Carmustine as a Supplementary Therapeutic Option for Glioblastoma: A Systematic Review and Meta-Analysis.

Abstract:

:Background: Glioblastoma (GBM) is the most aggressive type of primary malignant brain tumor. Carmustine is used by intravenous injection or local implantation in the resection cavity for gliomas, including GBMs. However, the therapeutic potential of carmustine is not well-recognized. This analysis aimed to evaluate the survival benefits of carmustine in glioma patients, especially those with GBM. Methods: Randomized controlled trials (RCTs) and cohort studies regarding carmustine for glioma treatment were searched in PubMed, the Cochrane Library, and Embase from January 1979 to March 2020. Quality assessment was conducted with Jadad and Newcastle-Ottawa scales (NOS). Statistical analysis was conducted by the Revman 5.3 software. Results: Twenty-two eligible RCTs and cohort studies involving 5,821 glioma patients were included. Overall, glioma patients receiving carmustine as an adjuvant therapy had better progression-free survival [PFS; hazard ratio (HR) = 0.85, 95% CI = 0.77-0.94, P = 0.002] and overall survival (OS; HR = 0.85, 95% CI = 0.79-0.92, P < 0.0001) than those without carmustine treatment. Subgroup analysis showed that the OS benefit was observed in GBM (HR = 0.84, 95% CI = 0.78-0.91, P < 0.00001) but not in anaplastic glioma patients (HR = 1.20, 95% CI = 0.70-2.07, P = 0.50). Additionally, both newly diagnosed and recurrent GBM patients who received carmustine treatment showed better OS (HR = 0.86, 95% CI = 0.79-0.95, P = 0.002; HR = 0.77, 95% CI = 0.67-0.89, P = 0.0002, respectively). Both carmustine implantation in resection cavity and intravenous administration significantly prolonged OS (HR = 0.84, 95% CI = 0.78-0.92, P < 0.0001; HR = 0.86, 95% CI = 0.75-0.99, P = 0.04, respectively). Moreover, GBM patients receiving a combined carmustine and temozolomide (TMZ) therapy had longer OS than those receiving TMZ alone (HR = 0.78, 95% CI = 0.63-0.97, P = 0.03). Conclusion: Carmustine implantation in resection cavity provides survival benefit for GBM patients, and it may be a promising supplement to standard therapeutic protocol by offering a bridge between surgical resection and onset of TMZ therapy.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Xiao ZZ,Wang ZF,Lan T,Huang WH,Zhao YH,Ma C,Li ZQ

doi

10.3389/fneur.2020.01036

subject

Has Abstract

pub_date

2020-09-17 00:00:00

pages

1036

issn

1664-2295

journal_volume

11

pub_type

  • Excessive Daytime Sleepiness in Tension-Type Headache: A Population Study.

    abstract::Excessive daytime sleepiness (EDS) is a prevalent sleep-related complaint across the general population and has been reported to be associated with headache. Tension-type headache (TTH) is the most commonly encountered headache and accounts for a significant amount of disease burden. However, the association between E...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01282

    authors: Kim KM,Kim J,Cho SJ,Kim WJ,Yang KI,Yun CH,Chu MK

    更新日期:2019-12-03 00:00:00

  • Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.

    abstract::Background: Agoraphobia was described in 1871 as a condition of fear-related alterations in spatial orientation and locomotor control triggered by places or situations that might cause a patient to panic and feel trapped. In contemporary nosology, however, this original concept of agoraphobia was split into two diagno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00874

    authors: Indovina I,Conti A,Lacquaniti F,Staab JP,Passamonti L,Toschi N

    更新日期:2019-08-13 00:00:00

  • Persistence of Gut Microbiota Dysbiosis and Chronic Systemic Inflammation After Cerebral Infarction in Cynomolgus Monkeys.

    abstract::Background: The bidirectional interaction between the gut and brain after stroke through the immune-mediated pathway has been studied. However, the long-term effects of gut microbiota and systemic immune homeostasis after cerebral ischemia remain unclear. We examined long-term changes in the gut microbiota and systemi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00661

    authors: Chen Y,Liang J,Ouyang F,Chen X,Lu T,Jiang Z,Li J,Li Y,Zeng J

    更新日期:2019-06-28 00:00:00

  • Mobility Deficits Assessed With Mobile Technology: What Can We Learn From Brain Iron-Altered Animal Models?

    abstract::Background: Recent developments in mobile technology have enabled the investigation of human movements and mobility under natural conditions, i.e., in the home environment. Iron accumulation in the basal ganglia is deleterious in Parkinson's disease (i.e., iron accumulation with lower striatal level of dopamine). The ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00833

    authors: Hopfner F,Hobert MA,Maetzler C,Hansen C,Pham MH,Moreau C,Berg D,Devos D,Maetzler W,Fair-Park II study group.

    更新日期:2019-08-08 00:00:00

  • Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target?

    abstract::Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway during sleep leading to intermittent hypoxia (IH). OSA has been associated with all components of the metabolic syndrome as well as with non-alcoholic fatty liver disease (NAFLD). NAFLD is a common condition ranging in severity from uncomplicat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00149

    authors: Mirrakhimov AE,Polotsky VY

    更新日期:2012-10-17 00:00:00

  • A Method for Whole Brain Ex Vivo Magnetic Resonance Imaging with Minimal Susceptibility Artifacts.

    abstract::Magnetic resonance imaging (MRI) is a non-destructive technique that is capable of localizing pathologies and assessing other anatomical features (e.g., tissue volume, microstructure, and white matter connectivity) in postmortem, ex vivo human brains. However, when brains are removed from the skull and cerebrospinal f...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2016.00208

    authors: Shatil AS,Matsuda KM,Figley CR

    更新日期:2016-11-29 00:00:00

  • CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis.

    abstract::Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activity and slowing of the electroencephalogram, progressive memory disturbances, as well as a variety of other behavioral,...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2015.00163

    authors: Ehling P,Melzer N,Budde T,Meuth SG

    更新日期:2015-07-15 00:00:00

  • A Family With a Complex Phenotype Caused by Two Different Rare Metabolic Disorders: GLUT1 and Very-Long-Chain Fatty Acid Dehydrogenase (VLCAD) Deficiencies.

    abstract::GLUT1 Deficiency Syndrome (GLUT1-DS) is a rare and potentially treatable neurometabolic condition, caused by a reduced glucose transport into the brain and clinically characterized by an epileptic encephalopathy with movement disorders. A wide inter-intrafamilial phenotypic variability has been reported. Very-long-cha...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00514

    authors: Musumeci O,Ferlazzo E,Rodolico C,Gambardella A,Gagliardi M,Aguglia U,Toscano A

    更新日期:2020-06-23 00:00:00

  • Sex-Specific Differences in Rodents Following a Single Primary Blast Exposure: Focus on the Monoamine and Galanin Systems.

    abstract::Most blast-induced traumatic brain injuries (bTBI) are mild in severity and culpable for the lingering and persistent neuropsychological complaints in affected individuals. There is evidence that the prevalence of symptoms post-exposure may be sex-specific. Our laboratory has focused on changes in the monoamine and th...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.540144

    authors: Kawa L,Arborelius UP,Hökfelt T,Risling M

    更新日期:2020-10-15 00:00:00

  • Informed consent: the rate-limiting step in acute stroke trials.

    abstract::Successful implementation of a randomized clinical trial (RCT) for neuro-vascular emergencies such as cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage is extraordinarily challenging. Besides establishing an accurate, hyper-expedited diagnosis among many mimics in a person with acute neurologic...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2011.00065

    authors: Rose DZ,Kasner SE

    更新日期:2011-10-17 00:00:00

  • The Vestibular Implant: Hearing Preservation during Intralabyrinthine Electrode Insertion-A Case Report.

    abstract:OBJECTIVE:The vestibular implant seems feasible as a clinically useful device in the near future. However, hearing preservation during intralabyrinthine implantation remains a challenge. It should be preserved to be able to treat patients with bilateral vestibulopathy and (partially) intact hearing. This case study inv...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00137

    authors: van de Berg R,Lucieer F,Guinand N,van Tongeren J,George E,Guyot JP,Kingma H,van Hoof M,Temel Y,van Overbeeke J,Perez-Fornos A,Stokroos R

    更新日期:2017-04-10 00:00:00

  • Dipeptidyl Peptidase-4 Inhibitors for the Potential Treatment of Brain Disorders; A Mini-Review With Special Focus on Linagliptin and Stroke.

    abstract::Cerebral stroke is a leading cause of death and persistent disability of elderly in the world. Although stroke prevention by targeting several risk factors such as diabetes and hypertension has decreased the stroke incidence, the total number of strokes is increasing due to the population aging and new preventive ther...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.00493

    authors: Darsalia V,Johansen OE,Lietzau G,Nyström T,Klein T,Patrone C

    更新日期:2019-05-08 00:00:00

  • Methods for examining electrophysiological coherence in epileptic networks.

    abstract::Epilepsy may reflect a focal abnormality of cerebral tissue, but the generation of seizures typically involves propagation of abnormal activity through cerebral networks. We examined epileptiform discharges (spikes) with dense array electroencephalography (dEEG) in five patients to search for the possible engagement o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2013.00055

    authors: Song J,Tucker DM,Gilbert T,Hou J,Mattson C,Luu P,Holmes MD

    更新日期:2013-05-15 00:00:00

  • Non-fluent/Agrammatic Variant of Primary Progressive Aphasia With Generalized Auditory Agnosia.

    abstract::Cortical neurodegeneration-induced non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a clinical syndrome characterized by non-fluent speech, such as apraxia of speech or agrammatism. We describe the case of an 80-year-old right-handed woman who exhibited nfvPPA. Atypically, our patient also pres...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.00519

    authors: Watanabe H,Ikeda M,Mori E

    更新日期:2020-06-26 00:00:00

  • Mixed effects of deep brain stimulation on depressive symptomatology in Parkinson's disease: a review of randomized clinical trials.

    abstract::Although ~50% of patients with Parkinson's disease (PD) experience depression, treatment for this important and debilitating comorbidity is relatively understudied. Deep brain stimulation (DBS) has been increasingly utilized for the management of tremors in progressive PD. Several preliminary studies have shown the po...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2014.00154

    authors: Gökbayrak NS,Piryatinsky I,Gavett RA,Ahmed OJ

    更新日期:2014-08-11 00:00:00

  • Resistant Hypertension after Hypertensive Intracerebral Hemorrhage Is Associated with More Medical Interventions and Longer Hospital Stays without Affecting Outcome.

    abstract:BACKGROUND:Hypertension (HTN) is the most common cause of spontaneous intracerebral hemorrhage (ICH). The aim of this study is to investigate the role of resistant HTN in patients with ICH. METHODS AND RESULTS:We conducted a retrospective study of all consecutive ICH admissions at our medical center from November 2013...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00184

    authors: Hong D,Stradling D,Dastur CK,Akbari Y,Groysman L,Al-Khoury L,Chen J,Small SL,Yu W

    更新日期:2017-05-03 00:00:00

  • Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury.

    abstract::Inflammation after traumatic spinal cord injury (SCI) is non-resolving and thus still present in chronic injury stages. It plays a key role in the pathophysiology of SCI and has been associated with further neurodegeneration and development of neuropathic pain. Neural precursor cells (NPCs) have been shown to reduce t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00428

    authors: Riemann L,Younsi A,Scherer M,Zheng G,Skutella T,Unterberg AW,Zweckberger K

    更新日期:2018-06-08 00:00:00

  • Why Cognitive-Cognitive Dual-Task Testing Assessment Should Be Implemented in Studies on Multiple Sclerosis and in Regular Clinical Practice.

    abstract::Cognitive impairment is prevalent and disabling in multiple sclerosis (MS) and is severely impacting quality of life (QoL). Aside its routine assessment in clinical care, it should more often be implemented as endpoint/outcome measure in clinical trials. However, a fundamental aspect-often neglected in clinical practi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00905

    authors: Beste C,Ziemssen T

    更新日期:2020-08-28 00:00:00

  • Integration of proteomics, bioinformatics, and systems biology in traumatic brain injury biomarker discovery.

    abstract::Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2013.00061

    authors: Guingab-Cagmat JD,Cagmat EB,Hayes RL,Anagli J

    更新日期:2013-05-31 00:00:00

  • Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Is Not Associated with Neurological Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage.

    abstract:OBJECT:Aneurysmal subarachnoid hemorrhage (aSAH) is a common cause of death or long-term disability. Despite advances in neurocritical care, there is still only a very limited ability to monitor the development of secondary brain injury or to predict neurological outcome after aSAH. Soluble urokinase-type plasminogen a...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00144

    authors: Kiiski H,Jalkanen V,Ala-Peijari M,Hämäläinen M,Moilanen E,Peltola J,Tenhunen J

    更新日期:2017-04-18 00:00:00

  • Ventricular Tract Hemorrhage Following Intracranial Nail Removal: Utility of Real-time Endovascular Assistance.

    abstract::Penetrating brain trauma commonly results in occult neurovascular injury. Detailed cerebrovascular imaging can evaluate the relationship of intracranial foreign bodies to major vascular structures, assess for traumatic pseudoaneurysms, and ensure hemostasis during surgical removal. We report a case of a self-inflicted...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2016.00112

    authors: Rennert RC,Steinberg JA,Sack J,Pannell JS,Khalessi AA

    更新日期:2016-07-14 00:00:00

  • Harnessing Real-World Data to Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS).

    abstract::Background: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is the first example of a learning health system in multiple sclerosis (MS). This paper describes the initial implementation of MS PATHS and initial patient characteristics. Methods: MS PATHS is an ongoing initiative conducted...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00632

    authors: Mowry EM,Bermel RA,Williams JR,Benzinger TLS,de Moor C,Fisher E,Hersh CM,Hyland MH,Izbudak I,Jones SE,Kieseier BC,Kitzler HH,Krupp L,Lui YW,Montalban X,Naismith RT,Nicholas JA,Pellegrini F,Rovira A,Schulze M,Tacke

    更新日期:2020-08-07 00:00:00

  • Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia.

    abstract::Rett Syndrome (RTT) is a neurodevelopmental disorder caused by loss of function of the transcriptional regulator Methyl-CpG-Binding Protein 2 (MeCP2). In addition to the characteristic loss of hand function and spoken language after the first year of life, people with RTT also have a variety of physiological and auton...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.593554

    authors: Ward CS,Huang TW,Herrera JA,Samaco RC,McGraw CM,Parra DE,Arvide EM,Ito-Ishida A,Meng X,Ure K,Zoghbi HY,Neul JL

    更新日期:2020-10-30 00:00:00

  • Microvascular Parameters Help to Predict Stroke Risk in the Asian Diabetic Population in Taiwan: A Population Based Case-Control Study.

    abstract::Intensive glycemic control has not shown consistent findings in stroke prevention for diabetes patients, particularly for those with microvascular complications. This case-control study evaluates the risks of stroke in Asian diabetic population with microvascular complications. From the insurance claims of Taiwan, we ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00719

    authors: Lo SF,Chen WL,Muo CH,Chen PC,Chen SY,Kuo CL,Sung FC

    更新日期:2018-08-29 00:00:00

  • Clinical Features and Correlates of Excessive Daytime Sleepiness in Parkinson's Disease.

    abstract::Objective: To explore the clinical features and correlates of excessive daytime sleepiness (EDS) in a Chinese population of Parkinson's disease (PD) patients. Methods: Patients with clinically established or clinically probable PD were recruited. Clinical and demographic data were collected, and participants were eval...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00121

    authors: Xiang YQ,Xu Q,Sun QY,Wang ZQ,Tian Y,Fang LJ,Yang Y,Tan JQ,Yan XX,Tang BS,Guo JF

    更新日期:2019-02-19 00:00:00

  • A fully integrated wireless system for intracranial direct cortical stimulation, real-time electrocorticography data transmission, and smart cage for wireless battery recharge.

    abstract::Wireless transmission of cortical signals is an essential step to improve the safety of epilepsy procedures requiring seizure focus localization and to provide chronic recording of brain activity for Brain Computer Interface (BCI) applications. Our group developed a fully implantable and externally rechargeable device...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00156

    authors: Piangerelli M,Ciavarro M,Paris A,Marchetti S,Cristiani P,Puttilli C,Torres N,Benabid AL,Romanelli P

    更新日期:2014-08-25 00:00:00

  • Longitudinal Neuroimaging in Pediatric Traumatic Brain Injury: Current State and Consideration of Factors That Influence Recovery.

    abstract::Traumatic brain injury (TBI) is a leading cause of death and disability for children and adolescents in the U.S. and other developed and developing countries. Injury to the immature brain varies greatly from that of the mature, adult brain due to numerous developmental, pre-injury, and injury-related factors that work...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01296

    authors: Lindsey HM,Wilde EA,Caeyenberghs K,Dennis EL

    更新日期:2019-12-13 00:00:00

  • Accuracy of Emergency Medical Services Dispatcher and Crew Diagnosis of Stroke in Clinical Practice.

    abstract:BACKGROUND:Accurate recognition of stroke symptoms by Emergency Medical Services (EMS) is necessary for timely care of acute stroke patients. We assessed the accuracy of stroke diagnosis by EMS in clinical practice in a major US city. METHODS AND RESULTS:Philadelphia Fire Department data were merged with data from a s...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00466

    authors: Jia J,Band R,Abboud ME,Pajerowski W,Guo M,David G,Mechem CC,Messé SR,Carr BG,Mullen MT

    更新日期:2017-09-14 00:00:00

  • Complex-value coherence mapping reveals novel abnormal resting-state functional connectivity networks in task-specific focal hand dystonia.

    abstract::Resting-state imaging designs are powerful in modeling functional networks in movement disorders because they eliminate task performance related confounds. However, the most common metric for quantifying functional connectivity, i.e., bivariate magnitude coherence (Coh), can sometimes be contaminated by spurious corre...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2013.00149

    authors: Hinkley LB,Sekihara K,Owen JP,Westlake KP,Byl NN,Nagarajan SS

    更新日期:2013-10-10 00:00:00

  • Keep an eye out for myasthenia gravis patients with an eye out.

    abstract::Eye trauma and blindness are common in the United States, with an incidence of over 2 million cases/year and 25 million blind adults, respectively. However, literature is surprisingly scarce on the potential confounding effect of eye trauma or blindness on the diagnosis of myasthenia gravis (MG), an autoimmune neuromu...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00112

    authors: Leis AA,Moore AR

    更新日期:2014-07-01 00:00:00