Abstract：
:The objective of this study was to determine the safety and feasibility of performing transendocardial electromechanical mapping and mesenchymal precursor stem cell injections after left ventricular assist device (LVAD) implantation in a sheep model of acute myocardial infarction. Six sheep were assigned to either an acute or chronic group. Then we created an acute myocardial infarction in each by occluding the distal left anterior descending coronary artery with a balloon for 90 minutes. All the sheep underwent LVAD implantation 30 days later. On the same day, sheep in the acute group underwent transendocardial cell injections and were euthanized. Sheep in the chronic group received cell injections 2 weeks after LVAD implantation and were euthanized 30 days later. The presence of the LVAD or the use of chest-closure wires did not interfere with electromechanical mapping. Furthermore, no adverse events were observed during electromechanical mapping or the stem cell injections. In all sheep, the LVAD flow rate was approximately 4 L/min during mapping and the injections, and no adjustments were required. Histologic analysis confirmed that the mesenchymal precursor stem cells were successfully delivered. No differences were observed between the acute and chronic groups. In conclusion, our study showed that transendocardial electromechanical mapping and stem cell injections are safe and feasible in the presence of an LVAD. Surgically implanted metal devices, including the LVAD, steel chest-closure wire, and skin staples, were compatible with the electromechanical mapping system.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Zheng Y,Sampaio LC,Li K,Silva GV,Cabreira-Hansen M,Vela D,Segura AM,Bovè C,Perin ECsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
229-34issue
3eissn
0730-2347issn
1526-6702journal_volume
40pub_type
杂志文章abstract：:Clostridium septicum infection is a rare cause of aortic dissection, and the mortality rate for the condition is high. Only 26 cases of C. septicum aortitis have been reported; all of those patients were elderly, and 20 of them had an associated colonic neoplasm. Herein, we present the case of a 22-year-old man whose ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:A few patients with traumatic aortic laceration remain undiagnosed and survive long enough to develop a chronic aneurysm. Such aneurysms are frequently asymptomatic; alternatively, they may manifest themselves in the form of chest pain, dysphonia, dysphagia, bronchial irritation, or sudden death. A case of aortobronch...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:We describe the single-stage surgical management of aortic coarctation and coronary artery disease in a 48-year-old man. Through a left thoracotomy, patch aortoplasty with a preserved bovine pericardial patch, and off-pump grafting of the circumflex and left anterior descending coronary arteries with a saphenous vein ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Massive isolated chylopericardium is a rare postoperative complication of coronary artery bypass surgery. In the following case, massive chylopericardium developed after a coronary artery bypass procedure in which the left internal mammary artery was used for revascularization. The chylopericardium resulted from direc...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Within a 40-month period ending in June 1992, we used the transseptal approach in performing mitral valve surgery on 18 patients. The patients selected had 1 or more of the following indications: small left atrium; adhesions from previous cardiac surgery or rheumatic activity; large, organized left atrial thrombus: th...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:We present a series of 4 patients in whom mechanical trauma was identified as a factor in the development of late complications after AneuRx Stent Graft placement for repair of abdominal aortic aneurysms. In all 4 patients, Type I or III endoleaks (and pseudoaneurysms in 2 patients) were discovered several months afte...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Few orthotopic heart transplantations have been performed in patients infected with the human immunodeficiency virus since the first such case was reported in 2001. Since that time, advances in highly active antiretroviral therapy have resulted in potent and durable suppression of the causative human immunodeficiency ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-14-4746
更新日期：2016-02-01 00:00:00
abstract：:We present the case of a 69-year-old man with a history of hypertension and a recent pelvic fracture who presented with acute chest pain, shortness of breath, and severe hypotension. The history of recent pelvic fracture and the clinical manifestations, including the sudden onset of acute respiratory distress, hypoten...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Malignant metastases to the heart and pericardium, which occur far more often than do primary cardiac neoplasms, typically lead to fatal outcomes. The phyllodes tumor is a rare, predominantly benign fibroepithelial breast neoplasm with variable malignancy potential. Herein, we describe the case of a 35-year-old woman ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Cardiac myxomas are primary cardiac tumors. In some cases of atrial myxoma, the standard left atriotomy alone does not enable safe tumor resection and easy access to the mitral valve. We report the cases of 2 patients with huge left atrial myxomas associated with severe mitral valve regurgitation who underwent an inve...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Lesions of the ascending aorta associated with aortic valve disease are usually treated by implanting a prosthetic valved conduit (Bentall procedure). In this report, we present our experience in which a valved homograft conduit was used for the procedure. Six patients underwent a Bentall procedure with the use of a c...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Many patients who undergo cardiac transplantation do so as a result of end-stage dilated cardiomyopathy (DC). Little is known about the causes of this condition, but long-term follow-up studies reveal a high incidence of DC in patients who have had acute viral myocarditis. The following article examines the role of my...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Treatment of total left main coronary artery occlusion is rarely reported (84 chronic and acute cases in the world literature), due to the high mortality rate from massive myocardial infarction. Acute occlusions have been treated with intracoronary streptokinase, with percutaneous transluminal coronary angioplasty, or...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Inferior vena cava filters are commonly used to prevent pulmonary embolism in patients who manifest deep vein thrombosis and recurrent pulmonary embolism despite anticoagulation, or in patients with contraindications to anticoagulation. We report the case of a 69-year-old man with a structurally normal heart who exper...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:A 60-year-old man with an acute inferior-wall myocardial infarction was noted, on arteriography, to have an occluded distal right coronary artery. The vessel was reopened with intravenous tissue plasminogen activator; during resolution of the clot, spasm was observed arteriographically but was successfully treated wit...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:This report describes the case of a 61-year-old woman who presented with dyspnea, aortic stenosis, and coronary artery disease-typical side effects of radiation therapy for Hodgkin lymphoma. A poor candidate for surgery, she underwent successful high-risk percutaneous coronary intervention and subsequent transcatheter...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-16-5806
更新日期：2016-08-01 00:00:00
abstract：:The pump's outflow connector of the Novel Left Ventricular Assist System I (Novel LVAS I) has been redesigned to be sutured to the infrarenal abdominal aorta either as a procedure of choice (due to its simplicity) or as an alternative in the presence of an unhealthy descending thoracic aorta. The implantation of the N...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:We reviewed the cases of 100 patients (mean age, 73 ± 10 yr; 64 men) who had mitral valve replacement with a Medtronic Mosaic porcine bioprosthesis from 1995 through 2011. The mean New York Heart Association (NYHA) class was 3 ± 0.7, and 52 patients were in atrial fibrillation. Prosthetic sizes were chiefly 27 mm (50 ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-14-4407
更新日期：2016-02-01 00:00:00
abstract：:The rupture of a mycotic femoral artery pseudoaneurysm in an intravenous drug abuser is a limb- and life-threatening condition that necessitates emergency intervention. Emergency stent-grafting appears to be a viable, minimally invasive alternative, or a bridge, to subsequent open surgery. Caution is required in cases...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3882
更新日期：2014-12-01 00:00:00
abstract：:Clinically encouraging results can be obtained with an intravenous high dosage, short-term infusion of streptokinase in patients with evolving myocardial infarction. The feasibility and efficacy of the systemic approach of streptokinase therapy is discussed in this report and includes topics such as recanalization suc...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:During the management of acute myocardial infarction, we observed that clinical and electrocardiographic indications of myocardial ischemia worsened upon nitroglycerin infusion and were promptly relieved upon streptokinase infusion. Subsequent coronary angiography revealed diffuse ectasia with no significant stenosis....
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:A 28-year-old man, who presented with pleural and pericardial chylous effusion secondary to superior vena cava syndrome, was diagnosed with Behcet's syndrome. A pericardial window was created by video-assisted thoracic surgery to relieve cardiac tamponade, and this technique also enabled lung biopsy, pleural abrasion,...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Minimally invasive cardiac surgery is rapidly gaining interest because of fast recovery, reduced morbidity, shorter hospital stay, lower costs, and better cosmetic results. Aortic valve surgery can be performed through a small (10- to 12-cm) transverse sternal incision, and femoro-femoral cannulation is used for cardi...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The efficiency and risks of a method that allows closed-chest decannulation of an intraoperatively inserted cardiac-assist balloon catheter are examined. The technique involves direct insertion of the balloon catheter into the ascending aorta under the protection of an indwelling silastic tourniquet. At the discretion...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Ischemic mitral regurgitation, a complication of myocardial infarction, is associated with a poor prognosis and can result in postinfarction congestive heart failure. The preferred treatment of its chronic form is a matter of debate. Herein, we report the early and midterm results in 44 patients with chronic ischemic ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The introduction of percutaneous ablative treatments for atrial fibrillation led to new information regarding the region of the left atrium and pulmonary veins, which electrophysiologists had previously overlooked. Initially, procedures for treating atrial fibrillation involved ablation and then the isolation of speci...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The aim of the study was to investigate, in adult patients after successful repair of aortic coarctation, potential relationships between B-type natriuretic peptide levels and exercise capacity and the following factors: arterial hypertension, residual stenosis of the ascending aorta, and age at the time of surgery. T...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Because of the rarity of isolated, nonrheumatic, noninfective tricuspid valvular disease, the long-term results of treatment by tricuspid valve replacement are uncertain. From June 1967 to April 1986, we implanted 23 biological or mechanical tricuspid valve prostheses in 20 patients for nonrheumatic, noninfective endo...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:One-stage surgery was successfully performed in a 44-year-old hypertensive man with uncontrolled angina, multiple coarctations of the thoracic and abdominal aorta, and a previous subtotal gastrectomy. There was a gradient of 120 mm Hg between the thoracic and abdominal aorta. A graft was placed retroperitoneally from ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Atrial fibrillation is the most common sustained arrhythmia, increases with age, and presents with a wide spectrum of symptoms and severity Paroxysmal, persistent, and permanent forms require very individualized approaches to management. New information about electrical and anatomic remodeling emphasizes the importanc...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
