Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms.

abstract：:Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose o...

journal_title：Frontiers in neuroscience

authors： Macefield VG

更新日期：2011-12-06 00:00:00

abstract：:Recent studies have shown that synaptic unreliability is a robust and sufficient mechanism for inducing the stochasticity observed in cortex. Here, we introduce Synaptic Sampling Machines (S2Ms), a class of neural network models that uses synaptic stochasticity as a means to Monte Carlo sampling and unsupervised learn...

journal_title：Frontiers in neuroscience

authors： Neftci EO,Pedroni BU,Joshi S,Al-Shedivat M,Cauwenberghs G

更新日期：2016-06-29 00:00:00

abstract：:The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in ...

journal_title：Frontiers in neuroscience

authors： Fernández E,Rajan N,Bagni C

更新日期：2013-10-24 00:00:00

abstract：:There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients wi...

journal_title：Frontiers in neuroscience

authors： Edvall NK,Gunan E,Genitsaridi E,Lazar A,Mehraei G,Billing M,Tullberg M,Bulla J,Whitton J,Canlon B,Hall DA,Cederroth CR

更新日期：2019-08-22 00:00:00

abstract：:Learning a new language requires the use of extensive neural networks and can represent a powerful tool to reorganize brain neuroplasticity. In this study, we analyze how a 4 months long second language learning program (16, 2 h sessions) can lead to functional changes in the brain of healthy elderly individuals. A la...

journal_title：Frontiers in neuroscience

authors： Bubbico G,Chiacchiaretta P,Parenti M,di Marco M,Panara V,Sepede G,Ferretti A,Perrucci MG

更新日期：2019-05-15 00:00:00

abstract：:Stimulation of the pineal gland via its sympathetic innervation pathway results in the production of N-acetylserotonin and melatonin. Melatonin has many therapeutic roles and is heavily implicated in the regulation of the sleep-wake cycle. In addition, N-acetylserotonin has recently been reported to promote neurogenes...

journal_title：Frontiers in neuroscience

authors： Lumsden SC,Clarkson AN,Cakmak YO

更新日期：2020-04-02 00:00:00

abstract：:Regaining communication abilities in patients who are unable to speak or move is one of the main goals in decoding brain waves for brain-computer interface (BCI) control. Many BCI approaches designed for communication rely on attention to visual stimuli, commonly applying an oddball paradigm, and require both eye move...

journal_title：Frontiers in neuroscience

authors： Reichert C,Tellez Ceja IF,Sweeney-Reed CM,Heinze HJ,Hinrichs H,Dürschmid S

更新日期：2020-12-01 00:00:00

abstract：:Object-location memory (OLM) is known to decline with normal aging, a process accelerated in pathological conditions like mild cognitive impairment (MCI). In order to maintain cognitive health and to delay the transition from healthy to pathological conditions, novel strategies are being explored. Tentative evidence s...

journal_title：Frontiers in neuroscience

authors： Külzow N,Cavalcanti de Sousa AV,Cesarz M,Hanke JM,Günsberg A,Harder S,Koblitz S,Grittner U,Flöel A

更新日期：2018-01-10 00:00:00

abstract：:Social memory, including the ability to recognize faces and voices, is essential for social relationships. It has a large heritable component, but the knowledge about the contributing genes is sparse. The genetic variation underlying inter-individual differences in social memory was investigated in an exploratory samp...

journal_title：Frontiers in neuroscience

authors： Henningsson S,Zettergren A,Hovey D,Jonsson L,Svärd J,Cortes DS,Melke J,Ebner NC,Laukka P,Fischer H,Westberg L

更新日期：2015-10-21 00:00:00

abstract：:Although the interplay between endogenous opioids and dopamine (DA) in the basal ganglia (BG) is known to underlie diverse motor functions, few studies exist on their role in modulating speech and vocalization. Vocal impairment is a common symptom of Parkinson's disease (PD), wherein DA depletion affects striosomes ri...

journal_title：Frontiers in neuroscience

authors： Kumar S,Mohapatra AN,Sharma HP,Singh UA,Kambi NA,Velpandian T,Rajan R,Iyengar S

更新日期：2019-07-03 00:00:00

abstract：:Cryptotanshinone (CTN), a monomer compound extracted from the dried roots and rhizomes of Salvia miltiorrhiza Bge, has a variety of pharmacological effects. However, little research has been done on the mechanism of CTN in attenuating neuroinflammation. The present study aimed to investigate whether CTN can ameliorate...

journal_title：Frontiers in neuroscience

authors： Zhou Y,Wang X,Ying W,Wu D,Zhong P

更新日期：2019-08-21 00:00:00

abstract：:[This corrects the article on p. 560 in vol. 10, PMID: 28008304.]. ...

journal_title：Frontiers in neuroscience

authors： Muñoz-Moreno E,Fischi-Gomez E,Batalle D,Borradori-Tolsa C,Eixarch E,Thiran JP,Gratacós E,Hüppi PS

更新日期：2017-05-09 00:00:00

abstract：:[This corrects the article on p. 589 in vol. 10, PMID: 28066172.]. ...

journal_title：Frontiers in neuroscience

authors： Wang H,Li X,Shan L,Zhu J,Chen R,Li Y,Yuan W,Yang L,Huang J

更新日期：2017-02-13 00:00:00

abstract：Background:The peak width of skeletonized mean diffusivity (PSMD) has been proposed as a fully automated imaging marker of relevance to cerebral small vessel disease (SVD). We assessed PSMD in relation to conventional SVD markers, global measures of neurodegeneration, and cognition. Methods:145 participants underwent ...

journal_title：Frontiers in neuroscience

authors： Low A,Mak E,Stefaniak JD,Malpetti M,Nicastro N,Savulich G,Chouliaras L,Markus HS,Rowe JB,O'Brien JT

更新日期：2020-03-19 00:00:00

abstract：:Neurodegenerative diseases are a challenge for drug discovery, as the biological mechanisms are complex and poorly understood, with a paucity of models that faithfully recapitulate these disorders. Recent advances in stem cell technology have provided a paradigm shift, providing researchers with tools to generate huma...

journal_title：Frontiers in neuroscience

authors： Han C,Chaineau M,Chen CX,Beitel LK,Durcan TM

更新日期：2018-02-06 00:00:00

abstract：:Magnetic resonance imaging (MRI) studies have highlighted subcortical, cortical, and structural connectivity abnormalities associated with attention-deficit/hyperactivity disorder (ADHD). Gyrification investigations of the cortex have been inconsistent and largely negative, potentially due to a lack of sensitivity of ...

journal_title：Frontiers in neuroscience

authors： Forde NJ,Ronan L,Zwiers MP,Alexander-Bloch AF,Faraone SV,Oosterlaan J,Heslenfeld DJ,Hartman CA,Buitelaar JK,Hoekstra PJ

更新日期：2017-04-20 00:00:00

abstract：:Recent intriguing evidence suggests that metabolites of amyloid precursor protein (APP), mutated in familial forms of Alzheimer's disease (AD), play critical roles in developmental and postnatal neurogenesis. Of note is soluble APPα (sAPPα) that regulates neural progenitor cell proliferation. The APP family encompasse...

journal_title：Frontiers in neuroscience

authors： Lazarov O,Demars MP

更新日期：2012-06-04 00:00:00

abstract：:The combination of electromyography (EMG) and transcranial magnetic stimulation (TMS) offers a powerful non-invasive approach for investigating corticospinal excitability in both humans and animals. Acquiring and analyzing the data produced with this combination of tools requires overcoming multiple technical hurdles....

journal_title：Frontiers in neuroscience

authors： Jackson N,Greenhouse I

更新日期：2019-09-13 00:00:00

abstract：:Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As mental disorders are chronic diseases, these drugs are often used over a life-time. However, APDs can cause serious glucometabolic side-effects including type 2 diabetes and hyperglycaemic emergency, leading to medication non-comp...

journal_title：Frontiers in neuroscience

authors： Chen J,Huang XF,Shao R,Chen C,Deng C

更新日期：2017-11-21 00:00:00

abstract：:For brain-computer interfaces (BCIs) that utilize visual cues to direct the user, the neural signals extracted by the computer are representative of ongoing processes, visual evoked responses, and voluntary modulation. We proposed to use three brain signatures for predicting success on a single trial of a BCI task. Th...

journal_title：Frontiers in neuroscience

authors： Geronimo A,Kamrunnahar M,Schiff SJ

更新日期：2016-04-26 00:00:00

abstract：:Social conflict is a major source of stress in humans. Animals also experience social conflicts and cope with them by stress responses that facilitate arousal and activate sympathetic and neuroendocrine systems. The effect of acute social defeat (SoD) stress on the sleep/wake behavior of mice has been reported in seve...

journal_title：Frontiers in neuroscience

authors： Fujii S,Kaushik MK,Zhou X,Korkutata M,Lazarus M

更新日期：2019-04-03 00:00:00

abstract：:Identifying the multiple contributors to the audiometric loss of a hearing impaired (HI) listener at a particular frequency is becoming gradually more useful as new treatments are developed. Here, we infer the contribution of inner (IHC) and outer hair cell (OHC) dysfunction to the total audiometric loss in a sample o...

journal_title：Frontiers in neuroscience

authors： Johannesen PT,Pérez-González P,Lopez-Poveda EA

更新日期：2014-07-23 00:00:00

abstract：:SpiNNaker is a digital neuromorphic architecture, designed specifically for the low power simulation of large-scale spiking neural networks at speeds close to biological real-time. Unlike other neuromorphic systems, SpiNNaker allows users to develop their own neuron and synapse models as well as specify arbitrary conn...

journal_title：Frontiers in neuroscience

authors： Mikaitis M,Pineda García G,Knight JC,Furber SB

更新日期：2018-02-27 00:00:00

abstract：:Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

journal_title：Frontiers in neuroscience

authors： Ekelem A,Goldfarb M

更新日期：2018-06-01 00:00:00

abstract：:HIGHLIGHTS Many AD target combinations are being explored for multi-target drug design.New databases and models increase the potential of computational drug designLiraglutide and other antidiabetics are strong candidates for repurposing to AD.Donecopride a dual 5-HT/AChE inhibitor shows promise in pre-clinical studies...

journal_title：Frontiers in neuroscience

authors： Hughes RE,Nikolic K,Ramsay RR

更新日期：2016-04-25 00:00:00

abstract：:Retinal and cortical mechanisms provide for persistence of visual information across intervals of many hundreds of milliseconds, which supports the integration of partial shape cues. The present experiments displayed unknown shapes in a match recognition task, wherein a target shape was quickly followed by a compariso...

journal_title：Frontiers in neuroscience

authors： Geoly A,Greene E

更新日期：2019-03-13 00:00:00

abstract：:Traditionally, the visual motion area (MT) is considered as a brain region specialized for visual motion perception. However, accumulating evidence showed that MT is also related to various functions, suggesting that it is a complex functional area and different functional subregions might exist in this area. To delin...

journal_title：Frontiers in neuroscience

authors： Gao J,Zeng M,Dai X,Yang X,Yu H,Chen K,Hu Q,Xu J,Cheng B,Wang J

更新日期：2020-05-27 00:00:00

abstract：:The linearity and stationarity of fMRI time series need to be understood due to their important roles in the choice of approach for brain network analysis. In this paper, we investigated the stationarity and linearity of resting-state fMRI (rs-fMRI) time-series data from the Midnight Scan Club datasets. The degree of ...

journal_title：Frontiers in neuroscience

authors： Guan S,Jiang R,Bian H,Yuan J,Xu P,Meng C,Biswal B

更新日期：2020-06-11 00:00:00

abstract：:The resting activity of the brain can be described by so-called intrinsic connectivity networks (ICNs), which consist of spatially and temporally distributed, but functionally connected, nodes. The coordinated activity of the resting state can be explored via magnetoencephalography (MEG) by studying frequency-dependen...

journal_title：Frontiers in neuroscience

authors： Dimitriadis SI,Routley B,Linden DE,Singh KD

更新日期：2018-08-03 00:00:00

abstract：:Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective therapy for obsessive compulsive disorder (OCD) and is currently under investigation as a treatment for eating disorders. DBS of this area is associated with altered food intake and pharmacological treatment of OCD is associated with the risk ...

journal_title：Frontiers in neuroscience

authors： Diepenbroek C,van der Plasse G,Eggels L,Rijnsburger M,Feenstra MG,Kalsbeek A,Denys D,Fliers E,Serlie MJ,la Fleur SE

更新日期：2013-12-10 00:00:00