Abstract:
:Our goal was to investigate the efficacy of degradable poly(D,L-lactic-coglycolic acid) (PLGA) scaffolds loaded with basic fibroblast growth factor (bFGF) in inducing cardiac neovascularization, increasing perfusion, and improving cardiac function.For ease of scaffold implantation into the ventricular wall, we developed a channel-producing device. Mini-swine, established as the animal model, were grouped as follows: channels-alone (control) group, channels and blank scaffolds (CBS) group, and channels and bFGF-incorporating scaffolds (CFS) group. Two scaffolds were implanted in each animal in the CBS and CFS groups. Six weeks postoperatively, endothelial cells were immunohistologically stained for von Willebrand factor, and proliferating cells for Ki-67 antigen. The density of new vessels was counted by image-analysis software. Left ventricular function and myocardial perfusion were documented by echocardiography and nuclear scanning, respectively, before implantation and 6 weeks postoperatively.The combined application of PLGA and bFGF ensured sustained release of growth factor in the target region. In the CFS group, Ki-67-positively stained cells, vascular density, and perfusion-defect percentage all showed significant improvement (P < 0.001), compared with the control and CBS groups, which did not. Moreover, the left ventricular fractional shortening percentage in the CFS group (28.98% +/- 1.24%) showed a significant increase, compared with the control group (26.57% +/- 1.92%, P = 0.009) and the CBS group (27.11% +/- 0.71%, P = 0.033), neither of which showed a difference (P = 0.508).The bFGF-incorporating PLGA scaffold can promote neovascular formation, enhance blood-flow perfusion, and improve myocardial function, although the original scaffold lumina were eventually occluded by inflammatory cells and scar tissue.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Wang Y,Liu XC,Zhao J,Kong XR,Shi RF,Zhao XB,Song CX,Liu TJ,Lu Fsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
89-97issue
2eissn
0730-2347issn
1526-6702journal_volume
36pub_type
杂志文章abstract::Sickle cell disease is a risk factor for cerebrovascular accidents in the pediatric population. This risk is compounded by hypoxemia. Cyanotic congenital heart disease can expose patients to prolonged hypoxemia. To our knowledge, the long-term outcome of patients who have combined sickle cell and cyanotic congenital h...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-15-5610
更新日期:2016-12-01 00:00:00
abstract::Because of physiologic R-R interval variability and arrhythmia, frame-mode acquisition of gated images may produce erroneous left ventricular volume curves, particularly in the diastolic filling phase. Eighteen patients in sinus rhythm underwent gated imaging in which both frame-mode and list-mode acquisitions were us...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Few reported cases document injury to the circumflex coronary artery secondary to repair of the mitral valve annulus. This potentially life-threatening sequela must be considered during mitral valve repair. In an effort to increase awareness of this sequela, we present the case of a patient who experienced a periopera...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::From January 2002 through June 2004, 17 patients (2% of all coronary cases) were treated with off-pump coronary artery bypass grafting combined with percutaneous coronary intervention. There were 13 men and 4 women, whose ages ranged from 54 to 78 years (mean, 63.1 +/- 20.9 yr). Preoperative angiography revealed 2-ves...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::The efficiency and risks of a method that allows closed-chest decannulation of an intraoperatively inserted cardiac-assist balloon catheter are examined. The technique involves direct insertion of the balloon catheter into the ascending aorta under the protection of an indwelling silastic tourniquet. At the discretion...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::The pump's outflow connector of the Novel Left Ventricular Assist System I (Novel LVAS I) has been redesigned to be sutured to the infrarenal abdominal aorta either as a procedure of choice (due to its simplicity) or as an alternative in the presence of an unhealthy descending thoracic aorta. The implantation of the N...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Malignant metastases to the heart and pericardium, which occur far more often than do primary cardiac neoplasms, typically lead to fatal outcomes. The phyllodes tumor is a rare, predominantly benign fibroepithelial breast neoplasm with variable malignancy potential. Herein, we describe the case of a 35-year-old woman ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::The preservation of pleural integrity during mammary artery harvesting may decrease atelectasis and pleural effusion during the postoperative period. We designed this retrospective study to evaluate the effects on postoperative pulmonary function of pleural integrity versus opened pleura, in patients who receive a lef...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Disease or dysfunction of the aortic valve in pediatric patients presents a substantial challenge. Valve preservation, even if not the definitive solution, is always optimal. Successful repair will enable somatic growth and avoid repeated valve replacement and the need for systemic anticoagulation. When repair of the ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::During an 11-year period ending January 1, 1985, 352 patients had insertions of an intraaortic balloon pump (IABP) as an adjunct to medical or surgical therapy. Group I, 175 patients, could not be weaned from cardiopulmonary bypass and required intraaortic balloon pump (IABP). Thirty-nine patients (22%) died in the op...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract::Because of the rarity of isolated, nonrheumatic, noninfective tricuspid valvular disease, the long-term results of treatment by tricuspid valve replacement are uncertain. From June 1967 to April 1986, we implanted 23 biological or mechanical tricuspid valve prostheses in 20 patients for nonrheumatic, noninfective endo...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::In this study, we retrospectively analyzed the outcomes of adults with bicuspid aortic valve (BAV) disease who underwent aortic valve reconstructive surgery (AVRS), consisting of replacement of the diseased BAV with 2 or 3 pericardial leaflets plus fixation of the sinotubular junction for accurate and constant leaflet...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-13-3619
更新日期:2014-12-01 00:00:00
abstract::Thrombosis involving a permanent infusion catheter in the subclavian vein and superior vena cava is relatively common, especially in cancer patients. Edema of the arms and head is a well-known clinical consequence of this thrombosis, with an intrinsic risk of pulmonary embolism; however, systemic embolization into the...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::We report on a case of premature atherosclerosis in a patient with short stature, dysmorphic features, mild diabetes mellitus, hypertriglyceridemia, Mönckeberg's sclerosis, and the general appearance of premature aging, compatible with the diagnosis of Werner's Syndrome. The patient was referred to us after suffering ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Permanent junctional reciprocating tachycardia, or atrioventricular reentrant tachycardia utilizing a slowly conducting posteroseptal accessory pathway, is a rare form of reentrant supraventricular tachycardia in children and adults. The characteristic features of this narrow complex tachycardia are a long RP interval...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::We describe our experience with the transseptal approach for mitral valve replacement, a technique that we applied especially in cases of 3rd and 4th operations wherein numerous adhesions made the usual left atrial approach difficult. We report 39 cases of mitral procedures in which we used 3 slightly different transs...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::To evaluate the possibility of providing, in vitro, an endothelial lining for artificial hearts, we cultivated adult autologous endothelial cells on two polyurethane and two silicone rubber surfaces. Over the ensuing 11-day period, we investigated the resulting cell proliferation and morphology by means of scanning el...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::In this report, 24 patients with partial anomalous pulmonary venous return were reviewed. Six of the eight patients with left-sided drainage were repaired without extracorporeal circulation by anastomosing the left-sided vein to the left atrium. Symptoms resolved in five of the six. Two of the eight were surgically re...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::In pulmonary arterial hypertension, the blood vessels that carry blood between the heart and lungs are constricted, making it difficult for the heart to pump blood through the lungs. Prostacyclin, a prostanoid metabolized from endogenous arachidonic acid through the cyclooxygenase (COX) pathway, is a potent vasodilato...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::We discuss the case of a 38-year-old black man who presented at our hospital with his first episode of syncope, recently developed atrial arrhythmias refractory to pharmacologic therapy, and a left atrial thrombus. He was diagnosed with primary cardiac sarcoidosis characterized by predominant involvement of the epicar...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章,评审
doi:10.14503/THIJ-14-4792
更新日期:2016-06-01 00:00:00
abstract::A 58-year-old man presented with chest pain and tightness and was diagnosed with a Q-wave anterior myocardial infarction. He then developed pulseless ventricular arrhythmias, which were treated with repeated direct-current shocks and intravenous amiodarone. He underwent emergency cardiac catheterization: stents were d...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::One-stage surgery was successfully performed in a 44-year-old hypertensive man with uncontrolled angina, multiple coarctations of the thoracic and abdominal aorta, and a previous subtotal gastrectomy. There was a gradient of 120 mm Hg between the thoracic and abdominal aorta. A graft was placed retroperitoneally from ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::A 36-year-old, otherwise-healthy woman with a 6-year history of progressive dysphagia underwent an esophagogram that revealed an oblique extrinsic defect with an inferior-to-superior (left-to-right) course consistent with an aberrant right subclavian artery. An aortogram confirmed the diagnosis of aberrant right subcl...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Inferior vena cava filters are commonly used to prevent pulmonary embolism in patients who manifest deep vein thrombosis and recurrent pulmonary embolism despite anticoagulation, or in patients with contraindications to anticoagulation. We report the case of a 69-year-old man with a structurally normal heart who exper...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::From January of 1984 through December of 1990, we implanted 739 Pop De Popa wild boar aortic valves in 626 patients, in all cardiac valvular positions. Of these patients, 562 received only the Pop De Popa xenobioprostheses, which numbered 620 valves. Only patients with contraindications for bioprosthetic valves (such ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Three patients with ventricular septal defect and coarctation of the aorta were treated successfully by simultaneous correction of both anomalies through a single incision via a left transsternal anterolateral thoracotomy. (Texas Heart Institute Journal 1994; 21:158-60) ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Right ventricular failure secondary to pulmonary embolism is associated with morbidity and death. The Impella RP System has often been used for percutaneous mechanical circulatory support in patients with right ventricular failure from other causes, including myocardial infarction, cardiac surgery, and left ventricula...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-17-6316
更新日期:2018-06-01 00:00:00
abstract::In this case report, we describe direct percutaneous delivery of a muscular-ventricular-septal-defect occluder device to close a left ventricular pseudoaneurysm. The occluder was positioned and deployed with the aid of concurrent transthoracic ultrasonography, transesophageal echocardiography, and fluoroscopy. In cont...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-14-4243
更新日期:2015-08-01 00:00:00
abstract::Surgically created arteriovenous fistulae (AVF) for hemodialysis can contribute to hemodynamic changes. We describe the cases of 2 male patients in whom new right ventricular enlargement developed after an AVF was created for hemodialysis. Patient 1 sustained high-output heart failure solely attributable to the AVF. A...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-15-5353
更新日期:2016-08-01 00:00:00
abstract::Atrioventricular septal defects represent a class of congenital cardiac malformations that vary in presentation and management strategy depending upon the severity of the particular lesions present. We present the case of a premature neonate who had a partial atrioventricular septal defect and an accessory mitral (or ...
journal_title:Texas Heart Institute journal
pub_type: 杂志文章
doi:10.14503/THIJ-15-5675
更新日期:2016-12-01 00:00:00