Abstract:
Background:The number of invasive group A Streptococcus (iGAS) infections due to hitherto extremely rare type emm74 strains has increased in several Canadian provinces since late 2015. We hypothesized that the cases recorded in the different provinces are linked and caused by strains of an emm74 clone that recently emerged and expanded explosively. Methods:We analyzed both active and passive surveillance data for iGAS infections and used whole-genome sequencing to investigate the phylogenetic relationships of the emm74 strains responsible for these invasive infections country-wide. Results:Genome analysis showed that highly clonal emm74 strains, genetically different from emm74 organisms previously circulating in Canada, were responsible for a country-wide epidemic of >160 invasive disease cases. The emerging clone belonged to multilocus sequence typing ST120. The analysis also revealed dissemination patterns of emm74 subclonal lineages across Canadian provinces. Clinical data analysis indicated that the emm74 epidemic disproportionally affected middle-aged or older male individuals. Homelessness, alcohol abuse, and intravenous drug usage were significantly associated with invasive emm74 infections. Conclusions:In a period of 20 months, an emm74 GAS clone emerged and rapidly spread across several Canadian provinces located more than 4500 km apart, causing invasive infections primarily among disadvantaged persons.
journal_name
Open Forum Infect Disjournal_title
Open forum infectious diseasesauthors
Teatero S,McGeer A,Tyrrell GJ,Hoang L,Smadi H,Domingo MC,Levett PN,Finkelstein M,Dewar K,Plevneshi A,Athey TBT,Gubbay JB,Mulvey MR,Martin I,Demczuk W,Fittipaldi Ndoi
10.1093/ofid/ofy085subject
Has Abstractpub_date
2018-04-20 00:00:00pages
ofy085issue
5issn
2328-8957pii
ofy085journal_volume
5pub_type
杂志文章abstract::Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients ...
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