Abstract:
:Left ventricular assist device (LVAD)-supported patients are evaluated routinely with use of transthoracic echocardiography. Values of left ventricular unloading in this unique patient population are needed to evaluate LVAD function and assist in patient follow-up. We introduce a new M-mode measurement, the slope of the anterior mitral valve leaflet (SLAM), and compare its efficacy with that of other standard echocardiographically evaluated values for left ventricular loading, including E/e' and pulmonary artery systolic pressures. Average SLAM values were determined retrospectively for cohorts of random, non-LVAD patients with moderately to severely impaired left ventricular ejection fraction (LVEF) (<0.35, n=60). In addition, pre- and post-LVAD implantation echocardiographic images of 81 patients were reviewed. The average SLAM in patients with an LVEF <0.35 was 11.6 cm/s (95% confidence interval, 10.4-12.8); SLAM had a moderately strong correlation with E/e' in these patients. Implantation of LVADs significantly increased the SLAM from 7.3 ± 2.44 to 14.7 ± 5.01 cm/s (n=42, P <0.0001). The LVAD-supported patients readmitted for exacerbation of congestive heart failure exhibited decreased SLAM from 12 ± 3.93 to 7.3 ± 3.5 cm/s (n=6, P=0.041). In addition, a cutpoint of 10 cm/s distinguished random patients with LVEF <0.35 from those in end-stage congestive heart failure (pre-LVAD) with an 88% sensitivity and a 55% specificity. Evaluating ventricular unloading in LVAD patients remains challenging. Our novel M-mode value correlates with echocardiographic values of left ventricular filling in patients with moderate-to-severe systolic function and dynamically improves with the ventricular unloading of an LVAD.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Martinez SC,Bradley EA,Novak EL,Rasalingam R,Cedars AM,Ewald GA,Silvestry SC,Joseph SMdoi
10.14503/THIJ-13-3604subject
Has Abstractpub_date
2014-06-01 00:00:00pages
262-72issue
3eissn
0730-2347issn
1526-6702journal_volume
41pub_type
杂志文章abstract::In pulmonary arterial hypertension, the blood vessels that carry blood between the heart and lungs are constricted, making it difficult for the heart to pump blood through the lungs. Prostacyclin, a prostanoid metabolized from endogenous arachidonic acid through the cyclooxygenase (COX) pathway, is a potent vasodilato...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::Anomalous origin of the left main coronary artery from the right sinus of Valsalva is extremely rare and can lead to sudden cardiac death. We report a case in which an 18-year-old college student collapsed immediately after a long-distance run of 10 km. After cardiopulmonary resuscitation and electrical shock for vent...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4249
更新日期:2015-12-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are thought to be associated with coronary artery disease. The association of these markers with incident coronary artery disease has not been well described. Using a case-cohort design, we selected 216 individuals who had inci...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Percutaneous coronary intervention in tortuous or calcified vessels poses a substantial challenge for interventional cardiologists. Many techniques have been described to overcome the challenge, including the use of stiffer wires, buddy wires, the anchor balloon technique, and deep seating of the guide catheter. Herei...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Understanding plaque formation in patients at risk for coronary artery disease-the leading cause of morbidity and death in the world-enables physicians to better determine whether and how to treat these individuals. We used computed tomographic angiography to quantitatively evaluate the progression of nonculprit coron...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-16-5805
更新日期:2017-10-01 00:00:00
abstract::Three groups of consecutive patients who had undergone primary elective coronary artery bypass operations were compared at 10 to 20 years of follow-up (mean, 13.6 years), in order to test the supposition that arterial conduits provide better long-term outcome than do the "standard" left internal mammary-to-left anteri...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::We report the case of a 65-year-old man who presented with an infrarenal aortic aneurysm in association with a congenital right pelvic kidney vascularized by 2 aortic arteries, 1 of which arose from the aneurysmal aorta and the other from the common right iliac artery. Successful surgery consisted of excising the aneu...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::We report a rare causal association between obstructed supracardiac totally anomalous pulmonary venous drainage and coronary sinus ostial atresia. Our 12-week-old patient developed venous myocardial infarction secondary to coronary venous hypertension because her sole route of coronary venous drainage was obstructed. ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4356
更新日期:2016-10-01 00:00:00
abstract::In selected patients, transcatheter closure of atrial septal defects with the AMPLATZER Septal Occluder has yielded excellent results. However, there is a slight risk of device embolization after deployment. We report the case of a 26-year-old woman in whom an embolized AMPLATZER device was retrieved percutaneously fr...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::A multidisciplinary team approach with focused objectives characterizes research at Baylor College of Medicine into the causes, prevention, and treatment of atherosclerotic disease. Current clinical activities range from programs to modify lifestyle for the primary prevention of coronary artery disease to a large, ang...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract::We report 4 consecutive cases in which the double-patch technique was used to repair an inferior postinfarction ventricular septal rupture. The ventricular septal perforation was closed directly by stitching, with the same sutures, 2 autologous pericardial patches onto both sides of the affected septum, through only a...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::As the indications for implanting left ventricular assist devices have expanded, some patients are qualifying for device removal after myocardial recovery. Whereas explantation has been described for previous generations of devices, no standard procedures have been developed. Removal of centrifugal-flow devices has cr...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-19-7097
更新日期:2020-08-01 00:00:00
abstract::Tricuspid regurgitation secondary to percutaneous lead extraction is uncommon, and it rarely requires surgical intervention. Most tricuspid regurgitation occurs during the implantation of tined leads, which can be entrapped in the tricuspid valve apparatus and may require immediate withdrawal. Severe tricuspid regurgi...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::Platelets play an important role in the development of acute coronary syndromes. Evidence indicates that platelet-inhibiting drugs, such as glycoprotein IIb/IIIa inhibitors, can be beneficial when they are administered at the time of primary percutaneous coronary intervention for acute ST-segment-elevation myocardial ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
abstract::We report the case of a patient with Alagille syndrome and severe pulmonary valve and bilateral pulmonary artery branch stenosis. In this patient, transcatheter balloon pulmonary valvuloplasty combined with bilateral pulmonary artery angioplasty and stent placement provided excellent immediate results and long-term im...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Lyme disease is the most prevalent tick-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi. Cardiac involvement is seen in 4% to 10% of patients with Lyme disease. The principal manifestation of Lyme carditis is self-limited conduction system disease, with predominant involvement o...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4126
更新日期:2015-06-01 00:00:00
abstract::The central question that faces coronary laser investigators is whether interaction between laser energy and target tissues can be controlled in a dynamic in vivo environment. In considering this question, the author reviews the in vitro and in vivo experiments that his center carried out before it began using laser a...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::This report summarizes results of the first 453 consecutive patients who had 491 low profile bioprostheses implanted at the Italian Hospital in Buenos Aires over a 5-year period. During this time, with the goal of long-term durability, the valve mounting technique was slightly modified, whereas the materials and desig...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract::Permanent junctional reciprocating tachycardia, or atrioventricular reentrant tachycardia utilizing a slowly conducting posteroseptal accessory pathway, is a rare form of reentrant supraventricular tachycardia in children and adults. The characteristic features of this narrow complex tachycardia are a long RP interval...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::From March 2004 through October 2007, we prospectively evaluated the benefits of cardiac resynchronization therapy as an adjunct to conventional procedures in patients who were undergoing surgery for heart failure.Twenty severely symptomatic patients (14 men and 6 women, with a mean age of 70 +/- 8 years) who displaye...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Unruptured aneurysms of the left sinus of Valsalva are extremely rare, and their clinical features are not well-documented in the literature. We describe an unusual case in which an unruptured aneurysm of the left sinus of Valsalva associated with previously undiagnosed Marfan syndrome caused extrinsic compression of ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::In spite of the efficacy of tricuspid annuloplasty, there remain occasional cases in which tricuspid valve replacement (TVR) is indicated. There is to date no late follow-up data on the Carpentier-Edwards porcine bioprosthesis (CEPB) in the tricuspid position. We present a series of twelve consecutive cases of TVR wit...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Our goal was to investigate the efficacy of degradable poly(D,L-lactic-coglycolic acid) (PLGA) scaffolds loaded with basic fibroblast growth factor (bFGF) in inducing cardiac neovascularization, increasing perfusion, and improving cardiac function.For ease of scaffold implantation into the ventricular wall, we develop...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::In order to determine the comparative merits of antegrade cardioplegia at moderate systemic hypothermia versus retrograde cardioplegia at systemic normothermia, we performed coronary artery bypass grafting using intermittent oxygenated blood cardioplegia in 2 sets of 50 consecutive patients with triple-vessel disease ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::We report a case of Carney's complex in a 12-year-old boy who had the characteristic features of multiple cutaneous tumors, pigmentation, and biatrial myxoma. His large right atrial myxoma almost occluded the tricuspid valve and presented a life-threatening emergency. Surgery saved his life, but recurrence of myxoma w...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::To evaluate the possibility of providing, in vitro, an endothelial lining for artificial hearts, we cultivated adult autologous endothelial cells on two polyurethane and two silicone rubber surfaces. Over the ensuing 11-day period, we investigated the resulting cell proliferation and morphology by means of scanning el...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::We report the cases of 2 patients who presented with clinical and echocardiographic evidence of cardiac tamponade. Therapeutic echocardiographic-guided pericardiocentesis yielded bloody fluid. In both patients, Definity perflutren lipid microspheres were used for echocardiographic contrast, which helped to assess the ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::A 55-year-old woman presented with dyspnea on exertion due to a right internal mammary artery-to-superior vena cava arteriovenous fistula that occurred after pacemaker lead extraction with a laser sheath. The fistula was successfully repaired by placing a covered stent in the right internal mammary artery. In this unu...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::We sought to compare outcomes in patients > or = 60 years of age with those of their younger counterparts who underwent ventricular assist device implantation intended as a bridge to cardiac transplantation and also to identify retrospectively additional pre- and postoperative factors that might portend adverse outcom...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic react...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,多中心研究
doi:10.14503/THIJ-16-6052
更新日期:2018-06-01 00:00:00