Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study.


Background:Patients with chronic hepatitis C virus (HCV) infection and active or previous hepatitis B virus (HBV) are at risk of HBV reactivation (HBV-R) during direct-acting antiviral (DAA) therapy. Recent reports suggest that HBV-R may even occur several months after completion of DAA therapy. The aim of this study was to assess the risk of HBV-R in patients with resolved HBV after successful DAA therapy during long-term follow-up (FU). Methods:Among 848 patients treated for chronic HCV, all patients with resolved HBV and long-term FU data were eligible for inclusion. Patients were HBV DNA/hepatitis B surface antigen (HBsAg)-negative at the end of therapy (EOT) and were followed for up to 52 weeks thereafter. Patients underwent regular alanine transaminase (ALT) testing, and additional HBV DNA/HBsAg testing was performed at FU week 12, end of FU, and in case of an ALT increase above the upper limit of normal (>ULN). Results:A total of 108 patients were followed up for a mean (range) of 41.5 (24-52) weeks after EOT. None of the patients experienced reverse HBsAg seroconversion or reappearance of HBV DNA. One patient received a liver transplantation; 1 patient was diagnosed with de novo hepatocellular carcinoma, and 2 patients died. Eighteen patients (16.7%) had increased ALT levels (grade 0/1). Of those, the majority were male (72.2%) and significantly more patients had cirrhosis (66.7% vs 36.2%, P = .015) or received ribavirin as part of their treatment regimen (86.7% vs 46.8%, P = .041). None of these were associated with HBV-R. Conclusions:Our results indicate that the risk of HBV-R in patients with resolved HBV treated with DAAs for HCV is low during long-term follow-up.


Open Forum Infect Dis


Mücke MM,Mücke VT,Peiffer KH,Sarrazin C,Zeuzem S,Berger A,Vermehren J




Has Abstract


2018-12-15 00:00:00












  • Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014.

    abstract::Background.  The majority of Lyme disease cases in the United States are acquired on the east coast between northern Virginia and New England. In recent years the geographic extent of Lyme disease has been expanding, raising the prospect of Lyme disease becoming endemic in the southeast. Methods.  We collected confirm...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Lantos PM,Nigrovic LE,Auwaerter PG,Fowler VG Jr,Ruffin F,Brinkerhoff RJ,Reber J,Williams C,Broyhill J,Pan WK,Gaines DN

    更新日期:2015-09-27 00:00:00

  • Rethinking risk for pneumococcal disease in adults: the role of risk stacking.

    abstract::Using data from 3 private healthcare claims repositories, we evaluated the incidence of pneumococcal disease among adults with US Advisory Committee on Immunization Practices (ACIP) defined at-risk conditions or rheumatoid arthritis, lupus, Crohn's disease, and neuromuscular disorder/seizures and those with traditiona...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Pelton SI,Shea KM,Weycker D,Farkouh RA,Strutton DR,Edelsberg J

    更新日期:2015-03-20 00:00:00

  • Ocular Actinomycosis Mimicking Meningioma.

    abstract::Orbital actinomycosis is an unusual clinical manifestation of orbital infection caused by Actinomyces species. Herein we report a case of orbital actinomycosis in a 67-year-old woman with recurrent swelling and erythema around her left eye with an orbital mass initially thought to be a meningioma. ...

    journal_title:Open forum infectious diseases



    authors: Kobayashi T,Ford B,Fujita N,Appenheimer AB

    更新日期:2020-05-19 00:00:00

  • Antibiotic Treatment Versus No Treatment for Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Multicenter Randomized Trial.

    abstract:Background:Whether antibiotic treatment of asymptomatic bacteriuria (AB) can prevent acute graft pyelonephritis (AGP) in kidney transplant (KT) recipients has not been elucidated. Methods:In this multicenter, open-label, nonblinded, prospective, noninferiority, randomized controlled trial, we compared antibiotic treat...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sabé N,Oriol I,Melilli E,Manonelles A,Bestard O,Polo C,Los Arcos I,Perelló M,Garcia D,Riera L,Tebé C,Len Ò,Moreso F,Cruzado JM,Carratalà J

    更新日期:2019-05-21 00:00:00

  • Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians.

    abstract:Background:In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gundlapalli AV,Beekmann SE,Graham DR,Polgreen PM,Members of the Emerging Infections Network.

    更新日期:2018-04-23 00:00:00

  • Clinical Management of Respiratory Adverse Events Associated With Amikacin Liposome Inhalation Suspension: Results From a Patient Survey.

    abstract::Patients with Mycobacterium avium complex lung disease treated with amikacin liposome inhalation suspension (ALIS) at 2 clinics in the United States were surveyed to assess the frequency and management of ALIS-associated respiratory adverse events. Most respondents experienced these events, but management through phys...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Swenson C,Lapinel NC,Ali J

    更新日期:2020-03-02 00:00:00

  • The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies.

    abstract::Ebola virus (EBOV) is a highly pathogenic filovirus that causes outbreaks of a severe hemorrhagic fever known as EBOV disease (EVD). Ebola virus disease is characterized in part by a dysregulated immune response and massive production of both pro- and anti-inflammatory cytokines. To better understand the immune respon...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Banadyga L,Siragam V,Zhu W,He S,Cheng K,Qiu X

    更新日期:2019-02-06 00:00:00

  • Difficulties of Identifying the Early HIV Antibody Seroconversion Period Depending on the Confirmatory Assay.

    abstract:Background:Identification of HIV infection at the early stage is valuable for patient management, for prevention, and for research purposes. In practice, identification of a recent HIV infection at diagnosis proves challenging after HIV antibody seroconversion but can be suspected using Western blots (WBs) or immunoblo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Stefic K,Mahjoub N,Desouche C,Néré ML,Thierry D,Delaugerre C,Barin F,Chaix ML

    更新日期:2020-04-21 00:00:00

  • Hourly Effect of Pretreatment With IV Antibiotics on Blood Culture Positivity Rate in Emergency Department Patients.

    abstract::Although it is intuitive that antibiotics administered before obtaining a blood culture would reduce the likelihood of obtaining a positive culture, it is not clear exactly how rapidly and to what extent blood becomes sterile after administration of intravenous (IV) antibiotics. Using a large data set of patients admi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rand KH,Beal SG,Rivera K,Allen B,Payton T,Lipori GP

    更新日期:2019-05-20 00:00:00

  • Delayed Diagnosis of Tuberculous Meningitis Misdiagnosed as Herpes Simplex Virus-1 Encephalitis With the FilmArray Syndromic Polymerase Chain Reaction Panel.

    abstract::The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encep...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gomez CA,Pinsky BA,Liu A,Banaei N

    更新日期:2016-12-07 00:00:00

  • Standardized electrolyte supplementation and fluid management improves survival during amphotericin therapy for cryptococcal meningitis in resource-limited settings.

    abstract:BACKGROUND:Amphotericin B is the preferred treatment for cryptococcal meningitis, but it has cumulative severe side effects, including nephrotoxicity, hypokalemia, and hypomagnesemia. Amphotericin-induced severe hypokalemia may predispose the patient to cardiac arrhythmias and death, and there is very little data avail...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bahr NC,Rolfes MA,Musubire A,Nabeta H,Williams DA,Rhein J,Kambugu A,Meya DB,Boulware DR

    更新日期:2014-08-25 00:00:00

  • Vaccine Effectiveness Against Influenza-Associated Lower Respiratory Tract Infections in Hospitalized Adults, Louisville, Kentucky, 2010-2013.

    abstract:Background:Preventing severe complications of influenza such as hospitalization is a public health priority; however, estimates of influenza vaccine effectiveness (VE) against influenza-associated acute lower respiratory tract infection (LRTI) hospitalizations are limited. We examined influenza VE against influenza-ass...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chow EJ,Rolfes MA,Carrico RL,Furmanek S,Ramirez JA,Ferdinands JM,Fry AM,Patel MM

    更新日期:2020-06-30 00:00:00

  • Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis.

    abstract:Background:Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods:We conducted a systematic review an...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Flokas ME,Andreatos N,Alevizakos M,Kalbasi A,Onur P,Mylonakis E

    更新日期:2017-11-20 00:00:00

  • A Randomized Switch From Nevirapine-Based Antiretroviral Therapy to Single Tablet Rilpivirine/Emtricitabine/Tenofovir Disoproxil Fumarate in Virologically Suppressed Human Immunodeficiency Virus-1-Infected Rwandans.

    abstract:: Background.  Many human immunodeficiency virus (HIV)-infected patients remain on nevirapine-based antiretroviral therapy (ART) despite safety and efficacy concerns. Switching to a rilpivirine-based regimen is an alternative, but there is little experience with rilpivirine ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Collins SE,Grant PM,Uwinkindi F,Talbot A,Seruyange E,Slamowitz D,Mugeni A,Remera E,Niyonsenga SP,Nyirimigabo J,Uwizihiwe JP,Dongier P,Muhayimpundu R,Mazarati JB,Zolopa A,Nsanzimana S

    更新日期:2016-07-01 00:00:00

  • Probiotics in Human Immunodeficiency Virus Infection: A Systematic Review and Evidence Synthesis of Benefits and Risks.

    abstract::People living with human immunodeficiency virus frequently use dietary supplements, including probiotics, but concern exists about ingesting live organisms. We performed a systematic review of the benefits of probiotics and a meta-analysis of sepsis risk. We undertook a protocol-driven, comprehensive review to identif...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Carter GM,Esmaeili A,Shah H,Indyk D,Johnson M,Andreae M,Sacks HS

    更新日期:2016-07-29 00:00:00

  • Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1.

    abstract::In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimiz...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Béguelin C,Vázquez M,Bertschi M,Yerly S,de Jong D,Gutbrod K,Rauch A,Cusini A

    更新日期:2015-12-28 00:00:00

  • Immunogenicity and Reactogenicity of a Reduced Schedule of a 4-component Capsular Group B Meningococcal Vaccine: A Randomized Controlled Trial in Infants.

    abstract:Background:The 4-component capsular group B meningococcal vaccine (4CMenB) was licensed as a 4-dose infant schedule but introduced into the United Kingdom as 3 doses at 2, 4, and 12 months of age. We describe the immunogenicity and reactogenicity of the 2 + 1 schedule in infants. Methods:Infants were randomized to rec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Valente Pinto M,O'Connor D,Galal U,Clutterbuck EA,Robinson H,Plested E,Bibi S,Camara Pellisso S,Hughes H,Kerridge S,Mujadidi YF,Findlow H,Borrow R,Snape MD,Pollard AJ

    更新日期:2020-04-29 00:00:00

  • The spread and control of norovirus outbreaks among hospitals in a region: a simulation model.

    abstract:BACKGROUND:Because hospitals in a region are connected via patient sharing, a norovirus outbreak in one hospital may spread to others. METHODS:We utilized our Regional Healthcare Ecosystem Analyst software to generate an agent-based model of all the acute care facilities in Orange County (OC), California and simulated...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bartsch SM,Huang SS,Wong KF,Avery TR,Lee BY

    更新日期:2014-07-02 00:00:00

  • Yellow Fever in an Unvaccinated Traveler to Peru.

    abstract::We present a case of an unvaccinated traveler who traveled from New York to Peru and contracted yellow fever. He likely acquired the infection while visiting the Amazon River, with a point of exit of Lima, Peru. Our case illustrates the dramatic course that yellow fever may take, as well as the importance of pretravel...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Winnicka L,Abdullah A,Yang T,Norville K,Irizarry-Acosta M

    更新日期:2017-12-20 00:00:00

  • West Nile Virus Central Nervous System Infection in Patients Treated With Rituximab: Implications for Diagnosis and Prognosis, With a Review of Literature.

    abstract::The spectrum of West Nile virus (WNV) infection continues to be elucidated. Many cases of WNV are asymptomatic; however, in immunocompromised patients, symptoms are more likely to be severe. We describe fatal WNV central nervous system disease in lymphoma patients who received rituximab, blunting the inflammatory resp...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Morjaria S,Arguello E,Taur Y,Sepkowitz K,Hatzoglou V,Nemade A,Rosenblum M,Cavalcanti MS,Palomba ML,Kaltsas A

    更新日期:2015-09-19 00:00:00

  • Risk Factors for Clinician-Diagnosed Lyme Arthritis, Facial Palsy, Carditis, and Meningitis in Patients From High-Incidence States.

    abstract:Background:Clinical features of Lyme disease (LD) range from localized skin lesions to serious disseminated disease. Information on risk factors for Lyme arthritis, facial palsy, carditis, and meningitis is limited but could facilitate disease recognition and elucidate pathophysiology. Methods:Patients from high-incid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Kwit NA,Nelson CA,Max R,Mead PS

    更新日期:2017-11-18 00:00:00

  • Ordering Patterns and Costs of Specialized Laboratory Testing by Hospitalists and House Staff in Hospitalized Patients With HIV at a County Hospital: An Opportunity for Diagnostic Stewardship.

    abstract:Background:Inpatient HIV care often requires specialized laboratory testing with which practitioners may not be familiar. In addition, computerized physician order entry allows for ordering tests without understanding test indications, but it can also provide a venue for education and diagnostic stewardship. Methods:A...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Bolles K,Woc-Colburn L,Hamill RJ,Hemmige V

    更新日期:2019-03-29 00:00:00

  • Implementing a Comprehensive HCV Clinic within an HIV Clinic: A Model of Care for HCV Micro-elimination.

    abstract:BACKGROUND:Among the 1.2 M persons living with HIV in the United States, 25% are co- infected with HCV. The availability of effective direct antiviral agents (DAAs) makes the goal of HCV elimination feasible, but implementation requires improvements to the HCV treatment cascade, especially linkage to and initiation of ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rizk C,Miceli J,Shiferaw B,Malinis M,Barakat L,Ogbuagu O,Villanueva M

    更新日期:2019-08-14 00:00:00

  • Physician Decisions to Defer Antiretroviral Therapy in Key Populations: Implications for Reducing Human Immunodeficiency Virus Incidence and Mortality in Malaysia.

    abstract:BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

    更新日期:2017-01-25 00:00:00

  • Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With Complicated Staphylococcus aureus Bacteremia.

    abstract:Background:Staphylococcus aureus (SA) bacteremia often requires a long treatment duration with antibiotics to prevent relapse due to the ability of SA to establish reservoirs of infection in sites such as heart and bone. These metastatic sites of infection cannot be serially sampled to monitor the clearance of SA infec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gutierrez J,Guimaraes AO,Lewin-Koh N,Berhanu A,Xu M,Cao Y,Kim J,Yan D,Chang JK,Dinoso JB,Koss CA,Clemenzi-Allen A,Chambers HF,Peck MC,Baruch A,Rosenberger CM

    更新日期:2019-02-26 00:00:00

  • Association Between Baseline Creatinine Clearance and Treatment Failure in Patients With Hepatitis C Virus Treated With Ledipasvir and Sofosbuvir.

    abstract:Background:Hepatitis C remains a major cause of liver disease globally and is responsible for approximately 500 000 deaths annually. Newer direct-acting antivirals achieve cure rates at or above 90% with excellent tolerability for most patients. The literature focusing on identification of predictors of efficacy and sa...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Jansen JW,Linneman TW,Powderly GM,Moenster RP,Nayak L

    更新日期:2019-02-19 00:00:00

  • HIV Care for Patients With Complex Needs: A Controlled Evaluation of a Walk-In, Incentivized Care Model.

    abstract:Background:New approaches are needed to provide care to persons with HIV who do not engage in conventionally organized HIV clinics. The Max Clinic in Seattle, Washington, is a walk-in, incentivized HIV care model located in a public health STD clinic that provides care in collaboration with a comprehensive HIV primary ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Dombrowski JC,Galagan SR,Ramchandani M,Dhanireddy S,Harrington RD,Moore A,Hara K,Eastment M,Golden MR

    更新日期:2019-06-26 00:00:00

  • Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

    abstract::Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

    更新日期:2016-02-08 00:00:00

  • Expanding Spectrum of Toxoplasma gondii: Thymoma and Toxoplasmic Encephalitis.

    abstract::In this brief report, we describe a 76-year-old patient with thymoma who underwent craniotomy for a left parietal lobe mass with pathologic findings consistent with Toxoplasma gondii encephalitis in the absence of any features of thymoma with immunodeficiency/Good's syndrome. His clinical course suggested likely Toxop...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chastain DB,Sams JI,Steele GM,Lowder LO,Franco-Paredes C

    更新日期:2018-07-07 00:00:00

  • Acute Weight Gain After Switch to Emtricitabine/Tenofovir Alafenamide for Human Immunodeficiency Virus Pre-Exposure Prophylaxis.

    abstract::We report a case of acute weight gain after switching from emtricitabine/tenofovir disoproxil to emtricitabine/tenofovir alafenamide for human immunodeficiency virus pre-exposure prophylaxis. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Selvaraj SV,Bares SH,Havens JP

    更新日期:2020-09-24 00:00:00