Development and validation of a magnetic resonance imaging-based model for the prediction of distant metastasis before initial treatment of nasopharyngeal carcinoma: A retrospective cohort study.


BACKGROUND:We aimed to identify a magnetic resonance imaging (MRI)-based model for assessment of the risk of individual distant metastasis (DM) before initial treatment of nasopharyngeal carcinoma (NPC). METHODS:This retrospective cohort analysis included 176 patients with NPC. Using the PyRadiomics platform, we extracted the imaging features of primary tumors in all patients who did not exhibit DM before treatment. Subsequently, we used minimum redundancy-maximum relevance and least absolute shrinkage and selection operator algorithms to select the strongest features and build a logistic model for DM prediction. The independent statistical significance of multiple clinical variables was tested using multivariate logistic regression analysis. FINDINGS:In total, 2780 radiomic features were extracted. A DM MRI-based model (DMMM) comprising seven features was constructed for the classification of patients into high- and low-risk groups in a training cohort and validated in an independent cohort. Overall survival was significantly shorter in the high-risk group than in the low-risk group (P < 0·001). A radiomics nomogram based on radiomic features and clinical variables was developed for DM risk assessment in each patient, and it showed a significant predictive ability in the training [area under the curve (AUC), 0·827; 95% confidence interval (CI), 0.754-0.900] and validation (AUC, 0.792; 95% CI, 0.633-0.952) cohorts. INTERPRETATION:DMMM can serve as a visual prognostic tool for DM prediction in NPC, and it can improve treatment decisions by aiding in the differentiation of patients with high and low risks of DM. FUND: This research received financial support from the National Natural Science Foundation of China (81571664, 81871323, 81801665, 81771924, 81501616, 81671851, and 81527805); the National Natural Science Foundation of Guangdong Province (2018B030311024); the Science and Technology Planning Project of Guangdong Province (2016A020216020); the Scientific Research General Project of Guangzhou Science Technology and Innovation Commission (201707010328); the China Postdoctoral Science Foundation (2016M600145); and the National Key R&D Program of China (2017YFA0205200, 2017YFC1308700, and 2017YFC1309100).






Zhang L,Dong D,Li H,Tian J,Ouyang F,Mo X,Zhang B,Luo X,Lian Z,Pei S,Dong Y,Huang W,Liang C,Liu J,Zhang S




Has Abstract


2019-02-01 00:00:00










  • Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression.

    abstract:BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...


    pub_type: 杂志文章


    authors: Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

    更新日期:2019-02-01 00:00:00

  • Liver Dysfunction during Pregnancy and Its Association of With Preterm Birth in China: A Prospective Cohort Study.

    abstract:BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...


    pub_type: 杂志文章


    authors: Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

    更新日期:2017-12-01 00:00:00

  • Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.

    abstract:BACKGROUND:Epidemiological, laboratory and clinical studies have established an association between elevated urate and high blood pressure (BP). However, the inference of causality remains controversial. A naturally occurring antioxidant, urate may also be neuroprotective, and urate-elevating treatment with its precurs...


    pub_type: 杂志文章,随机对照试验


    authors: Chen X,Umeh CC,Tainsh RE,Feng DD,Maguire M,Zuo F,Rahimian M,Logan R,Wang X,Ascherio A,Macklin EA,Buys ES,Schwarzschild MA,Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators.

    更新日期:2018-11-01 00:00:00

  • Fatty Acid Metabolism is Associated With Disease Severity After H7N9 Infection.

    abstract:BACKGROUND:Human infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated with a high mortality rate. However, the metabolic basis of such systemic alterations remains unknown. METHODS:This study included hospitalized patients (n = 4) with laboratory-confirm...


    pub_type: 杂志文章


    authors: Sun X,Song L,Feng S,Li L,Yu H,Wang Q,Wang X,Hou Z,Li X,Li Y,Zhang Q,Li K,Cui C,Wu J,Qin Z,Wu Q,Chen H

    更新日期:2018-07-01 00:00:00

  • Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction.

    abstract:BACKGROUND:The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susceptibility, but gaps ...


    pub_type: 杂志文章


    authors: Chen ML,Doddi A,Royer J,Freschi L,Schito M,Ezewudo M,Kohane IS,Beam A,Farhat M

    更新日期:2019-05-01 00:00:00

  • Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer.

    abstract:BACKGROUND:Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. METHODS:Utilising 915 colon and rectal carcinomas in...


    pub_type: 杂志文章


    authors: Fujiyoshi K,Väyrynen JP,Borowsky J,Papke DJ Jr,Arima K,Haruki K,Kishikawa J,Akimoto N,Ugai T,Lau MC,Gu S,Shi S,Zhao M,Da Silva AFL,Twombly TS,Nan H,Meyerhardt JA,Song M,Zhang X,Wu K,Chan AT,Fuchs CS,Lennerz JK

    更新日期:2020-07-01 00:00:00

  • AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

    abstract::Nonalcoholic fatty liver disease is a highly prevalent component of disorders associated with disrupted energy homeostasis. Although dysregulation of the energy sensor AMP-activated protein kinase (AMPK) is viewed as a pathogenic factor in the development of fatty liver its role has not been directly demonstrated. Une...


    pub_type: 杂志文章


    authors: Boudaba N,Marion A,Huet C,Pierre R,Viollet B,Foretz M

    更新日期:2018-02-01 00:00:00

  • OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling.

    abstract:BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...


    pub_type: 杂志文章


    authors: Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

    更新日期:2019-03-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract:BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...


    pub_type: 杂志文章


    authors: Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期:2020-12-01 00:00:00

  • Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells.

    abstract::Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...


    pub_type: 杂志文章


    authors: Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

    更新日期:2018-09-01 00:00:00

  • CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.

    abstract:BACKGROUND:Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and extracellular matrix...


    pub_type: 杂志文章


    authors: Xiang Q,Kang L,Wang J,Liao Z,Song Y,Zhao K,Wang K,Yang C,Zhang Y

    更新日期:2020-03-01 00:00:00

  • Reporting of Cardiovascular Medical Device Adverse Events to Pharmaceuticals and Medical Devices Agency, Japan.

    abstract:BACKGROUND:Marketing authorization holders (MAHs) are obligated to report adverse events (AEs) within 15 days (some cases 30 days) to the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan. METHODS:To analyze the timeliness of AE reporting to the PMDA, 6610 reports for five categories of cardiovascular devices...


    pub_type: 杂志文章


    authors: Handa N,Ishii K,Matsui Y,Ando Y

    更新日期:2015-07-10 00:00:00

  • The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.

    abstract::Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calculations and experimental approaches including cellular studies, X-ray c...


    pub_type: 杂志文章


    authors: Bunney TD,Wan S,Thiyagarajan N,Sutto L,Williams SV,Ashford P,Koss H,Knowles MA,Gervasio FL,Coveney PV,Katan M

    更新日期:2015-03-01 00:00:00

  • Intratumor Heterogeneity in Primary Kidney Cancer Revealed by Metabolic Profiling of Multiple Spatially Separated Samples within Tumors.

    abstract::Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation of the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated in kidney cancer. However, intratumor metabolic heterogeneity has not been investigated. Here...


    pub_type: 杂志文章


    authors: Okegawa T,Morimoto M,Nishizawa S,Kitazawa S,Honda K,Araki H,Tamura T,Ando A,Satomi Y,Nutahara K,Hara T

    更新日期:2017-05-01 00:00:00

  • PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.

    abstract::Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyro...


    pub_type: 杂志文章


    authors: Lopez-Campistrous A,Adewuyi EE,Benesch MGK,Ko YM,Lai R,Thiesen A,Dewald J,Wang P,Chu K,Ghosh S,Williams DC,Vos LJ,Brindley DN,McMullen TPW

    更新日期:2016-10-01 00:00:00

  • Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats.

    abstract:BACKGROUND:Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits cardiorespiratory morbidity. We investigated if treatment with prebiot...


    pub_type: 杂志文章


    authors: O'Connor KM,Lucking EF,Bastiaanssen TFS,Peterson VL,Crispie F,Cotter PD,Clarke G,Cryan JF,O'Halloran KD

    更新日期:2020-09-01 00:00:00

  • Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection.

    abstract::Individual differences in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection have been of interest for decades. We aimed to determine the contribution of large isoform of Mammalian DnaJ (MRJ-L), a HIV-1 Vpr-interacting cellular protein, to this natural variation. Expression of MRJ-L in monocyte-de...


    pub_type: 杂志文章


    authors: Chiang YP,Sheng WH,Shao PL,Chi YH,Chen YM,Huang SW,Shih HM,Chang LY,Lu CY,Chang SC,Hung CC,Huang LM

    更新日期:2014-10-07 00:00:00

  • Developed and validated a prognostic nomogram for recurrence-free survival after complete surgical resection of local primary gastrointestinal stromal tumors based on deep learning.

    abstract::This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...


    pub_type: 杂志文章


    authors: Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

    更新日期:2019-01-01 00:00:00

  • Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.

    abstract::Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future off...


    pub_type: 杂志文章


    authors: Wu D,Feng B,Dai Y,Wu X,Chen B,Xu C,Tang Y,Wang K,Zhang S,Wang S,Luo B,Chen Z

    更新日期:2017-03-01 00:00:00

  • Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation.

    abstract:BACKGROUND:Acute lung injury (ALI) is a severe life-threatening inflammatory disease. Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT regulates diverse cellular responses, but the significance in neutrophilic inflammation and ALI remains unknown. METHODS:Human neutrophils and neut...


    pub_type: 杂志文章


    authors: Chen PJ,Ko IL,Lee CL,Hu HC,Chang FR,Wu YC,Leu YL,Wu CC,Lin CY,Pan CY,Tsai YF,Hwang TL

    更新日期:2019-02-01 00:00:00

  • Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma.

    abstract:BACKGROUND:Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive study, novel therapeuti...


    pub_type: 杂志文章


    authors: Siebenthall KT,Miller CP,Vierstra JD,Mathieu J,Tretiakova M,Reynolds A,Sandstrom R,Rynes E,Haugen E,Johnson A,Nelson J,Bates D,Diegel M,Dunn D,Frerker M,Buckley M,Kaul R,Zheng Y,Himmelfarb J,Ruohola-Baker H,Akiles

    更新日期:2019-03-01 00:00:00

  • Programming and Regulation of Metabolic Homeostasis by HDAC11.

    abstract::Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues. They play pivotal roles in governing cell behaviors and are indispensable in numerous biological processes. HDAC11, the last identified and sole member of class IV HDACs, w...


    pub_type: 杂志文章


    authors: Sun L,Marin de Evsikova C,Bian K,Achille A,Telles E,Pei H,Seto E

    更新日期:2018-07-01 00:00:00

  • The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies.

    abstract:BACKGROUND:α4β7 is a gut-homing integrin heterodimer that can act as a non-essential binding molecule for HIV. A previous study in heterosexual African women found that individuals with higher proportions of α4β7 expressing CD4+ T cells were more likely to become infected with HIV, as well as present with faster diseas...


    pub_type: 杂志文章


    authors: Martin AR,Patel EU,Kirby C,Astemborski J,Kirk GD,Mehta SH,Marshall K,Janes H,Clayton A,Corey L,Hammer SM,Sobieszczyk ME,Arthos J,Cicala C,Redd AD,Quinn TC

    更新日期:2020-12-01 00:00:00

  • Therapeutic Targeting of Autophagy.

    abstract::Autophagy is a catabolic process that facilitates nutrient recycling via degradation of damaged organelles and proteins through lysosomal mediated degradation. Alterations in this complex, and tightly regulated process, lead to disease. Autophagy is widely accepted as cytoprotective against neurodegenerative diseases ...


    pub_type: 杂志文章,评审


    authors: Towers CG,Thorburn A

    更新日期:2016-12-01 00:00:00

  • Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice.

    abstract:BACKGROUND:The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to t...


    pub_type: 杂志文章


    authors: Kosztyu P,Kuchar M,Cerny J,Barkocziova L,Maly M,Petrokova H,Czernekova L,Liskova V,Raskova Kafkova L,Knotigova P,Masek J,Turanek J,Maly P,Raska M

    更新日期:2019-09-01 00:00:00

  • A prognostic gene expression signature for oropharyngeal squamous cell carcinoma.

    abstract:BACKGROUND:Robust prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is important for developing individualized treatment plans. This study was conducted to develop and validate a clinically feasible prognostic classifier based on transcriptome-wide gene expression profiles. METHO...


    pub_type: 杂志文章


    authors: Liu X,Liu P,Chernock RD,Kuhs KAL,Lewis JS Jr,Luo J,Gay HA,Thorstad WL,Wang X

    更新日期:2020-11-01 00:00:00

  • HIV Transmission Networks in the San Diego-Tijuana Border Region.

    abstract:BACKGROUND:HIV sequence data can be used to reconstruct local transmission networks. Along international borders, like the San Diego-Tijuana region, understanding the dynamics of HIV transmission across reported risks, racial/ethnic groups, and geography can help direct effective prevention efforts on both sides of the...


    pub_type: 杂志文章


    authors: Mehta SR,Wertheim JO,Brouwer KC,Wagner KD,Chaillon A,Strathdee S,Patterson TL,Rangel MG,Vargas M,Murrell B,Garfein R,Little SJ,Smith DM

    更新日期:2015-07-18 00:00:00

  • Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug.

    abstract::The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking alone. However, virtually all glioblastoma patients experience disease progression...


    pub_type: 杂志文章


    authors: Sharpe MA,Livingston AD,Gist TL,Ghosh P,Han J,Baskin DS

    更新日期:2015-08-08 00:00:00

  • Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

    abstract:BACKGROUND:Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) migh...


    pub_type: 杂志文章


    authors: Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z

    更新日期:2019-11-01 00:00:00

  • Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury.

    abstract::Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients ...


    pub_type: 杂志文章,多中心研究


    authors: Orešič M,Posti JP,Kamstrup-Nielsen MH,Takala RSK,Lingsma HF,Mattila I,Jäntti S,Katila AJ,Carpenter KLH,Ala-Seppälä H,Kyllönen A,Maanpää HR,Tallus J,Coles JP,Heino I,Frantzén J,Hutchinson PJ,Menon DK,Tenovuo O,Hyötyl

    更新日期:2016-10-01 00:00:00