Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders.

abstract：:Retinal and cortical mechanisms provide for persistence of visual information across intervals of many hundreds of milliseconds, which supports the integration of partial shape cues. The present experiments displayed unknown shapes in a match recognition task, wherein a target shape was quickly followed by a compariso...

journal_title：Frontiers in neuroscience

authors： Geoly A,Greene E

更新日期：2019-03-13 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public health concern that affects 69 million individuals each year worldwide. Neuropsychologists report that up to 40% of individuals undergoing evaluations for TBI may be malingering neurocognitive deficits for a compensatory reward. The memory recognition test of malingering ...

journal_title：Frontiers in neuroscience

authors： Neal J,Strothkamp S,Bedingar E,Cordero P,Wagner B,Vagnini V,Jiang Y

更新日期：2019-09-25 00:00:00

abstract：:Background: Stroke is the second leading cause of death worldwide. Angiogenesis facilitates the formation of microvascular networks and promotes recovery after stroke. The Shh/Gli signaling pathway is implicated in angiogenesis and cerebral ischemia-reperfusion (I/R) injury. This study aimed at investigating the influ...

journal_title：Frontiers in neuroscience

authors： Peng L,Yin J,Ge M,Wang S,Xie L,Li Y,Si JQ,Ma K

更新日期：2019-04-09 00:00:00

abstract：:Decoding laminar information across deep brain structures and cortical regions is necessary in order to understand the neuronal ensembles that represent cognition and memory. Large animal models are essential for translational research due to their gyrencephalic neuroanatomy and significant white matter composition. A...

journal_title：Frontiers in neuroscience

authors： Ulyanova AV,Cottone C,Adam CD,Gagnon KG,Cullen DK,Holtzman T,Jamieson BG,Koch PF,Chen HI,Johnson VE,Wolf JA

更新日期：2019-04-26 00:00:00

abstract：:The oxytocin receptor (OXTR) has been observed in the periphery of neonatal C57BL/6J mice (Mus musculus), including facial regions and the anogenital area. In those studies, ligand specificity was confirmed with a congenital OXTR knockout mouse as well as competitive binding techniques. The aim of this study was to de...

journal_title：Frontiers in neuroscience

authors： Greenwood MA,Hammock EAD

更新日期：2019-05-24 00:00:00

abstract：:[This retracts the article on p. 303 in vol. 10, PMID: 27445673.]. ...

journal_title：Frontiers in neuroscience

authors： Frontiers Editorial Office.

更新日期：2016-10-07 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnins.2019.00117.]. ...

journal_title：Frontiers in neuroscience

authors： Zuo XN,Biswal BB,Poldrack RA

更新日期：2019-04-16 00:00:00

abstract：:Transsynaptic connections enabling cell-cell adhesion and cellular communication are a vital part of synapse formation, maintenance and function. A recently discovered interaction between the Adhesion GPCRs Latrophilins and the type II single transmembrane proteins Teneurins at mammalian synapses is vital for synapse ...

journal_title：Frontiers in neuroscience

authors： Schöneberg T,Prömel S

更新日期：2019-03-12 00:00:00

abstract：:Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose o...

journal_title：Frontiers in neuroscience

authors： Macefield VG

更新日期：2011-12-06 00:00:00

abstract：:Recent studies have identified the Drosophila brain circuits involved in the sleep/wake switch and have pointed to the modulation of neuronal excitability as one of the underlying mechanisms triggering sleep need. In this study we aimed to explore the link between the homeostatic regulation of neuronal excitability an...

journal_title：Frontiers in neuroscience

authors： De Jesús-Olmo LA,Rodríguez N,Francia M,Alemán-Rios J,Pacheco-Agosto CJ,Ortega-Torres J,Nieves R,Fuenzalida-Uribe N,Ghezzi A,Agosto JL

更新日期：2020-04-17 00:00:00

abstract：:Overview- One hundred and ten years since its first description Alzheimer's disease (AD) still retains its prominent status: (i) as the industrialized world's number one cause of age-related intellectual impairment and cognitive decline; (ii) as this country's most rapidly expanding socioeconomic and healthcare concer...

journal_title：Frontiers in neuroscience

authors： Zhao Y,Alexandrov PN,Lukiw WJ

更新日期：2016-02-25 00:00:00

abstract：:Recent intriguing evidence suggests that metabolites of amyloid precursor protein (APP), mutated in familial forms of Alzheimer's disease (AD), play critical roles in developmental and postnatal neurogenesis. Of note is soluble APPα (sAPPα) that regulates neural progenitor cell proliferation. The APP family encompasse...

journal_title：Frontiers in neuroscience

authors： Lazarov O,Demars MP

更新日期：2012-06-04 00:00:00

abstract：:Previous studies have demonstrated that total flavonoid extracts from Caragana sinica (TFC) exert multiple therapeutic effects, promote blood flow, and exhibit anti-inflammatory and antioxidant properties. The present study aimed to investigate whether TFC promotes angiogenesis and exerts neuroprotective effects in a ...

journal_title：Frontiers in neuroscience

authors： He Q,Li S,Li L,Hu F,Weng N,Fan X,Kuang S

更新日期：2018-09-12 00:00:00

abstract：:Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer's disease. While they are individually rarer, a range of other disorders, the tauopathies (including Pick's disease, progressive supranuclear palsy, corticoba...

journal_title：Frontiers in neuroscience

authors： Novak P,Kontsekova E,Zilka N,Novak M

更新日期：2018-11-02 00:00:00

abstract：:Environmental sounds form part of our daily life. With the advancement of deep learning models and the abundance of training data, the performance of automatic sound classification (ASC) systems has improved significantly in recent years. However, the high computational cost, hence high power consumption, remains a ma...

journal_title：Frontiers in neuroscience

authors： Wu J,Chua Y,Zhang M,Li H,Tan KC

更新日期：2018-11-19 00:00:00

abstract：:We hypothesized that assessment of brain connectivity may shed light on the underpinnings of ocular hypertension (OHT), characterized by raised intraocular pressure (IOP) and no typical glaucomatous findings. OHT carries a risk for future glaucoma development, thus representing a model of presymptomatic condition. In ...

journal_title：Frontiers in neuroscience

authors： Giorgio A,Zhang J,Costantino F,De Stefano N,Frezzotti P

更新日期：2020-03-05 00:00:00

abstract：:Graph neural networks (GNN) rely on graph operations that include neural network training for various graph related tasks. Recently, several attempts have been made to apply the GNNs to functional magnetic resonance image (fMRI) data. Despite recent progresses, a common limitation is its difficulty to explain the clas...

journal_title：Frontiers in neuroscience

authors： Kim BH,Ye JC

更新日期：2020-06-30 00:00:00

abstract：:Background: The relationship between awareness and attention is complex and controversial. A growing body of literature has shown that the neural bases of consciousness and endogenous attention (voluntary attention) are independent. The important role of exogenous attention (reflexive attention) on conscious experienc...

journal_title：Frontiers in neuroscience

authors： Chen Y,Wang X,Yu Y,Liu Y

更新日期：2017-11-13 00:00:00

abstract：:Event-related potentials (ERPs) are often used in brain-computer interfaces (BCIs) for communication or system control for enhancing or regaining control for motor-disabled persons. Especially results from single-trial EEG classification approaches for BCIs support correlations between single-trial ERP detection perfo...

journal_title：Frontiers in neuroscience

authors： Kirchner EA,Kim SK

更新日期：2018-03-27 00:00:00

abstract：:Brain state classification for communication and control has been well established in the area of brain-computer interfaces over the last decades. Recently, the passive and automatic extraction of additional information regarding the psychological state of users from neurophysiological signals has gained increased att...

journal_title：Frontiers in neuroscience

authors： Hettich DT,Bolinger E,Matuz T,Birbaumer N,Rosenstiel W,Spüler M

更新日期：2016-06-10 00:00:00

abstract：:Previous studies suggested that both robot-assisted rehabilitation and non-invasive brain stimulation can produce a slight improvement in severe chronic stroke patients. It is still unknown whether their combination can produce synergistic and more consistent improvements. Safety and efficacy of this combination has b...

journal_title：Frontiers in neuroscience

authors： Di Lazzaro V,Capone F,Di Pino G,Pellegrino G,Florio L,Zollo L,Simonetti D,Ranieri F,Brunelli N,Corbetto M,Miccinilli S,Bravi M,Milighetti S,Guglielmelli E,Sterzi S

更新日期：2016-03-08 00:00:00

abstract：:Neuromorphic computing employs models of neuronal circuits to solve computing problems. Neuromorphic hardware systems are now becoming more widely available and "neuromorphic algorithms" are being developed. As they are maturing toward deployment in general research environments, it becomes important to assess and com...

journal_title：Frontiers in neuroscience

authors： Diamond A,Nowotny T,Schmuker M

更新日期：2016-01-08 00:00:00

abstract：:The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging ...

journal_title：Frontiers in neuroscience

authors： Wang C,Kipping J,Bao C,Ji H,Qiu A

更新日期：2016-05-02 00:00:00

abstract：:Monoamine oxidase-A (MAO-A) and MAO-B have both been implicated in the pathology of Alzheimer disease (AD). We examined 60 autopsied control and AD donor brain samples to determine how well MAO function aligned with two major risk factors for AD, namely sex and APOE ε4 status. MAO-A activity was increased in AD cortic...

journal_title：Frontiers in neuroscience

authors： Quartey MO,Nyarko JNK,Pennington PR,Heistad RM,Klassen PC,Baker GB,Mousseau DD

更新日期：2018-06-26 00:00:00

abstract：:The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral pr...

journal_title：Frontiers in neuroscience

authors： Lukasik KM,Lehtonen M,Salmi J,Meinzer M,Joutsa J,Laine M

更新日期：2018-01-10 00:00:00

abstract：:Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, a...

journal_title：Frontiers in neuroscience

authors： Ekelem A,Goldfarb M

更新日期：2018-06-01 00:00:00

abstract：Background:Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known on the extent to which early pain may affect brain connectivity. We aim to evaluate brain functional connectivity changes in preterm n...

journal_title：Frontiers in neuroscience

authors： Tortora D,Severino M,Di Biase C,Malova M,Parodi A,Minghetti D,Traggiai C,Uccella S,Boeri L,Morana G,Rossi A,Ramenghi LA

更新日期：2019-08-23 00:00:00

abstract：:Pitch is an essential category for musical sensations. Models of pitch perception are vividly discussed up to date. Most of them rely on definitions of mathematical methods in the spectral or temporal domain. Our proposed pitch perception model is composed of an active auditory model extended by octopus cells. The act...

journal_title：Frontiers in neuroscience

authors： Harczos T,Klefenz FM

更新日期：2018-09-25 00:00:00

abstract：Background:Since subjective cognitive decline (SCD) was standardized in 2014, many studies have investigated its features. However, the risk of SCD (plus) progressing to AD is much higher, and yet there have been few studies reporting the risk factors and neuropsychological assessment characteristics of SCD (plus). Ob...

journal_title：Frontiers in neuroscience

authors： Hao L,Xing Y,Li X,Mu B,Zhao W,Wang G,Wang T,Jia J,Han Y

更新日期：2019-08-14 00:00:00

abstract：:Anorexia nervosa (AN) has the highest mortality rate of any psychiatric disease, yet available pharmacological treatments are largely ineffective due, in part, to an inadequate understanding of the neurobiological drivers that underpin the condition. The recent resurgence of research into the clinical applications of ...

journal_title：Frontiers in neuroscience

authors： Foldi CJ,Liknaitzky P,Williams M,Oldfield BJ

更新日期：2020-02-04 00:00:00