No Effects of Non-invasive Brain Stimulation on Multiple Sessions of Object-Location-Memory Training in Healthy Older Adults.

Abstract:

:Object-location memory (OLM) is known to decline with normal aging, a process accelerated in pathological conditions like mild cognitive impairment (MCI). In order to maintain cognitive health and to delay the transition from healthy to pathological conditions, novel strategies are being explored. Tentative evidence suggests that combining cognitive training and anodal transcranial direct current stimulation (atDCS), both reported to induce small and often inconsistent behavioral improvements, could generate larger or more consistent improvements or both, compared to each intervention alone. Here, we explored the combined efficacy of these techniques on OLM. In a subject-blind sham-controlled cross-over design 32 healthy older adults underwent a 3-day visuospatial training paired with either anodal (20 min) or sham (30 s) atDCS (1 mA, temporoparietal). Subjects were asked to learn the correct object-location pairings on a street map, shown over five learning blocks on each training day. Acquisition performance was assessed by accuracy on a given learning block in terms of percentage of correct responses. Training success (performance on last training day) and delayed memory after 1-month were analyzed by mixed model analysis and were controlled for gender, age, education, sequence of stimulation and baseline performance. Exploratory analysis of atDCS effects on within-session (online) and between-session (offline) memory performance were conducted. Moreover, transfer effects on similar trained (visuospatial) and less similar (visuo-constructive, verbal) untrained memory tasks were explored, both immediately after training, and on follow-up. We found that atDCS paired with OLM-training did not enhance success in training or performance in 1-month delayed memory or transfer tasks. In sum, this study did not support the notion that the combined atDCS-training approach improves immediate or delayed OLM in older adults. However, specifics of the experimental design, and a non-optimal timing of atDCS between sessions might have masked beneficial effects and should be more systematically addressed in future studies.

journal_name

Front Neurosci

authors

Külzow N,Cavalcanti de Sousa AV,Cesarz M,Hanke JM,Günsberg A,Harder S,Koblitz S,Grittner U,Flöel A

doi

10.3389/fnins.2017.00746

subject

Has Abstract

pub_date

2018-01-10 00:00:00

pages

746

eissn

1662-4548

issn

1662-453X

journal_volume

11

pub_type

杂志文章
  • Merging functional and structural properties of the monkey auditory cortex.

    abstract::Recent neuroimaging studies in primates aim to define the functional properties of auditory cortical areas, especially areas beyond A1, in order to further our understanding of the auditory cortical organization. Precise mapping of functional magnetic resonance imaging (fMRI) results and interpretation of their locali...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00198

    authors: Joly O,Baumann S,Balezeau F,Thiele A,Griffiths TD

    更新日期:2014-07-21 00:00:00

  • Corrigendum: Recombinant hNeuritin Promotes Structural and Functional Recovery of Sciatic Nerve Injury in Rats.

    abstract::[This corrects the article on p. 589 in vol. 10, PMID: 28066172.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2017.00065

    authors: Wang H,Li X,Shan L,Zhu J,Chen R,Li Y,Yuan W,Yang L,Huang J

    更新日期:2017-02-13 00:00:00

  • Autism Pathogenesis: The Superior Colliculus.

    abstract::After been exposed to the visual input, in the first year of life, the brain experiences subtle but massive changes apparently crucial for communicative/emotional and social human development. Its lack could be the explanation of the very high prevalence of autism in children with total congenital blindness. The prese...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.01029

    authors: Jure R

    更新日期:2019-01-09 00:00:00

  • Endovascular Treatment of Large or Giant Non-saccular Vertebrobasilar Aneurysms: Pipeline Embolization Devices Versus Conventional Stents.

    abstract:Background:Endovascular treatment of large or giant non-saccular vertebrobasilar aneurysms (VBAs) by conventional stents is difficult and has unsatisfactory outcomes. Object:This study was performed to retrospectively analyze the safety and efficacy of a flow diverter in treating large and giant non-saccular VBAs. Me...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01253

    authors: Wang J,Jia L,Duan Z,Wang Z,Yang X,Zhang Y,Lv M

    更新日期:2019-11-28 00:00:00

  • Multimodal Integration of M/EEG and f/MRI Data in SPM12.

    abstract::We describe the steps involved in analysis of multi-modal, multi-subject human neuroimaging data using the SPM12 free and open source software (https://www.fil.ion.ucl.ac.uk/spm/) and a publically-available dataset organized according to the Brain Imaging Data Structure (BIDS) format (https://openneuro.org/datasets/ds...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00300

    authors: Henson RN,Abdulrahman H,Flandin G,Litvak V

    更新日期:2019-04-24 00:00:00

  • Auditory Mismatch Negativity in Response to Changes of Counter-Balanced Interaural Time and Level Differences.

    abstract::Interaural time differences (ITD) and interaural level differences (ILD) both signal horizontal sound source location. To achieve a unified percept of our acoustic environment, these two cues require integration. In the present study, we tested this integration of ITD and ILD with electroencephalography (EEG) by measu...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00387

    authors: Altmann CF,Ueda R,Furukawa S,Kashino M,Mima T,Fukuyama H

    更新日期:2017-07-06 00:00:00

  • Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.

    abstract::Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00114

    authors: Okita Y,Rcom-H'cheo-Gauthier AN,Goulding M,Chung RS,Faller P,Pountney DL

    更新日期:2017-04-04 00:00:00

  • A framework to analyze cerebral mean diffusivity using surface guided diffusion mapping in diffusion tensor imaging.

    abstract::The mean diffusivity (MD) value has been used to describe microstructural properties in Diffusion Tensor Imaging (DTI) in cortical gray matter (GM). Recently, researchers have applied a cortical surface generated from the T1-weighted volume. When the DTI data are analyzed using the cortical surface, it is important to...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00236

    authors: Kwon OH,Park H,Seo SW,Na DL,Lee JM

    更新日期:2015-07-14 00:00:00

  • Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis.

    abstract::Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2016.00603

    authors: Conde-Sieira M,Soengas JL

    更新日期:2017-01-05 00:00:00

  • Impaired Levels of Gangliosides in the Corpus Callosum of Huntington Disease Animal Models.

    abstract::Huntington Disease (HD) is a genetic neurodegenerative disorder characterized by broad types of cellular and molecular dysfunctions that may affect both neuronal and non-neuronal cell populations. Among all the molecular mechanisms underlying the complex pathogenesis of the disease, alteration of sphingolipids has bee...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00457

    authors: Di Pardo A,Amico E,Maglione V

    更新日期:2016-10-06 00:00:00

  • Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes.

    abstract::Data from animal models and Alzheimer's disease (AD) subjects provide clear evidence for an activation of inflammatory pathways during the pathogenetic course of such illness. Biochemical and neuropathological studies highlighted an important cause/effect relationship between inflammation and AD progression, revealing...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00259

    authors: Steardo L Jr,Bronzuoli MR,Iacomino A,Esposito G,Steardo L,Scuderi C

    更新日期:2015-07-29 00:00:00

  • Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2.

    abstract::Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstr...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01009

    authors: Pitake S,Middleton LJ,Abdus-Saboor I,Mishra SK

    更新日期:2019-09-19 00:00:00

  • Online tracking of the contents of conscious perception using real-time fMRI.

    abstract::Perception is an active process that interprets and structures the stimulus input based on assumptions about its possible causes. We use real-time functional magnetic resonance imaging (rtfMRI) to investigate a particularly powerful demonstration of dynamic object integration in which the same physical stimulus interm...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00116

    authors: Reichert C,Fendrich R,Bernarding J,Tempelmann C,Hinrichs H,Rieger JW

    更新日期:2014-05-23 00:00:00

  • Corrigendum: Structural Brain Network Reorganization and Social Cognition Related to Adverse Perinatal Condition from Infancy to Early Adolescence.

    abstract::[This corrects the article on p. 560 in vol. 10, PMID: 28008304.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2017.00257

    authors: Muñoz-Moreno E,Fischi-Gomez E,Batalle D,Borradori-Tolsa C,Eixarch E,Thiran JP,Gratacós E,Hüppi PS

    更新日期:2017-05-09 00:00:00

  • Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans.

    abstract::In patients with impaired liver function and hepatic encephalopathy (HE), consistent elevations of blood ammonia concentration suggest a crucial role in the pathogenesis of HE. Ammonia and acetate are metabolized in brain both primarily in astrocytes. Here, we used dynamic [(11)C]acetate PET of the brain to measure th...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00353

    authors: Iversen P,Mouridsen K,Hansen MB,Jensen SB,Sørensen M,Bak LK,Waagepetersen HS,Schousboe A,Ott P,Vilstrup H,Keiding S,Gjedde A

    更新日期:2014-11-03 00:00:00

  • On the Digital Psychopharmacology of Valproic Acid in Mice.

    abstract::Antiepileptic drugs (AEDs) require daily ingestion for maximal seizure prophylaxis. Adverse psychiatric consequences of AEDs present as: (i) reversible changes in mood, anxiety, anger and/or irritability that often necessitate drug discontinuation, and (ii) autism and/or cognitive/psychomotor delays following fetal ex...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.594612

    authors: Bass JS,Tuo AH,Ton LT,Jankovic MJ,Kapadia PK,Schirmer C,Krishnan V

    更新日期:2020-11-06 00:00:00

  • Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior.

    abstract::Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide that is involved in stress-related physiology and behavior, including control of the hypothalamic-pituitary-adrenal (HPA) axis. Members of the CRF family of neuropeptides, including urocortin 1 (UCN 1), UCN 2, and UCN 3, bind to the G protein-coupled...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2013.00169

    authors: Fox JH,Lowry CA

    更新日期:2013-09-20 00:00:00

  • Endocannabinoid System and Migraine Pain: An Update.

    abstract::The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00172

    authors: Greco R,Demartini C,Zanaboni AM,Piomelli D,Tassorelli C

    更新日期:2018-03-19 00:00:00

  • Alzheimer Disease and Selected Risk Factors Disrupt a Co-regulation of Monoamine Oxidase-A/B in the Hippocampus, but Not in the Cortex.

    abstract::Monoamine oxidase-A (MAO-A) and MAO-B have both been implicated in the pathology of Alzheimer disease (AD). We examined 60 autopsied control and AD donor brain samples to determine how well MAO function aligned with two major risk factors for AD, namely sex and APOE ε4 status. MAO-A activity was increased in AD cortic...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00419

    authors: Quartey MO,Nyarko JNK,Pennington PR,Heistad RM,Klassen PC,Baker GB,Mousseau DD

    更新日期:2018-06-26 00:00:00

  • The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime.

    abstract::Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory. In search of more efficacious broad-spectrum oximes, new bispyridinium (K-) oximes have been synthesized, with K027 be...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00427

    authors: Lorke DE,Petroianu GA

    更新日期:2019-05-22 00:00:00

  • Evaluating auditory stream segregation of SAM tone sequences by subjective and objective psychoacoustical tasks, and brain activity.

    abstract::Auditory stream segregation refers to a segregated percept of signal streams with different acoustic features. Different approaches have been pursued in studies of stream segregation. In psychoacoustics, stream segregation has mostly been investigated with a subjective task asking the subjects to report their percept....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00119

    authors: Dolležal LV,Brechmann A,Klump GM,Deike S

    更新日期:2014-06-06 00:00:00

  • Impact of Temporomandibular Joint Complaints on Tinnitus-Related Distress.

    abstract::There is increasing evidence of associations between the presence of temporomandibular joint (TMJ) disorders and tinnitus. It has been recently proposed that tinnitus patients with TMJ complaints could constitute a subtype, meaning a subgroup of tinnitus patients responsive to specific treatments. Tinnitus patients wi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00879

    authors: Edvall NK,Gunan E,Genitsaridi E,Lazar A,Mehraei G,Billing M,Tullberg M,Bulla J,Whitton J,Canlon B,Hall DA,Cederroth CR

    更新日期:2019-08-22 00:00:00

  • Electrophysiological characterization of male goldfish (Carassius auratus) ventral preoptic area neurons receiving olfactory inputs.

    abstract::Chemical communication via sex pheromones is critical for successful reproduction but the underlying neural mechanisms are not well-understood. The goldfish is a tractable model because sex pheromones have been well-characterized in this species. We used male goldfish forebrain explants in vitro and performed whole-ce...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00185

    authors: Lado WE,Spanswick DC,Lewis JE,Trudeau VL

    更新日期:2014-06-30 00:00:00

  • Multi-Tasking and Choice of Training Data Influencing Parietal ERP Expression and Single-Trial Detection-Relevance for Neuroscience and Clinical Applications.

    abstract::Event-related potentials (ERPs) are often used in brain-computer interfaces (BCIs) for communication or system control for enhancing or regaining control for motor-disabled persons. Especially results from single-trial EEG classification approaches for BCIs support correlations between single-trial ERP detection perfo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00188

    authors: Kirchner EA,Kim SK

    更新日期:2018-03-27 00:00:00

  • Coding of reward probability and risk by single neurons in animals.

    abstract::Probability and risk are important factors for value-based decision making and optimal foraging. In order to survive in an unpredictable world, organisms must be able to assess the probability and risk attached to future events and use this information to generate adaptive behavior. Recent studies in non-human primate...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00121

    authors: Burke CJ,Tobler PN

    更新日期:2011-10-11 00:00:00

  • Comparison of IVA and GIG-ICA in Brain Functional Network Estimation Using fMRI Data.

    abstract::Spatial group independent component analysis (GICA) methods decompose multiple-subject functional magnetic resonance imaging (fMRI) data into a linear mixture of spatially independent components (ICs), some of which are subsequently characterized as brain functional networks. Group information guided independent compo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00267

    authors: Du Y,Lin D,Yu Q,Sui J,Chen J,Rachakonda S,Adali T,Calhoun VD

    更新日期:2017-05-19 00:00:00

  • 2-Chloroethanol Induced Upregulation of Matrix Metalloproteinase-2 in Primary Cultured Rat Astrocytes Via MAPK Signal Pathways.

    abstract::This study was to explore the mechanisms underlying 1,2-dichloroethane (1,2-DCE) induced brain edema by focusing on alteration of matrix metalloproteinase-2 (MMP-2) in rat astrocytes induced by 2-chloroethanol (2-CE), an intermediate metabolite of 1,2-DCE in vivo. Protein and mRNA levels of MMP-2, and the phosphorylat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00593

    authors: Sun Q,Liao Y,Wang T,Tang H,Wang G,Zhao F,Jin Y

    更新日期:2017-01-04 00:00:00

  • Encoding of Sucrose's Palatability in the Nucleus Accumbens Shell and Its Modulation by Exteroceptive Auditory Cues.

    abstract::Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory s...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00265

    authors: Villavicencio M,Moreno MG,Simon SA,Gutierrez R

    更新日期:2018-05-04 00:00:00

  • Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics.

    abstract::Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet c...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00485

    authors: Nuno-Perez A,Tchenio A,Mameli M,Lecca S

    更新日期:2018-07-23 00:00:00

  • A Model for a Filling-in Process Triggered by Edges Predicts "Conflicting" Afterimage Effects.

    abstract::The goal of our research was to develop a compound computational model that predicts the "opposite" effects of the alternating aftereffects stimuli, such as the "color dove illusion" (Barkan and Spitzer, 2017), and the "filling in the afterimage after the image" (van Lier et al., 2009). The model is based on a filling...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00559

    authors: Cohen-Duwek H,Spitzer H

    更新日期:2018-08-17 00:00:00