Abstract：
:Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacterial signaling molecule for pathogenic bacteria. Specifically, we found that serotonin acts as an interkingdom signaling molecule via quorum sensing and that it stimulates the production of bacterial virulence factors and increases biofilm formation in vitro and in vivo in a novel mouse infection model. This discovery points out at roles of serotonin both in bacteria and humans, and at phenotypic implications not only manifested in mood behavior but also in infection processes in the host. Thus, regulating serotonin concentrations in the gut may provide with paradigm shifting therapeutic approaches.
journal_name
EBioMedicinejournal_title
EBioMedicineauthors
Knecht LD,O'Connor G,Mittal R,Liu XZ,Daftarian P,Deo SK,Daunert Sdoi
10.1016/j.ebiom.2016.05.037subject
Has Abstractpub_date
2016-07-01 00:00:00pages
161-169issn
2352-3964pii
S2352-3964(16)30239-0journal_volume
9pub_type
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