Soluble Tumor Necrosis Factor-α Receptor 2 in Urine Is a Potential Biomarker for Noninvasive Diagnosis of Malaria During Pregnancy.

Abstract:

:Background.  During pregnancy, the placenta is inaccessible for diagnosis of placental malaria (PM), but soluble tumor necrosis factor-α receptors (sTNFR) are elevated in the plasma of women with PM. Methods.  In this study, sTNFR-1 and sTNFR-2 were quantified in urine of pregnant and nonpregnant Cameroonian women who were positive or negative for malaria by blood-smear microscopy. Results.  We found that levels of both sTNFR in urine were higher in pregnant compared with nonpregnant women, but malaria-positive pregnant women excreted substantially more sTNFR-1 (P = .005) and sTNFR-2 (P < .001) than malaria-negative pregnant women. The amount of sTNFR-1(rs = 0.784, P < .001) and sTNFR-2 (rs = 0.816, P < .001) in urine correlated with parasitemia, even in afebrile pregnant women. Urine sTNFR-2 predicted maternal malaria with an area under curve of 0.892 (95% confidence interval, .787-.898). At cutoff concentrations of 9.8 ng and 13.6 ng of sTNFR-2 per mL urine, the sensitivity/specificity were 82.6%/87.0% and 78.3%/95.7%, respectively. Conclusions.  The sTNFR-2 in noninvasive urine samples may be useful for diagnosis of malaria during pregnancy.

journal_name

Open Forum Infect Dis

authors

Tassi Yunga S,Thévenon AD,Leke RG,Taylor DW

doi

10.1093/ofid/ofw084

subject

Has Abstract

pub_date

2016-04-26 00:00:00

pages

ofw084

issue

2

issn

2328-8957

pii

ofw084

journal_volume

3

pub_type

杂志文章
  • Lack of Awareness of Human Immunodeficiency Virus (HIV) Infection: Problems and Solutions With Self-reported HIV Serostatus of Men Who Have Sex With Men.

    abstract:BACKGROUND:Lack of human immunodeficiency virus (HIV) infection awareness may be a driver of racial disparities in HIV infection among men who have sex with men (MSM). Lack of awareness is typically measured by comparing HIV test result to self-reported HIV status. This measure may be subject to reporting bias and alte...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofu084

    authors: Sanchez TH,Kelley CF,Rosenberg E,Luisi N,O'Hara B,Lambert R,Coleman R,Frew P,Salazar LF,Tao S,Clarke W,Del Rio C,Sullivan PS

    更新日期:2014-09-13 00:00:00

  • Recombinant Human Plasma Gelsolin Improves Survival and Attenuates Lung Injury in a Murine Model of Multidrug-Resistant Pseudomonas aeruginosa Pneumonia.

    abstract:Background:Plasma gelsolin (pGSN) is an abundant circulating protein quickly consumed by extensive tissue damage. Marked depletion is associated with later poor outcomes in diverse clinical circumstances. Repletion with recombinant human (rhu)-pGSN in animal models of inflammation lessens mortality and morbidity. Meth...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa236

    authors: DiNubile MJ,Levinson SL,Stossel TP,Lawrenz MB,Warawa JM

    更新日期:2020-06-19 00:00:00

  • Detection of Loa loa Microfilariae in Follicular Fluid During Assisted Reproductive Technology: Case Report and Review of the Literature.

    abstract::We report on a case of loiasis revealed during an assisted reproductive technology (ART) cycle. Loa loa could limit implantation outcome. We propose to focus on an ART strategy with frozen embryos to treat the patient before any transfer. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofx208

    authors: Puy V,Scheffler F,Tinez C,Belhadri-Mansouri N,Huguenin A,Capelle S,Agnamey P,Devaux A,Frydman N,Copin H,Benkhalifa M

    更新日期:2017-10-06 00:00:00

  • Erratum.

    abstract::[This corrects the article DOI: 10.1093/ofid/ofx156.][This corrects the article DOI: 10.1093/ofid/ofx156.]. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,已发布勘误

    doi:10.1093/ofid/ofx191

    authors:

    更新日期:2018-01-30 00:00:00

  • Prevention of Cardiac Implantable Electronic Device-Related Infection in Patients With Cancer: The Role of a Comprehensive Prophylactic Bundle Approach That Includes the Antimicrobial Mesh.

    abstract:Background:Oncological patients have several additional risk factors for developing a cardiac implantable electronic device (CIED)-related infection. Therefore, we evaluated the clinical impact of our comprehensive bundle approach that includes the novel minocycline and rifampin antimicrobial mesh (TYRX) for the preven...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa433

    authors: Khalil M,Karimzad K,Durand JB,Malek AE,Raad II,Viola GM

    更新日期:2020-09-13 00:00:00

  • Missed Visits Associated With Future Preexposure Prophylaxis (PrEP) Discontinuation Among PrEP Users in a Municipal Primary Care Health Network.

    abstract:Background:Maintaining retention in preexposure prophylaxis (PrEP) care among diverse patient populations will be needed to support PrEP's efficacy. We characterized patterns of PrEP care retention in a US municipal primary care health network and examined whether missed visits, a metric of care retention that is easy ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofz101

    authors: Spinelli MA,Scott HM,Vittinghoff E,Liu AY,Gonzalez R,Morehead-Gee A,Gandhi M,Buchbinder SP

    更新日期:2019-02-26 00:00:00

  • Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial.

    abstract:BACKGROUND:Avian influenza A/H5N1 has threatened human health for nearly 2 decades. Avian influenza A vaccine without adjuvant is poorly immunogenic. A flexible rapid tactic for mass vaccination will be needed if a pandemic occurs. METHODS:A multicenter, randomized, blinded phase 1 clinical trial evaluated safety and ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofu102

    authors: Mulligan MJ,Bernstein DI,Frey S,Winokur P,Rouphael N,Dickey M,Edupuganti S,Spearman P,Anderson E,Graham I,Noah DL,Mangal B,Kim S,Hill H,Whitaker J,Emery W,Beck A,Stephens K,Hartwell B,Ogilvie M,Rimann N,Osinski

    更新日期:2014-11-18 00:00:00

  • Counterfeit Rabies Vaccines: The Philippine Experience.

    abstract:Background:In December 2018, a large, tertiary, university-affiliated hospital in the Philippines discovered that their legitimate supply chain was infiltrated with counterfeit rabies vaccines. Methods:All vials suspected to be counterfeit were quarantined and surrendered to the Philippine Food and Drug Administration...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa313

    authors: Henson KER,Santiago AAC,Namqui SS

    更新日期:2020-07-22 00:00:00

  • Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients.

    abstract::Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptom...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofw130

    authors: Lehloenya RJ,Dlamini S,Muloiwa R,Kakande B,Ngwanya MR,Todd G,Dheda K

    更新日期:2016-06-20 00:00:00

  • Considerations for the Selection and Use of Disinfectants Against SARS-CoV-2 in a Health Care Setting.

    abstract::Proper disinfection using adequate disinfecting agents will be necessary for infection control strategies against coronavirus disease 2019 (COVID-19). However, limited guidance exists on effective surface disinfectants or best practices for their use against severe acute respiratory coronavirus 2. We outlined a proces...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa396

    authors: Tyan K,Levin A,Avalos-Pacheco A,Plana D,Rand EA,Yang H,Maliszewski LE,Chylek LA,Atta L,Tye MA,Carmack MM,Oglesby NS,Burgin S,Yu SH,LeBoeuf NR,Kemp JM

    更新日期:2020-08-31 00:00:00

  • Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles.

    abstract::Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (P...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofw185

    authors: Rahman R,Martin MJ,Persaud S,Ceron N,Kellman D,Musset L,Carter KH,Ringwald P

    更新日期:2016-08-30 00:00:00

  • Evaluation of Real-time PCR for Diagnosis of Post-Kala-azar Dermal Leishmaniasis in Endemic Foci of Bangladesh.

    abstract:Background:Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis (VL), which is found in VL-endemic countries including Bangladesh. Because of these enigmatic cases, the success of the National Kala-azar Elimination Program is under threat. To date, diagnostic methods for PKDL cases in endemi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofy234

    authors: Ghosh P,Hasnain MG,Hossain F,Khan MAA,Chowdhury R,Faisal K,Mural MA,Baker J,Nath R,Ghosh D,Maruf S,Shomik MS,Haque R,Matlashewski G,Hamano S,Duthie MS,Mondal D

    更新日期:2018-09-15 00:00:00

  • The Yield and Consistency of the Detection of SARS-CoV-2 in Multiple Respiratory Specimens.

    abstract:Background:Few studies have compared the yield of reverse transcription polymerase chain reaction (RT-PCR) assays in nasopharyngeal swabs, oropharyngeal swabs, and sputum for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. Methods:We conducted an observational study in Beijing Ditan Hospital, C...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa379

    authors: Zhang H,Chen M,Zhang Y,Wen J,Wang Y,Wang L,Guo J,Liu C,Li D,Wang Y,Bai J,Gao G,Wang S,Yang D,Yu F,Yan L,Wan G,Zhang F

    更新日期:2020-08-26 00:00:00

  • Antimicrobial Management of Respiratory Infections in Severe Acute Respiratory Syndrome Coronavirus 2 Patients: Clinical and Antimicrobial Stewardship Programs Conundrums.

    abstract::The role of empirical and even directed antimicrobial management of patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is problematic; antibiotics are used frequently among these patients to treat confirmed or suspected coinfection or just the symptoms. In the rapidly cha...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa517

    authors: Goldstein EJC,Tillotson G,Redell M

    更新日期:2020-10-26 00:00:00

  • Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

    abstract::Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofw024

    authors: Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

    更新日期:2016-02-08 00:00:00

  • Host Characteristics and Bacterial Traits Predict Experimental Virulence for Escherichia coli Bloodstream Isolates From Patients With Urosepsis.

    abstract::Background.  Extraintestinal Escherichia coli infections are common, costly, and potentially serious. A better understanding of their pathogenesis is needed. Methods.  Sixty-seven E coli bloodstream isolates from adults with urosepsis (Seattle, WA; 1980s) underwent extensive molecular characterization and virulence as...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofv083

    authors: Johnson JR,Porter S,Johnston B,Kuskowski MA,Spurbeck RR,Mobley HL,Williamson DA

    更新日期:2015-06-06 00:00:00

  • A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy.

    abstract:BACKGROUND:Immune activation persists despite suppressive antiretroviral therapy (ART) in human immunodeficiency virus (HIV) infection and predicts non-Acquired Immune Deficiency Syndrome (AIDS) comorbidities including cardiovascular disease. Activated platelets play a key role in atherothrombosis and inflammation, and...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofw278

    authors: O'Brien MP,Hunt PW,Kitch DW,Klingman K,Stein JH,Funderburg NT,Berger JS,Tebas P,Clagett B,Moisi D,Utay NS,Aweeka F,Aberg JA

    更新日期:2017-01-19 00:00:00

  • Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis?

    abstract::Splenic infarction is a rare complication of infectious mononucleosis. We describe 3 cases of splenic infarction attributed to infectious mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious mononucleosis and discuss the differential diagno...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofy041

    authors: Li Y,George A,Arnaout S,Wang JP,Abraham GM

    更新日期:2018-02-17 00:00:00

  • Incidence and Predictors of Serological Treatment Response in Early and Late Syphilis Among People Living With HIV.

    abstract:Background:Few studies have investigated predictors of serological response to syphilis treatment in people living with HIV (PLWH). Methods:This was a retrospective, longitudinal study on PLWH who were diagnosed with and treated for syphilis who had an assessable serological response between January 2004 and June 2016...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofy324

    authors: Spagnuolo V,Poli A,Galli L,Nozza S,Bossolasco S,Cernuschi M,Maillard M,Hasson H,Gianotti N,Guffanti M,Lazzarin A,Castagna A

    更新日期:2018-11-30 00:00:00

  • Delayed Diagnosis of Tuberculous Meningitis Misdiagnosed as Herpes Simplex Virus-1 Encephalitis With the FilmArray Syndromic Polymerase Chain Reaction Panel.

    abstract::The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encep...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofw245

    authors: Gomez CA,Pinsky BA,Liu A,Banaei N

    更新日期:2016-12-07 00:00:00

  • Hepatitis C Virus Treatment Access Among Human Immunodeficiency Virus and Hepatitis C Virus (HCV)-Coinfected People Who Inject Drugs in Guangzhou, China: Implications for HCV Treatment Expansion.

    abstract::Background.  Hepatitis C virus (HCV) treatment access among human immunodeficiency virus (HIV)/HCV-coinfected people who inject drugs is poor, despite a high burden of disease in this population. Understanding barriers and facilitators to HCV treatment uptake is critical to the implementation of new direct-acting anti...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofw065

    authors: Chu CE,Wu F,He X,Zhou K,Cheng Y,Cai W,Geng E,Volberding P,Tucker JD

    更新日期:2016-06-24 00:00:00

  • Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis.

    abstract:Background:Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asy...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofz283

    authors: Ahmadpour E,Foroutan-Rad M,Majidiani H,Moghaddam SM,Hatam-Nahavandi K,Hosseini SA,Rahimi MT,Barac A,Rubino S,Zarean M,Mathioudakis AG,Cevik M

    更新日期:2019-06-11 00:00:00

  • Errors in Diagnostic Test Use and Interpretation Contribute to the High Number of Lyme Disease Referrals in a Low-Incidence State.

    abstract::Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa009

    authors: Boyce RM,Speight C,Lin JT,Farel CE

    更新日期:2020-01-11 00:00:00

  • Corrigendum: Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.

    abstract::[This corrects the article DOI: 10.1093/ofid/ofy251.]. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,已发布勘误

    doi:10.1093/ofid/ofz142

    authors: Abdullahi A,Fopoussi OM,Torimiro J,Atkins M,Kouanfack C,Geretti AM

    更新日期:2019-04-03 00:00:00

  • Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1.

    abstract::In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimiz...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofv210

    authors: Béguelin C,Vázquez M,Bertschi M,Yerly S,de Jong D,Gutbrod K,Rauch A,Cusini A

    更新日期:2015-12-28 00:00:00

  • Chagas Disease in the New York City Metropolitan Area.

    abstract:Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chaga...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofaa156

    authors: Zheng C,Quintero O,Revere EK,Oey MB,Espinoza F,Puius YA,Ramirez-Baron D,Salama CR,Hidalgo LF,Machado FS,Saeed O,Shin J,Patel SR,Coyle CM,Tanowitz HB

    更新日期:2020-05-06 00:00:00

  • Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians.

    abstract:Background:In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofy068

    authors: Gundlapalli AV,Beekmann SE,Graham DR,Polgreen PM,Members of the Emerging Infections Network.

    更新日期:2018-04-23 00:00:00

  • Development and Validation of a Model to Predict Growth of Potentially Antibiotic-Resistant Gram-Negative Bacilli in Critically Ill Children With Suspected Infection.

    abstract:Background:Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofy278

    authors: Karsies T,Moore-Clingenpeel M,Hall M

    更新日期:2018-10-24 00:00:00

  • Acute Human Immunodeficiency Virus (HIV) Syndrome After Nonadherence to Antiretroviral Therapy in a Patient With Chronic HIV Infection: A Case Report.

    abstract::We report a rare case of acute human immunodeficiency virus (HIV) syndrome in a patient with chronic HIV infection with acute illness indistinguishable from acute retroviral syndrome. The patient presented with an acute febrile mononucleosis-like illness after increasing nonadherence to antiretroviral therapy. A marke...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofu112

    authors: Choi SK,Graber CJ

    更新日期:2014-12-23 00:00:00

  • Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial.

    abstract::Background.  First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness. The focus of this study was to compare the safety and immunogenicity of...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章

    doi:10.1093/ofid/ofv040

    authors: Overton ET,Stapleton J,Frank I,Hassler S,Goepfert PA,Barker D,Wagner E,von Krempelhuber A,Virgin G,Meyer TP,Müller J,Bädeker N,Grünert R,Young P,Rösch S,Maclennan J,Arndtz-Wiedemann N,Chaplin P

    更新日期:2015-05-05 00:00:00