Abstract:
:In order to determine the comparative merits of antegrade cardioplegia at moderate systemic hypothermia versus retrograde cardioplegia at systemic normothermia, we performed coronary artery bypass grafting using intermittent oxygenated blood cardioplegia in 2 sets of 50 consecutive patients with triple-vessel disease (complete occlusion of 1 coronary artery and greater than 90% narrowing of the other 2, with poor distal runoff). Group 1 had antegrade cardioplegia at moderate systemic hypothermia (28 degrees C). Group 2 had retrograde cardioplegia at systemic normothermia. This resulted in no deaths and in no differences in complication rates. Group 2's postoperative need for inotropic agents or vasodilators was significantly less (epinephrine, p < 0.0009; dopamine, p < 0.002; nitroglycerin, p < 0.001). Elevations of CKMB fraction were significantly more common in Group 1: 46% had CKMB levels greater than 9%, versus 16% of Group 2 patients (p < 0.0001). Intraoperative transesophageal echocardiography was performed in 39 Group-1 patients and in 42 Group-2 patients. Development of a new wall-motion abnormality after bypass was significantly only in Group 1 (p < 0.009, by chi 2 analysis). We conclude that retrograde cardioplegia at normothermia provides myocardial protection that equals or surpasses that of antegrade delivery at moderate systemic hypothermia, while avoiding the possible deleterious side effects of hypothermia.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Hoffman D,Fernandes S,Frater RW,Sisto Dsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
83-8issue
2eissn
0730-2347issn
1526-6702journal_volume
20pub_type
杂志文章abstract::The echocardiographic aspects of the coronary sinus have not received much attention in the literature. In the few published articles about anomalous venous connection to the coronary sinus, the parasternal long axis view has been suggested as ideal for its visualization. More recently, it has been suggested that the ...
journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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更新日期:2000-01-01 00:00:00
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journal_title:Texas Heart Institute journal
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更新日期:1982-06-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Texas Heart Institute journal
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更新日期:1984-06-01 00:00:00
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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更新日期:1998-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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