Immunohistochemical Analysis of Brainstem Lesions in the Autopsy Cases with Severe Motor and Intellectual Disabilities Showing Sudden Unexplained Death.

abstract：:Background: Tract-based spatial statistics (TBSS) is suitable for the assessment of voxel-wise changes in fiber integrity in WM tracts in the entire brain. Longitudinal TBSS analyses of early multiple sclerosis (MS) using 3 Tesla magnetic resonance imaging (MRI) are not common. Objective: To characterize microstructur...

journal_title：Frontiers in neurology

authors： Schneider R,Genç E,Ahlborn C,Gold R,Lukas C,Bellenberg B

更新日期：2019-11-05 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercis...

journal_title：Frontiers in neurology

authors： Paré MF,Jasmin BJ

更新日期：2017-09-27 00:00:00

abstract：:Different subtypes of Alzheimer's disease (AD) with characteristic distributions of neurofibrillary tangles and corresponding brain atrophy patterns have been identified using structural magnetic resonance imaging (MRI). However, the underlying biological mechanisms that determine this differential expression of neuro...

journal_title：Frontiers in neurology

authors： Ferreira D,Pereira JB,Volpe G,Westman E

更新日期：2019-05-28 00:00:00

abstract：:Background: Spinal and Bulbar Muscular Atrophy (SBMA) is caused by the extension of the polyglutamine tract within the androgen receptor (AR) gene, and results in a multisystem presentation, including the degeneration of lower motor neurons. The androgen receptor (AR) is known to modulate the expression of endogenous ...

journal_title：Frontiers in neurology

authors： Rex C,Nadeau MJ,Douville R,Schellenberg K

更新日期：2019-09-04 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, including sensorineural h...

journal_title：Frontiers in neurology

authors： Katsumi S,Sahin MI,Lewis RM,Iyer JS,Landegger LD,Stankovic KM

更新日期：2020-02-10 00:00:00

abstract：:Eye trauma and blindness are common in the United States, with an incidence of over 2 million cases/year and 25 million blind adults, respectively. However, literature is surprisingly scarce on the potential confounding effect of eye trauma or blindness on the diagnosis of myasthenia gravis (MG), an autoimmune neuromu...

journal_title：Frontiers in neurology

authors： Leis AA,Moore AR

更新日期：2014-07-01 00:00:00

abstract：:Increasing evidence suggests an association between gastrointestinal (GI) disorders and susceptibility and progress of Parkinson's disease (PD). Gut-brain axis has been proposed to play important roles in the pathogenesis of PD, though the exact pathophysiologic mechanism has yet to be elucidated. Here, we discuss the...

journal_title：Frontiers in neurology

authors： Chao YX,Gulam MY,Chia NSJ,Feng L,Rotzschke O,Tan EK

更新日期：2020-08-25 00:00:00

abstract：:It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several ...

journal_title：Frontiers in neurology

authors： Yang D,Zhao D,Ali Shah SZ,Wu W,Lai M,Zhang X,Li J,Guan Z,Zhao H,Li W,Gao H,Zhou X,Yang L

更新日期：2019-11-06 00:00:00

abstract：:Purpose: To assess the efficacy and safety of rituximab treatment as second-line immunotherapy in pediatric cases of anti-NMDA receptor (NMDAR) encephalitis. Methods: We retrospectively recruited 8 patients with anti-NMDAR encephalitis who were treated with rituximab as second-line immunotherapy. We evaluated the clin...

journal_title：Frontiers in neurology

authors： Dou X,Li D,Wu Y,Wang Z,Yang L,Ma N,Wang D,Li X

更新日期：2020-12-14 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fneur.2018.00184.]. ...

journal_title：Frontiers in neurology

authors： Janca R,Krsek P,Jezdik P,Cmejla R,Tomasek M,Komarek V,Marusic P,Jiruska P

更新日期：2019-06-14 00:00:00

abstract：:Epilepsy may reflect a focal abnormality of cerebral tissue, but the generation of seizures typically involves propagation of abnormal activity through cerebral networks. We examined epileptiform discharges (spikes) with dense array electroencephalography (dEEG) in five patients to search for the possible engagement o...

journal_title：Frontiers in neurology

authors： Song J,Tucker DM,Gilbert T,Hou J,Mattson C,Luu P,Holmes MD

更新日期：2013-05-15 00:00:00

abstract：Objective:To investigate the correlation between initial response to antiepileptic drugs (AEDs) and long-term outcomes after 3 years in patients with newly diagnosed epilepsy. Methods:This prospective study included 204 patients with newly diagnosed epilepsy, who were followed-up for at least 36 months. The long-term ...

journal_title：Frontiers in neurology

authors： Xia L,Ou S,Pan S

更新日期：2017-12-08 00:00:00

abstract：:Background: Essential tremor (ET) is a common, progressive neurological syndrome with bilateral upper-limb dysfunction of at least 3-year duration, with or without tremor in other body locations. This disorder has a negative impact on daily function and quality of life. A single oral therapy has been approved by FDA f...

journal_title：Frontiers in neurology

authors： Papapetropoulos S,Lee MS,Boyer S,Newbold EJ

更新日期：2019-06-11 00:00:00

abstract：Introduction:The current standard treatment for patients with Duchenne muscular dystrophy (DMD) involves corticosteroids. Granulocyte colony-stimulating factor (G-CSF) induces the proliferation of satellite cells and myoblasts and, in turn, muscle regeneration. Beneficial effects of G-CSF were also described for skelet...

journal_title：Frontiers in neurology

authors： Sienkiewicz D,Kułak W,Okurowska-Zawada B,Paszko-Patej G,Wojtkowski J,Sochoń K,Kalinowska A,Okulczyk K,Sienkiewicz J,McEachern E

更新日期：2017-10-26 00:00:00

abstract：:Previous studies have suggested that the corticoreticular tract (CRT) has an important role in motor function almost next to the corticospinal tract (CST) in the human brain. Herein, the CRT is reviewed with regard to its anatomy, function, and recovery mechanisms after injury, with particular focus on previous diffus...

journal_title：Frontiers in neurology

authors： Jang SH,Lee SJ

更新日期：2019-11-12 00:00:00

abstract：:Hand-Arm Bimanual Intensive Therapy (HABIT) promotes hand function using intensive practice of bimanual functional and play tasks. This intervention has shown to be efficacious to improve upper-extremity (UE) function in children with unilateral spastic cerebral palsy (USCP). In addition to UE function deficits, lower...

journal_title：Frontiers in neurology

authors： Saussez G,Brandão MB,Gordon AM,Bleyenheuft Y

更新日期：2017-09-26 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the presence of renal cysts and specific extrarenal abnormalities. ADPKD is caused by mutations in either PKD1 or PKD2 genes that encode for integral membrane proteins Polycystin-1 (PC1) and Polycystin-2 (PC2), respectively. Ex...

journal_title：Frontiers in neurology

authors： Thomas C,Zühlsdorf A,Hörtnagel K,Mulahasanovic L,Grauer OM,Kümpers P,Wiendl H,Meuth SG

更新日期：2018-05-25 00:00:00

abstract：:Clinicians are regularly faced with the difficult challenge of diagnosing consciousness after severe brain injury. As such, as many as 40% of minimally conscious patients who demonstrate fluctuations in arousal and awareness are known to be misdiagnosed as unresponsive/vegetative based on clinical consensus. Further, ...

journal_title：Frontiers in neurology

authors： Bareham CA,Allanson J,Roberts N,Hutchinson PJA,Pickard JD,Menon DK,Chennu S

更新日期：2018-08-21 00:00:00

abstract：:Background: The sequence effect (SE), referring to step-to-step reduction in amplitude, is considered to lead to freezing of gait (FOG) in Parkinson's disease (PD). Visual cues may alleviate SE and help reduce freezing episodes. FOG patients show significant SE prior to turning or toward a doorway, but the SE toward a...

journal_title：Frontiers in neurology

authors： Cao SS,Yuan XZ,Wang SH,Taximaimaiti R,Wang XP

更新日期：2020-08-12 00:00:00

abstract：:Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute and adaptive changes in heart rhythm in epilepsy implicate cardiac dysfunction as a potential pathogenic mechanism in SUDEP. Furthermore, variants in genes associated with Long QT syndrome (L...

journal_title：Frontiers in neurology

authors： Bleakley LE,Soh MS,Bagnall RD,Sadleir LG,Gooley S,Semsarian C,Scheffer IE,Berkovic SF,Reid CA

更新日期：2020-09-08 00:00:00

abstract：:Purpose: Rapid muscle fatigue limits clinical applications of functional electrical stimulation (FES) for individuals with motor impairments. This study aimed to characterize the sustainability of muscle force elicited with a novel transcutaneous nerve stimulation technique. Method: A hemiplegic chronic stroke survivo...

journal_title：Frontiers in neurology

authors： Zheng Y,Shin H,Hu X

更新日期：2018-12-04 00:00:00

abstract：:Investigation of the perception of verticality permits to disclose the perceptual mechanisms that underlie balance control and spatial navigation. Estimation of verticality in unusual body orientation with respect to gravity (e.g., laterally tilted in the roll plane) leads to biases that change depending on the encodi...

journal_title：Frontiers in neurology

authors： Cuturi LF,Gori M

更新日期：2019-01-07 00:00:00

abstract：:Huntington's Disease (HD) is a genetic neurodegenerative disease caused by a CAG expansion in the gene encoding Huntingtin (Htt). It is characterized by chorea, cognitive, and psychiatric disorders. The most affected brain region is the striatum, and the clinical symptoms are directly correlated to the rate of striata...

journal_title：Frontiers in neurology

authors： Moumné L,Betuing S,Caboche J

更新日期：2013-10-23 00:00:00

abstract：:Non-linear relations of brain amyloid beta (Aβ) with task- based functional connectivity (tbFC) measured with functional magnetic resonance imaging (fMRI) have been reported in late middle age. Our objective was to examine the association between brain Aβ and resting-state functional connectivity (rsFC) in late middle...

journal_title：Frontiers in neurology

authors： Tahmi M,Rippon B,Palta P,Soto L,Ceballos F,Pardo M,Sherwood G,Hernandez G,Arevalo R,He H,Sedaghat A,Arabshahi S,Teresi J,Moreno H,Brickman AM,Razlighi QR,Luchsinger JA

更新日期：2020-10-06 00:00:00

abstract：:Background: Magnetic resonance imaging is a key diagnostic and monitoring tool in multiple Sclerosis (MS). While the substrates of motor and neuropsychological symptoms in MS have been extensively investigated, nystagmus-associated imaging signatures are relatively under studied. Accordingly, the objective of this stu...

journal_title：Frontiers in neurology

authors： Bede P,Finegan E,Chipika RH,Li Hi Shing S,Lambe J,Meaney J,Redmond J

更新日期：2018-08-23 00:00:00

abstract：:Mitochondrial complex III deficiency nuclear type 2 is an autosomal-recessive disorder caused by mutations in TTC19 gene. TTC19 is involved in the preservation of mitochondrial complex III, which is responsible for transfer of electrons from reduced coenzyme Q to cytochrome C and thus, contributes to the formation of ...

journal_title：Frontiers in neurology

authors： Habibzadeh P,Inaloo S,Silawi M,Dastsooz H,Farazi Fard MA,Sadeghipour F,Faghihi Z,Rezaeian M,Yavarian M,Böhm J,Faghihi MA

更新日期：2019-09-04 00:00:00

abstract：:Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several neuropsychological test scores into composite, or summary, scores exists. This study examined several possible composite scores for the test battery used in the large...

journal_title：Frontiers in neurology

authors： Stenberg J,Karr JE,Terry DP,Saksvik SB,Vik A,Skandsen T,Silverberg ND,Iverson GL

更新日期：2020-07-17 00:00:00

abstract：:Resting state functional MRI (rs-fMRI) has provided important insights into functional reorganization in subjects with Multiple Sclerosis (MS) at different stage of disease. In this cross-sectional study we first assessed, by means of rs-fMRI, the impact of overall T2 lesion load (T2LL) and MS severity score (MSSS) on...

journal_title：Frontiers in neurology

authors： Castellazzi G,Debernard L,Melzer TR,Dalrymple-Alford JC,D'Angelo E,Miller DH,Gandini Wheeler-Kingshott CAM,Mason DF

更新日期：2018-08-20 00:00:00

abstract：:Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation of promising findings between preclinical disease models and patients....

journal_title：Frontiers in neurology

authors： Heath CJ,O'Callaghan C,Mason SL,Phillips BU,Saksida LM,Robbins TW,Barker RA,Bussey TJ,Sahakian BJ

更新日期：2019-08-09 00:00:00

abstract：:Background: Glioblastoma (GBM) is the most aggressive type of primary malignant brain tumor. Carmustine is used by intravenous injection or local implantation in the resection cavity for gliomas, including GBMs. However, the therapeutic potential of carmustine is not well-recognized. This analysis aimed to evaluate th...

journal_title：Frontiers in neurology

authors： Xiao ZZ,Wang ZF,Lan T,Huang WH,Zhao YH,Ma C,Li ZQ

更新日期：2020-09-17 00:00:00