Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19.

abstract：BACKGROUND:The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to t...

journal_title：EBioMedicine

authors： Kosztyu P,Kuchar M,Cerny J,Barkocziova L,Maly M,Petrokova H,Czernekova L,Liskova V,Raskova Kafkova L,Knotigova P,Masek J,Turanek J,Maly P,Raska M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Accumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed to investigate the crucial role of imbalanced gut microbiota on the progression of intestinal adenoma. METHODS:The Apcmin/+ mice gavage with phosphate-buffere...

journal_title：EBioMedicine

authors： Li L,Li X,Zhong W,Yang M,Xu M,Sun Y,Ma J,Liu T,Song X,Dong W,Liu X,Chen Y,Liu Y,Abla Z,Liu W,Wang B,Jiang K,Cao H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat...

journal_title：EBioMedicine

authors： Huang R,Hu Z,Cao Y,Li H,Zhang H,Su W,Xu Y,Liang L,Melgiri ND,Jiang L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tis...

journal_title：EBioMedicine

authors： Sangaletti S,Iannelli F,Zanardi F,Cancila V,Portararo P,Botti L,Vacca D,Chiodoni C,Di Napoli A,Valenti C,Rizzello C,Vegliante MC,Pisati F,Gulino A,Ponzoni M,Colombo MP,Tripodo C

更新日期：2020-11-01 00:00:00

abstract：:Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calculations and experimental approaches including cellular studies, X-ray c...

journal_title：EBioMedicine

authors： Bunney TD,Wan S,Thiyagarajan N,Sutto L,Williams SV,Ashford P,Koss H,Knowles MA,Gervasio FL,Coveney PV,Katan M

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...

journal_title：EBioMedicine

authors： Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determin...

journal_title：EBioMedicine

authors： Wang H,Huang B,Wang W,Li J,Chen Y,Flynn T,Zhao M,Zhou Z,Lin X,Zhang Y,Xu M,Li K,Tian K,Yuan D,Zhou P,Hu L,Zhong D,Zhu S,Li J,Chen D,Wang K,Liang J,He Q,Sun J,Shi J,Yan L,Sands JM,Xie Z,Lian X,Xu

更新日期：2019-10-01 00:00:00

abstract：:To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2-3weeks) which either underwent unilateral or bilateral lens-induced myopization (group 1) or which were primarily myopic at baseline (group 2) received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15μg) t...

journal_title：EBioMedicine

authors： Jiang WJ,Song HX,Li SY,Guo B,Wu JF,Li GP,Guo DD,Shi L,Bi HS,Jonas JB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) is the most bioactive ingredient of boswellic aci...

journal_title：EBioMedicine

authors： Bai J,Gao Y,Chen L,Yin Q,Lou F,Wang Z,Xu Z,Zhou H,Li Q,Cai W,Sun Y,Niu L,Wang H,Wei Z,Lu S,Zhou A,Zhang J,Wang H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

journal_title：EBioMedicine

authors： Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer ne...

journal_title：EBioMedicine

authors： Moreau GB,Ramakrishnan G,Cook HL,Fox TE,Nayak U,Ma JZ,Colgate ER,Kirkpatrick BD,Haque R,Petri WA Jr

更新日期：2019-06-01 00:00:00

abstract：:Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...

journal_title：EBioMedicine

authors： Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:KRAS mutations are the most frequent oncogenic aberration in lung adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence drug responses. This heterogeneity challenges the development of effective therapies for patients with KRAS-driven non-small cell lung cancer (NSCLC). METH...

journal_title：EBioMedicine

authors： Wang H,Lv Q,Xu Y,Cai Z,Zheng J,Cheng X,Dai Y,Jänne PA,Ambrogio C,Köhler J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS:Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducib...

journal_title：EBioMedicine

authors： Tejero R,Huang Y,Katsyv I,Kluge M,Lin JY,Tome-Garcia J,Daviaud N,Wang Y,Zhang B,Tsankova NM,Friedel CC,Zou H,Friedel RH

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC inci...

journal_title：EBioMedicine

authors： Tan TZ,Ye J,Yee CV,Lim D,Ngoi NYL,Tan DSP,Huang RY

更新日期：2019-12-01 00:00:00

abstract：:Compelling evidence shows that fine particulate matters (PMs) from air pollution penetrate lower airways and are associated with adverse health effects even within concentrations below those recommended by the WHO. A paper reported a dose-dependent link between carbon content in alveolar macrophages (assessed only by ...

journal_title：EBioMedicine

authors： Kolosnjaj-Tabi J,Just J,Hartman KB,Laoudi Y,Boudjemaa S,Alloyeau D,Szwarc H,Wilson LJ,Moussa F

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

journal_title：EBioMedicine

authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS:We recruited 86 Chinese children born to OHSS women and 172 c...

journal_title：EBioMedicine

authors： Xu GF,Zhou CL,Xiong YM,Li JY,Yu TT,Tian S,Lin XH,Liao Y,Lv Y,Zhang FH,Liu ZW,Shi YY,Shen Y,Sha J,Zhang D,Zhu YM,Sheng JZ,Huang HF

更新日期：2017-06-01 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed cancer in males in the Western world. Although prostate-specific antigen (PSA) has been widely used as a biomarker for PCa diagnosis, its results can be controversial. Therefore, new biomarkers are needed to enhance the clinical management of PCa. From publicly avai...

journal_title：EBioMedicine

authors： Hou Q,Bing ZT,Hu C,Li MY,Yang KH,Mo Z,Xie XW,Liao JL,Lu Y,Horie S,Lou MW

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:HIV drug resistance (HIVDR) testing can assist clinicians in selecting treatments. However, high complexity and cost of genotyping assays limit routine testing in settings where HIVDR prevalence has reached high levels. METHODS:The oligonucleotide ligation assay (OLA)-Simple kit was developed for detection ...

journal_title：EBioMedicine

authors： Panpradist N,Beck IA,Vrana J,Higa N,McIntyre D,Ruth PS,So I,Kline EC,Kanthula R,Wong-On-Wing A,Lim J,Ko D,Milne R,Rossouw T,Feucht UD,Chung M,Jourdain G,Ngo-Giang-Huong N,Laomanit L,Soria J,Lai J,Klavins ED,Fr

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:While PARP inhibitors and CDK4/6 inhibitors, the two classes of FDA-approved agents, have shown promising clinical benefits, there is an urgent need to develop new therapeutic strategies to improve clinical response. Meanwhile, extending the utility of these inhibitors beyond their respective molecularly def...

journal_title：EBioMedicine

authors： Yi J,Liu C,Tao Z,Wang M,Jia Y,Sang X,Shen L,Xue Y,Jiang K,Luo F,Liu P,Cheng H

更新日期：2019-05-01 00:00:00

abstract：:Dendritic cells (DCs) play an important role in controlling T cell-mediated adaptive immunity in atherogenesis. However, the role of the basic leucine zipper transcription factor, ATF-like 3 (Batf3)-dependent CD8α+ DC subset in atherogenesis remains unclear. Here we show that Batf3-/-Apoe-/- mice, lacking CD8α+ DCs, e...

journal_title：EBioMedicine

authors： Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by emphysema and/or obstructive bronchiolitis. Deficiency in vitamin D3 (VD3), which regulates gene expression through binding to vitamin D receptor (VDR), is associated with high risks of COPD susceptibility. Alveolar macrophages (AM), which are ...

journal_title：EBioMedicine

authors： Hu G,Dong T,Wang S,Jing H,Chen J

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS:We have now investigated the relationship between ...

journal_title：EBioMedicine

authors： Podlesniy P,Puigròs M,Serra N,Fernández-Santiago R,Ezquerra M,Tolosa E,Trullas R

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

journal_title：EBioMedicine

authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

更新日期：2019-02-01 00:00:00

abstract：:Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that the HIV protein, V...

journal_title：EBioMedicine

authors： Gargan S,Ahmed S,Mahony R,Bannan C,Napoletano S,O'Farrelly C,Borrow P,Bergin C,Stevenson NJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. METHODS:Glycoengineered cell lines were...

journal_title：EBioMedicine

authors： Freitas D,Campos D,Gomes J,Pinto F,Macedo JA,Matos R,Mereiter S,Pinto MT,Polónia A,Gartner F,Magalhães A,Reis CA

更新日期：2019-02-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activa...

journal_title：EBioMedicine

authors： Matsunaga N,Ikeda E,Kakimoto K,Watanabe M,Shindo N,Tsuruta A,Ikeyama H,Hamamura K,Higashi K,Yamashita T,Kondo H,Yoshida Y,Matsuda M,Ogino T,Tokushige K,Itcho K,Furuichi Y,Nakao T,Yasuda K,Doi A,Amamoto T,Aramaki

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Human infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated with a high mortality rate. However, the metabolic basis of such systemic alterations remains unknown. METHODS:This study included hospitalized patients (n = 4) with laboratory-confirm...

journal_title：EBioMedicine

authors： Sun X,Song L,Feng S,Li L,Yu H,Wang Q,Wang X,Hou Z,Li X,Li Y,Zhang Q,Li K,Cui C,Wu J,Qin Z,Wu Q,Chen H

更新日期：2018-07-01 00:00:00

abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

journal_title：EBioMedicine

authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

更新日期：2019-01-01 00:00:00