Abstract：
:Growing evidence has revealed that the initiation of various malignancies is closely associated with alternative splicing (AS) events in certain key oncogenes. However, in diffuse large B-cell lymphoma (DLBCL), there is still a great deal to learn about AS variants. In this study, 33,724 AS variant profiles were obtained from 16,278 genes in 48 DLBCL cases. A total of 10 AS variants were identified as overall survival (OS)- related events via multivariate Cox regression analysis. Notably, alternative donor (AD) sites in AS events in the low-risk group showed a significantly better outcome in DLBCL patients than in the high-risk group (P=0.0002). The area under the curve (AUC) of the receiver-operator characteristic curve (ROC) for ADs in DLBCL was 0.746. Furthermore, 66 related splicing factors were obtained to investigate their potential correlations with AS events. Factors SF1, HNRNPC, HNRNPD, and HNRNPH3 were significantly involved in different OS-related AS variants. Collectively, we constructed valuable prognostic predictors for DLBCL patients and mapped novel splicing networks for further investigation of the underlying mechanisms related to AS variants in DLBCLs.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Zhang R,Lin P,Yang X,He RQ,Wu HY,Dang YW,Gu YY,Peng ZG,Feng ZB,Chen Gsubject
Has Abstractpub_date
2018-08-15 00:00:00pages
2636-2647issue
8issn
1943-8141journal_volume
10pub_type
杂志文章abstract：:[This corrects the article on p. 1295 in vol. 10, PMID: 29887946.]. ...
journal_title：American journal of translational research
pub_type： 杂志文章,已发布勘误
doi：
更新日期：2018-07-15 00:00:00
abstract：BACKGROUND:Cyclosporin A (CsA) and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the transcription factor Nuclear Factor of Activated T cells (NFAT). NFAT compose a family of transcription factors that are turned on during ...
journal_title：American journal of translational research
pub_type： 杂志文章
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更新日期：2009-01-22 00:00:00
abstract：:Interleukin-21 (IL-21) and T helper 17 (Th17) cells are known to be involved in the pathogenesis of psoriasis, but little is known about their relationship in psoriasis. Herein, we investigated whether IL-21 could regulate Th17 cell induction in patients with psoriasis vulgaris. 32 patients with psoriasis vulgaris and...
journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
pub_type： 杂志文章
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journal_title：American journal of translational research
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journal_title：American journal of translational research
pub_type： 杂志文章
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
pub_type： 杂志文章
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更新日期：2017-11-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-10-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2011-02-01 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
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更新日期：2011-05-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2015-06-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-08-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2019-02-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2010-10-30 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2009-07-15 00:00:00
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journal_title：American journal of translational research
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doi：
更新日期：2016-05-15 00:00:00
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journal_title：American journal of translational research
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doi：
更新日期：2016-11-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-09-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2017-09-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
doi：
更新日期：2016-05-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2017-01-15 00:00:00
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journal_title：American journal of translational research
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doi：
更新日期：2009-01-01 00:00:00
