Abstract：
:Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress-precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors. We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044-1.867; P <0.05) indicated that G6PD-deficient individuals have 39.6% greater odds of developing cardiovascular disease than do those with normal levels. Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Thomas JE,Kang S,Wyatt CJ,Kim FS,Mangelsdorff AD,Weigel FKdoi
10.14503/THIJ-16-6052subject
Has Abstractpub_date
2018-06-01 00:00:00pages
144-150issue
3eissn
0730-2347issn
1526-6702journal_volume
45pub_type
杂志文章,多中心研究abstract：:A 49-year-old patient, referred with a diagnosis of right atrial myxoma, was found at surgery to have extensive cardiac metastases from a previously undetected cutaneous melanoma. In reviewing the literature, we found 5 other patients with a clinical diagnosis of melanoma metastatic to the heart, all of whom had a pre...
journal_title：Texas Heart Institute journal
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journal_title：Texas Heart Institute journal
pub_type： 杂志文章
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journal_title：Texas Heart Institute journal
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更新日期：1994-01-01 00:00:00
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更新日期：2004-01-01 00:00:00
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更新日期：2008-01-01 00:00:00
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journal_title：Texas Heart Institute journal
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journal_title：Texas Heart Institute journal
pub_type： 杂志文章
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journal_title：Texas Heart Institute journal
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更新日期：2012-01-01 00:00:00
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