heal...

journal_title：Frontiers in immunology

authors： Iannetta M,Isnard S,Manuzak J,Guillerme JB,Notin M,Bailly K,Andrieu M,Amraoui S,Vimeux L,Figueiredo S,Charmeteau-de Muylder B,Vaton L,Hatton EX,Samri A,Autran B,Thiébaut R,Chaghil N,Glohi D,Charpentier C,Descamps D

更新日期：2020-08-13 00:00:00

abstract：:DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune thrombocytopenia. B cells in DiGeorge syndrome show impaired maturation, wit...

journal_title：Frontiers in immunology

authors： Klocperk A,Paračková Z,Bloomfield M,Rataj M,Pokorný J,Unger S,Warnatz K,Šedivá A

更新日期：2018-07-23 00:00:00

abstract：:Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

journal_title：Frontiers in immunology

authors： Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

更新日期：2017-03-24 00:00:00

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase. The syndrome encompasses combined immunodeficiency and various degrees of neurological a...

journal_title：Frontiers in immunology

authors： Mandola AB,Reid B,Sirror R,Brager R,Dent P,Chakroborty P,Bulman DE,Roifman CM

更新日期：2019-12-20 00:00:00

abstract：:Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities. No HDP has been reported in plants so fa...

journal_title：Frontiers in immunology

authors： Petre B

更新日期：2020-08-21 00:00:00

abstract：:Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers and a large number of clinical studies continue to explore immunotherapy alone and as part of combination therapies in patients with cancer. It is evident that c...

journal_title：Frontiers in immunology

authors： Holl EK,Frazier VN,Landa K,Beasley GM,Hwang ES,Nair SK

更新日期：2019-07-31 00:00:00

abstract：:Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a crucial role in maintaining epithelial barrier i...

journal_title：Frontiers in immunology

authors： Caër C,Wick MJ

更新日期：2020-03-18 00:00:00

abstract：:CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4+ T lymphocytes from healthy donors, mul...

journal_title：Frontiers in immunology

authors： Kunkl M,Mastrogiovanni M,Porciello N,Caristi S,Monteleone E,Arcieri S,Tuosto L

更新日期：2019-04-24 00:00:00

abstract：:Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4+Foxp3+ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to IL-2 to elaborate numerous suppressive mechanisms that limit immune-me...

journal_title：Frontiers in immunology

authors： Abo H,Flannigan KL,Geem D,Ngo VL,Harusato A,Denning TL

更新日期：2019-03-14 00:00:00

abstract：:B-1 cells constitute a unique subpopulation of lymphocytes residing mainly in body cavities like the peritoneal cavity (PerC) but are also found in spleen and bone marrow (BM). As innate-like B cells, they mediate first line immune defense through low-affinity natural IgM (nIgM) antibodies. PerC B-1 cells can egress t...

journal_title：Frontiers in immunology

authors： Bröker K,Figge J,Magnusen AF,Manz RA,Köhl J,Karsten CM

更新日期：2018-02-19 00:00:00