Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7.

Abstract:

:Rabbits (Oryctolagus cuniculus) have been the very frequently used as animal models in the study of human lipid metabolism and atherosclerosis, because they have similar lipoprotein metabolism to humans. Most of hyperlipidemia and atherosclerosis rabbit models are produced by feeding rabbits a high-cholesterol diet. Gene editing or knockout (KO) offered another means of producing rabbit models for study of the metabolism of lipids and lipoproteins. Even so, apolipoprotein (Apo)E KO rabbits must be fed a high-cholesterol diet to induce hyperlipidemia. In this study, we used the CRISPR/Cas9 system anchored exon 7 of low-density lipoprotein receptor (LDLR) in an attempt to generate KO rabbits. We designed two sgRNA sequences located in E7:g.7055-7074 and E7:g.7102-7124 of rabbit LDLR gene, respectively. Seven LDLR-KO founder rabbits were generated, and all of them contained biallelic modifications. Various mutational LDLR amino acid sequences of the 7 founder rabbits were subjected to tertiary structure modeling with SWISS-MODEL, and results showed that the structure of EGF-A domain of each protein differs from the wild-type. All the founder rabbits spontaneously developed hypercholesterolemia and atherosclerosis on a normal chow (NC) diet. Analysis of their plasma lipids and lipoproteins at the age of 12 weeks revealed that all these KO rabbits exhibited markedly increased levels of plasma TC (the highest of which was 1013.15 mg/dl, 20-fold higher than wild-type rabbits), LDL-C (the highest of which was 730.00 mg/dl, 35-fold higher than wild-type rabbits) and TG accompanied by reduced HDL-C levels. Pathological examinations of a founder rabbit showed prominent aortic atherosclerosis lesions and coronary artery atherosclerosis.In conclusion, we have reported the generation LDLR-KO rabbit model for the study of spontaneous hypercholesterolemia and atherosclerosis on a NC diet. The LDLR-KO rabbits should be a useful rabbit model of human familial hypercholesterolemia (FH) for the simulations of human primary hypercholesterolemia and such models would allow more exact research into cardio-cerebrovascular disease.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Lu R,Yuan T,Wang Y,Zhang T,Yuan Y,Wu D,Zhou M,He Z,Lu Y,Chen Y,Fan J,Liang J,Cheng Y

doi

10.1016/j.ebiom.2018.09.020

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

29-38

issn

2352-3964

pii

S2352-3964(18)30380-3

journal_volume

36

pub_type

杂志文章
  • Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by emphysema and/or obstructive bronchiolitis. Deficiency in vitamin D3 (VD3), which regulates gene expression through binding to vitamin D receptor (VDR), is associated with high risks of COPD susceptibility. Alveolar macrophages (AM), which are ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2019.06.039

    authors: Hu G,Dong T,Wang S,Jing H,Chen J

    更新日期:2019-07-01 00:00:00

  • Implementation and use of whole exome sequencing for metastatic solid cancer.

    abstract:BACKGROUND:Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we address the feasibility and utility of routine somatic and constitutional exome analysis in metastatic cancer patients. METHODS:Exoma trial (NCT02840604) i...

    journal_title:EBioMedicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.ebiom.2019.102624

    authors: Réda M,Richard C,Bertaut A,Niogret J,Collot T,Fumet JD,Blanc J,Truntzer C,Desmoulins I,Ladoire S,Hennequin A,Favier L,Bengrine L,Vincent J,Hervieu A,Dusserre JG,Lepage C,Foucher P,Borg C,Albuisson J,Arnould L,Na

    更新日期:2020-01-01 00:00:00

  • Bach1-induced suppression of angiogenesis is dependent on the BTB domain.

    abstract::The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for the anti-angiogenic effects of Bach1 remain unclear. This study determined the role of the BTB domain of Bach1 in ischemic angiogenesis. Bach1 is highly expres...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2019.102617

    authors: Jiang L,Jia M,Wei X,Guo J,Hao S,Mei A,Zhi X,Wang X,Li Q,Jin J,Zhang J,Li S,Meng D

    更新日期:2020-01-01 00:00:00

  • Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.

    abstract::Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2018.08.014

    authors: Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

    更新日期:2018-09-01 00:00:00

  • Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

    abstract:BACKGROUND:Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. METHODS:In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (e...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2016.01.011

    authors: Wei FF,Drummen NE,Schutte AE,Thijs L,Jacobs L,Petit T,Yang WY,Smith W,Zhang ZY,Gu YM,Kuznetsova T,Verhamme P,Allegaert K,Schutte R,Lerut E,Evenepoel P,Vermeer C,Staessen JA

    更新日期:2016-01-13 00:00:00

  • OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories.

    abstract:BACKGROUND:HIV drug resistance (HIVDR) testing can assist clinicians in selecting treatments. However, high complexity and cost of genotyping assays limit routine testing in settings where HIVDR prevalence has reached high levels. METHODS:The oligonucleotide ligation assay (OLA)-Simple kit was developed for detection ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2019.11.002

    authors: Panpradist N,Beck IA,Vrana J,Higa N,McIntyre D,Ruth PS,So I,Kline EC,Kanthula R,Wong-On-Wing A,Lim J,Ko D,Milne R,Rossouw T,Feucht UD,Chung M,Jourdain G,Ngo-Giang-Huong N,Laomanit L,Soria J,Lai J,Klavins ED,Fr

    更新日期:2019-12-01 00:00:00

  • TP63 isoform expression is linked with distinct clinical outcomes in cancer.

    abstract:BACKGROUND:Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple is...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2019.11.022

    authors: Bankhead A 3rd,McMaster T,Wang Y,Boonstra PS,Palmbos PL

    更新日期:2020-01-01 00:00:00

  • Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing.

    abstract::The emergence and prevalence of antibiotic-resistant bacteria are an increasing cause of death worldwide, resulting in a global 'call to action' to avoid receding into an era lacking effective antibiotics. Despite the urgency, the healthcare industry still relies on a single in vitro bioassay to determine antibiotic e...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2017.05.026

    authors: Ersoy SC,Heithoff DM,Barnes L 5th,Tripp GK,House JK,Marth JD,Smith JW,Mahan MJ

    更新日期:2017-06-01 00:00:00

  • Transcription factor EB regulates cardiovascular homeostasis.

    abstract::Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

    journal_title:EBioMedicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ebiom.2020.103207

    authors: Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

    更新日期:2021-01-01 00:00:00

  • Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human.

    abstract:BACKGROUND:The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103176

    authors: Schellekens H,Torres-Fuentes C,van de Wouw M,Long-Smith CM,Mitchell A,Strain C,Berding K,Bastiaanssen TFS,Rea K,Golubeva AV,Arboleya S,Verpaalen M,Pusceddu MM,Murphy A,Fouhy F,Murphy K,Ross P,Roy BL,Stanton C,Dinan

    更新日期:2021-01-01 00:00:00

  • Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks.

    abstract::Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that ...

    journal_title:EBioMedicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ebiom.2016.11.020

    authors: Mallikarjun V,Swift J

    更新日期:2016-12-01 00:00:00

  • Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces.

    abstract:BACKGROUND:Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and metabolic adaptations within different tissue microenvironments. How tis...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103055

    authors: Sangaletti S,Iannelli F,Zanardi F,Cancila V,Portararo P,Botti L,Vacca D,Chiodoni C,Di Napoli A,Valenti C,Rizzello C,Vegliante MC,Pisati F,Gulino A,Ponzoni M,Colombo MP,Tripodo C

    更新日期:2020-11-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract:BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103129

    authors: Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期:2020-12-01 00:00:00

  • Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use.

    abstract:BACKGROUND:The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology. METHODS:1) Forty-eight high a...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2017.11.025

    authors: Shakra MA,Leyton M,Moghnieh H,Pruessner J,Dagher A,Pihl R

    更新日期:2018-01-01 00:00:00

  • Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.

    abstract::Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective inhibitor of the c...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2015.10.010

    authors: Osawa Y,Oboki K,Imamura J,Kojika E,Hayashi Y,Hishima T,Saibara T,Shibasaki F,Kohara M,Kimura K

    更新日期:2015-10-08 00:00:00

  • Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow.

    abstract:BACKGROUND:Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. However, the mechanism(s) by which stem cells/EVs limit stroke injury have ye...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103161

    authors: Barzegar M,Wang Y,Eshaq RS,Yun JW,Boyer CJ,Cananzi SG,White LA,Chernyshev O,Kelley RE,Minagar A,Stokes KY,Lu XH,Alexander JS

    更新日期:2021-01-01 00:00:00

  • Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancer.

    abstract:BACKGROUND:Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology. Owing to the rapid development of phosphoproteomics, we can now measure thousands of phosphoproteins in human cancer tissues. However, limited studie...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2018.12.039

    authors: Tong M,Yu C,Zhan D,Zhang M,Zhen B,Zhu W,Wang Y,Wu C,He F,Qin J,Li T

    更新日期:2019-02-01 00:00:00

  • Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells.

    abstract::In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2018.03.014

    authors: Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

    更新日期:2018-04-01 00:00:00

  • Pathophysiologic Response to Burns in the Elderly.

    abstract::Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. Th...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2015.07.040

    authors: Jeschke MG,Patsouris D,Stanojcic M,Abdullahi A,Rehou S,Pinto R,Chen P,Burnett M,Amini-Nik S

    更新日期:2015-07-31 00:00:00

  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

    abstract::Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activa...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2016.10.008

    authors: Matsunaga N,Ikeda E,Kakimoto K,Watanabe M,Shindo N,Tsuruta A,Ikeyama H,Hamamura K,Higashi K,Yamashita T,Kondo H,Yoshida Y,Matsuda M,Ogino T,Tokushige K,Itcho K,Furuichi Y,Nakao T,Yasuda K,Doi A,Amamoto T,Aramaki

    更新日期:2016-11-01 00:00:00

  • Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

    abstract:BACKGROUND:Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) migh...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2019.10.043

    authors: Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z

    更新日期:2019-11-01 00:00:00

  • SARS-CoV-2 leads to a small vessel endotheliitis in the heart.

    abstract:BACKGROUND:SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the coronary tree is not explored yet. METHODS:Cardiac autopsy tissue of the ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.103182

    authors: Maccio U,Zinkernagel AS,Shambat SM,Zeng X,Cathomas G,Ruschitzka F,Schuepbach RA,Moch H,Varga Z

    更新日期:2021-01-01 00:00:00

  • Childhood growth and neurocognition are associated with distinct sets of metabolites.

    abstract:BACKGROUND:Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer ne...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2019.05.043

    authors: Moreau GB,Ramakrishnan G,Cook HL,Fox TE,Nayak U,Ma JZ,Colgate ER,Kirkpatrick BD,Haque R,Petri WA Jr

    更新日期:2019-06-01 00:00:00

  • Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.

    abstract::Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a trigger of neurodegenera...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2017.05.012

    authors: Kobayashi S,Tanaka T,Soeda Y,Almeida OFX,Takashima A

    更新日期:2017-06-01 00:00:00

  • TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia.

    abstract:BACKGROUND:Decidual natural killer (dNK) cells are the predominant lymphocytes accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in preeclampsia, a gestational complication characterized by high blood pressure and increased proteinuria occurring after 20 weeks pregnancy, is not completely u...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2018.12.015

    authors: Zhang J,Dunk CE,Shynlova O,Caniggia I,Lye SJ

    更新日期:2019-01-01 00:00:00

  • Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology.

    abstract::Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haem...

    journal_title:EBioMedicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ebiom.2014.12.006

    authors: Brousse V,Colin Y,Pereira C,Arnaud C,Odièvre MH,Boutemy A,Guitton C,de Montalembert M,Lapouméroulie C,Picot J,Le Van Kim C,El Nemer W

    更新日期:2014-12-18 00:00:00

  • Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.

    abstract:BACKGROUND:Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease. METHODS:Cardiomyocytes wer...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102845

    authors: Sanchez-Alonso JL,Loucks A,Schobesberger S,van Cromvoirt AM,Poulet C,Chowdhury RA,Trayanova N,Gorelik J

    更新日期:2020-07-01 00:00:00

  • Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

    abstract:INTRODUCTION:Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival rates, patients eventually succumb to disease progression. We investigated splicing deregulation both as molecular prognostic factor and potential ...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2018.12.025

    authors: Sciarrillo R,Wojtuszkiewicz A,El Hassouni B,Funel N,Gandellini P,Lagerweij T,Buonamici S,Blijlevens M,Zeeuw van der Laan EA,Zaffaroni N,Deraco M,Kusamura S,Würdinger T,Peters GJ,Molthoff CFM,Jansen G,Kaspers GJL,Cloos J

    更新日期:2019-01-01 00:00:00

  • Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy.

    abstract:BACKGROUND:There is large variation in treatment responses in children with cerebral palsy. Experimental and clinical results suggest that dopamine neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are involved in motor learning and plasticity, which are key factors in modern habilitation succes...

    journal_title:EBioMedicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ebiom.2017.12.028

    authors: Diaz Heijtz R,Almeida R,Eliasson AC,Forssberg H

    更新日期:2018-02-01 00:00:00

  • CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.

    abstract:BACKGROUND:Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and extracellular matrix...

    journal_title:EBioMedicine

    pub_type: 杂志文章

    doi:10.1016/j.ebiom.2020.102679

    authors: Xiang Q,Kang L,Wang J,Liao Z,Song Y,Zhao K,Wang K,Yang C,Zhang Y

    更新日期:2020-03-01 00:00:00