Abstract:
:To evaluate the possibility of providing, in vitro, an endothelial lining for artificial hearts, we cultivated adult autologous endothelial cells on two polyurethane and two silicone rubber surfaces. Over the ensuing 11-day period, we investigated the resulting cell proliferation and morphology by means of scanning electron and light microscopy. On the silicone rubber surfaces, seeding of 200,000 human saphenous vein endothelial cells per cm(2) produced an ideal cobblestone monolayer within a single day. In contrast, the polyurethane surfaces displayed an uneven, patchy distribution of endothelial cells. Scanning electron microscopy revealed microvilli and marginal overlapping in both groups. After the first day, the cell count on the polyurethane surfaces increased, whereas the count on the silicone rubber surfaces decreased. Morphologic investigations revealed that the ideally shaped cells initially on the silicone rubber had begun to overspread and subsequently to become detached, leaving denuded spheroid areas. Moreover, cultivation for 11 days on the polyurethane surfaces resulted in an unevenness of cell distribution that far exceeded the unevenness seen on the first day. Thus, despite the fact that materials with a high surface tension (such as silicone rubbers) seem to be ideal for initial cell spreading, subsequent cultivation results in cell detachment and death. On materials with a lower surface tension (such as polyurethanes), the less differentiated monolayers do at least proliferate, although their morphology remains unsatisfactory. Even if adult human endothelial cells should prove shear-stress-resistant, a minimum of 6 to 8 weeks would be required to establish autologous endothelial cell monolayers on the inner surface. Therefore, the endothelialization of artificial hearts is not possible when such hearts are used for urgent "bridging" before cardiac transplantation.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Fasol R,Zilla P,Deutsch M,Fischlein T,Kadletz M,Griesmacher A,Müller MMsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
119-26issue
2eissn
0730-2347issn
1526-6702journal_volume
14pub_type
杂志文章abstract::We report the case of a 14-year-old boy who developed ischemic contracture of the heart after open heart surgery to correct complex congenital heart disease. Because he had no cardiac function, an extracorporeal, continuous-flow device was used to support him until he was transferred to our institution. Shortly after ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Anomalous origin of the left main coronary artery from the right sinus of Valsalva is extremely rare and can lead to sudden cardiac death. We report a case in which an 18-year-old college student collapsed immediately after a long-distance run of 10 km. After cardiopulmonary resuscitation and electrical shock for vent...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4249
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-17-6521
更新日期:2019-06-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4296
更新日期:2015-06-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-13-3314
更新日期:2014-10-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-13-3727
更新日期:2015-04-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-18-6658
更新日期:2020-06-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-17-6190
更新日期:2017-10-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-13-3943
更新日期:2015-04-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4470
更新日期:2015-10-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00