Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway.

Abstract:

:Cryptotanshinone (CTN), a monomer compound extracted from the dried roots and rhizomes of Salvia miltiorrhiza Bge, has a variety of pharmacological effects. However, little research has been done on the mechanism of CTN in attenuating neuroinflammation. The present study aimed to investigate whether CTN can ameliorate neuroinflammation induced by lipopolysaccharide (LPS) through the Nrf2/heme-oxygenase 1 (HO-1) signaling pathway in BV-2 microglial cells. We found that CTN attenuated the upregulated expression of inducible nitric oxide synthase, cyclooxygenase 2, NOD-like receptor pyrin domains-3, and nitric oxide induced by LPS in microglial cells. In addition, it curtailed the increased release of pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α in LPS-activated microglial cells. Furthermore, CTN significantly increased the levels of NF-κB, Nrf2, HO-1, and Akt proteins. We demonstrated that the anti-inflammatory action of CTN in BV-2 microglial cells was partially through the activation of the Nrf2/HO-1 pathway, which was regulated by the PI3K/Akt signaling pathway. Taken together, our results indicated that CTN downregulated the production and release of proinflammatory mediators in BV-2 microglial cells through activating the Nrf2/HO-1 pathway and subsequently protected neurons from inflammatory injury.

journal_name

Front Neurosci

authors

Zhou Y,Wang X,Ying W,Wu D,Zhong P

doi

10.3389/fnins.2019.00852

subject

Has Abstract

pub_date

2019-08-21 00:00:00

pages

852

eissn

1662-4548

issn

1662-453X

journal_volume

13

pub_type

杂志文章
  • Anatomical pathways for auditory memory II: information from rostral superior temporal gyrus to dorsolateral temporal pole and medial temporal cortex.

    abstract::Auditory recognition memory in non-human primates differs from recognition memory in other sensory systems. Monkeys learn the rule for visual and tactile delayed matching-to-sample within a few sessions, and then show one-trial recognition memory lasting 10-20 min. In contrast, monkeys require hundreds of sessions to ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00158

    authors: Muñoz-López M,Insausti R,Mohedano-Moriano A,Mishkin M,Saunders RC

    更新日期:2015-05-18 00:00:00

  • Double Flash Illusions: Current Findings and Future Directions.

    abstract::Twenty years ago, the first report on the sound-induced double flash illusion, a visual illusion induced by sound, was published. In this paradigm, participants are presented with different numbers of auditory and visual stimuli. In case of an incongruent number of auditory and visual stimuli, the influence of auditor...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00298

    authors: Keil J

    更新日期:2020-04-03 00:00:00

  • Spatiotemporal Processing of Bimodal Odor Lateralization in the Brain Using Electroencephalography Microstates and Source Localization.

    abstract::The neuronal cascade related to the perception of either purely olfactory or trigeminal airborne chemicals has been investigated using electroencephalography (EEG) microstate analyses and source localization. However, most airborne chemicals are bimodal in nature, encompassing both properties. Moreover, there is an on...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.620723

    authors: Hucke CI,Heinen RM,Pacharra M,Wascher E,van Thriel C

    更新日期:2021-01-13 00:00:00

  • Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation.

    abstract::Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility, secretion and visceral sensation. Abnormal regulation of 5-HT occurs in gastrointestinal disorders and Inflammatory Bowel Diseases (IBD...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2016.00564

    authors: Linan-Rico A,Ochoa-Cortes F,Beyder A,Soghomonyan S,Zuleta-Alarcon A,Coppola V,Christofi FL

    更新日期:2016-12-19 00:00:00

  • Menstrual cycle influence on cognitive function and emotion processing-from a reproductive perspective.

    abstract::The menstrual cycle has attracted research interest ever since the 1930s. For many researchers the menstrual cycle is an excellent model of ovarian steroid influence on emotion, behavior, and cognition. Over the past years methodological improvements in menstrual cycle studies have been noted, and this review summariz...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2014.00380

    authors: Sundström Poromaa I,Gingnell M

    更新日期:2014-11-24 00:00:00

  • GRP78 Level Is Altered in the Brain, but Not in Plasma or Cerebrospinal Fluid in Parkinson's Disease Patients.

    abstract::Accumulation of misfolded proteins results in cellular stress, and is detected by specific sensors in the endoplasmic reticulum, collectively known as the unfolded protein response (UPR). It has been prominently proposed that the UPR is involved in the pathophysiology of Parkinson's disease (PD). In the present study,...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00697

    authors: Baek JH,Mamula D,Tingstam B,Pereira M,He Y,Svenningsson P

    更新日期:2019-07-05 00:00:00

  • Modulation of Illusory Auditory Perception by Transcranial Electrical Stimulation.

    abstract::The aim of the present study was to test whether transcranial electrical stimulation can modulate illusory perception in the auditory domain. In two separate experiments we applied transcranial Direct Current Stimulation (anodal/cathodal tDCS, 2 mA; N = 60) and high-frequency transcranial Random Noise Stimulation (hf-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00351

    authors: Prete G,D'Anselmo A,Tommasi L,Brancucci A

    更新日期:2017-06-20 00:00:00

  • Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology.

    abstract::Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme genetic heterogene...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00477

    authors: Barnard RA,Pomaville MB,O'Roak BJ

    更新日期:2015-12-17 00:00:00

  • Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit.

    abstract::Functional magnetic resonance imaging (fMRI) is a powerful noninvasive tool for studying spontaneous resting state functional connectivity (RSFC) in laboratory animals. Brain function can be significantly affected by generally used anesthetics, however, rendering the need for awake imaging. Only a few different awake ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00548

    authors: Stenroos P,Paasonen J,Salo RA,Jokivarsi K,Shatillo A,Tanila H,Gröhn O

    更新日期:2018-08-20 00:00:00

  • The speed-accuracy tradeoff: history, physiology, methodology, and behavior.

    abstract::There are few behavioral effects as ubiquitous as the speed-accuracy tradeoff (SAT). From insects to rodents to primates, the tendency for decision speed to covary with decision accuracy seems an inescapable property of choice behavior. Recently, the SAT has received renewed interest, as neuroscience approaches begin ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2014.00150

    authors: Heitz RP

    更新日期:2014-06-11 00:00:00

  • Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics.

    abstract::Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disruption, we developed ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00816

    authors: Oliva MK,Pérez-Moreno JJ,O'Shaughnessy J,Wardill TJ,O'Kane CJ

    更新日期:2020-08-10 00:00:00

  • A Benchmark Dataset for RSVP-Based Brain-Computer Interfaces.

    abstract::This paper reports on a benchmark dataset acquired with a brain-computer interface (BCI) system based on the rapid serial visual presentation (RSVP) paradigm. The dataset consists of 64-channel electroencephalogram (EEG) data from 64 healthy subjects (sub1,…, sub64) while they performed a target image detection task. ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.568000

    authors: Zhang S,Wang Y,Zhang L,Gao X

    更新日期:2020-10-02 00:00:00

  • Simultaneous Optogenetics and Cellular Resolution Calcium Imaging During Active Behavior Using a Miniaturized Microscope.

    abstract::The ability to precisely monitor and manipulate neural circuits is essential to understand the brain. Advancements over the last decade in optical techniques such as calcium imaging and optogenetics have empowered researchers to gain insight into brain function by systematically manipulating or monitoring defined neur...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00496

    authors: Stamatakis AM,Schachter MJ,Gulati S,Zitelli KT,Malanowski S,Tajik A,Fritz C,Trulson M,Otte SL

    更新日期:2018-07-24 00:00:00

  • Long-Range GABAergic Connections Distributed throughout the Neocortex and their Possible Function.

    abstract::Features and functions of long-range GABAergic projection neurons in the developing cerebral cortex have been reported previously, although until now their significance in the adult cerebral cortex has remained uncertain. The septo-hippocampal circuit is one exception - in this system, long-range mature GABAergic proj...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2010.00202

    authors: Tamamaki N,Tomioka R

    更新日期:2010-12-08 00:00:00

  • A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography.

    abstract:Introduction:Optical coherence tomography angiography (OCT-A) is a novel diagnostic tool with increasing applications in ophthalmology clinics that provides non-invasive high-resolution imaging of the retinal microvasculature. Our aim is to report in detail an experimental protocol for analyzing both vasodilatory and v...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00566

    authors: Sousa DC,Leal I,Moreira S,do Vale S,Silva-Herdade AS,Aguiar P,Dionísio P,Abegão Pinto L,Castanho MARB,Marques-Neves C

    更新日期:2019-06-12 00:00:00

  • Cellular and molecular cues of glucose sensing in the rat olfactory bulb.

    abstract::In the brain, glucose homeostasis of extracellular fluid is crucial to the point that systems specifically dedicated to glucose sensing are found in areas involved in energy regulation and feeding behavior. Olfaction is a major sensory modality regulating food consumption. Nutritional status in turn modulates olfactor...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00333

    authors: Al Koborssy D,Palouzier-Paulignan B,Salem R,Thevenet M,Romestaing C,Julliard AK

    更新日期:2014-10-29 00:00:00

  • White Matter Tract Segmentation as Multiple Linear Assignment Problems.

    abstract::Diffusion magnetic resonance imaging (dMRI) allows to reconstruct the main pathways of axons within the white matter of the brain as a set of polylines, called streamlines. The set of streamlines of the whole brain is called the tractogram. Organizing tractograms into anatomically meaningful structures, called tracts,...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00754

    authors: Sharmin N,Olivetti E,Avesani P

    更新日期:2018-02-06 00:00:00

  • Online tracking of the contents of conscious perception using real-time fMRI.

    abstract::Perception is an active process that interprets and structures the stimulus input based on assumptions about its possible causes. We use real-time functional magnetic resonance imaging (rtfMRI) to investigate a particularly powerful demonstration of dynamic object integration in which the same physical stimulus interm...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00116

    authors: Reichert C,Fendrich R,Bernarding J,Tempelmann C,Hinrichs H,Rieger JW

    更新日期:2014-05-23 00:00:00

  • Memory-Efficient Synaptic Connectivity for Spike-Timing- Dependent Plasticity.

    abstract::Spike-Timing-Dependent Plasticity (STDP) is a bio-inspired local incremental weight update rule commonly used for online learning in spike-based neuromorphic systems. In STDP, the intensity of long-term potentiation and depression in synaptic efficacy (weight) between neurons is expressed as a function of the relative...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00357

    authors: Pedroni BU,Joshi S,Deiss SR,Sheik S,Detorakis G,Paul S,Augustine C,Neftci EO,Cauwenberghs G

    更新日期:2019-04-24 00:00:00

  • Auditory Perceptual Learning for Speech Perception Can be Enhanced by Audiovisual Training.

    abstract::Speech perception under audiovisual (AV) conditions is well known to confer benefits to perception such as increased speed and accuracy. Here, we investigated how AV training might benefit or impede auditory perceptual learning of speech degraded by vocoding. In Experiments 1 and 3, participants learned paired associa...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00034

    authors: Bernstein LE,Auer ET Jr,Eberhardt SP,Jiang J

    更新日期:2013-03-18 00:00:00

  • Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats.

    abstract::Alzheimer's disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell death was induced by in...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00146

    authors: Dobryakova YV,Volobueva MN,Manolova AO,Medvedeva TM,Kvichansky AA,Gulyaeva NV,Markevich VA,Stepanichev MY,Bolshakov AP

    更新日期:2019-03-12 00:00:00

  • Pyff - a pythonic framework for feedback applications and stimulus presentation in neuroscience.

    abstract::This paper introduces Pyff, the Pythonic feedback framework for feedback applications and stimulus presentation. Pyff provides a platform-independent framework that allows users to develop and run neuroscientific experiments in the programming language Python. Existing solutions have mostly been implemented in C++, wh...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2010.00179

    authors: Venthur B,Scholler S,Williamson J,Dähne S,Treder MS,Kramarek MT,Müller KR,Blankertz B

    更新日期:2010-12-02 00:00:00

  • Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion.

    abstract::Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural network. Both intrapancreatic ganglia and extrapancreatic nerves have ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00021

    authors: Li W,Yu G,Liu Y,Sha L

    更新日期:2019-02-20 00:00:00

  • A Framework for Adapting Deep Brain Stimulation Using Parkinsonian State Estimates.

    abstract::The mechanisms underlying the beneficial effects of deep brain stimulation (DBS) for Parkinson's disease (PD) remain poorly understood and are still under debate. This has hindered the development of adaptive DBS (aDBS). For further progress in aDBS, more insight into the dynamics of PD is needed, which can be obtaine...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00499

    authors: Mohammed A,Bayford R,Demosthenous A

    更新日期:2020-05-19 00:00:00

  • Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals.

    abstract::In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in the adult zebrafish and mouse telencephalon share many similarities at the cellular and molecular level. However, upon injury durin...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.568930

    authors: Diotel N,Lübke L,Strähle U,Rastegar S

    更新日期:2020-09-23 00:00:00

  • Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes.

    abstract::Defects in the endoplasmic reticulum (ER) membrane shaping and interaction with other organelles seem to be a crucial mechanism underlying Hereditary Spastic Paraplegia (HSP) neurodegeneration. REEP1, a transmembrane protein belonging to TB2/HVA22 family, is implicated in SPG31, an autosomal dominant form of HSP, and ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01202

    authors: Napoli B,Gumeni S,Forgiarini A,Fantin M,De Filippis C,Panzeri E,Vantaggiato C,Orso G

    更新日期:2019-11-19 00:00:00

  • Decoding continuous variables from neuroimaging data: basic and clinical applications.

    abstract::The application of statistical machine learning techniques to neuroimaging data has allowed researchers to decode the cognitive and disease states of participants. The majority of studies using these techniques have focused on pattern classification to decode the type of object a participant is viewing, the type of co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00075

    authors: Cohen JR,Asarnow RF,Sabb FW,Bilder RM,Bookheimer SY,Knowlton BJ,Poldrack RA

    更新日期:2011-06-15 00:00:00

  • Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design.

    abstract::Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great potential for combating bacterial resistance. AMPs can be both bacteriostatic and bactericidal, induce rapid killing and display a lower propensity to develop resistance than do conventional antibiotics. Despite significant progres...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00073

    authors: Li J,Koh JJ,Liu S,Lakshminarayanan R,Verma CS,Beuerman RW

    更新日期:2017-02-14 00:00:00

  • Molecular and neural bases underlying roles of BDNF in the control of body weight.

    abstract::Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal development and synaptic plasticity that is fundamental to neural circuit formation and cognition. It is also involved in the control of appetite and body weight, with mutations in the genes for BDNF and its receptor, TrkB, resulting in remarka...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00037

    authors: Vanevski F,Xu B

    更新日期:2013-03-21 00:00:00

  • Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System.

    abstract::Amyloid fibrils are physiologically insoluble biophysically specific β-sheet rich structures formed by the aggregation of misfolded proteins. In vivo tissue amyloid formation is responsible for more than 30 different disease states in humans and other mammals. One of these, Alzheimer's disease (AD), is the most common...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00119

    authors: Buxbaum JN,Johansson J

    更新日期:2017-03-15 00:00:00