Abstract：
:Activated protein C (APC) is a vitamin-K dependent natural anticoagulant protein. With its function in blood clotting reaction, APC can reduce the risk of venous thrombosis to prevent ischemic disease. A number of in vivo and in vitro studies over the past few decades have revealed that APC also exerted cytoprotective effects to decrease the mortality caused by endotoxin, sepsis, and brain ischemic stroke. The direct cytoprotective role requires APC binding to the endothelial protein C receptor (EPCR) and activating protease activated receptor-1 (PAR-1). It is now believed that the beneficial characters of APC are partially independent from its anticoagulant activity, though more studies need to be done to demonstrate the exact molecular mechanism. In this review, we have linked the cytoprotective effects of APC including the anti-inflammatory and anti-apoptosis activities to myocardial ischemic injury caused by cardiac ischemia reperfusion. Specifically, we have tried to combine the potential signaling pathways initiated by APC with the well-known adaptive signaling such as AMP-activated protein kinase (AMPK), PI3K/Akt and ERK/MAPK pathways that contribute to the cardioprotection against myocardial ischemia injury. We speculate that APC protects against cardiac ischemia injury via triggering crucial cardioprotective signaling pathways, and these effects are mostly associated with its cytoprotective activity but independent on its anticoagulant activity.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Wang J,Li Jsubject
Has Abstractpub_date
2009-07-15 00:00:00pages
381-92issue
4issn
1943-8141journal_volume
1pub_type
杂志文章abstract：BACKGROUND:There is conflicting evidence regarding the prognostic value of cytotoxic T cell infiltration in breast cancer. The aims of this study were to detect the expression levels and localization of FoxP3 and CD8 in invasive ductal carcinoma of the breast and to investigate the correlations among FoxP3+ regulatory ...
journal_title：American journal of translational research
pub_type： 杂志文章
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更新日期：2019-08-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2016-07-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2016-10-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2018-06-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-06-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2016-10-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2018-12-15 00:00:00
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journal_title：American journal of translational research
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journal_title：American journal of translational research
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更新日期：2016-11-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：American journal of translational research
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更新日期：2015-12-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2015-02-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2016-08-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-04-15 00:00:00
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journal_title：American journal of translational research
pub_type： 杂志文章,评审
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更新日期：2019-09-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2019-09-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2017-11-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2016-10-15 00:00:00
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更新日期：2020-12-15 00:00:00
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更新日期：2016-10-15 00:00:00
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更新日期：2019-07-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2020-07-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2020-06-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2018-01-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2018-04-15 00:00:00
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journal_title：American journal of translational research
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更新日期：2017-11-15 00:00:00
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journal_title：American journal of translational research
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doi：
更新日期：2020-09-15 00:00:00
