Quantitative Evaluation of Coronary Plaque Progression by Computed Tomographic Angiography.

Abstract:

:Understanding plaque formation in patients at risk for coronary artery disease-the leading cause of morbidity and death in the world-enables physicians to better determine whether and how to treat these individuals. We used computed tomographic angiography to quantitatively evaluate the progression of nonculprit coronary plaques along the full length of the right coronary artery in 21 patients with acute coronary syndrome. Each right coronary artery was analyzed in sequential, 3-mm-long segments, and the minimum luminal area, plaque burden, and plaque volume within each segment were evaluated at baseline and at 12-month follow-up. Serial remodeling of the right coronary artery was also evaluated. In total, 625 arterial segments were analyzed. At 12-month follow-up, the plaque burden had increased slightly by 0.34% (interquartile range [IQR], -4.32% to 6.35%; P=0.02), and the plaque volume was not significantly changed (0.33 mm3; IQR, -3.05 to 3.54; P=0.213). The minimum luminal area decreased 0.05 mm2 (IQR, -1.33 to 0.87 mm2; P=0.012), and this was accompanied by vessel reduction, as evidenced by negative remodeling in 43% of the 625 segments. We conclude that serial computed tomographic angiography can be used to quantitatively evaluate the morphologic progression of coronary plaques.

journal_name

Tex Heart Inst J

authors

Liu X,Wu G,Xu C,He Y,Shu L,Liu Y,Zhang N,Lin C

doi

10.14503/THIJ-16-5805

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

312-319

issue

5

eissn

0730-2347

issn

1526-6702

journal_volume

44

pub_type

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